KEGG   PATHWAY: cjc04713
Entry
cjc04713                    Pathway                                
Name
Circadian entrainment - Callithrix jacchus (white-tufted-ear marmoset)
Description
Circadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhythms are synchronized to environmental cues. In mammals, a master clock is located in the suprachiasmatic nuclei (SCN) of the hypothalamus and may synchronize circadian oscillators in peripheral tissues. Light signal is the dominant synchronizer for master SCN clock. Downstream from the retina, glutamate and PACAP are released and trigger the activation of signal transduction cascades, including CamKII and nNOS activity, cAMP- and cGMP-dependent protein kinases, and mitogen-activated protein kinase (MAPK). Of non-photic entrainment, important phase shifting capabilities have been found for melatonin, which inhibits light-induced phase shifts through inhibition of adenylate cyclase (AC). Multiple entrainment pathways converge into CREB regulation. In turn, phosphorylated CREB activates clock gene expression.
Class
Organismal Systems; Environmental adaptation
Pathway map
cjc04713  Circadian entrainment
cjc04713

Other DBs
GO: 0009649
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100413857  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100411569  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
100415252  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
100388195  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X4 [KO:K05211]
100401859  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
100390180  CALM1; calmodulin-1 [KO:K02183]
100386819  CALM2; calmodulin-2 isoform X2 [KO:K02183]
100406081  CALM3; calmodulin-3 [KO:K02183]
100408289  CALML3; calmodulin-like protein 3 [KO:K02183]
100392199  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100396690  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
108592443  CALML5; calmodulin-like protein 5 [KO:K02183]
118148021  calmodulin-1-like [KO:K02183]
100397956  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9 [KO:K04515] [EC:2.7.11.17]
100405903  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100391424  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
100390938  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100410352  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4 [KO:K04515] [EC:2.7.11.17]
100895717  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100411926  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
100407681  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100385763  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100390843  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100405957  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
100406916  RYR2; ryanodine receptor 2 isoform X7 [KO:K04962]
100397905  RYR3; ryanodine receptor 3 isoform X6 [KO:K04963]
100390463  uncharacterized protein C1orf226 isoform X11 [KO:K16513]
100402942  RASD1; dexamethasone-induced Ras-related protein 1 isoform X1 [KO:K07843]
100404474  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100405745  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630]
100388113  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100389396  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100412968  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2 [KO:K04536]
100395033  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100407336  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100395633  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
100415506  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X2 [KO:K04539]
100391372  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100397915  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100411028  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103787193  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108590740  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
108593490  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118150544  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
128930422  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100411155  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
108589488  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100385281  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
108588980  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
100412160  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100396640  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100394978  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108594009  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100412503  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100394732  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100389125  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
100392029  GRIA2; glutamate receptor 2 isoform X2 [KO:K05198]
100399063  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100398622  GRIA4; glutamate receptor 4 isoform X4 [KO:K05200]
100415104  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X10 [KO:K04854]
100408935  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X6 [KO:K04855]
100401632  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
100390670  ADCYAP1; pituitary adenylate cyclase-activating polypeptide isoform X3 [KO:K05262]
100387025  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
100408515  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
103787209  neuroendocrine secretory protein 55 [KO:K04632]
100394265  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100385658  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100415165  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100415141  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100412782  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100406617  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100404620  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100404484  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100405403  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100411024  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
100392123  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100408115  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
100407692  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100400737  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100409206  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
118151333  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
100396127  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X2 [KO:K12318] [EC:4.6.1.2]
100387768  GUCY1A2; guanylate cyclase soluble subunit alpha-2 isoform X2 [KO:K12318] [EC:4.6.1.2]
100395297  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
100390920  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
100388016  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
100384937  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
100406735  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X36 [KO:K04850]
100397940  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
100393341  MTNR1B; LOW QUALITY PROTEIN: melatonin receptor type 1B [KO:K04286]
100408854  MTNR1A; melatonin receptor type 1A [KO:K04285]
100403006  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
100400803  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100386921  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100409716  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100410075  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100410336  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X2 [KO:K04997]
100412518  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
100389403  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
100401709  KCNJ9; G protein-activated inward rectifier potassium channel 3 isoform X1 [KO:K05002]
100390005  PER1; period circadian protein homolog 1 isoform X1 [KO:K21944]
100410942  PER2; period circadian protein homolog 2 isoform X2 [KO:K02633]
100394501  PER3; period circadian protein homolog 3 isoform X3 [KO:K21945]
100390054  FOS; protein c-Fos [KO:K04379]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00238  Potassium cation
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01330  Sodium cation
C01598  Melatonin
Reference
PMID:17646042
  Authors
Brown TM, Piggins HD
  Title
Electrophysiology of the suprachiasmatic circadian clock.
  Journal
Prog Neurobiol 82:229-55 (2007)
DOI:10.1016/j.pneurobio.2007.05.002
Reference
PMID:19109992
  Authors
Dickson L, Finlayson K
  Title
VPAC and PAC receptors: From ligands to function.
  Journal
Pharmacol Ther 121:294-316 (2009)
DOI:10.1016/j.pharmthera.2008.11.006
Reference
PMID:20664079
  Authors
Golombek DA, Rosenstein RE
  Title
Physiology of circadian entrainment.
  Journal
Physiol Rev 90:1063-102 (2010)
DOI:10.1152/physrev.00009.2009
Reference
PMID:16217123
  Authors
Dubocovich ML, Markowska M
  Title
Functional MT1 and MT2 melatonin receptors in mammals.
  Journal
Endocrine 27:101-10 (2005)
DOI:10.1385/ENDO:27:2:101
Reference
PMID:20605968
  Authors
Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J
  Title
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors.
  Journal
Pharmacol Rev 62:343-80 (2010)
DOI:10.1124/pr.110.002832
Reference
PMID:19449447
  Authors
Hardeland R
  Title
Melatonin: signaling mechanisms of a pleiotropic agent.
  Journal
Biofactors 35:183-92 (2009)
DOI:10.1002/biof.23
Reference
PMID:12700026
  Authors
Golombek DA, Ferreyra GA, Agostino PV, Murad AD, Rubio MF, Pizzio GA, Katz ME, Marpegan L, Bekinschtein TA
  Title
From light to genes: moving the hands of the circadian clock.
  Journal
Front Biosci 8:s285-93 (2003)
DOI:10.2741/1038
Reference
PMID:17586087
  Authors
Mertens I, Husson SJ, Janssen T, Lindemans M, Schoofs L
  Title
PACAP and PDF signaling in the regulation of mammalian and insect circadian rhythms.
  Journal
Peptides 28:1775-83 (2007)
DOI:10.1016/j.peptides.2007.05.005
Reference
PMID:15813931
  Authors
Kim DY, Choi HJ, Kim JS, Kim YS, Jeong DU, Shin HC, Kim MJ, Han HC, Hong SK, Kim YI
  Title
Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock.
  Journal
Eur J Neurosci 21:1215-22 (2005)
DOI:10.1111/j.1460-9568.2005.03950.x
Reference
PMID:15016477
  Authors
Agostino PV, Ferreyra GA, Murad AD, Watanabe Y, Golombek DA
  Title
Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.
  Journal
Neurochem Int 44:617-25 (2004)
DOI:10.1016/j.neuint.2003.09.005
Reference
PMID:11294753
  Authors
Ferreyra GA, Golombek DA
  Title
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
  Journal
Am J Physiol Regul Integr Comp Physiol 280:R1348-55 (2001)
DOI:10.1152/ajpregu.2001.280.5.R1348
Reference
PMID:15930378
  Authors
Butcher GQ, Lee B, Cheng HY, Obrietan K
  Title
Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism.
  Journal
J Neurosci 25:5305-13 (2005)
DOI:10.1523/JNEUROSCI.4361-04.2005
Reference
PMID:10446325
  Authors
Hamada T, Niki T, Ziging P, Sugiyama T, Watanabe S, Mikoshiba K, Ishida N
  Title
Differential expression patterns of inositol trisphosphate receptor types 1 and 3 in the rat suprachiasmatic nucleus.
  Journal
Brain Res 838:131-5 (1999)
DOI:10.1016/S0006-8993(99)01719-9
Reference
PMID:10208575
  Authors
Diaz-Munoz M, Dent MA, Granados-Fuentes D, Hall AC, Hernandez-Cruz A, Harrington ME, Aguilar-Roblero R
  Title
Circadian modulation of the ryanodine receptor type 2 in the SCN of rodents.
  Journal
Neuroreport 10:481-6 (1999)
DOI:10.1097/00001756-199902250-00007
Reference
PMID:11086993
  Authors
Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH
  Title
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.
  Journal
Neuron 28:183-93 (2000)
DOI:10.1016/S0896-6273(00)00095-7
Reference
PMID:12573527
  Authors
Takahashi H, Umeda N, Tsutsumi Y, Fukumura R, Ohkaze H, Sujino M, van der Horst G, Yasui A, Inouye ST, Fujimori A, Ohhata T, Araki R, Abe M
  Title
Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus.
  Journal
Brain Res Mol Brain Res 110:1-6 (2003)
DOI:10.1016/S0169-328X(02)00543-0
Reference
PMID:17167088
  Authors
Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K
  Title
The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.
  Journal
J Neurosci 26:12984-95 (2006)
DOI:10.1523/JNEUROSCI.4253-06.2006
Related
pathway
cjc04010  MAPK signaling pathway
cjc04710  Circadian rhythm
KO pathway
ko04713   
LinkDB

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