KEGG   PATHWAY: csab04640
Entry
csab04640                   Pathway                                
Name
Hematopoietic cell lineage - Chlorocebus sabaeus (green monkey)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
csab04640  Hematopoietic cell lineage
csab04640

Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103238826  KITLG; KIT ligand [KO:K05461]
103237005  IL7; interleukin 7 [KO:K05431]
103244520  IL4; interleukin 4 [KO:K05430]
103244503  CSF2; colony stimulating factor 2 [KO:K05427]
103235035  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
103244512  IL5; interleukin 5 [KO:K05428]
103243524  CSF3; colony stimulating factor 3 [KO:K05423]
103244501  IL3; interleukin 3 [KO:K04736]
103226390  IL6; interleukin 6 [KO:K05405]
103235305  IL11; interleukin 11 [KO:K05417]
103241279  IL1A; interleukin 1 alpha [KO:K04383]
103241278  IL1B; interleukin 1 beta [KO:K04519]
103224269  CSF1; colony stimulating factor 1 [KO:K05453]
103246719  EPO; erythropoietin [KO:K05437]
103221127  THPO; thrombopoietin [KO:K06854]
103230170  CD34; CD34 molecule [KO:K06474]
103249072  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
103216324  DNTT; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
103221682  MHC-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
103221683  MHC-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
103221684  MHC-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
103221688  MHC-DMA; HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
103221689  MHC-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
103221695  MHC-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
103221696  MHC-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
103221698  MHC-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
103221700  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
103221702  HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752]
103221704  MHC-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
103247136  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
103247138  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
103247148  HLA class II histocompatibility antigen, DRB1-15 beta chain [KO:K06752]
103237736  CD44; CD44 molecule (Indian blood group) [KO:K06256]
103235672  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
103237839  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
103215123  IL7R; interleukin 7 receptor [KO:K05072]
103242011  TFRC; transferrin receptor [KO:K06503]
103246326  CD38; CD38 molecule [KO:K01242] [EC:3.2.2.6 2.4.99.20]
103243765  CD7; CD7 molecule [KO:K06457]
103224135  CD2; CD2 molecule [KO:K06449]
103234563  CD5; CD5 molecule [KO:K06455]
103223791  CD1E; CD1e molecule [KO:K06448]
103223792  CD1B; CD1b molecule [KO:K06448]
103223793  CD1C; CD1c molecule [KO:K06448]
103223794  T-cell surface glycoprotein CD1a [KO:K06448]
103223798  CD1D; CD1d molecule [KO:K06448]
103225866  T-cell surface glycoprotein CD1a-like [KO:K06448]
103218480  CD4; CD4 molecule [KO:K06454]
103241361  CD8A; CD8a molecule [KO:K06458]
103241359  CD8B; CD8b molecule [KO:K06459]
103248585  CD3D; CD3d molecule [KO:K06450]
103248584  CD3E; CD3e molecule [KO:K06451]
103248587  CD3G; CD3g molecule [KO:K06452]
103241443  MME; membrane metalloendopeptidase [KO:K01389] [EC:3.4.24.11]
103218443  CD9; CD9 molecule [KO:K06460]
103231655  B-lymphocyte antigen CD19 [KO:K06465]
103230281  B-lymphocyte antigen CD19-like [KO:K06465]
103234504  CD22; CD22 molecule [KO:K06467]
103240638  CD24; CD24 molecule [KO:K06469]
103234713  MS4A1; membrane spanning 4-domains A1 [KO:K06466]
103230175  CR2; complement C3d receptor 2 [KO:K04012]
103235028  CD37; CD37 molecule [KO:K06475]
103229828  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103224088  uncharacterized LOC103224088 [KO:K06856]
103229820  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229838  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229839  uncharacterized LOC103229839 [KO:K06856]
103229845  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229849  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229850  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229864  uncharacterized LOC103229864 [KO:K06856]
103247608  uncharacterized LOC103247608 [KO:K06856]
103229935  uncharacterized LOC103229935 [KO:K06856]
103229939  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229942  uncharacterized LOC103229942 [KO:K06856]
103229943  uncharacterized LOC103229943 [KO:K06856]
103233811  FCER2; Fc fragment of IgE receptor II [KO:K06468]
103230172  CR1L; complement C3b/C4b receptor 1 like [KO:K04011]
103231020  CR1; complement C3b/C4b receptor 1 (Knops blood group) [KO:K04011]
103247514  CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066]
103247515  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
103235122  CD33; CD33 molecule [KO:K06473]
103230069  IL4R; interleukin 4 receptor [KO:K05071]
103223920  IL6R; interleukin 6 receptor [KO:K05055]
103247163  high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
103244788  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103231162  ANPEP; alanyl aminopeptidase, membrane [KO:K11140] [EC:3.4.11.2]
103231383  ITGAM; integrin subunit alpha M [KO:K06461]
103244663  CD14; CD14 molecule [KO:K04391]
103232867  IL9R; interleukin 9 receptor [KO:K05073]
103241149  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
103241146  IL1R2; interleukin 1 receptor type 2 [KO:K04387]
103225104  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
103227929  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
103233928  EPOR; erythropoietin receptor [KO:K05079]
103226648  CD36; CD36 molecule [KO:K06259]
103236316  GYPA; glycophorin A (MNS blood group) [KO:K06575]
103230176  CD55; CD55 molecule (Cromer blood group) [KO:K04006]
103237990  CD59; CD59 molecule [KO:K04008]
103219253  IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
103243277  ITGB3; integrin subunit beta 3 [KO:K06493]
103243322  ITGA2B; integrin subunit alpha 2b [KO:K06476]
103228081  GP9; glycoprotein IX platelet [KO:K06263]
103242552  GP1BA; glycoprotein Ib platelet alpha subunit [KO:K06261]
103222996  GP1BB; glycoprotein Ib platelet beta subunit [KO:K06262]
103241942  GP5; glycoprotein V platelet [KO:K06260]
103221277  ITGA1; integrin subunit alpha 1 [KO:K06480]
103221285  ITGA2; integrin subunit alpha 2 [KO:K06481]
103242953  ITGA3; integrin subunit alpha 3 [KO:K06482]
103217451  ITGA4; integrin subunit alpha 4 [KO:K06483]
103238438  ITGA5; integrin subunit alpha 5 [KO:K06484]
103217327  ITGA6; integrin subunit alpha 6 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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