KEGG   PATHWAY: dnm04145
Entry
dnm04145                    Pathway                                
Name
Phagosome - Dasypus novemcinctus (nine-banded armadillo)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
dnm04145  Phagosome
dnm04145

Other DBs
GO: 0045335
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101417693  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
101435280  STX12; syntaxin-12 [KO:K13813]
101417223  STX7; syntaxin-7 [KO:K08488]
101419023  actin, cytoplasmic 1 [KO:K05692]
101428967  actin, cytoplasmic 1-like [KO:K05692]
101440550  LOW QUALITY PROTEIN: actin, clone 302-like [KO:K05692]
101442163  actin, clone 302-like [KO:K05692]
101411761  actin, clone 302-like [KO:K05692]
101432418  CORO1A; coronin-1A [KO:K13882]
101420872  STX18; LOW QUALITY PROTEIN: syntaxin-18 [KO:K08492]
101438633  LOW QUALITY PROTEIN: vesicle-trafficking protein SEC22b [KO:K08517]
101428513  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
101420800  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101415823  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101418741  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
101446223  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101415391  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
101439136  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101439564  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101435448  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
111758663  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
101430252  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X2 [KO:K06751]
101444704  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101426756  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101438484  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101411165  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101427038  HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751]
101412608  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101447227  HLA class I histocompatibility antigen, Cw-14 alpha chain-like [KO:K06751]
101442840  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
101411454  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101413764  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101415824  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
105744147  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101441690  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101444673  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101428809  HLA class I histocompatibility antigen, B-59 alpha chain-like [KO:K06751]
101412139  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101442557  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101432742  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101437850  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X3 [KO:K06751]
101422560  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101427325  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101445227  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101421532  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101424781  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101430113  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101435675  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X2 [KO:K06751]
101419419  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
101442251  HLA class I histocompatibility antigen, Cw-3 alpha chain-like [KO:K06751]
101439095  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101411831  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
101422917  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101412902  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101422259  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101412468  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101414493  HLA class I histocompatibility antigen, B-42 alpha chain-like isoform X1 [KO:K06751]
101442691  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101432034  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
101424334  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101415212  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101442654  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
101415145  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
101437028  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101443412  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101438478  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101440773  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
101433781  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
101435501  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
101435917  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
101436345  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
101437751  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101415573  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X1 [KO:K06752]
101417015  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
101417743  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
101421271  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101421706  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
101424456  RAB5A; ras-related protein Rab-5A [KO:K07887]
101447878  LOW QUALITY PROTEIN: ras-related protein Rab-5B [KO:K07888]
101415602  RAB5B; ras-related protein Rab-5B [KO:K07888]
101440834  RAB5C; ras-related protein Rab-5C [KO:K07889]
101443361  EEA1; early endosome antigen 1 isoform X3 [KO:K12478]
101421948  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101429828  TFRC; transferrin receptor protein 1 [KO:K06503]
101431016  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
101423869  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101419014  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
101429637  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101428578  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101435586  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X4 [KO:K02148]
101427733  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
101433846  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101411644  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101429634  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
101442355  V-type proton ATPase subunit F [KO:K02151]
101418970  V-type proton ATPase subunit G 1-like isoform X1 [KO:K02152]
101420809  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101443829  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101429654  V-type proton ATPase subunit G 1-like [KO:K02152]
101441323  V-type proton ATPase subunit G 1 [KO:K02152]
101414894  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
111765656  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
101431715  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
101446774  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X5 [KO:K02154]
101435750  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101413935  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101413115  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101439719  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101430782  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
101439037  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101442162  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101437187  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
101443121  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101439272  RAB7A; ras-related protein Rab-7a [KO:K07897]
101428677  RAB7B; ras-related protein Rab-7b [KO:K07898]
101419850  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
101440825  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
101412418  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
101411707  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
101413340  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X2 [KO:K10415]
101447939  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
101434730  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
101412632  tubulin alpha-1B chain-like [KO:K07374]
101426121  tubulin alpha-1C chain-like [KO:K07374]
101419528  tubulin alpha-1B chain-like [KO:K07374]
101436325  tubulin alpha-1B chain [KO:K07374]
101437300  tubulin alpha-1A chain [KO:K07374]
101437740  tubulin alpha-1C chain [KO:K07374]
101435656  LRRC74B; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 74B [KO:K07374]
101434103  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101430720  tubulin alpha-1D chain [KO:K07374]
101431165  TUBA4A; tubulin alpha-4A chain [KO:K07374]
101438629  tubulin alpha-8 chain [KO:K07374]
101425810  TUBB1; tubulin beta-1 chain [KO:K07375]
101428068  tubulin beta chain [KO:K07375]
101439203  TUBB4A; tubulin beta-4A chain [KO:K07375]
101414865  TUBB4B; tubulin beta-4B chain [KO:K07375]
101414361  LOW QUALITY PROTEIN: uncharacterized protein LOC101414361 [KO:K07375]
101432667  TUBB; tubulin beta chain [KO:K07375]
101418816  tubulin beta-2A chain [KO:K07375]
101429135  TUBB6; tubulin beta-6 chain isoform X2 [KO:K07375]
101414830  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
101444490  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
101442598  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
101440017  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
101418274  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
101411311  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101415126  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
101419436  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
101429282  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
101441455  CTSS; LOW QUALITY PROTEIN: cathepsin S [KO:K01368] [EC:3.4.22.27]
101438398  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
101414162  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
101411140  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
111764501  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
111765996  protein transport protein Sec61 subunit gamma-like [KO:K07342]
111760796  LOW QUALITY PROTEIN: protein transport protein Sec61 subunit gamma-like [KO:K07342]
101433457  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101423323  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101426244  CALR; calreticulin [KO:K08057]
101439276  calreticulin-like [KO:K08057]
101438057  CANX; calnexin [KO:K08054]
111762112  FCAR; immunoglobulin alpha Fc receptor isoform X1 [KO:K06513]
101427594  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
101417741  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560]
101413806  uncharacterized protein LOC101413806 isoform X2 [KO:K06463]
101423469  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
101422209  complement C1r subcomponent-like [KO:K01330] [EC:3.4.21.41]
101432429  ITGAM; integrin alpha-M [KO:K06461]
101436037  LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
101421283  LOW QUALITY PROTEIN: complement C3-like [KO:K03990]
101411049  complement C3-like [KO:K03990]
101438746  COLEC11; collectin-11 isoform X1 [KO:K10066]
101443841  COLEC12; collectin-12 [KO:K10062]
101412928  MBL2; mannose-binding protein C isoform X1 [KO:K03991]
101423661  mannose-binding protein A-like isoform X1 [KO:K03991]
101425279  SFTPA2; pulmonary surfactant-associated protein A2 [KO:K10067]
101423215  SFTPD; pulmonary surfactant-associated protein D isoform X2 [KO:K10068]
101438715  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101416957  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
101422146  ITGA5; integrin alpha-5 [KO:K06484]
101428656  ITGB1; integrin beta-1 [KO:K05719]
101436471  ITGB3; integrin beta-3 [KO:K06493]
101413834  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
101424204  THBS1; thrombospondin-1 [KO:K16857]
101440768  THBS2; thrombospondin-2 [KO:K04659]
101421000  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101432371  THBS4; thrombospondin-4 [KO:K04659]
101421345  TLR2; toll-like receptor 2 [KO:K10159]
100913181  TLR6; toll-like receptor 6 precursor [KO:K10169]
101436464  TLR4; toll-like receptor 4 [KO:K10160]
101425522  monocyte differentiation antigen CD14-like [KO:K04391]
101428020  monocyte differentiation antigen CD14 [KO:K04391]
101445498  MRC1; LOW QUALITY PROTEIN: macrophage mannose receptor 1 [KO:K06560]
101436322  PLA2R1; LOW QUALITY PROTEIN: secretory phospholipase A2 receptor [KO:K06560]
101424785  MRC2; C-type mannose receptor 2 isoform X2 [KO:K06560]
101437713  CD209; CD209 antigen [KO:K06563]
101437275  CD209 antigen-like protein C [KO:K06563]
101415913  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
101416927  C-type lectin domain family 7 member A-like isoform X1 [KO:K10074]
101427331  MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
101430888  MARCO; macrophage receptor MARCO [KO:K13884]
101418828  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
101416759  SCARB1; LOW QUALITY PROTEIN: scavenger receptor class B member 1 [KO:K13885]
101447090  CD36; LOW QUALITY PROTEIN: platelet glycoprotein 4 [KO:K06259]
101435396  cytochrome b-245 heavy chain isoform X3 [KO:K21421] [EC:1.-.-.-]
101421086  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101422303  neutrophil cytosol factor 1-like [KO:K08011]
101439361  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101422829  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
dnm04142  Lysosome
dnm04144  Endocytosis
dnm04610  Complement and coagulation cascades
dnm04612  Antigen processing and presentation
dnm04620  Toll-like receptor signaling pathway
dnm04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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