KEGG   PATHWAY: dre00600
Entry
dre00600                    Pathway                                
Name
Sphingolipid metabolism - Danio rerio (zebrafish)
Class
Metabolism; Lipid metabolism
Pathway map
dre00600  Sphingolipid metabolism
dre00600

Module
dre_M00066  Lactosylceramide biosynthesis [PATH:dre00600]
dre_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:dre00600]
dre_M00094  Ceramide biosynthesis [PATH:dre00600]
dre_M00099  Sphingosine biosynthesis [PATH:dre00600]
dre_M00100  Sphingosine degradation [PATH:dre00600]
Other DBs
GO: 0006665
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
553646  sptlc2a; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
553981  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
445168  sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
557286  sptlc2b; serine palmitoyltransferase 2b [KO:K00654] [EC:2.3.1.50]
394114  kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
568169  cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
565295  cers2b; ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
259251  cers2a; ceramide synthase 2a [KO:K24621] [EC:2.3.1.297]
259250  cers4a; ceramide synthase 4a [KO:K24621] [EC:2.3.1.297]
100330155  cers4b; ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
100332380  cers3a; ceramide synthase 3 isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
100141367  cers3b; uncharacterized protein LOC100141367 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
564867  cers6; ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
323020  cers5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
393549  asah1b; acid ceramidase precursor [KO:K12348] [EC:3.5.1.23]
450068  asah1a; N-acylsphingosine amidohydrolase (acid ceramidase) 1a precursor [KO:K12348] [EC:3.5.1.23]
493602  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
550266  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
100331179  acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
555411  acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
327075  degs1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
402799  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
566563  sgms1b; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
556193  sgms2a; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
492359  sgms1a; uncharacterized protein LOC492359 [KO:K04714] [EC:2.7.8.27]
556700  smpd1; sphingomyelin phosphodiesterase precursor [KO:K12350] [EC:3.1.4.12]
567548  smpd2a; sphingomyelin phosphodiesterase 2a [KO:K12351] [EC:3.1.4.12]
797914  smpd2b; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
567592  smpd5; sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
568381  smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
793294  smpd4; sphingomyelin phosphodiesterase 4 [KO:K12353] [EC:3.1.4.12]
557756  enpp7.1; ectonucleotide pyrophosphatase/phosphodiesterase family member 7.1 precursor [KO:K12354] [EC:3.1.4.12]
557817  enpp7.2; uncharacterized protein LOC557817 precursor [KO:K12354] [EC:3.1.4.12]
569930  zgc:153896; uncharacterized protein LOC569930 precursor [KO:K12354] [EC:3.1.4.12]
558496  cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
791197  zgc:158263; ceramide kinase family protein [KO:K04715] [EC:2.7.1.138]
559124  ppap2d; phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
557680  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
563806  plpp2a; phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
335485  plpp2b; phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
794598  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
569053  plpp1a; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
100003745  sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
556439  si:ch211-212g7.6; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
100330698  sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
100331840  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100150090  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
100037312  sgpl1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
553944  ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
559072  gba; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
559240  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
393912  b4galt6; beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
724080  b4galt5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
548343  glb1; beta-galactosidase precursor [KO:K12309] [EC:3.2.1.23]
553508  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor [KO:K04628] [EC:2.4.1.47]
406385  galcb; galactocerebrosidase precursor [KO:K01202] [EC:3.2.1.46]
449649  galca; galactocerebrosidase precursor [KO:K01202] [EC:3.2.1.46]
793735  gal3st1a; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
793584  gal3st1b; galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
101884228  galactose-3-O-sulfotransferase 2-like isoform X1 [KO:K01019] [EC:2.8.2.11]
541416  arsa; arylsulfatase A precursor [KO:K01134] [EC:3.1.6.8]
559850  neu1; sialidase-1 precursor [KO:K01186] [EC:3.2.1.18]
100000684  neu3.5; sialidase 3 (membrane sialidase), tandem duplicate 5 [KO:K12357] [EC:3.2.1.18]
445250  neu3.2; sialidase-3.2 [KO:K12357] [EC:3.2.1.18]
555206  neu3.3; sialidase 3 (membrane sialidase), tandem duplicate 3 [KO:K12357] [EC:3.2.1.18]
793046  neu3.4; uncharacterized protein LOC793046 [KO:K12357] [EC:3.2.1.18]
780844  neu3.1; sialidase-3.1 [KO:K12357] [EC:3.2.1.18]
553569  neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
450083  gla; alpha-galactosidase A precursor [KO:K01189] [EC:3.2.1.22]
793635  b4galnt1b; beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
558684  b4galnt1a; beta-1,4 N-acetylgalactosaminyltransferase 1a [KO:K00725] [EC:2.4.1.92]
323613  hexb; beta-hexosaminidase subunit beta isoform 1 precursor [KO:K12373] [EC:3.2.1.52]
550460  hexa; beta-hexosaminidase subunit alpha precursor [KO:K12373] [EC:3.2.1.52]
550529  gm2a; ganglioside GM2 activator precursor [KO:K12383]
140811  psap; prosaposin isoform 2 precursor [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
dre00260  Glycine, serine and threonine metabolism
dre00601  Glycosphingolipid biosynthesis - lacto and neolacto series
dre00603  Glycosphingolipid biosynthesis - globo and isoglobo series
dre00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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