KEGG   PATHWAY: etf04310
Entry
etf04310                    Pathway                                
Name
Wnt signaling pathway - Echinops telfairi (small Madagascar hedgehog)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
etf04310  Wnt signaling pathway
etf04310

Other DBs
GO: 0016055
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101644616  PORCN; protein-serine O-palmitoleoyltransferase porcupine isoform X3 [KO:K00181] [EC:2.3.1.250]
101648285  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101660424  WNT2B; protein Wnt-2b isoform X2 [KO:K00182]
101651785  WNT2; protein Wnt-2 [KO:K00182]
101638407  WNT3A; protein Wnt-3a [KO:K00312]
101653676  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101647219  WNT4; protein Wnt-4 [KO:K00408]
101658376  WNT5B; protein Wnt-5b [KO:K00444]
101663396  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101661610  WNT6; protein Wnt-6 [KO:K00445]
101651048  WNT7A; protein Wnt-7a [KO:K00572]
101656448  WNT7B; protein Wnt-7b [KO:K00572]
101644829  WNT8A; protein Wnt-8a [KO:K00714]
101637931  WNT8B; protein Wnt-8b [KO:K00714]
101653050  WNT9B; protein Wnt-9b [KO:K01064]
101664591  WNT9A; protein Wnt-9a [KO:K01064]
101662542  WNT10A; protein Wnt-10a [KO:K01357]
101648596  WNT10B; protein Wnt-10b [KO:K01357]
101642476  WNT11; protein Wnt-11 [KO:K01384]
101653677  WNT16; protein Wnt-16 [KO:K01558]
101645528  CER1; cerberus [KO:K01645]
101645329  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
101664206  WIF1; wnt inhibitory factor 1 [KO:K01691]
101641120  SOST; sclerostin [KO:K16834]
101657624  DKK4; dickkopf-related protein 4 [KO:K02165]
101644885  DKK2; dickkopf-related protein 2 [KO:K02165]
101643586  DKK1; dickkopf-related protein 1 [KO:K02165]
101641425  SERPINF1; pigment epithelium-derived factor [KO:K19614]
101653564  SFRP1; secreted frizzled-related protein 1 [KO:K02166]
101640155  secreted frizzled-related protein 2 [KO:K02176]
101664665  SFRP2; secreted frizzled-related protein 2 [KO:K02176]
101641399  FRZB; secreted frizzled-related protein 3 isoform X1 [KO:K25481]
101656294  SFRP4; secreted frizzled-related protein 4 [KO:K02185]
101653466  RSPO1; R-spondin-1 [KO:K19471]
101640109  RSPO2; R-spondin-2 isoform X2 [KO:K23097]
101652818  RSPO3; R-spondin-3 [KO:K23098]
101647993  RSPO4; R-spondin-4 [KO:K23099]
101640376  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
101638042  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308]
101662733  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
101661009  RNF43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
101655308  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [KO:K16273] [EC:2.3.2.27]
101640257  FZD7; frizzled-7 [KO:K02432]
101643067  FZD1; frizzled-1 [KO:K02432]
101643509  FZD2; frizzled-2 [KO:K02235]
101664566  FZD3; frizzled-3 [KO:K02329]
101657948  FZD4; frizzled-4 [KO:K02354]
101647407  FZD5; frizzled-5 [KO:K02375]
101639796  FZD6; frizzled-6 isoform X1 [KO:K02376]
101652101  FZD10; frizzled-10 [KO:K02842]
101650133  FZD9; frizzled-9 [KO:K02842]
101653088  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101638974  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
101656778  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
101656143  APCDD1L; LOW QUALITY PROTEIN: protein APCDD1-like [KO:K25812]
101651460  APCDD1; protein APCDD1 [KO:K25812]
101639185  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
101646322  CCDC88C; protein Daple [KO:K25811]
101646191  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101659671  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
101652831  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
101654581  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
101651641  LOW QUALITY PROTEIN: casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
105979787  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
101641785  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
101654183  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101657545  CSNK2B; casein kinase II subunit beta [KO:K03115]
101661628  NKD1; protein naked cuticle homolog 1 [KO:K03213]
101641888  NKD2; protein naked cuticle homolog 2 [KO:K03213]
101642448  CXXC4; CXXC-type zinc finger protein 4 [KO:K03344]
101652764  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
101660025  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
101657537  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101656388  CTNNB1; catenin beta-1 [KO:K02105]
101647742  AXIN1; axin-1 [KO:K02157]
101646063  AXIN2; axin-2 [KO:K04385]
101656287  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
101640142  APC2; adenomatous polyposis coli protein 2 isoform X4 [KO:K02085]
101650200  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101662490  CSNK1A1; casein kinase I isoform X4 [KO:K08957] [EC:2.7.11.1]
101656891  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101657040  TCF7; transcription factor 7 isoform X2 [KO:K02620]
101655177  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101657493  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
101645834  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
101662640  LZTS2; leucine zipper putative tumor suppressor 2 [KO:K26471]
101640363  CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493]
101640651  CBY1; protein chibby homolog 1 [KO:K23402]
101656327  CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X2 [KO:K04494] [EC:5.6.2.-]
101660245  MCC; colorectal mutant cancer protein [KO:K26734]
101654107  CCAR2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
101655735  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
101662186  SOX17; transcription factor SOX-17 [KO:K04495]
101647375  CTBP1; C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
101653846  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
101655375  TLE3; transducin-like enhancer protein 3 isoform X3 [KO:K04497]
101656419  TLE1; transducin-like enhancer protein 1 [KO:K04497]
101648417  TLE2; transducin-like enhancer protein 2 isoform X1 [KO:K04497]
101656114  TLE4; transducin-like enhancer protein 4 [KO:K04497]
101658296  CTNND2; catenin delta-2 [KO:K23491]
101641939  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101647070  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
101661082  RUVBL1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
101648760  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
105979476  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
101647452  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101659623  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101649029  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
101656959  JUN; transcription factor AP-1 [KO:K04448]
101642188  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
101657154  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101657079  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101639447  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
101645253  CCN4; CCN family member 4 [KO:K22471]
101658317  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
101660004  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
101649991  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101645802  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101647784  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
101639413  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
101657957  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
101638398  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
105979230  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101649850  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101660484  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101641235  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101644904  calcyclin-binding protein isoform X1 [KO:K04507]
101648514  S-phase kinase-associated protein 1-like [KO:K03094]
105978575  S-phase kinase-associated protein 1 [KO:K03094]
101663453  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101640066  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
101648026  TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
101644874  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
101660400  FBXW11; F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362]
101648516  CUL1; cullin-1 isoform X3 [KO:K03347]
101662489  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
101646762  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101640639  GPC4; glypican-4 [KO:K08110]
101649458  inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
101639586  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:2.7.10.1]
101641272  RYK; tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
101639056  VANGL1; vang-like protein 1 [KO:K04510]
101651852  VANGL2; vang-like protein 2 [KO:K04510]
101647022  PRICKLE4; prickle-like protein 4 isoform X1 [KO:K04511]
101640885  PRICKLE2; prickle-like protein 2 [KO:K04511]
101658179  PRICKLE1; prickle-like protein 1 [KO:K04511]
101661968  PRICKLE3; prickle planar cell polarity protein 3 isoform X2 [KO:K04511]
101656207  INVS; inversin isoform X1 [KO:K19626]
101661741  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X3 [KO:K04512]
101660944  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X2 [KO:K04512]
101662299  RHOA; transforming protein RhoA [KO:K04513]
101646611  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101644576  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101656762  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101660384  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101654493  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101653598  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101645489  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101651304  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101650582  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101647679  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
101656854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101644337  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101651457  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
101664486  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101638605  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101639952  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101642124  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101638696  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101660901  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101647023  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101657103  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101651846  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101641174  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101639478  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101664022  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101645262  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
etf04010  MAPK signaling pathway
etf04110  Cell cycle
etf04115  p53 signaling pathway
etf04120  Ubiquitin mediated proteolysis
etf04350  TGF-beta signaling pathway
etf04510  Focal adhesion
etf04520  Adherens junction
etf05010  Alzheimer disease
KO pathway
ko04310   
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