KEGG   PATHWAY: etf04510
Entry
etf04510                    Pathway                                
Name
Focal adhesion - Echinops telfairi (small Madagascar hedgehog)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
etf04510  Focal adhesion
etf04510

Other DBs
GO: 0005925
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101647520  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101647433  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101654123  COL2A1; collagen alpha-1(II) chain [KO:K19719]
101643909  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101644236  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
101652633  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
101653376  COL4A5; collagen alpha-5(IV) chain isoform X3 [KO:K06237]
101641415  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101640794  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101663069  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101656273  collagen alpha-4(VI) chain-like [KO:K06238]
101655976  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
101640842  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101655657  collagen alpha-6(VI) chain [KO:K06238]
101661038  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101649332  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101638906  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
101661473  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101656678  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101644673  LAMA1; laminin subunit alpha-1 [KO:K05637]
101656584  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
101646645  LAMA5; laminin subunit alpha-5 [KO:K06240]
101638457  LAMA4; laminin subunit alpha-4 [KO:K06241]
101659204  LAMB1; laminin subunit beta-1 [KO:K05636]
101657059  laminin subunit beta-2-like [KO:K06243]
101661367  LAMB2; laminin subunit beta-2 [KO:K06243]
101651331  LAMB3; laminin subunit beta-3 [KO:K06244]
101650046  LAMC1; laminin subunit gamma-1 [KO:K05635]
101649731  LAMC2; laminin subunit gamma-2 [KO:K06246]
101658928  LAMC3; laminin subunit gamma-3 [KO:K06247]
101645956  CHAD; chondroadherin [KO:K06248]
101651758  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101656527  THBS1; thrombospondin-1 isoform X2 [KO:K16857]
101660448  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
101661187  cartilage oligomeric matrix protein [KO:K04659]
101639732  THBS4; thrombospondin-4 [KO:K04659]
101662616  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101653760  FN1; fibronectin [KO:K05717]
101650745  SPP1; osteopontin [KO:K06250]
101658038  VTN; vitronectin [KO:K06251]
101646924  TNC; tenascin isoform X1 [KO:K06252]
101645767  TNXB; tenascin-X [KO:K06252]
101664456  TNR; tenascin-R [KO:K06252]
101638287  TNN; tenascin-N [KO:K06252]
101651446  VWF; von Willebrand factor [KO:K03900]
101656585  bone sialoprotein 2 [KO:K06253]
101651763  ITGA1; integrin alpha-1 [KO:K06480]
101651459  ITGA2; integrin alpha-2 [KO:K06481]
101644908  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
101648576  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
101640152  ITGA4; integrin alpha-4 [KO:K06483]
101640652  ITGA5; integrin alpha-5 [KO:K06484]
101663608  ITGA6; integrin alpha-6 [KO:K06485]
101639933  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
101659770  ITGA8; integrin alpha-8 [KO:K06584]
101653341  ITGA9; integrin alpha-9 [KO:K06585]
101654263  ITGA10; integrin alpha-10 [KO:K06586]
101653494  ITGA11; integrin alpha-11 [KO:K06587]
101643277  ITGAV; integrin alpha-V [KO:K06487]
101652501  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
101653361  ITGB3; integrin beta-3 [KO:K06493]
101660073  ITGB4; integrin beta-4 [KO:K06525]
101645557  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
101653236  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101660910  ITGB7; integrin beta-7 [KO:K06590]
101662870  ITGB8; integrin beta-8 [KO:K06591]
101649496  EMP2; epithelial membrane protein 2 [KO:K26256]
101657212  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101642424  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101647643  PDGFC; platelet-derived growth factor C [KO:K05450]
101654830  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101645300  EGF; pro-epidermal growth factor [KO:K04357]
101644114  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101655464  VEGFA; vascular endothelial growth factor A [KO:K05448]
101650383  VEGFB; vascular endothelial growth factor B [KO:K16858]
101654245  PGF; placenta growth factor [KO:K16859]
101664676  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101649959  VEGFC; vascular endothelial growth factor C [KO:K05449]
101659919  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101663213  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101650381  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101643319  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101643189  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101652848  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101653928  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101648303  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101651069  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101647544  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101643784  EMP1; epithelial membrane protein 1 [KO:K26255]
101640115  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101639130  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101651623  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
101662299  RHOA; transforming protein RhoA [KO:K04513]
101651608  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
101642345  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101646611  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101663637  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
101650809  MYL5; myosin light chain 5 [KO:K12753]
101642992  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
101664182  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101641625  MYL10; myosin regulatory light chain 10 [KO:K12756]
101664547  myosin regulatory light chain 12B [KO:K12757]
101648460  myosin regulatory light chain 12B-like [KO:K12757]
101662723  myosin regulatory light chain 12B-like [KO:K12757]
101641066  myosin regulatory light chain 12B-like isoform X1 [KO:K12757]
101657522  myosin regulatory light chain 12B-like [KO:K12757]
101641841  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101653184  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101663948  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101656573  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
101638709  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101646224  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
101662729  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X2 [KO:K12329]
101648322  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101654866  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101647217  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101660330  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101647140  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101663584  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
101658099  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
101661139  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101659333  LOW QUALITY PROTEIN: actin, cytoplasmic 2-like [KO:K05692]
101655627  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101648937  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
101649676  ACTN4; alpha-actinin-4 isoform X5 [KO:K05699]
101641688  ACTN1; alpha-actinin-1 [KO:K05699]
101649891  TLN2; talin-2 [KO:K06271]
101655067  TLN1; talin-1 isoform X3 [KO:K06271]
101650939  FLNA; filamin-A isoform X1 [KO:K04437]
101648458  FLNB; filamin-B [KO:K27392]
101653688  PXN; paxillin [KO:K05760]
101652908  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
101642921  ZYX; zyxin [KO:K06273]
101661427  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
101645821  VCL; vinculin isoform X2 [KO:K05700]
101638980  PARVB; beta-parvin [KO:K06275]
101661509  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101657537  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101656388  CTNNB1; catenin beta-1 [KO:K02105]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101657103  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101651846  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101647889  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101638863  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
101639268  VAV1; proto-oncogene vav [KO:K05730]
101656425  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101644576  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101656762  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101660384  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101645746  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101655687  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101657127  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
101640920  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101646840  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101658717  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101644037  cell division control protein 42 homolog [KO:K04393]
101647533  CDC42; cell division control protein 42 homolog [KO:K04393]
101642973  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
101644047  CRK; adapter molecule crk [KO:K04438]
101660211  CRKL; crk-like protein [KO:K04438]
101664536  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
101657149  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X6 [KO:K06277]
101661777  RAP1A; ras-related protein Rap-1A [KO:K04353]
101659498  RAP1B; ras-related protein Rap-1b [KO:K07836]
101664314  ras-related protein Rap-1b-like [KO:K07836]
101641765  ras-related protein Rap-1b [KO:K07836]
101654493  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101653598  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101645489  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101656959  JUN; transcription factor AP-1 [KO:K04448]
101657046  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
101655882  CAV1; caveolin-1 [KO:K06278]
101655557  CAV2; caveolin-2 [KO:K12958]
101646670  CAV3; caveolin-3 [KO:K12959]
101664321  FYN; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
101638643  SHC1; SHC-transforming protein 1 [KO:K06279]
101644867  SHC2; SHC-transforming protein 2 [KO:K17447]
101644193  SHC3; SHC-transforming protein 3 [KO:K17448]
101654517  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
101660259  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101649001  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101646109  SOS2; son of sevenless homolog 2 [KO:K03099]
101663997  HRAS; GTPase HRas isoform X1 [KO:K02833]
101656360  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101650474  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101647149  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101657154  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101657079  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101639447  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
101655890  baculoviral IAP repeat-containing protein 3 [KO:K16060]
101659133  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
115869468  baculoviral IAP repeat-containing protein 2 [KO:K16060]
101662600  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101658729  BAD; bcl2-associated agonist of cell death [KO:K02158]
101659722  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
etf04010  MAPK signaling pathway
etf04060  Cytokine-cytokine receptor interaction
etf04070  Phosphatidylinositol signaling system
etf04110  Cell cycle
etf04151  PI3K-Akt signaling pathway
etf04310  Wnt signaling pathway
etf04512  ECM-receptor interaction
etf04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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