KEGG   PATHWAY: etf05010
Entry
etf05010                    Pathway                                
Name
Alzheimer disease - Echinops telfairi (small Madagascar hedgehog)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
etf05010  Alzheimer disease
etf05010

Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101639437  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
101641143  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
101649379  LOW QUALITY PROTEIN: amyloid-beta precursor protein-like [KO:K04520]
101656411  amyloid-beta precursor protein isoform X1 [KO:K04520]
101646682  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
101648132  APBB1; amyloid beta precursor protein binding family B member 1 [KO:K04529]
101659943  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
105978642  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101645056  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101659821  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101652698  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
101644672  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101652412  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101640691  glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
105979225  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
115871329  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101638317  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
101653908  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
101647573  RTN3; reticulon-3 isoform X2 [KO:K20723]
101650253  RTN4; reticulon-4 [KO:K20720]
101658948  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
101660004  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
101660961  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
101650724  NCSTN; nicastrin isoform X1 [KO:K06171]
101648633  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
101651640  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
101661484  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
101662978  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
101649733  MAPT; microtubule-associated protein tau [KO:K04380]
802330  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
802331  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
802332  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
802333  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
802334  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
802335  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
802336  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
101654446  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101648307  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101649115  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
115871646  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101652658  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105979080  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
101642634  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
115871468  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
115871615  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
115871629  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
101654708  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
115873240  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
101654892  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101660982  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101639113  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
101655451  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101653317  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101653949  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101641344  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101657923  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101654342  acyl carrier protein, mitochondrial-like [KO:K03955]
101642903  acyl carrier protein, mitochondrial [KO:K03955]
101658197  acyl carrier protein, mitochondrial-like [KO:K03955]
101658798  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101644308  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
115869492  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
101660948  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
101657908  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101644575  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
115868737  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
115873199  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
115869395  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
101656638  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
115872092  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
115872006  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101654519  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101643828  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101640401  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101643885  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101647046  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
101664420  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101654859  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101658030  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101649968  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101644338  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101658539  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101651179  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
101651054  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101643499  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101660829  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101640767  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
101655488  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
101657196  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101649217  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101647009  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101640009  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
101653242  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101660670  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
101660430  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101640820  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101644773  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
802338  CYTB; cytochrome b [KO:K00412]
101641779  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101639006  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101658800  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101641378  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
101660663  cytochrome b-c1 complex subunit 7-like [KO:K00417]
101655377  cytochrome b-c1 complex subunit 7 [KO:K00417]
115870168  cytochrome b-c1 complex subunit 7-like [KO:K00417]
101655167  cytochrome b-c1 complex subunit 8 [KO:K00418]
101649136  cytochrome b-c1 complex subunit 9 [KO:K00419]
101647848  cytochrome b-c1 complex subunit 10-like [KO:K00420]
101646763  cytochrome b-c1 complex subunit 10 [KO:K00420]
101641433  cytochrome b-c1 complex subunit 10-like [KO:K00420]
802329  COX3; cytochrome c oxidase subunit III [KO:K02262]
802327  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
802328  COX2; cytochrome c oxidase subunit II [KO:K02261]
101662244  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101644516  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101663125  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
105979674  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101645126  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
101657136  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
101641935  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105979995  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101656692  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101660222  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101640324  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101654913  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101649535  cytochrome c oxidase subunit 6B1-like [KO:K02267]
115868703  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101655402  cytochrome c oxidase subunit 6B2 [KO:K02267]
101657672  cytochrome c oxidase subunit 6B1 [KO:K02267]
115869234  cytochrome c oxidase subunit 6B1-like [KO:K02267]
115868698  cytochrome c oxidase subunit 6C isoform X2 [KO:K02268]
115871260  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
101652550  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
115871755  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101663987  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101651542  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
115868983  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
101655666  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101650318  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
115871644  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115872385  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123522755  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115873769  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115868264  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115868682  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115869232  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115872049  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
115872554  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
115872007  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101647414  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101659808  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101648654  ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
101640525  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
101641389  ATP synthase subunit delta, mitochondrial [KO:K02134]
101650207  ATP synthase subunit delta, mitochondrial-like [KO:K02134]
115871972  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
115868774  LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
802337  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
101649586  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
101662086  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101642029  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
101638576  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
105979491  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
101657495  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105979765  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
101651440  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
101654301  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
101660847  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
105979066  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
101658560  ATP synthase subunit d, mitochondrial-like [KO:K02138]
101663222  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
101648762  ATP synthase subunit d, mitochondrial-like [KO:K02138]
101643680  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
101640972  ATP synthase subunit O, mitochondrial-like [KO:K02137]
101661561  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
101653269  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
101655801  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
101638485  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
802326  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
101643918  3-hydroxyacyl-CoA dehydrogenase type-2-like [KO:K08683] [EC:1.1.1.35 1.1.1.178]
101654022  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
101650982  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
101656727  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101653907  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
101649902  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101642569  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101638395  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101643848  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101648707  ADP/ATP translocase 2 [KO:K05863]
101655091  ADP/ATP translocase 3 [KO:K05863]
101646088  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101653289  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
101649341  ADP/ATP translocase 2-like [KO:K05863]
101642037  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase F, mitochondrial-like [KO:K09565] [EC:5.2.1.8]
101638230  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101645959  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
101642382  APOE; apolipoprotein E isoform X2 [KO:K04524]
101655513  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X2 [KO:K04550]
101657422  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101638051  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101659226  BID; BH3-interacting domain death agonist [KO:K04726]
115871000  calmodulin-A-like [KO:K02183]
101651650  neo-calmodulin-like [KO:K02183]
101662569  CALML6; calmodulin-like protein 6 [KO:K02183]
101656820  CALM3; calmodulin-3 [KO:K02183]
101638094  calmodulin-alpha-like [KO:K02183]
101650375  CALML3; calmodulin-like protein 3 [KO:K02183]
101662916  CALML5; calmodulin-like protein 5 [KO:K02183]
101654870  CALM1; calmodulin-1 [KO:K02183]
101649322  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101643468  CALM2; calmodulin-2 [KO:K02183]
101639952  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101642124  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101638696  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101660901  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101647023  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101658729  BAD; bcl2-associated agonist of cell death [KO:K02158]
101661288  cytochrome c, testis-specific [KO:K08738]
101650600  cytochrome c-like [KO:K08738]
101656765  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101659735  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101643856  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101641566  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101641017  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101649961  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101659445  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
101637893  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101651304  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101650582  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101647679  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
101656854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101650392  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
101648867  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101644422  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101638487  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101656925  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
101651425  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101662493  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101658956  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101656805  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101640880  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101645879  RYR3; ryanodine receptor 3 [KO:K04963]
101654141  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101638553  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101657031  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101661059  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101639123  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101651580  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
101659622  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
101654999  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101652164  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101660158  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101641434  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101643556  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101645193  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101663385  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101654493  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101653598  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101645489  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101639489  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101650311  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101655936  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
101659004  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101654154  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
101651352  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
101647600  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101644957  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101652319  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
101659790  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
101662625  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
101659272  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
101660884  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
101652514  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
101658302  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101650120  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101649257  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101653452  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101654357  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101642584  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101651118  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
101649508  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
101658898  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
101656842  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101655850  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101649413  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101642788  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
101663315  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101638919  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101640356  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101654289  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101662737  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
101663895  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
101651663  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101638659  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 14-like [KO:K03030]
101647694  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101661784  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
105978618  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
101653369  caspase-12 [KO:K04741] [EC:3.4.22.-]
101649945  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101659155  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101648937  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
101639228  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
101652988  zinc transporter ZIP2-like [KO:K14709]
101653301  SLC39A2; zinc transporter ZIP2 [KO:K14709]
101649768  SLC39A3; zinc transporter ZIP3 [KO:K14709]
101659477  SLC39A1; zinc transporter ZIP1 [KO:K14709]
101650075  SLC39A4; zinc transporter ZIP4 [KO:K14710]
101663057  SLC39A5; zinc transporter ZIP5 [KO:K14711]
101664323  SLC39A6; zinc transporter ZIP6 [KO:K14712]
101641862  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
101640265  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
101653925  SLC39A9; zinc transporter ZIP9 isoform X2 [KO:K14715]
101653329  SLC39A10; zinc transporter ZIP10 [KO:K14716]
101642887  SLC39A11; zinc transporter ZIP11 isoform X2 [KO:K14717]
101650928  SLC39A12; zinc transporter ZIP12 [KO:K14718]
101660473  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
101653789  SLC39A14; metal cation symporter ZIP14 isoform X2 [KO:K14720]
101663643  SLC11A2; natural resistance-associated macrophage protein 2 isoform X2 [KO:K21398]
101660666  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
101657537  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101657187  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101657624  DKK4; dickkopf-related protein 4 [KO:K02165]
101644885  DKK2; dickkopf-related protein 2 [KO:K02165]
101643586  DKK1; dickkopf-related protein 1 [KO:K02165]
101648285  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101660424  WNT2B; protein Wnt-2b isoform X2 [KO:K00182]
101651785  WNT2; protein Wnt-2 [KO:K00182]
101638407  WNT3A; protein Wnt-3a [KO:K00312]
101653676  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101647219  WNT4; protein Wnt-4 [KO:K00408]
101658376  WNT5B; protein Wnt-5b [KO:K00444]
101663396  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101661610  WNT6; protein Wnt-6 [KO:K00445]
101651048  WNT7A; protein Wnt-7a [KO:K00572]
101656448  WNT7B; protein Wnt-7b [KO:K00572]
101644829  WNT8A; protein Wnt-8a [KO:K00714]
101637931  WNT8B; protein Wnt-8b [KO:K00714]
101653050  WNT9B; protein Wnt-9b [KO:K01064]
101664591  WNT9A; protein Wnt-9a [KO:K01064]
101662542  WNT10A; protein Wnt-10a [KO:K01357]
101648596  WNT10B; protein Wnt-10b [KO:K01357]
101642476  WNT11; protein Wnt-11 [KO:K01384]
101653677  WNT16; protein Wnt-16 [KO:K01558]
101640257  FZD7; frizzled-7 [KO:K02432]
101643067  FZD1; frizzled-1 [KO:K02432]
101643509  FZD2; frizzled-2 [KO:K02235]
101664566  FZD3; frizzled-3 [KO:K02329]
101657948  FZD4; frizzled-4 [KO:K02354]
101647407  FZD5; frizzled-5 [KO:K02375]
101639796  FZD6; frizzled-6 isoform X1 [KO:K02376]
101652101  FZD10; frizzled-10 [KO:K02842]
101650133  FZD9; frizzled-9 [KO:K02842]
101653088  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101638974  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
101639185  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
101646191  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101659671  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
101652831  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
101654581  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
101651641  LOW QUALITY PROTEIN: casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
105979787  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
101641785  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
101654183  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101657545  CSNK2B; casein kinase II subunit beta [KO:K03115]
101647742  AXIN1; axin-1 [KO:K02157]
101646063  AXIN2; axin-2 [KO:K04385]
101656287  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
101640142  APC2; adenomatous polyposis coli protein 2 isoform X4 [KO:K02085]
101656388  CTNNB1; catenin beta-1 [KO:K02105]
101650200  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101662490  CSNK1A1; casein kinase I isoform X4 [KO:K08957] [EC:2.7.11.1]
101656891  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101651348  KIF5B; kinesin-1 heavy chain [KO:K10396]
101639531  KIF5C; kinesin heavy chain [KO:K10396]
101650624  KIF5A; kinesin heavy chain isoform X2 [KO:K10396]
101651085  KLC4; kinesin light chain 4 [KO:K10407]
101660584  KLC3; kinesin light chain 3 [KO:K10407]
101646529  KLC1; kinesin light chain 1 isoform X2 [KO:K10407]
101643439  KLC2; kinesin light chain 2 [KO:K10407]
101663498  TUBA4A; tubulin alpha-4A chain [KO:K07374]
101640153  tubulin alpha-1D chain [KO:K07374]
101654209  TUBA8; tubulin alpha-8 chain [KO:K07374]
101660474  tubulin alpha-4A chain [KO:K07374]
101651696  LOW QUALITY PROTEIN: tubulin alpha-1C chain [KO:K07374]
101662276  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
101642837  tubulin alpha-3 chain [KO:K07374]
101654715  tubulin alpha-1C chain-like [KO:K07374]
101664407  tubulin alpha-8 chain [KO:K07374]
101641475  TUBB4A; LOW QUALITY PROTEIN: tubulin beta-4A chain [KO:K07375]
101658886  TUBB6; tubulin beta-6 chain [KO:K07375]
101660038  tubulin beta-4B chain [KO:K07375]
101654809  TUBB3; tubulin beta-3 chain [KO:K07375]
101641139  TUBB2A; tubulin beta-2A chain [KO:K07375]
101649529  TUBB; tubulin beta chain [KO:K07375]
101651329  TUBB1; tubulin beta-1 chain [KO:K07375]
101646399  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
101663997  HRAS; GTPase HRas isoform X1 [KO:K02833]
101639926  KRAS; GTPase KRas isoform X3 [KO:K07827]
101649328  GTPase NRas-like [KO:K07828]
101653520  NRAS; GTPase NRas [KO:K07828]
101648298  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
101657046  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
101656360  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101650474  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101643986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101640739  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101663531  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
101663870  RELA; transcription factor p65 [KO:K04735]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101657111  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101653785  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101654642  TNF; tumor necrosis factor [KO:K03156]
123522712  interleukin-6-like [KO:K05405]
101644240  IL6; interleukin-6 [KO:K05405]
101638698  IL1A; interleukin-1 alpha [KO:K04383]
101639333  IL1B; interleukin-1 beta [KO:K04519]
101657479  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
101658333  SNCA; alpha-synuclein [KO:K04528]
101640829  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101649582  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101657011  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101648136  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101641705  INS; insulin [KO:K04526]
101657077  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101650216  IRS1; insulin receptor substrate 1 [KO:K16172]
101640484  IRS2; insulin receptor substrate 2 [KO:K07187]
101652949  IRS4; insulin receptor substrate 4 [KO:K17446]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101664135  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101648588  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
101654162  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
101659547  ATG101; autophagy-related protein 101 [KO:K19730]
101643199  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
101656640  autophagy-related protein 13-like [KO:K08331]
101658931  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101642059  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X3 [KO:K17985]
101638290  BECN1; beclin-1 [KO:K08334]
101643579  beclin-2-like [KO:K08334]
101647419  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
101657057  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101652595  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101644561  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101655387  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
101643770  ATG2B; autophagy-related protein 2 homolog B isoform X2 [KO:K17906]
101647959  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
101640179  WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
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J Clin Invest 114:23-7 (2004)
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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
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Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
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Calcium dysregulation in Alzheimer's disease.
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Ion channels in the regulation of apoptosis.
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Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
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Antioxid Redox Signal 29:1176-1188 (2018)
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Tan Y, Deng Y, Qing H
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Calcium channel blockers and Alzheimer's disease.
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Neural Regen Res 7:137-40 (2012)
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Alzheimer's disease and Abeta toxicity: from top to bottom.
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Nat Rev Neurosci 2:595-8 (2001)
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Alzheimer's disease pathogenesis and therapeutic interventions.
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J Clin Neurosci 11:456-67 (2004)
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Presenilin-mediated signal transduction.
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Physiol Behav 92:93-7 (2007)
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PMID:22842534
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Honarnejad K, Herms J
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Presenilins: role in calcium homeostasis.
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Int J Biochem Cell Biol 44:1983-6 (2012)
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Supnet C, Bezprozvanny I
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Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
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Cell Calcium 50:303-9 (2011)
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Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
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Exp Gerontol 41:668-73 (2006)
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APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
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J Cell Biol 163:27-33 (2003)
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March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
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Biochim Biophys Acta 1842:1258-66 (2014)
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Strickland MR, Holtzman DM
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Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
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J Clin Invest 129:969-971 (2019)
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Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
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Neurobiol Dis 6:440-9 (1999)
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Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
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Mol Cell Neurosci 101:103414 (2019)
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Related
pathway
etf00190  Oxidative phosphorylation
etf03050  Proteasome
etf04020  Calcium signaling pathway
etf04140  Autophagy - animal
etf04141  Protein processing in endoplasmic reticulum
etf04210  Apoptosis
etf04310  Wnt signaling pathway
etf04910  Insulin signaling pathway
etf04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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