KEGG   PATHWAY: etf04010
Entry
etf04010                    Pathway                                
Name
MAPK signaling pathway - Echinops telfairi (small Madagascar hedgehog)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
etf04010  MAPK signaling pathway
etf04010

Other DBs
GO: 0000165
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101655311  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101659681  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101656925  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
101651425  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101654417  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101662493  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101659216  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101653041  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101650625  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [KO:K04856]
101658956  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101641825  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
101664293  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
101649275  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101662048  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
101663627  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
101647286  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
101650161  CACNB3; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
101662240  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101664457  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101658227  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101656281  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101662773  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
123522716  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101641691  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
101641067  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101641376  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101649991  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101645802  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101657103  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101651846  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101637962  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
115869515  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
115870155  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115872073  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101639952  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101642124  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101638696  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101660901  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101647023  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101655627  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101644988  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
101655797  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
101660297  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
101664472  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
101646752  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
101644473  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
101661008  NF1; neurofibromin [KO:K08052]
101638369  RASA1; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352]
101649748  RASA2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
101661777  RAP1A; ras-related protein Rap-1A [KO:K04353]
101659498  RAP1B; ras-related protein Rap-1b [KO:K07836]
101664314  ras-related protein Rap-1b-like [KO:K07836]
101641765  ras-related protein Rap-1b [KO:K07836]
101645300  EGF; pro-epidermal growth factor [KO:K04357]
101659761  TGFA; protransforming growth factor alpha [KO:K08774]
101648960  EREG; proepiregulin [KO:K09784]
101649279  AREG; amphiregulin [KO:K09782]
101654974  FGF1; fibroblast growth factor 1 [KO:K18496]
101640090  FGF2; fibroblast growth factor 2 [KO:K18497]
101657384  FGF6; fibroblast growth factor 6 [KO:K04358]
101655892  FGF7; fibroblast growth factor 7 [KO:K04358]
101645725  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101658407  FGF3; fibroblast growth factor 3 [KO:K04358]
101654224  FGF20; fibroblast growth factor 20 [KO:K04358]
101659774  FGF18; fibroblast growth factor 18 [KO:K04358]
101641057  FGF9; fibroblast growth factor 9 [KO:K04358]
101645168  FGF16; fibroblast growth factor 16 [KO:K04358]
101649614  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101656763  FGF22; fibroblast growth factor 22 [KO:K04358]
101644233  FGF8; fibroblast growth factor 8 [KO:K04358]
101657770  FGF19; fibroblast growth factor 19 [KO:K22603]
101645758  FGF21; fibroblast growth factor 21 [KO:K22429]
101659280  FGF23; fibroblast growth factor 23 [KO:K22428]
101658298  NGF; beta-nerve growth factor [KO:K02582]
101643198  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101649580  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
101647770  NTF4; neurotrophin-4 [KO:K12457]
101641705  INS; insulin [KO:K04526]
101644114  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101657076  IGF2; insulin-like growth factor II [KO:K13769]
101657212  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101642424  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101647643  PDGFC; platelet-derived growth factor C [KO:K05450]
101654830  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101657479  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
101644116  KITLG; kit ligand isoform X1 [KO:K05461]
101655782  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
101655464  VEGFA; vascular endothelial growth factor A [KO:K05448]
101650383  VEGFB; vascular endothelial growth factor B [KO:K16858]
101654245  PGF; placenta growth factor [KO:K16859]
101664676  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101649959  VEGFC; vascular endothelial growth factor C [KO:K05449]
101659919  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101640418  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101645535  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101648310  ANGPT4; angiopoietin-4 [KO:K05467]
101641001  EFNA5; ephrin-A5 [KO:K05462]
123520870  EFNA4; ephrin-A4 [KO:K05462]
101660733  EFNA1; ephrin-A1 [KO:K05462]
101660415  EFNA3; ephrin-A3 [KO:K05462]
101644402  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101638529  NRTN; neurturin [KO:K25414]
101642723  PSPN; persephin [KO:K25416]
101652848  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101647544  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101663176  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101652176  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101650479  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101658234  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
101644525  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101644075  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101662350  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101647167  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101654367  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101657077  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101643319  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101663213  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101650381  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101650070  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101663524  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
101654556  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101653928  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101648303  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101643189  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101651069  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101658503  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
101657615  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101651034  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101660259  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101649001  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101646109  SOS2; son of sevenless homolog 2 [KO:K03099]
101663997  HRAS; GTPase HRas isoform X1 [KO:K02833]
101639926  KRAS; GTPase KRas isoform X3 [KO:K07827]
101649328  GTPase NRas-like [KO:K07828]
101653520  NRAS; GTPase NRas [KO:K07828]
101657858  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101655065  MRAS; ras-related protein M-Ras [KO:K07831]
101648298  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
101657046  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
101656360  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101650474  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101643986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101638772  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101638134  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101654563  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
101652067  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
101659525  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
101648994  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101655079  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
101650311  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101647149  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101643890  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
101649029  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
101644600  SRF; serum response factor isoform X1 [KO:K04378]
101656124  FOS; proto-oncogene c-Fos [KO:K04379]
101649733  MAPT; microtubule-associated protein tau [KO:K04380]
101662859  stathmin-like [KO:K04381]
101644559  stathmin-like [KO:K04381]
101663615  STMN1; stathmin [KO:K04381]
101644594  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101645229  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101653474  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101643951  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101654642  TNF; tumor necrosis factor [KO:K03156]
101638698  IL1A; interleukin-1 alpha [KO:K04383]
101639333  IL1B; interleukin-1 beta [KO:K04519]
101650988  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101639819  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101642513  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101657422  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101660872  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
101662924  interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
101652427  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101660774  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101652025  monocyte differentiation antigen CD14-like [KO:K04391]
101652337  monocyte differentiation antigen CD14-like [KO:K04391]
101644576  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101656762  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101660384  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101644037  cell division control protein 42 homolog [KO:K04393]
101647533  CDC42; cell division control protein 42 homolog [KO:K04393]
101643813  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
101643856  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101643556  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101644605  DAXX; death domain-associated protein 6 [KO:K02308]
101644448  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101652271  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101643108  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
101658809  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101650390  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101660000  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101641486  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101649684  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101642439  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101657907  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2 [KO:K04405]
101644281  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
101661502  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
101650925  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
101645746  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101655687  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101651219  STK4; serine/threonine-protein kinase 4 [KO:K04411]
101646100  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
123522491  mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
101649071  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101645836  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101662607  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101647418  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101657417  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101658423  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
101644379  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101659030  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
101659398  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
101653397  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101660993  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
101655438  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
101645193  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101647452  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101639947  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
101656709  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101647106  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
101650357  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101647011  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101663385  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101639675  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101643832  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
101657014  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
101650727  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
101656177  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X4 [KO:K04436]
101650939  FLNA; filamin-A isoform X1 [KO:K04437]
101644047  CRK; adapter molecule crk [KO:K04438]
101660211  CRKL; crk-like protein [KO:K04438]
101640070  ARRB1; beta-arrestin-1 isoform X3 [KO:K04439]
101650408  ARRB2; beta-arrestin-2 [KO:K04439]
101654493  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101653598  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101645489  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101657745  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101656204  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101653430  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101653940  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101651379  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
101650104  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101644731  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
101645368  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101652875  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
101664078  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
101641174  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101664022  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101656959  JUN; transcription factor AP-1 [KO:K04448]
101652397  JUND; transcription factor jun-D [KO:K04449]
101656771  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101647784  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
101652164  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101647489  MAX; protein max isoform X2 [KO:K04453]
101659295  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101655758  HSPB1; heat shock protein beta-1 [KO:K04455]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101663673  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
101654064  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
101657639  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101662095  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101661665  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101661605  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101645401  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101641975  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101643140  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101639817  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101652690  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101638133  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101638138  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101645272  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101664248  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101655575  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
101647386  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101660675  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
101659653  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101660593  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
101639818  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101650652  MECOM; histone-lysine N-methyltransferase MECOM isoform X6 [KO:K04462] [EC:2.1.1.367]
101651393  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
101654790  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101659859  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
101650553  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101649582  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101657011  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101648136  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101659623  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101654694  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
101663870  RELA; transcription factor p65 [KO:K04735]
101643323  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Trends Immunol 34:307-16 (2013)
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Related
pathway
etf04070  Phosphatidylinositol signaling system
etf04110  Cell cycle
etf04115  p53 signaling pathway
etf04210  Apoptosis
etf04310  Wnt signaling pathway
etf04668  TNF signaling pathway
KO pathway
ko04010   
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