KEGG   PATHWAY: mleu04820
Entry
mleu04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Mandrillus leucophaeus (drill)
Class
Cellular Processes; Cell motility
Pathway map
mleu04820  Cytoskeleton in muscle cells
mleu04820

Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105553265  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105535560  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
105535239  COL3A1; collagen alpha-1(III) chain [KO:K19720]
105552757  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
105541219  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
105547820  COL5A1; collagen alpha-1(V) chain [KO:K19721]
105535238  COL5A2; collagen alpha-2(V) chain [KO:K19721]
105536485  COL11A1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
105537162  COL11A2; collagen alpha-2(XI) chain isoform X1 [KO:K19721]
105550092  COL5A3; collagen alpha-3(V) chain [KO:K19721]
105531466  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
105548366  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105537944  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105545870  DCN; decorin isoform X1 [KO:K04660]
105551286  VCAN; versican core protein isoform X1 [KO:K06793]
105536878  ELN; elastin [KO:K14211]
105551554  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
105551555  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105539834  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
105538157  collagen alpha-4(VI) chain-like [KO:K06238]
105538158  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
105538159  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
105546194  THBS1; thrombospondin-1 [KO:K16857]
105553558  THBS2; thrombospondin-2 [KO:K04659]
105547095  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105548283  THBS4; thrombospondin-4 [KO:K04659]
105544845  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105529986  FBN1; fibrillin-1 [KO:K06825]
105540523  FBN2; fibrillin-2 [KO:K23342]
105541147  FBN3; fibrillin-3 [KO:K23342]
105546552  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105546564  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105541413  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
105541512  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
105543172  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105543173  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105542186  FBLN2; fibulin-2 isoform X1 [KO:K17307]
105542489  FBLN1; fibulin-1 [KO:K17307]
105546844  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
105553606  NID2; nidogen-2 [KO:K06826]
105536909  NID1; nidogen-1 [KO:K06826]
105528087  FN1; fibronectin [KO:K05717]
105533090  SDC1; syndecan-1 [KO:K06257]
105538734  SDC2; syndecan-2 isoform X1 [KO:K16336]
105535032  SDC3; syndecan-3 [KO:K16337]
105552084  SDC4; syndecan-4 isoform X1 [KO:K16338]
105555186  AGRN; agrin [KO:K06254]
105555344  BGN; biglycan isoform X1 [KO:K08118]
105535332  DSC2; desmocollin-2 [KO:K07601]
105535368  DSG2; desmoglein-2 [KO:K07597]
105530190  PKP2; plakophilin-2 [KO:K12642]
105552975  JUP; junction plakoglobin [KO:K10056]
105546480  DSP; desmoplakin [KO:K10381]
105530523  VIM; vimentin isoform X1 [KO:K07606]
105528071  DES; desmin [KO:K07610]
105551977  LAMA2; laminin subunit alpha-2 [KO:K05637]
105549719  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
105552123  ITGA1; integrin alpha-1 [KO:K06480]
105552128  ITGA2; integrin alpha-2 [KO:K06481]
105543805  ITGA2B; integrin alpha-IIb [KO:K06476]
105553271  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105553874  ITGA4; integrin alpha-4 [KO:K06483]
105548552  ITGA5; integrin alpha-5 [KO:K06484]
105548065  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105532010  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105530532  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105553436  ITGA9; integrin alpha-9 [KO:K06585]
105550282  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105530986  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
105553894  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105549004  ITGB1; integrin beta-1 [KO:K05719]
105534546  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105528575  ITGB4; integrin beta-4 [KO:K06525]
105533226  ITGB5; integrin beta-5 [KO:K06588]
105547780  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105555020  ITGB7; integrin beta-7 [KO:K06590]
105534972  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105539716  TLN1; talin-1 [KO:K06271]
105530250  TLN2; talin-2 [KO:K06271]
105547512  VCL; vinculin isoform X1 [KO:K05700]
105536893  ACTN2; alpha-actinin-2 [KO:K21073]
105544436  ACTN3; LOW QUALITY PROTEIN: alpha-actinin-3 [KO:K21073]
105551087  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105549083  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105540177  ACTG2; actin, gamma-enteric smooth muscle isoform X1 [KO:K12315]
105540344  DAG1; dystroglycan [KO:K06265]
105553267  SGCA; alpha-sarcoglycan isoform X1 [KO:K12565]
105535562  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
105534598  SGCB; beta-sarcoglycan isoform X1 [KO:K12566]
105529545  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
105553783  SGCG; gamma-sarcoglycan [KO:K12564]
105554251  SGCZ; zeta-sarcoglycan [KO:K27062]
105555453  SSPN; sarcospan isoform X1 [KO:K22194]
105555622  dystrophin [KO:K10366]
105528413  SNTA1; alpha-1-syntrophin [KO:K24063]
105537173  SNTB2; beta-2-syntrophin [KO:K24064]
105535349  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
105550841  FLNC; filamin-C isoform X1 [KO:K27393]
105532275  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
105532277  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
105554375  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
105542535  ATP1A3; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
105539598  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 isoform X1 [KO:K01540]
105555629  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
105549867  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
105537539  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
105545390  ANK3; ankyrin-3 isoform X1 [KO:K09259]
105545620  SPTAN1; spectrin alpha chain, non-erythrocytic 1 [KO:K06114]
105551333  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
105546211  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
105542616  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
105544448  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
105540692  CSRP2; cysteine and glycine-rich protein 2 isoform X1 [KO:K09377]
105547116  CSRP1; cysteine and glycine-rich protein 1 isoform X1 [KO:K09377]
105537609  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
105533846  MYH7B; myosin-7B [KO:K24220]
105534439  MYH3; myosin-3 [KO:K24220]
105534441  MYH2; myosin-2 [KO:K24220]
105534442  MYH1; myosin-1 [KO:K24220]
105534443  MYH4; myosin-4 isoform X1 [KO:K24220]
105534453  MYH13; myosin-13 [KO:K24220]
105534454  MYH8; myosin-8 [KO:K24220]
105550626  MYH15; LOW QUALITY PROTEIN: myosin-15 [KO:K24220]
105547195  MYH6; myosin-6 [KO:K17751]
105547210  MYH7; myosin-7 [KO:K17751]
105538920  MYH9; myosin-9 [KO:K10352]
105528149  LOW QUALITY PROTEIN: myosin-11-like [KO:K10352]
105529006  MYH14; myosin-14 [KO:K10352]
105549834  MYH10; myosin-10 isoform X1 [KO:K10352]
105529407  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
105540417  MYL3; myosin light chain 3 [KO:K12749]
105534548  MYL4; myosin light chain 4 [KO:K12750]
105532701  MYL5; myosin light chain 5 [KO:K12753]
105541942  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
105533817  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
105541434  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105534468  myosin-binding protein C, slow-type isoform X1 [KO:K12557]
105529481  MYBPC1; myosin-binding protein C, slow-type [KO:K12557]
105529004  MYBPC2; myosin-binding protein C, fast-type [KO:K12558]
105554820  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
105547084  MYBPH; myosin-binding protein H [KO:K24494]
105530957  MYBPHL; myosin-binding protein H-like isoform X1 [KO:K24494]
105553712  ACTA1; actin, alpha skeletal muscle [KO:K10354]
105548603  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
105544004  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
105547119  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
105551620  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
105542303  TNNC2; troponin C, skeletal muscle [KO:K12042]
105545332  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
105545329  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
105551621  TNNI3; troponin I, cardiac muscle [KO:K12044]
105547121  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
105530258  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
105539710  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
105540689  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
105554059  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
105540104  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
105548088  titin [KO:K12567] [EC:2.7.11.1]
105531279  MYOT; myotilin isoform X1 [KO:K19875]
105553067  TCAP; telethonin isoform X1 [KO:K19879]
105537914  SYNPO2; synaptopodin-2 isoform X1 [KO:K24066]
105545085  NEB; nebulin isoform X1 [KO:K18267]
105552135  NEBL; nebulette isoform X1 [KO:K25865]
105547501  MYOZ1; myozenin-1 isoform X1 [KO:K26050]
105543421  MYOZ3; myozenin-3 [KO:K26050]
105537913  MYOZ2; myozenin-2 [KO:K26050]
105531365  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
105553752  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
105553974  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
105531017  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
105554327  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
105548486  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
105536171  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
105548901  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
105553412  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
105545294  XIRP2; xin actin-binding repeat-containing protein 2 [KO:K27381]
105530142  NRAP; nebulin-related-anchoring protein isoform X1 [KO:K24421]
105549500  MYPN; myopalladin isoform X1 [KO:K22028]
105546700  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
105530612  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
105550471  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
105534735  TMOD4; tropomodulin-4 isoform X1 [KO:K10370]
105549281  TMOD1; tropomodulin-1 [KO:K10370]
105543981  TMOD2; tropomodulin-2 [KO:K10370]
105543991  TMOD3; tropomodulin-3 [KO:K10370]
105546624  ZYX; zyxin [KO:K06273]
105549751  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
105531596  FHL2; four and a half LIM domains protein 2 isoform X1 [KO:K14380]
105531570  FHL3; four and a half LIM domains protein 3 [KO:K24414]
105532968  LMOD3; leiomodin-3 [KO:K22030]
105547110  LMOD1; leiomodin-1 [KO:K22030]
105550880  LMOD2; leiomodin-2 [KO:K22030]
105528576  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
105554155  ANKRD2; ankyrin repeat domain-containing protein 2 isoform X1 [KO:K21434]
105531663  ANKRD23; ankyrin repeat domain-containing protein 23 isoform X1 [KO:K21438]
105528229  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
105543831  FMNL1; formin-like protein 1 [KO:K23957]
105545091  FMNL2; formin-like protein 2 [KO:K23957]
105541753  INF2; inverted formin-2 [KO:K23958]
105546391  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
105544264  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
105534889  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
105544877  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
105547338  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
105550151  FMN2; formin-2 [KO:K02184]
105551197  MYOM1; myomesin-1 [KO:K24495]
105530871  MYOM2; myomesin-2 [KO:K24495]
105538099  MYOM3; myomesin-3 [KO:K24495]
105540791  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
105541810  ENO2; gamma-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
105549953  ENO3; beta-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
105544606  alpha-enolase-like [KO:K01689] [EC:4.2.1.11]
105551853  ANK2; ankyrin-2 isoform X1 [KO:K09255]
105535852  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
105533982  TRIM54; tripartite motif-containing protein 54 isoform X1 [KO:K10653]
105536976  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
105540876  TRIM63; E3 ubiquitin-protein ligase TRIM63 isoform X1 [KO:K10655] [EC:2.3.2.27]
105531908  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
105554354  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
105530946  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
105528822  OBSCN; LOW QUALITY PROTEIN: obscurin [KO:K17531] [EC:2.7.11.1]
105546143  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
105536355  PLEC; plectin [KO:K10388]
105547910  SYNE3; nesprin-3 isoform X1 [KO:K21761]
105551531  SYNE1; nesprin-1 [KO:K19326]
105538459  SYNE2; nesprin-2 [KO:K19346]
105538869  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
105537868  SUN1; SUN domain-containing protein 1 [KO:K19347]
105542190  TMEM43; transmembrane protein 43 [KO:K27488]
105552325  LBR; lamin-B receptor [KO:K19532] [EC:1.3.1.70]
105548635  LMNA; lamin isoform X1 [KO:K12641]
105552007  LMNB2; lamin-B2 [KO:K07611]
105540548  LMNB1; lamin-B1 [KO:K07611]
Reference
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
mleu04512  ECM-receptor interaction
mleu04814  Motor proteins
KO pathway
ko04820   
LinkDB

DBGET integrated database retrieval system