KEGG ORTHOLOGY: K27393

ORTHOLOGY: K27393

Entry

K27393                      KO

Symbol

FLNC

Name

filamin-C

Pathway

map04820

Cytoskeleton in muscle cells

Disease

H00292

Hypertrophic cardiomyopathy

H00594

Distal myopathy

H00595

Myofibrillar myopathies

H01219

Restrictive cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K27393  FLNC; filamin-C
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K27393  FLNC; filamin-C
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     K27393  FLNC; filamin-C
  Intermediate filaments
   Intermediate filament-binding proteins
    K27393  FLNC; filamin-C

Genes

HSA:	2318(FLNC)

PTR:	463711(FLNC)

PPS:	100991254(FLNC)

GGO:

101142657

PON:	100447210(FLNC)

PPYG:

129040349(FLNC)

NLE:	100584689(FLNC)

HMH:	116814327(FLNC)

SSYN:

129484979(FLNC)

MCC:	700223(FLNC)

MCF:	102114837(FLNC)

MTHB:

126951163

MNI:	105471454 105474513

CSAB:

103226867(FLNC)

CATY:

105598551(FLNC)

PANU:

101023700

TGE:	112620505(FLNC)

MLEU:

105550841(FLNC)

RRO:	104674436(FLNC)

RBB:	108544858(FLNC)

TFN:	117073460(FLNC)

PTEH:

111550210(FLNC)

CANG:

105510004(FLNC)

CJC:	100397531(FLNC)

SBQ:	101030782(FLNC)

CIMI:

108318472(FLNC)

ANAN:

105731987(FLNC)

CSYR:

103265960(FLNC)

MMUR:

105884847(FLNC)

LCAT:

123647006(FLNC)

PCOQ:

105826754(FLNC)

OGA:	100958068(FLNC)

MMU:	68794(Flnc)

MCAL:

110297122(Flnc)

MPAH:

110316290(Flnc)

RNO:	362332(Flnc)

MCOC:

116098662(Flnc)

ANU:	117720348(Flnc)

ASYL:

127678415(Flnc)

MUN:	110564415(Flnc)

CGE:	100751994(Flnc)

MAUA:

101825498(Flnc)

PROB:

127215386(Flnc)

PLEU:

114691085(Flnc)

PMAV:

102923929(Flnc)

MORG:

121463330(Flnc)

MFOT:

126501153

AAMP:

119806719(Flnc)

NGI:	103744557(Flnc)

HGL:	101714775(Flnc)

CPOC:

100730013(Flnc)

CCAN:

109684086(Flnc)

DORD:

105988337(Flnc)

DSP:	122121776(Flnc)

DMER:

138809774(Flnc)

PLOP:

125347112(Flnc)

NCAR:

124990636

MMMA:

107144532(Flnc)

ITI:	101973589(Flnc)

OCU:

100353671

OPI:	101529389(FLNC)

OCZ:	121170727(FLNC)

TUP:	102498440(FLNC)

GVR:	103601013(FLNC)

CFA:	482266(FLNC)

CLUD:

112675061(FLNC)

VVP:	112928910(FLNC)

VLG:	121474725(FLNC)

NPO:	129498188(FLNC)

AML:	100475857(FLNC)

UMR:	103676641(FLNC)

UAH:	113263925(FLNC)

UAR:	123788968(FLNC)

ELK:

111151946

LLV:

125080716

MPUF:

101692958(FLNC)

MNP:	132015726(FLNC)

MLK:	131829734(FLNC)

NVS:	122905048(FLNC)

ORO:	101383660(FLNC)

EJU:	114210621(FLNC)

ZCA:	113911761(FLNC)

MLX:	118021061(FLNC)

NSU:	110589034(FLNC)

LWW:	102750801(FLNC)

FCA:	101081210(FLNC)

PYU:	121028360(FLNC)

PCOO:

112866408(FLNC)

PBG:	122488235(FLNC)

PVIV:

125160615(FLNC)

LRUF:

124523470

LGF:	123606831(FLNC)

AJU:

106973900

PTG:	102958609(FLNC)

PPAD:

109268963(FLNC)

PUC:

125930129

PLEZ:

122211007(FLNC)

HHV:	120238724(FLNC)

BTA:	528415(FLNC)

BOM:	102287936(FLNC)

BIU:	109557606(FLNC)

BBUB:

102398881(FLNC)

BBIS:

104982399(FLNC)

CHX:	102170485(FLNC)

OAS:	101104655(FLNC)

BTAX:

128046608(FLNC)

CSUM:

138080097(FLNC)

ODA:	120877330(FLNC)

CCAD:

122438618(FLNC)

MREE:

136170505(FLNC)

OVR:	110125566(FLNC)

MBEZ:

129552625(FLNC)

SSC:	100518997(FLNC)

CFR:	102522311(FLNC)

CBAI:

105063098(FLNC)

CDK:	105085371(FLNC)

VPC:	102539882(FLNC)

BACU:

103001285(FLNC)

BMUS:

118900775(FLNC)

LVE:	103085481(FLNC)

OOR:	101277589(FLNC)

LALB:

132524585(FLNC)

GMF:	115851645(FLNC)

DDP:	132431186(FLNC)

DLE:	111178654(FLNC)

PCAD:

102994181(FLNC)

PSIU:

116759097(FLNC)

PPHC:

136127805(FLNC)

NASI:

112411763(FLNC)

ECB:	100071760(FLNC)

EPZ:	103544267(FLNC)

EAI:	106839532(FLNC)

MYB:	102246018(FLNC)

MYD:	102756703(FLNC)

MMYO:

118666430(FLNC)

MLF:	102437988(FLNC)

MDT:	132242737(FLNC)

MYUM:

139016181(FLNC)

PKL:	118712554(FLNC)

EFUS:

103297338(FLNC)

MNA:	107537382(FLNC)

DRO:	112299880(FLNC)

SHON:

118989170(FLNC)

AJM:	119065637(FLNC)

PDIC:

114507257(FLNC)

PHAS:

123829664(FLNC)

MMF:	118619908(FLNC)

PPAM:

129062788(FLNC)

HAI:	109384635(FLNC)

RFQ:	117018159(FLNC)

PALE:

102894137(FLNC)

PGIG:

120601221(FLNC)

PVP:	105290185(FLNC)

RAY:	107512795(FLNC)

MJV:	108392169(FLNC)

TOD:	119246559(FLNC)

SARA:

101542229(FLNC)

SFUM:

130027470(FLNC)

SETR:

126012132(FLNC)

LAV:	100666153(FLNC)

TMU:

101344651

ETF:	101663319(FLNC)

DNM:	101428317(FLNC)

MDO:	100014995(FLNC)

GAS:	123250488(FLNC)

SHR:	100932639(FLNC)

AFZ:

127538254

PCW:	110219227(FLNC)

TVP:	118850431(FLNC)

PBRV:

138160568(FLNC)

MLAO:

141492965(FLNC)

OAA:	100078338(FLNC)

TACU:

119933037(FLNC)

GGA:	395260(FLNC)

APLA:

113841470 119715213

ACYG:

106048920(FLNC)

CATA:

118260797(FLNC)

TGU:	100224625(FLNC)

LSR:	110479584(FLNC)

SCAN:

103822494(FLNC)

PMOA:

120500092(FLNC)

OTC:	121337180(FLNC)

PRUF:

121355073(FLNC)

ATRC:

139585631(FLNC)

GFR:	102039906(FLNC)

FAB:	101807613(FLNC)

OMA:	130248705(FLNC)

PHI:	102109930(FLNC)

PMAJ:

107198769(FLNC)

CCAE:

111923226

CCW:	120411918(FLNC)

CBRC:

103619221

ACOE:

138120531(FLNC)

ETL:

114072022

ZLE:	135442870(FLNC)

SVG:	106861998(FLNC)

MMEA:

130585770

HRT:	120751444(FLNC)

SATI:

136361202(FLNC)

CCIC:

134043332(FLNC)

FPG:	101921248(FLNC)

FCH:	102048385(FLNC)

ACHC:

115341642(FLNC)

HLE:

104832551

AGEN:

126044302

DPUB:

104300045(FLNC)

PPUS:

135175002(FLNC)

NNI:

104015311

CBOR:

142078619(FLNC)

CBOY:

140649404(FLNC)

MAME:

142404552(FLNC)

CLV:

102090285

CUCA:

104061382(FLNC)

RTD:

CRID:

AAM:

AROW:

ASN:	102367807(FLNC)

AMJ:	102572603(FLNC)

CIZ:	142001196(FLNC)

CMY:	102942474(FLNC)

CCAY:

125630612(FLNC)

DCC:	119841943(FLNC)

CPIC:

101948714(FLNC)

TST:	117873501(FLNC)

CABI:

116837626(FLNC)

MRV:	120395515(FLNC)

ACS:	100555896(flnc) 100559302

ASAO:

132775623(FLNC)

PVT:	110089402(FLNC)

SUND:

121930858(FLNC)

PBI:	103050411(FLNC)

PMUR:

107298381

CTIG:

120308966(FLNC)

PGUT:

117656232(FLNC)

PCAE:

139319792(FLNC)

APRI:

131201714(FLNC)

VKO:	123023084(FLNC)

PMUA:

114606020(FLNC)

PRAF:

128422693(FLNC)

ZVI:	118091488(FLNC)

HCG:	128326324(FLNC)

GJA:	107116981(FLNC)

STOW:

125435273

EMC:	129336238(FLNC)

XLA:	733321 734178(flnc.L)

XTR:	100329116(flnc)

NPR:	108794883(FLNC)

RTEM:

120931618(FLNC)

ACAT:

141131727(FLNC)

PADS:

140324223(FLNC)

BBUF:

120985258(FLNC)

BGAR:

122927771(FLNC)

DTC:	141092891(FLNC)

PWL:	138288133(FLNC)

MUO:	115479287(FLNC)

GSH:	117366630(FLNC)

DRE:	100048921(flnca) 570288(flncb)

SRX:	107728418 107740233 107743297 107744996

SANH:

107656281 107658721 107667687 107695945

SGH:	107555727 107560077 107580954 107592205

CCAR:

109050942 109051217 109062869 109066092

CAUA:

113043646 113048322 113058046 113067181

CGIB:

127947110 127956511 127976594 128014340

PTET:

122330776(flnca) 122343491(flncb)

LROH:

127156658(flnca) 127164608(flncb)

GRF:	141302094(flnca) 141333590(flncb)

OMC:	131534283(flnca)

PPRM:

120468057(flnca) 120476795(flncb)

RKG:	130069557(flncb) 130080327(flnca)

MAMB:

125244336(flncb) 125247095(flnca)

CIDE:

127507313 127510496

CERY:

137015455(flnca) 137024318(flncb)

MASI:

127435478 127435759 127436748 127437268

TROS:

130547764(flncb) 130552112(flnca)

TDW:	130414525(flnca) 130420397(flncb)

MANU:

129432036(flncb) 129433603(flnca)

PDAB:

135779223(flncb) 135788010(flnca)

IPU:	108269034 108279881(flncb)

IFU:	128611062 128622991(flncb)

PHYP:

113525442 113532351

SMEO:

124386424(flnca) 124400844(flncb)

TFD:	113645694(flncb) 113651940

TVC:	132856426 132859305(flncb)

CGAR:

128531644 128534347(flncb)

NGRA:

132869853(flncb) 132889968

TRN:	134314114(flncb) 134319208

AMEX:

103028247(flncb) 103033794(flnca)

CMAO:

118803227(flncb) 118806564(flnca)

EEE:	113582685 113588770

CHAR:

105909553(flncb) 105910408

SPIL:

134061920 134093688

ASAD:

121696976 121723410

TRU:	101076847 101077561

TFS:	130519199(flncb) 130535973

TNG:	GSTEN00011646G001 GSTEN00029754G001

LCO:	104936893 104940629

NCC:	104963709(flnc)

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

134879225(flncb) 134882577

ELY:	117249175 117262190

EFO:	125883177 125887132

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

114550004 114559568(flnc)

GAT:	120809378 120818436(flncb)

PPUG:

119196412 119210754(flncb)

AFB:	129107782 129112717

CLUM:

117726290 117731975

PSWI:

130195129 130200855

CANA:

137791269 137803788

CVE:	137881895 137889997

MSAM:

119895382 119909726

SCHU:

122871354 122874940

CUD:	121505703 121514966

SPUL:

138599445(flncb) 138612426

LMIX:

132956073 132972687

HTC:	141796882 141810394

ALAT:

119024871 119032460

ASTR:

137589475 137593684

MZE:	101468348 101481790

ONL:	100698591 100703257

OAU:	116313787 116332647

OLA:	101165476(flnc) 101166705

OML:	112152688 112154050

CSAI:

133424353 133424577 133443772

XMA:	102226553 102231807

XCO:	114160393 114160779

XHE:	116736344 116736551

PRET:

103459815(flnc) 103466366

PFOR:

103129975(flnc) 103154890

PLAI:

106940355 106947966

PMEI:

106916484 106934123

GAF:	122826469 122835406

PPRL:

129351953 129358499

CVG:	107086022(flnc) 107100771

CTUL:

119789455 119794133

GMU:	124881197 124882873

NFU:	107387851(flnc) 107388592

KMR:	108230074 108248408

ALIM:

106523651 106535645

NWH:	119416391 119428422

AOCE:

111574658 111585313

EJA:	138195798 138206049

BFRE:

138614387 138618996

MCEP:

125000291 125015120

CSEM:

103380304 103382463

POV:	109624441 109646377

SSEN:

122766570(flncb) 122776442

SSOE:

131456255(flncb) 131469754

HHIP:

117757608 117763330

HSP:	118101796(flncb) 118109132

PPLT:

128429034(flncb) 128444510

SMAU:

118289329(flncb) 118315564

LCF:	108882420 108888498

SDU:	111229481 111229537

SLAL:

111669172 111670874

XGL:	120792976 120803742

HCQ:	109522986 109532675

SSCV:

125970249 125991916

SBIA:

133493580(flncb) 133502230

PEE:	133397005(flncb) 133402865

PTAO:

133471610 133477783

BPEC:

110161376(flnc) 110169294

ENY:	140349432 140367459(flncb)

MALB:

109974778 109974858

BSPL:

114856842 114861952

SJO:	128353164(flncb) 128358494

SSCO:

133981530 134004361(flncb)

TTY:	137175989(flncb) 137183255

GMH:	115541412 115550748

SASA:

106561692 106573040 106576205 106609299

STRU:

115152412 115180558 115197662 115198815

OTW:	112214278 112217177 112219043 112232475

OMY:	110490751 110500158 110502465 110525505

OGO:	123993160 123994583 124013603 124032290

ONE:	115109745 115119787 115122999 115133111

OKI:	109879970 109888738 109910367

OKE:	118365956 118374087 118396076 118400943

OMM:	135508962 135514869 135515932

OCLA:

139376005 139378650 139393325 139409016

SALP:

111951555 111953025 112071583 112080586

SNH:	120032010 120050043 120053550 120066495

SFON:

129838247 129861987 129865218 129866626

CCLU:

121531594 121543597 121559146 121577088

ELS:	105021804(flnc)

OEP:	134021428 134038065(flncb)

SFM:	108920915 108931558

PKI:	111844361 111847024

AANG:

118219093 118231779(flncb)

AROT:

135245907 135258865(flncb)

CCOG:

133119411 133134438(flncb)

LOC:	102692617(flnc)

PSPA:

121318300 121319813

ARUT:

117415233 117419693

PSEX:

120534011(flncb)

LCM:	102352444(FLNC)

CMK:	103190015(flncb)

RTP:

109919721

CPLA:

122561772(flncb)

CPUN:

140466921(flncb)

HOC:	132826696(flncb)

SCAU:

119973795(flncb)

STOZ:

140387924(flncb)

LERI:

129707837(flncb)

HAKA:

140738824(flncb)

PMRN:

116949264(FLNC)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

BARL:

YBA:

RES:

Reference

PMID:38016530

Authors

Muranova LK, Vostrikova VM, Shatov VM, Sluchanko NN, Gusev NB

Title

Interaction of the C-terminal immunoglobulin-like domains (Ig 22-24) of filamin C with human small heat shock proteins.

Journal

Biochimie 219:146-154 (2024)
DOI:10.1016/j.biochi.2023.11.010

Sequence

[hsa:2318]

LinkDB

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