Entry
Name
Nucleocytoplasmic transport - Mus musculus (house mouse)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
223921 Aaas; achalasia, adrenocortical insufficiency, alacrimia [KO:K14320 ]
19386 Ranbp2; RAN binding protein 2 [KO:K12172 ] [EC:2.3.2.-]
19387 Rangap1; RAN GTPase activating protein 1 [KO:K14319 ]
22196 Ube2i; ubiquitin-conjugating enzyme E2I [KO:K10577 ]
20610 Sumo3; small ubiquitin-like modifier 3 [KO:K12160 ]
22218 Sumo1; small ubiquitin-like modifier 1 [KO:K12160 ]
110379 Sec13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004 ]
226747 Ahctf1; AT hook containing transcription factor 1 [KO:K25129 ]
107939 Pom121; nuclear pore membrane protein 121 [KO:K14316 ]
195236 Pom121l2; POM121 transmembrane nucleoporin like 2 [KO:K14316 ]
108989 Tpr; translocated promoter region, nuclear basket protein [KO:K09291 ]
212999 Tnpo2; transportin 2 (importin 3, karyopherin beta 2b) [KO:K18727 ]
73192 Xpot; exportin, tRNA (nuclear export receptor for tRNAs) [KO:K14288 ]
75471 1700009N14Rik; RIKEN cDNA 1700009N14 gene [KO:K07936 ]
13628 Eef1a2; eukaryotic translation elongation factor 1 alpha 2 [KO:K03231 ]
13627 Eef1a1; eukaryotic translation elongation factor 1 alpha 1 [KO:K03231 ]
56698 Phax; phosphorylated adaptor for RNA export [KO:K14291 ]
433702 Ncbp1; nuclear cap binding protein subunit 1 [KO:K12882 ]
68092 Ncbp2; nuclear cap binding protein subunit 2 [KO:K12883 ]
17149 Magoh; mago homolog, exon junction complex core component [KO:K12877 ]
66441 Magohb; mago homolog B, exon junction complex core component [KO:K12877 ]
56215 Acin1; apoptotic chromatin condensation inducer 1 [KO:K12875 ]
20220 Sap18; Sin3-associated polypeptide 18 [KO:K14324 ]
19826 Rnps1; RNA binding protein with serine rich domain 1 [KO:K14325 ]
326622 Upf2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327 ]
68134 Upf3b; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328 ]
67031 Upf3a; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328 ]
237082 Nxt2; nuclear transport factor 2-like export factor 2 [KO:K14285 ]
51796 Srrm1; serine/arginine repetitive matrix 1 [KO:K13171 ]
78428 Pym1; PYM homolog 1, exon junction complex associated factor [KO:K14294 ]
Reference
Authors
Tran EJ, Wente SR
Title
Dynamic nuclear pore complexes: life on the edge.
Journal
Reference
Authors
Rodriguez MS, Dargemont C, Stutz F
Title
Nuclear export of RNA.
Journal
Reference
Authors
Palancade B, Doye V
Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
Journal
Reference
Authors
Reed R, Cheng H
Title
TREX, SR proteins and export of mRNA.
Journal
Reference
Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
Journal
Reference
Authors
Beck M, Schirmacher P, Singer S
Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
Journal
Related pathway
KO pathway
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