KEGG   PATHWAY: morg04728
Entry
morg04728                   Pathway                                
Name
Dopaminergic synapse - Microtus oregoni (creeping vole)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
morg04728  Dopaminergic synapse
morg04728

Other DBs
GO: 0001963
Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121457807  Th; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
121459409  Ddc; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
121454285  Slc18a2; synaptic vesicular amine transporter [KO:K08155]
121462875  Slc18a1; chromaffin granule amine transporter [KO:K08155]
121453616  Drd1; D(1A) dopamine receptor [KO:K04144]
121444491  D(1A) dopamine receptor [KO:K04144]
121436529  Drd5; D(1B) dopamine receptor [KO:K05840]
121457761  Caly; neuron-specific vesicular protein calcyon isoform X1 [KO:K15493]
121454687  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
121460541  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
121454560  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121465646  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
121460033  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
121440758  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121433763  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
121435401  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
121462368  calmodulin-1 [KO:K02183]
121465992  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
121432548  Calml5; calmodulin-like protein 5 isoform X1 [KO:K02183]
121432747  calmodulin-like protein 3 [KO:K02183]
121432887  Calm2; calmodulin-2 [KO:K02183]
121434435  Calm1; calmodulin-1 [KO:K02183]
121449209  Calm3; calmodulin-3 [KO:K02183]
121459565  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
121445229  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121438612  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121440610  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121449426  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
121461739  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121453244  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121438600  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121436286  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
121458065  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
121449728  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
121452580  Fos; proto-oncogene c-Fos [KO:K04379]
121440831  neuroendocrine secretory protein 55-like [KO:K04632]
121440830  Gnas; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
121438780  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
121461694  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
121455756  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121451033  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121433487  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
121439096  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
121439299  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
121461039  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121463404  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
121458259  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
121459918  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
121450873  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
121437635  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
121439698  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
121435241  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
121461212  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
121461365  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
121435212  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121435574  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
121455025  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121456117  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121440925  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121456970  protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
121442323  protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
121454539  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
121446369  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
121432896  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121433274  Scn1a; sodium channel protein type 1 subunit alpha isoform X1 [KO:K04833]
121441414  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121454953  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121455716  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
121462813  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
121433213  Kcnj3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
121461817  Kcnj6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
121442059  Kcnj9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
121452002  Kcnj5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
121461963  Drd3; D(3) dopamine receptor isoform X1 [KO:K04146]
121458134  Drd4; D(4) dopamine receptor [KO:K04147]
121464390  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
121458947  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121437910  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121446778  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121434752  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121446774  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
121448045  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
121441334  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
121443529  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
121445292  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
121437224  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
121452935  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
121466217  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
121438645  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
121454312  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
121432656  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4-like [KO:K04541]
121432753  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
121452966  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
121447724  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
121459792  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
121450195  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
121451544  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
121463435  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
121447476  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
121447130  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
121434081  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121462469  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
121463952  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
121463507  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
121456481  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
121438300  Drd2; D(2) dopamine receptor isoform X1 [KO:K04145]
121455237  beta-arrestin-1 isoform X1 [KO:K04439]
121456412  Arrb2; beta-arrestin-2 [KO:K04439]
121458738  beta-arrestin-1-like isoform X1 [KO:K04439]
121462294  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
121457153  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121438281  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
121449197  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
121457440  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
121457507  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
121458392  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
121453633  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
121436473  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
121442259  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
121455096  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
121464273  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
121452278  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
121454177  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
121452145  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
121450864  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
121434405  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121435833  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
121434429  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121449224  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121435875  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121450113  Gsk3a; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
121461919  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121463917  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
121433987  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
121456665  Gria1; glutamate receptor 1 isoform X1 [KO:K05197]
121452885  Gria2; glutamate receptor 2 isoform X1 [KO:K05198]
121439510  Gria3; glutamate receptor 3 isoform X1 [KO:K05199]
121451688  Gria4; glutamate receptor 4 isoform X1 [KO:K05200]
121455924  Kif5a; kinesin heavy chain isoform X1 [KO:K10396]
121433144  Kif5c; kinesin heavy chain [KO:K10396]
121440697  Kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
121460743  Clock; circadian locomoter output cycles protein kaput isoform X1 [KO:K02223] [EC:2.3.1.48]
121457517  Arntl; aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1 [KO:K02296]
121433667  Slc6a3; sodium-dependent dopamine transporter isoform X1 [KO:K05036]
121441029  amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
121441037  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
121441131  amine oxidase [flavin-containing] B-like isoform X1 [KO:K00274] [EC:1.4.3.4]
121441151  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
121463688  Tomt; transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
121465188  Comt; catechol O-methyltransferase [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
morg00350  Tyrosine metabolism
morg04020  Calcium signaling pathway
morg04721  Synaptic vesicle cycle
morg04724  Glutamatergic synapse
morg05012  Parkinson disease
KO pathway
ko04728   
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