Entry
Name
Gap junction - Oncorhynchus gorbuscha (pink salmon)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Oncorhynchus gorbuscha (pink salmon) [GN:
ogo ]
Gene
123994437 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
124003571 gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630 ]
124004229 guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630 ]
124004356 guanine nucleotide-binding protein G(i) subunit alpha-2-like isoform X1 [KO:K04630 ]
124035303 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
124014006 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
124044985 guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630 ]
124031253 guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630 ]
124031303 guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630 ]
124031574 guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
124002451 guanine nucleotide-binding protein G(i) subunit alpha-1-like isoform X1 [KO:K04630 ]
124032374 guanine nucleotide-binding protein G(i) subunit alpha-3-like isoform X1 [KO:K04630 ]
123999192 platelet-derived growth factor subunit A-like isoform X1 [KO:K04359 ]
123999674 platelet-derived growth factor subunit A-like isoform X1 [KO:K04359 ]
124001321 sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099 ]
124037367 map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368 ] [EC:2.7.12.2 ]
124037445 LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368 ] [EC:2.7.12.2 ]
124033821 LOW QUALITY PROTEIN: tight junction protein ZO-1-like [KO:K05701 ]
124031591 LOW QUALITY PROTEIN: tight junction protein ZO-1-like [KO:K05701 ]
124009729 guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632 ]
124012564 guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632 ]
124045728 guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632 ]
124031747 guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632 ]
124013614 htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157 ]
124010445 guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635 ]
124007768 guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635 ]
123997052 guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04634 ]
124048624 guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634 ]
124034538 guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634 ]
124036062 guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634 ]
123999214 guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634 ]
124037689 gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04634 ]
123990995 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
123990996 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
123995278 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
123995279 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
124013828 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
124008217 LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858 ] [EC:3.1.4.11 ]
124046548 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
124002240 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
124002317 plcb2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
124003822 inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
124003962 inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958 ]
124031230 inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958 ]
124031497 itpr1b; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
124035132 inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959 ]
124002508 LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959 ]
124045536 LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960 ]
Compound
C00681 1-Acyl-sn-glycerol 3-phosphate
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
Title
Plasma membrane channels formed by connexins: their regulation and functions.
Journal
Reference
Authors
Warn-Cramer BJ, Lau AF.
Title
Regulation of gap junctions by tyrosine protein kinases.
Journal
Reference
Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
Journal
Reference
Authors
Roerig B, Feller MB.
Title
Neurotransmitters and gap junctions in developing neural circuits.
Journal
Reference
Authors
Hatton GI.
Title
Synaptic modulation of neuronal coupling.
Journal
Reference
Authors
Cruciani V, Mikalsen SO.
Title
Connexins, gap junctional intercellular communication and kinases.
Journal
Reference
Authors
Giepmans BN.
Title
Gap junctions and connexin-interacting proteins.
Journal
Reference
Authors
Laird DW.
Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
Journal
Reference
Authors
Peracchia C.
Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
Journal
Reference
Authors
Bukauskas FF, Verselis VK.
Title
Gap junction channel gating.
Journal
Related pathway
ogo04060 Cytokine-cytokine receptor interaction
ogo04070 Phosphatidylinositol signaling system
ogo04080 Neuroactive ligand-receptor interaction
KO pathway
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