KEGG   PATHWAY: pki04144
Entry
pki04144                    Pathway                                
Name
Endocytosis - Paramormyrops kingsleyae
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pki04144  Endocytosis
pki04144

Other DBs
GO: 0006897
Organism
Paramormyrops kingsleyae [GN:pki]
Gene
111844476  ADP-ribosylation factor 6 [KO:K07941]
111838414  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111839723  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111839411  pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
111836580  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111860294  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111849854  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
111858689  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
111853476  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
111850486  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
111860820  pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
111842677  dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
111834776  dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
111843453  dynamin-1-like isoform X1 [KO:K01528] [EC:3.6.5.5]
111849205  dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
111859933  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
111835494  clta; clathrin light chain A isoform X1 [KO:K04644]
111855410  clathrin light chain A-like isoform X1 [KO:K04644]
111855513  cltb; clathrin light chain B isoform X1 [KO:K04645]
111854379  clathrin heavy chain 1-like isoform X1 [KO:K04646]
111854750  clathrin heavy chain 1 isoform X1 [KO:K04646]
111859712  clathrin heavy chain 1-like isoform X1 [KO:K04646]
111836882  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
111834516  AP-2 complex subunit alpha-2-like [KO:K11824]
111851303  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
111835439  ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
111847861  ap2b1; AP-2 complex subunit beta [KO:K11825]
111836644  AP-2 complex subunit mu-B isoform X1 [KO:K11826]
111849027  ap2m1; AP-2 complex subunit mu isoform X1 [KO:K11826]
111844864  ap2s1; AP-2 complex subunit sigma [KO:K11827]
111838034  EH domain-containing protein 2-like [KO:K12469]
111841486  ehd2; EH domain-containing protein 2 [KO:K12469]
111851387  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
111838972  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
111857200  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111857846  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
111846005  zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
111857767  zinc finger FYVE domain-containing protein 16-like isoform X1 [KO:K04679]
111842093  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
111856558  mothers against decapentaplegic homolog 2-like [KO:K04500]
111845594  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
111839917  transferrin receptor protein 1-like [KO:K06503]
111847402  tfrc; transferrin receptor protein 1 [KO:K06503]
111845900  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
111841598  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
111850064  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
111839944  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
111844207  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
111847950  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
111860895  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111845000  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111845734  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111846264  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
111851345  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
111855703  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
111854831  cblc; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
111836770  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
111837416  endophilin-A1-like isoform X1 [KO:K11247]
111844942  endophilin-A3-like isoform X1 [KO:K11247]
111852093  endophilin-A1-like [KO:K11247]
111836596  endophilin-A2-like isoform X1 [KO:K11247]
111846644  sh3gl3; endophilin-A3 isoform X1 [KO:K11247]
111860307  sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
111840810  sh3glb1; endophilin-B1 isoform X1 [KO:K11248]
111858687  sh3glb2; endophilin-B2 isoform X1 [KO:K21269]
111849885  endophilin-B2-like [KO:K21269]
111849409  endophilin-B1-like isoform X1 [KO:K21269]
111852225  bin1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
111846197  amphiphysin-like isoform X1 [KO:K12562]
111840748  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
111841578  amph; amphiphysin [KO:K12562]
111845512  epsin-2-like isoform X1 [KO:K12471]
111852871  epsin-3-like isoform X1 [KO:K12471]
111839725  epsin-1-like [KO:K12471]
111845770  epsin-1-like isoform X1 [KO:K12471]
111835404  epsin-3-like isoform X1 [KO:K12471]
111849185  epn2; epsin-2 isoform X1 [KO:K12471]
111848956  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
111860393  eps15l1; epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
111847638  epidermal growth factor receptor substrate 15-like isoform X1 [KO:K12472]
111847688  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
111840474  spart; spartin isoform X1 [KO:K19366]
111851361  spartin-like isoform X1 [KO:K19366]
111845033  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
111852603  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
111851197  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
111841418  TNF receptor-associated factor 6-like isoform X1 [KO:K03175] [EC:2.3.2.27]
111859511  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
111840341  E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
111855147  rnf41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
111842301  itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
111856426  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
111845486  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
111854083  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
111843285  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
111848147  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
111846204  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
111835152  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
111833450  low-density lipoprotein receptor-like isoform X1 [KO:K12473]
111856344  ldlr; low-density lipoprotein receptor [KO:K12473]
111854454  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
111837997  low density lipoprotein receptor adapter protein 1-like isoform X1 [KO:K12474]
111848276  low density lipoprotein receptor adapter protein 1-B-like isoform X1 [KO:K12474]
111850641  low density lipoprotein receptor adapter protein 1-B-like [KO:K12474]
111859641  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
111847286  disabled homolog 2-like isoform X1 [KO:K12475]
111847072  dab2; disabled homolog 2 isoform X1 [KO:K12475]
111860170  disabled homolog 2-like isoform X1 [KO:K12475]
111842881  C-X-C chemokine receptor type 1-like [KO:K05050]
111859326  C-X-C chemokine receptor type 1-like [KO:K05050]
111859328  C-X-C chemokine receptor type 1-like [KO:K05050]
111849246  C-X-C chemokine receptor type 4-like [KO:K04189]
111858385  C-X-C chemokine receptor type 4-like [KO:K04189]
111836639  grk7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
111850644  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
111855924  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
111851486  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
111847947  G protein-coupled receptor kinase 6-like [KO:K08291] [EC:2.7.11.16]
111853108  grk4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
111860778  G protein-coupled receptor kinase 6-like [KO:K08291] [EC:2.7.11.16]
111861162  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
111857546  G protein-coupled receptor kinase 5-like isoform X1 [KO:K08291] [EC:2.7.11.16]
111838069  beta-arrestin-1-like [KO:K04439]
111852918  arrestin red cell-like [KO:K04439]
111846337  arrb2; beta-arrestin-2 [KO:K04439]
111841525  beta-arrestin-1 [KO:K04439]
111851291  wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
111840605  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
111857535  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
111855200  SH3 and multiple ankyrin repeat domains protein 1-like [KO:K23612]
111850806  actin-related protein 2-A-like isoform X1 [KO:K17260]
111834218  actin-related protein 2 isoform X1 [KO:K17260]
111859516  actin-related protein 2-B-like [KO:K17260]
111851668  actr3b; actin-related protein 3B isoform X1 [KO:K18584]
111857197  actin-related protein 3 [KO:K18584]
111860690  actr3; actin-related protein 3 isoform X1 [KO:K18584]
111845476  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
111845494  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
111854098  actin-related protein 2/3 complex subunit 1A [KO:K05757]
111856748  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
111854062  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
111859322  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
111842229  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
111855110  actin-related protein 2/3 complex subunit 3-like isoform X1 [KO:K05756]
111837493  actin-related protein 2/3 complex subunit 4 [KO:K05755]
111840580  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
111840116  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
111841075  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
111858700  arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
111859012  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
111840739  WAS/WASL-interacting protein family member 1-like [KO:K19475]
111856116  wipf2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
111846896  wipf3; WAS/WASL-interacting protein family member 3 [KO:K19475]
111838639  WAS/WASL-interacting protein family member 1-like [KO:K19475]
111855675  heat shock cognate 71 kDa protein-like [KO:K03283]
111834334  heat shock 70 kDa protein [KO:K03283]
111855702  heat shock cognate 71 kDa protein [KO:K03283]
111833700  heat shock cognate 71 kDa protein-like [KO:K03283]
111840993  putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
111834852  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
111844313  washc4; WASH complex subunit 4 [KO:K18465]
111845746  washc5; WASH complex subunit 5 isoform X1 [KO:K18464]
111850374  WASH complex subunit 2-like isoform X1 [KO:K18462]
111846158  washc1; WASH complex subunit 1 isoform X1 [KO:K18461]
111846564  washc3; WASH complex subunit 3 [KO:K18463]
111836014  F-actin-capping protein subunit alpha-2 [KO:K10364]
111839829  F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
111842388  F-actin-capping protein subunit alpha-2-like [KO:K10364]
111853084  F-actin-capping protein subunit beta isoforms 1 and 2 isoform X1 [KO:K10365]
111855583  F-actin-capping protein subunit beta isoforms 1 and 2-like [KO:K10365]
111842227  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
111852833  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
111844807  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
111846965  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
111849654  vacuolar protein sorting-associated protein 35-like [KO:K18468]
111836449  sorting nexin-12 [KO:K17918]
111834607  sorting nexin-12-like isoform X1 [KO:K17918]
111856543  snx3; sorting nexin-3 [KO:K17918]
111844925  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
111857570  stambp; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
111837492  ras-related protein rab7-like [KO:K07897]
111838508  ras-related protein rab7-like isoform X1 [KO:K07897]
111840579  ras-related protein rab7 [KO:K07897]
111857334  ras-related protein rab7-like [KO:K07897]
111856934  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
111849278  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
111834284  stam; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
111851739  stam2; signal transducing adapter molecule 2 [KO:K04705]
111859524  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
111859526  tumor susceptibility gene 101 protein-like isoform X1 [KO:K12183]
111835399  mvb12a; multivesicular body subunit 12A [KO:K12186]
111833129  mvb12b; multivesicular body subunit 12B isoform X1 [KO:K12186]
111858665  multivesicular body subunit 12B-like isoform X1 [KO:K12186]
111832794  vps28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
111851451  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
111853584  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
111848547  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
111854794  vacuolar protein sorting-associated protein 37D-like [KO:K12185]
111861070  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
111856127  snf8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
111840485  vps36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
111856790  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
111852848  charged multivesicular body protein 6-like [KO:K12195]
111846590  charged multivesicular body protein 6-like [KO:K12195]
111844709  charged multivesicular body protein 4b-like isoform X1 [KO:K12194]
111835289  chmp4b; charged multivesicular body protein 4b isoform X1 [KO:K12194]
111836233  charged multivesicular body protein 4c-like isoform X1 [KO:K24782]
111855409  chmp3; charged multivesicular body protein 3 [KO:K12193]
111850713  chmp2a; charged multivesicular body protein 2a [KO:K12191]
111852761  charged multivesicular body protein 2b-like isoform X1 [KO:K12192]
111836215  chmp2b; charged multivesicular body protein 2b [KO:K12192]
111857530  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
111845957  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
111851674  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
111851860  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
111858836  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
111846305  charged multivesicular body protein 1b-like [KO:K12197]
111851861  chmp1a; charged multivesicular body protein 1a [KO:K12197]
111855318  chmp1b; charged multivesicular body protein 1b [KO:K12197]
111852552  charged multivesicular body protein 5-like [KO:K12198]
111857738  chmp5; charged multivesicular body protein 5 [KO:K12198]
111857431  IST1 homolog isoform X1 [KO:K19476]
111832942  ist1; IST1 homolog isoform X1 [KO:K19476]
111844940  programmed cell death 6-interacting protein-like [KO:K12200]
111839714  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
111845100  spg21; maspardin [KO:K19367]
111859900  maspardin-like [KO:K19367]
111836154  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
111840989  sorting nexin-1-like [KO:K17917]
111857404  snx1; sorting nexin-1 [KO:K17917]
111856585  snx2; sorting nexin-2 isoform X1 [KO:K17917]
111840534  uncharacterized protein LOC111840534 [KO:K17920]
111835691  snx5; sorting nexin-5 [KO:K17920]
111855017  snx6; sorting nexin-6 [KO:K17920]
111835923  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
111855741  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111840699  GTPase HRas-like [KO:K02833]
111859528  hras; GTPase HRas [KO:K02833]
111835968  interleukin-2 receptor subunit beta-like [KO:K05069]
111845191  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
111836422  cytokine receptor common subunit gamma-like [KO:K05070]
111834615  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
111836318  cytokine receptor common subunit gamma-like [KO:K05070]
111842305  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
111839832  rho-related GTP-binding protein RhoA-D [KO:K04513]
111851074  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
111855859  rhoa; transforming protein RhoA [KO:K04513]
111857025  rho-related GTP-binding protein RhoA-C-like isoform X1 [KO:K04513]
111860004  transforming protein RhoA-like [KO:K04513]
111860372  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111835639  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111842358  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111841791  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111841989  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111841995  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111843853  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111846291  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111856890  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111837240  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111860223  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111842728  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
111842729  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111853508  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111833471  riboflavin-binding protein-like [KO:K13649]
111834890  riboflavin-binding protein-like isoform X1 [KO:K13649]
111833885  folate receptor alpha-like [KO:K13649]
111842435  caveolin-1-like [KO:K06278]
111836013  caveolin-1-like [KO:K06278]
111842436  caveolin-2-like [KO:K12958]
111836012  caveolin-2-like [KO:K12958]
111837470  caveolin-2-like [KO:K12958]
111835920  caveolin-3-like [KO:K12959]
111840522  caveolin-3-like [KO:K12959]
111858816  EH domain-containing protein 3 isoform X1 [KO:K12476]
111842391  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
111839052  ras-related protein Rab-5A-like [KO:K07887]
111842739  ras-related protein Rab-5A [KO:K07887]
111840667  ras-related protein Rab-5B-like [KO:K07888]
111857204  ras-related protein Rab-5B-like [KO:K07888]
111854212  ras-related protein Rab-5B-like [KO:K07888]
111842550  ras-related protein Rab-5C [KO:K07889]
111856002  ras-related protein Rab-5C-like [KO:K07889]
111854792  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
111847806  rbsn; rabenosyn-5 [KO:K12481]
111855066  rab4a; ras-related protein Rab-4A isoform X1 [KO:K07879]
111855158  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
111849020  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
111835133  EH domain-containing protein 1-like [KO:K12483]
111852989  EH domain-containing protein 3-like [KO:K12483]
111838436  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
111857201  snx4; sorting nexin-4 [KO:K17919]
111835315  rab22a; ras-related protein Rab-22A [KO:K07891]
111851532  rab10; ras-related protein Rab-10 [KO:K07903]
111857968  ras-related protein Rab-10-like [KO:K07903]
111847608  ras-related protein Rab-8A-like isoform X1 [KO:K07901]
111860317  rab8a; ras-related protein Rab-8A [KO:K07901]
111842210  ras-related protein Rab-35-like [KO:K07876]
111836821  ras-related protein Rab-35-like [KO:K07876]
111851356  ras-related protein Rab-35-like [KO:K07876]
111858745  rab35; ras-related protein Rab-35 [KO:K07876]
111843537  ras-related protein Rab-11A-like [KO:K07904]
111845628  ras-related protein Rab-11A [KO:K07904]
111853499  ras-related protein Rab-11A-like [KO:K07904]
111847606  ras-related protein Rab-11B-like [KO:K07905]
111860156  ras-related protein Rab-11B-like [KO:K07905]
111860402  rab11b; ras-related protein Rab-11B [KO:K07905]
111838544  titin-like isoform X1 [KO:K12484]
111835802  rab11 family-interacting protein 5-like isoform X1 [KO:K12484]
111837705  rab11fip5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
111857325  biorientation of chromosomes in cell division protein 1-like 1 isoform X1 [KO:K12484]
111859026  rab11fip2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
111848508  zfyve27; protrudin isoform X1 [KO:K19368]
111840240  kinesin-1 heavy chain [KO:K10396]
111835302  kif5a; kinesin heavy chain isoform X1 [KO:K10396]
111844687  kinesin heavy chain-like isoform X1 [KO:K10396]
111846111  kinesin heavy chain isoform X1 [KO:K10396]
111849479  kinesin heavy chain-like [KO:K10396]
111858161  kinesin-like protein K39 isoform X1 [KO:K10396]
111833454  rab11fip4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
111843298  rab11 family-interacting protein 4A-like isoform X1 [KO:K12485]
111841937  rab11fip3; rab11 family-interacting protein 3 [KO:K12485]
111840756  pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
111840222  partitioning defective 3 homolog [KO:K04237]
111843992  pard6g; partitioning defective 6 homolog gamma [KO:K06093]
111835177  pard6b; partitioning defective 6 homolog beta [KO:K06093]
111839837  partitioning defective 6 homolog beta-like [KO:K06093]
111851806  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
111859363  partitioning defective 6 homolog beta-like [KO:K06093]
111859097  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
111853452  protein kinase C iota type-like isoform X1 [KO:K06069] [EC:2.7.11.13]
111850461  prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
111834408  cell division control protein 42 homolog isoform X1 [KO:K04393]
111834477  cell division control protein 42 homolog isoform X1 [KO:K04393]
111835374  cell division control protein 42 homolog isoform X1 [KO:K04393]
111836813  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
111859497  stromal membrane-associated protein 1-like [KO:K12486]
111854267  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
111861062  ARF GTPase-activating protein GIT1-like isoform X1 [KO:K05737]
111854915  git2; ARF GTPase-activating protein GIT2 [KO:K12487]
111854985  ARF GTPase-activating protein GIT2-like [KO:K12487]
111857222  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
111846206  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
111859648  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
111841587  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
111850689  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
111857997  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
111836658  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12489]
111848179  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
111854480  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
111855746  acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
111857292  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
111838049  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
111833859  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
111849670  LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2-like [KO:K18440]
111836366  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
111845842  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3-like [KO:K12491]
111850201  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [KO:K12491]
111837095  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
111861105  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
111835338  ADP-ribosylation factor GTPase-activating protein 3-like [KO:K12493]
111851913  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
111858531  ADP-ribosylation factor GTPase-activating protein 2-like [KO:K12493]
111836432  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
111852982  PH and SEC7 domain-containing protein 2-like [KO:K12494]
111839836  uncharacterized protein LOC111839836 [KO:K12494]
111848393  PH and SEC7 domain-containing protein 1-like [KO:K12494]
111835349  PH and SEC7 domain-containing protein 3-like isoform X1 [KO:K12494]
111848587  PH and SEC7 domain-containing protein 3-like isoform X1 [KO:K12494]
111846167  IQ motif and SEC7 domain-containing protein 3-like isoform X1 [KO:K12495]
111840325  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
111847777  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
111835854  IQ motif and SEC7 domain-containing protein 3-like isoform X1 [KO:K12495]
111857033  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 1-like [KO:K12495]
111857041  iqsec1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
111843312  cytohesin-2-like [KO:K18441]
111853183  cytohesin-1-like isoform X1 [KO:K18441]
111853354  cyth2; cytohesin-2 [KO:K18441]
111848414  cyth1; cytohesin-1 isoform X1 [KO:K18441]
111856028  cytohesin-3-like isoform X1 [KO:K18441]
111859726  cytohesin-3-like isoform X1 [KO:K18441]
111853839  cytohesin-3-like isoform X1 [KO:K18441]
111853873  cytohesin-3 [KO:K18441]
111834851  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
111835170  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like isoform X1 [KO:K18442]
111839704  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
111832888  ADP-ribosylation factor 1-like [KO:K07937]
111845946  arf1; ADP-ribosylation factor 1 [KO:K07937]
111855997  ADP-ribosylation factor 1-like [KO:K07937]
111860635  ADP-ribosylation factor 3-like [KO:K07938]
111854171  arf3; ADP-ribosylation factor 3 [KO:K07938]
111837530  arf4; ADP-ribosylation factor 4 [KO:K07939]
111842417  ADP-ribosylation factor 4-like [KO:K07939]
111846134  ADP-ribosylation factor 4-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pki04060  Cytokine-cytokine receptor interaction
pki04070  Phosphatidylinositol signaling system
pki04130  SNARE interactions in vesicular transport
pki04142  Lysosome
pki04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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