KEGG   PATHWAY: pmur04218
Entry
pmur04218                   Pathway                                
Name
Cellular senescence - Protobothrops mucrosquamatus (Taiwan habu)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
pmur04218  Cellular senescence
pmur04218

Other DBs
GO: 0090398
Organism
Protobothrops mucrosquamatus (Taiwan habu) [GN:pmur]
Gene
107295274  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
107299193  transforming growth factor beta-2 proprotein-like [KO:K13376]
107293669  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
107285957  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
107298532  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
107299546  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
107284378  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
107290268  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
107283914  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
107291540  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
107283642  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
107285821  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107293964  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
107284299  RB1; retinoblastoma-associated protein [KO:K06618]
107285577  RBL1; retinoblastoma-like protein 1 [KO:K04681]
107289912  RBL2; retinoblastoma-like protein 2 [KO:K16332]
107294015  E2F1; transcription factor E2F1 [KO:K17454]
107302908  E2F2; transcription factor E2F2 [KO:K09389]
107302570  E2F3; transcription factor E2F3 [KO:K06620]
107294439  E2F5; transcription factor E2F5 [KO:K04682]
107288919  E2F4; transcription factor E2F4 [KO:K04682]
107285699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107292340  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107284997  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107292269  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
107282273  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107283596  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107286152  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107289857  FOXO1; forkhead box protein O1 [KO:K07201]
107292237  forkhead box protein O3 [KO:K09408]
107287054  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
107286965  cyclin-dependent kinase inhibitor 1 [KO:K06625]
107287774  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
107292735  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
107289143  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
107296724  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107300169  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107299542  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
107298893  HLA class I histocompatibility antigen, B-40 alpha chain-like [KO:K06751]
107295302  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
107300939  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107297239  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297243  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297666  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297667  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297668  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107301684  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
107299227  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297241  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299226  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107299474  major histocompatibility complex class I-related gene protein [KO:K06751]
107298387  zinc-alpha-2-glycoprotein-like [KO:K06751]
107298892  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107296727  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107296788  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107297665  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107300336  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107300372  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299473  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299476  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299543  major histocompatibility complex class I-related gene protein [KO:K06751]
107296728  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107294635  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107296790  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299846  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
114923648  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107300904  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107296734  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107296736  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107296789  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107297240  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297242  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297244  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107298793  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299225  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107299585  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
107301189  major histocompatibility complex class I-related gene protein-like [KO:K06751]
114923271  major histocompatibility complex class I-related gene protein-like [KO:K06751]
114923714  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107295639  KRAS; GTPase KRas isoform X1 [KO:K07827]
107296269  GTPase HRas [KO:K07827]
107282493  GTPase HRas [KO:K07827]
107284053  NRAS; GTPase NRas [KO:K07828]
107294100  RRAS2; ras-related protein R-Ras2 [KO:K07830]
107282439  RRAS; ras-related protein R-Ras [KO:K07830]
107295186  MRAS; ras-related protein M-Ras [KO:K07831]
107287923  HRAS; GTPase HRas [KO:K02833]
107292994  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107302433  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107285678  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107296501  TSC1; hamartin [KO:K07206]
107302611  TSC2; tuberin [KO:K07207]
107303314  RHEB; GTP-binding protein Rheb [KO:K07208]
107294607  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107285111  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107288080  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
107296600  CCNA2; cyclin-A2 [KO:K06627]
107287659  CCNA1; cyclin-A1 [KO:K06627]
107290469  MYBL2; myb-related protein B [KO:K21769]
107291209  LIN9; protein lin-9 homolog [KO:K21773]
107287997  LIN37; protein lin-37 homolog isoform X1 [KO:K21774]
107290493  LIN52; protein lin-52 homolog [KO:K21775]
107303185  LIN54; protein lin-54 homolog isoform X1 [KO:K21776]
114922619  tesmin-like [KO:K21776]
107283713  RBBP4; histone-binding protein RBBP4 [KO:K10752]
114923524  FOXM1; forkhead box protein M1 [KO:K09406]
107299311  MYC; myc proto-oncogene protein [KO:K04377]
107284408  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
107299049  cellular tumor antigen p53-like [KO:K04451]
107286171  RASSF5; ras association domain-containing protein 5 isoform X2 [KO:K08015]
107285262  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
107285651  HIPK4; homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
107288368  HIPK1; homeodomain-interacting protein kinase 1 [KO:K08826] [EC:2.7.11.1]
107289395  HIPK2; homeodomain-interacting protein kinase 2 [KO:K08826] [EC:2.7.11.1]
107302407  HIPK3; homeodomain-interacting protein kinase 3 [KO:K08826] [EC:2.7.11.1]
107298021  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
107302715  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
107286959  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
107295520  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
107283932  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107295320  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107282702  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107293871  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107293420  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107291170  ETS1; protein C-ets-1 [KO:K02678]
107282569  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
107292823  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
107292825  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
107286325  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
107286326  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
107299406  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
107296840  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
107302294  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
107290157  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
107297330  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
107300638  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
107303272  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
107297670  MRE11; double-strand break repair protein MRE11 [KO:K10865]
107290655  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
107285753  NBN; nibrin [KO:K10867]
107284835  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
107287280  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
107302716  RAD9A; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
107287000  RAD9B; cell cycle checkpoint control protein RAD9B [KO:K10995]
107296959  RAD1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
107299837  HUS1; checkpoint protein HUS1 isoform X1 [KO:K10903]
107292039  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
107296402  serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
107296403  serine/threonine-protein kinase Chk1-like [KO:K02216] [EC:2.7.11.1]
107296620  SQSTM1; sequestosome-1 [KO:K14381]
107289315  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
107287163  TRAF3IP2; adapter protein CIKS [KO:K21124]
107299002  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
107297118  RELA; transcription factor p65 [KO:K04735]
107282781  IL6; interleukin-6 [KO:K05405]
107282386  platelet basic protein [KO:K10030]
107295282  IGFBP3; LOW QUALITY PROTEIN: insulin-like growth factor-binding protein 3 [KO:K10138]
107285052  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
107284974  ZFP36L2; mRNA decay activator protein ZFP36L2 [KO:K18753]
107285834  ZFP36L1; mRNA decay activator protein ZFP36L1 [KO:K18753]
107287678  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
107287302  TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
107293588  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
107294458  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
107294378  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
107288074  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
107297355  calmodulin-A [KO:K02183]
107290686  CALML6; calmodulin-like protein 6 [KO:K02183]
107302156  calmodulin, striated muscle-like [KO:K02183]
107287851  CALM2; calmodulin-2 [KO:K02183]
107283902  CALML4; calmodulin-like protein 4 [KO:K02183]
107292392  CALM1; calmodulin-1 [KO:K02183]
107292429  calmodulin-like [KO:K02183]
107291942  CALM3; calmodulin-3 [KO:K02183]
114923392  calmodulin, striated muscle-like [KO:K02183]
107298959  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107289259  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
107287411  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
107286073  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
107295032  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
107286616  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
107293430  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
107296465  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
107287061  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
107302668  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
107301632  ADP/ATP translocase 2 [KO:K05863]
107289684  ADP/ATP translocase 3 [KO:K05863]
107290576  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
107286043  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
107294898  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
107298679  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
107287946  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
107295795  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
pmur04020  Calcium signaling pathway
pmur04068  FoxO signaling pathway
pmur04110  Cell cycle
pmur04115  p53 signaling pathway
pmur04150  mTOR signaling pathway
KO pathway
ko04218   
LinkDB

DBGET integrated database retrieval system