KEGG   PATHWAY: prob04640
Entry
prob04640                   Pathway                                
Name
Hematopoietic cell lineage - Phodopus roborovskii (desert hamster)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
prob04640  Hematopoietic cell lineage
prob04640

Organism
Phodopus roborovskii (desert hamster) [GN:prob]
Gene
127237937  Kitlg; kit ligand isoform X1 [KO:K05461]
127231164  Il7; interleukin-7 [KO:K05431]
127219302  Il4; interleukin-4 [KO:K05430]
127219779  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
127213872  Flt3lg; fms-related tyrosine kinase 3 ligand [KO:K05454]
127219782  Il5; interleukin-5 [KO:K05428]
127220934  Csf3; granulocyte colony-stimulating factor [KO:K05423]
127219855  interleukin-3 [KO:K04736]
127235558  Il6; interleukin-6 [KO:K05405]
127221461  Il1a; interleukin-1 alpha [KO:K04383]
127221462  Il1b; interleukin-1 beta [KO:K04519]
127224347  Tnf; tumor necrosis factor [KO:K03156]
127216878  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
127237335  Epo; erythropoietin [KO:K05437]
127226978  Thpo; thrombopoietin isoform X1 [KO:K06854]
127223970  Cd34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
127237147  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
127233335  Dntt; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
127224272  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X1 [KO:K06752]
127224273  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
127224274  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
127224276  class II histocompatibility antigen, M alpha chain [KO:K06752]
127224277  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
127224283  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
127224284  H-2 class II histocompatibility antigen, I-E beta chain isoform X1 [KO:K06752]
127224285  H-2 class II histocompatibility antigen, A-D beta chain [KO:K06752]
127224286  H-2 class II histocompatibility antigen, A-F alpha chain [KO:K06752]
127224287  H-2 class II histocompatibility antigen, E-U alpha chain [KO:K06752]
127224288  H-2 class II histocompatibility antigen, E-D beta chain-like [KO:K06752]
127224291  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
127222170  Cd44; CD44 antigen isoform X1 [KO:K06256]
127232399  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
127229952  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
127220635  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
127227077  Tfrc; transferrin receptor protein 1 [KO:K06503]
127233692  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
127221589  Cd7; T-cell antigen CD7 [KO:K06457]
127232695  Cd2; T-cell surface antigen CD2 [KO:K06449]
127228860  Cd5; T-cell surface glycoprotein CD5 [KO:K06455]
127233023  Cd1d; antigen-presenting glycoprotein CD1d [KO:K06448]
127213006  Cd4; T-cell surface glycoprotein CD4 [KO:K06454]
127235574  Cd8a; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
127235729  Cd8b; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
127231639  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
127231638  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
127231627  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
127232562  Mme; neprilysin [KO:K01389] [EC:3.4.24.11]
127239138  Cd9; CD9 antigen [KO:K06460]
127228321  Cd19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
127238627  Cd22; B-cell receptor CD22 isoform X1 [KO:K06467]
127228868  Ms4a1; B-lymphocyte antigen CD20 [KO:K06466]
127223972  Cr2; complement receptor type 2 isoform X1 [KO:K04012]
127213729  Cd37; leukocyte antigen CD37 [KO:K06475]
127237228  Fcer2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
127223973  Cr1l; complement component receptor 1-like protein isoform X1 [KO:K04011]
127231950  Csf2ra; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
127217573  interleukin-3 receptor subunit alpha [KO:K04737]
127213754  myeloid cell surface antigen CD33 [KO:K06473]
127213802  myeloid cell surface antigen CD33 [KO:K06473]
127228311  Il4r; interleukin-4 receptor subunit alpha [KO:K05071]
127232640  Il6r; interleukin-6 receptor subunit alpha [KO:K05055]
127232830  Fcgr1a; high affinity immunoglobulin gamma Fc receptor I isoform X1 [KO:K06498]
127234180  Csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
127238156  Anpep; aminopeptidase N [KO:K11140] [EC:3.4.11.2]
127228416  Itgam; integrin alpha-M isoform X1 [KO:K06461]
127235120  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
127219471  LOW QUALITY PROTEIN: interleukin-9 receptor-like [KO:K05073]
127236676  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
127236720  Il1r2; interleukin-1 receptor type 2 [KO:K04387]
127225324  Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
127236061  Il5ra; LOW QUALITY PROTEIN: interleukin-5 receptor subunit alpha [KO:K05067]
127236086  interleukin-5 receptor subunit alpha [KO:K05067]
127231484  Epor; erythropoietin receptor isoform X1 [KO:K05079]
127214375  Cd36; platelet glycoprotein 4 [KO:K06259]
127237534  glycophorin-A-like [KO:K06575]
127236337  Cd55; complement decay-accelerating factor [KO:K04006]
127222190  Cd59; CD59 glycoprotein [KO:K04008]
127224548  Il11ra; interleukin-11 receptor subunit alpha [KO:K05056]
127217777  Itgb3; integrin beta-3 [KO:K06493]
127217149  Itga2b; integrin alpha-IIb [KO:K06476]
127235976  Gp9; platelet glycoprotein IX [KO:K06263]
127218997  Gp1ba; platelet glycoprotein Ib alpha chain [KO:K06261]
127226892  Gp1bb; platelet glycoprotein Ib beta chain [KO:K06262]
127226845  Gp5; platelet glycoprotein V [KO:K06260]
127221141  Itga1; integrin alpha-1 [KO:K06480]
127221163  Itga2; integrin alpha-2 [KO:K06481]
127236765  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
127222361  Itga4; integrin alpha-4 [KO:K06483]
127226174  Itga5; integrin alpha-5 [KO:K06484]
127222422  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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