KEGG   PATHWAY: pspa04114
Entry
pspa04114                   Pathway                                
Name
Oocyte meiosis - Polyodon spathula (Mississippi paddlefish)
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle.
Class
Cellular Processes; Cell growth and death
Pathway map
pspa04114  Oocyte meiosis
pspa04114

Other DBs
GO: 0051321
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121295106  insulin-like [KO:K04526]
121330389  insulin-like [KO:K04526]
121305882  insulin-2 [KO:K04526]
121300243  uncharacterized protein LOC121300243 [KO:K05459]
121300319  uncharacterized protein LOC121300319 [KO:K05459]
121318433  igf1; insulin-like growth factor I [KO:K05459]
121319666  insulin-like growth factor I [KO:K05459]
121298882  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121294410  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
121321261  progesterone receptor-like [KO:K08556]
121295415  androgen receptor-like [KO:K08557]
121318934  androgen receptor-like isoform X1 [KO:K08557]
121313146  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
121314511  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
121314788  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
121309305  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
121316002  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121305249  adenylate cyclase type 2-like [KO:K08044] [EC:4.6.1.1]
121307360  adenylate cyclase type 2-like isoform X1 [KO:K08044] [EC:4.6.1.1]
121322506  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
121322974  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
121309011  adcy6a; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121296167  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
121325516  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
121309014  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
121300452  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
121330489  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
121326749  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121310175  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
121331016  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
121309295  aurora kinase C-like [KO:K11481] [EC:2.7.11.1]
121319424  aurora kinase B-like isoform X1 [KO:K11481] [EC:2.7.11.1]
121319425  aurora kinase B-like isoform X1 [KO:K11481] [EC:2.7.11.1]
121296885  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
121298851  cytoplasmic polyadenylation element-binding protein 1-like isoform X1 [KO:K02602]
121294278  cytoplasmic polyadenylation element-binding protein 1-like [KO:K02602]
121321878  cytoplasmic polyadenylation element-binding protein 3-like isoform X1 [KO:K02602]
121329934  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
121324240  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
121324613  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
121325233  cytoplasmic polyadenylation element-binding protein 3-like isoform X1 [KO:K02602]
121309449  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
121294557  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121298929  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121304127  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121297147  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121306857  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
121307738  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121305215  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121295601  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
121315764  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
121316869  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
121302926  ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
121303256  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
121318776  ribosomal protein S6 kinase alpha-6-like isoform X1 [KO:K04373] [EC:2.7.11.1]
121305212  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
121297946  14-3-3 protein beta/alpha-1-like [KO:K16197]
121314939  14-3-3 protein beta/alpha-1-like [KO:K16197]
121315401  14-3-3 protein beta/alpha-1-like [KO:K16197]
121317537  ywhaqa; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a [KO:K16197]
121313242  14-3-3 protein beta/alpha-1-like [KO:K16197]
121319475  ywhaba; 14-3-3 protein beta/alpha-A isoform X1 [KO:K16197]
121308632  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
121297394  14-3-3 protein eta isoform X1 [KO:K16198]
121300130  14-3-3 protein eta isoform X1 [KO:K16198]
121308007  14-3-3 protein gamma-B [KO:K16198]
121317335  spdya; speedy protein A [KO:K08694]
121325792  cyclin-dependent kinase 1-B-like isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
121321871  cyclin-dependent kinase 1-B [KO:K02087] [EC:2.7.11.22 2.7.11.23]
121321977  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
121309065  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
121298255  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121299882  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121299883  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121328667  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
121317948  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121317949  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
121304626  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121304667  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
121297200  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A isoform X1 [KO:K06269] [EC:3.1.3.16]
121300004  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
121307312  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
121316199  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121302127  serine/threonine-protein phosphatase PP1-alpha catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
121317328  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121310072  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
121325707  slka; STE20-like serine/threonine-protein kinase isoform X1 [KO:K08836] [EC:2.7.11.1]
121321721  STE20-like serine/threonine-protein kinase isoform X1 [KO:K08836] [EC:2.7.11.1]
121302085  serine/threonine-protein kinase 10-like [KO:K08836] [EC:2.7.11.1]
121302987  STE20-like serine/threonine-protein kinase [KO:K08836] [EC:2.7.11.1]
121300783  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
121330472  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
121323933  M-phase inducer phosphatase 1-B-like [KO:K05867] [EC:3.1.3.48]
121294513  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
121299044  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
121304856  cyclin N-terminal domain-containing protein 2 [KO:K21770]
121306254  cth1; cysteine three histidine 1 [KO:K13056]
121306188  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
121312791  cullin-1 isoform X1 [KO:K03347]
121314253  cullin-1 isoform X1 [KO:K03347]
121297582  S-phase kinase-associated protein 1 [KO:K03094]
121324310  S-phase kinase-associated protein 1-like [KO:K03094]
121297128  F-box/WD repeat-containing protein 11-like isoform X1 [KO:K03362]
121326084  beta-TrCP-like isoform X1 [KO:K03362]
121321847  beta-TrCP isoform X1 [KO:K03362]
121324395  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
121316550  fbxo5; F-box only protein 5 [KO:K10292]
121317167  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
121310839  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
121301897  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
121324587  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
121319808  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
121299765  anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
121320698  LOW QUALITY PROTEIN: cell division cycle protein 16 homolog [KO:K03353]
121327963  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
121297533  anaphase-promoting complex subunit 7 [KO:K03354]
121300219  anaphase-promoting complex subunit 7-like [KO:K03354]
121297010  cdc23; cell division cycle protein 23 homolog [KO:K03355]
121296987  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
121321149  anaphase-promoting complex subunit 10-like isoform X1 [KO:K03357]
121296548  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
121306659  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
121309512  anaphase-promoting complex subunit 13-like [KO:K12456]
121302730  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
121326257  anaphase-promoting complex subunit 16-like [KO:K25229]
121321838  anaphase-promoting complex subunit 16 [KO:K25229]
121327247  cell division cycle protein 20 homolog isoform X1 [KO:K03363]
121331183  cell division cycle protein 20 homolog [KO:K03363]
121313235  F-box only protein 43-like [KO:K10318]
121313877  F-box only protein 43-like [KO:K10318]
121297530  securin-like [KO:K06635]
121297569  securin-like [KO:K06635]
121324811  securin-like [KO:K06635]
121308896  espl1; separin [KO:K02365] [EC:3.4.22.49]
121305202  rec8b; REC8 meiotic recombination protein b [KO:K13054]
121318529  smc1b; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
121305362  structural maintenance of chromosomes protein 1A isoform X1 [KO:K06636]
121325778  LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 3-like [KO:K06669]
121321859  structural maintenance of chromosomes protein 3 [KO:K06669]
121300671  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121300682  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121326955  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121317063  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121317073  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121316757  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
121322670  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
121328376  mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
121328397  mitotic spindle assembly checkpoint protein MAD2B-like isoform X1 [KO:K13728]
121300878  mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
121296104  G1/S-specific cyclin-E1-like [KO:K06626]
121314970  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
121313217  LOW QUALITY PROTEIN: G1/S-specific cyclin-E2-like [KO:K06626]
121325210  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
121315139  shugoshin 1-like isoform X1 [KO:K11580]
121313658  shugoshin 1-like isoform X1 [KO:K11580]
121306333  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
121315690  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
121315959  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
121316772  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like [KO:K11584]
121317086  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like isoform X1 [KO:K11584]
121329871  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121330040  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
121324264  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121324682  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
121298657  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
121309384  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
121303981  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
121304409  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
121301154  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121297320  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121316582  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121324408  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
121318987  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like [KO:K05861] [EC:3.1.4.11]
121298161  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121328701  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121318388  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
121319707  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
121299669  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
121304724  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
121294605  calmodulin-like protein 4 [KO:K02183]
121298942  calml4a; calmodulin-like protein 4a [KO:K02183]
121316330  calmodulin-1 [KO:K02183]
121316692  calmodulin-1 [KO:K02183]
121303849  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
121329906  calmodulin-1 [KO:K02183]
121323988  calmodulin-1 [KO:K02183]
121304911  calmodulin-1 [KO:K02183]
121296291  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121297616  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
121325811  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121321999  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121302376  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121303088  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121324996  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121316113  calcineurin subunit B type 1 [KO:K06268]
121317240  calcineurin subunit B type 1-like [KO:K06268]
121318631  plastin-3-like [KO:K06268]
121295509  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
121296837  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121321778  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
121322582  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
121303013  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
121323838  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
121325571  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
Compound
C00076  Calcium cation
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16760654
  Authors
Haccard O, Jessus C
  Title
Oocyte maturation, Mos and cyclins--a matter of synthesis: two functionally redundant ways to induce meiotic maturation.
  Journal
Cell Cycle 5:1152-9 (2006)
DOI:10.4161/cc.5.11.2800
Reference
PMID:15182704
  Authors
Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV
  Title
Aurora A, meiosis and mitosis.
  Journal
Biol Cell 96:215-29 (2004)
DOI:10.1016/j.biolcel.2003.09.008
Reference
PMID:15136768
  Authors
Perdiguero E, Nebreda AR
  Title
Regulation of Cdc25C activity during the meiotic G2/M transition.
  Journal
Cell Cycle 3:733-7 (2004)
DOI:10.4161/cc.3.6.906
Reference
PMID:17480229
  Authors
Perry JA, Kornbluth S
  Title
Cdc25 and Wee1: analogous opposites?
  Journal
Cell Div 2:12 (2007)
DOI:10.1186/1747-1028-2-12
Reference
PMID:15182701
  Authors
Jessus C, Ozon R
  Title
How does Xenopus oocyte acquire its competence to undergo meiotic maturation?
  Journal
Biol Cell 96:187-92 (2004)
DOI:10.1016/j.biolcel.2003.12.007
Reference
PMID:16518630
  Authors
Revenkova E, Jessberger R
  Title
Shaping meiotic prophase chromosomes: cohesins and synaptonemal complex proteins.
  Journal
Chromosoma 115:235-40 (2006)
DOI:10.1007/s00412-006-0060-x
Reference
PMID:18631137
  Authors
Belloc E, Pique M, Mendez R
  Title
Sequential waves of polyadenylation and deadenylation define a translation circuit that drives meiotic progression.
  Journal
Biochem Soc Trans 36:665-70 (2008)
DOI:10.1042/BST0360665
Reference
PMID:18598214
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
DOI:10.1146/annurev.cellbio.041408.115949
Reference
PMID:18550795
  Authors
Tang W, Wu JQ, Guo Y, Hansen DV, Perry JA, Freel CD, Nutt L, Jackson PK, Kornbluth S
  Title
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
  Journal
Mol Biol Cell 19:3536-43 (2008)
DOI:10.1091/mbc.E08-04-0417
Reference
PMID:18946022
  Authors
Wu JQ, Kornbluth S
  Title
Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
  Journal
J Cell Sci 121:3509-14 (2008)
DOI:10.1242/jcs.036855
Reference
PMID:16554437
  Authors
Schmidt A, Rauh NR, Nigg EA, Mayer TU
  Title
Cytostatic factor: an activity that puts the cell cycle on hold.
  Journal
J Cell Sci 119:1213-8 (2006)
DOI:10.1242/jcs.02919
Reference
PMID:18096427
  Authors
Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U
  Title
Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
  Journal
Mutat Res 651:14-29 (2008)
DOI:10.1016/j.mrgentox.2007.10.015
Reference
PMID:18311174
  Authors
Perry AC, Verlhac MH
  Title
Second meiotic arrest and exit in frogs and mice.
  Journal
EMBO Rep 9:246-51 (2008)
DOI:10.1038/embor.2008.22
Reference
PMID:14691134
  Authors
Tunquist BJ, Eyers PA, Chen LG, Lewellyn AL, Maller JL
  Title
Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.
  Journal
J Cell Biol 163:1231-42 (2003)
DOI:10.1083/jcb.200306153
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Related
pathway
pspa04010  MAPK signaling pathway
pspa04120  Ubiquitin mediated proteolysis
pspa04914  Progesterone-mediated oocyte maturation
KO pathway
ko04114   
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