KEGG   PATHWAY: pspa04120
Entry
pspa04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Polyodon spathula (Mississippi paddlefish)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
pspa04120  Ubiquitin mediated proteolysis
pspa04120

Other DBs
GO: 0016567
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121294171  ube2ia; SUMO-conjugating enzyme UBC9-B [KO:K10577]
121294299  ddb2; DNA damage-binding protein 2 [KO:K10140]
121294310  [KO:K10571]
121294481  [KO:K10582] [EC:2.3.2.23]
121294526  [KO:K10054] [EC:2.3.2.-]
121294606  [KO:K04706] [EC:2.3.2.-]
121294648  [KO:K10594] [EC:2.3.2.26]
121294702  [KO:K10591] [EC:2.3.2.26]
121294705  [KO:K03175] [EC:2.3.2.27]
121294765  [KO:K10699] [EC:6.2.1.45]
121294899  [KO:K10054] [EC:2.3.2.-]
121295091  [KO:K10054] [EC:2.3.2.-]
121295491  klhl13; kelch-like protein 13 isoform X1 [KO:K10447]
121295547  [KO:K04678] [EC:2.3.2.26]
121295567  [KO:K04725] [EC:2.3.2.27]
121295672  [KO:K04696]
121295690  [KO:K10609]
121296338  [KO:K10685] [EC:6.2.1.45]
121296342  [KO:K06689] [EC:2.3.2.23]
121296358  [KO:K04678] [EC:2.3.2.26]
121296491  [KO:K04696]
121296548  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
121296555  [KO:K04506] [EC:2.3.2.27]
121296559  [KO:K10581] [EC:2.3.2.24]
121296627  [KO:K05630] [EC:2.3.2.26]
121296712  [KO:K10260]
121296987  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
121297010  cdc23; cell division cycle protein 23 homolog [KO:K03355]
121297053  [KO:K10588] [EC:2.3.2.26]
121297121  ube2d2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
121297128  [KO:K03362]
121297159  [KO:K10598] [EC:5.2.1.8]
121297197  [KO:K10575] [EC:2.3.2.23]
121297221  [KO:K08770]
121297254  [KO:K10574] [EC:2.3.2.23]
121297338  [KO:K04552] [EC:2.3.2.23]
121297533  [KO:K03354]
121297582  [KO:K03094]
121297887  [KO:K10686] [EC:6.2.1.64]
121298016  [KO:K05632] [EC:2.3.2.26]
121298257  [KO:K06688] [EC:2.3.2.23]
121298654  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
121298777  [KO:K22517] [EC:2.3.2.27]
121298941  [KO:K04706] [EC:2.3.2.-]
121299035  [KO:K10582] [EC:2.3.2.23]
121299038  [KO:K10594] [EC:2.3.2.26]
121299089  [KO:K10571]
121299165  [KO:K10591] [EC:2.3.2.26]
121299280  [KO:K10054] [EC:2.3.2.-]
121299465  [KO:K10598] [EC:5.2.1.8]
121299691  [KO:K16063] [EC:2.3.2.-]
121299765  anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
121299782  [KO:K04552] [EC:2.3.2.23]
121299923  [KO:K10264]
121299939  ube3b; LOW QUALITY PROTEIN: ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
121300049  [KO:K10575] [EC:2.3.2.23]
121300090  [KO:K08770]
121300219  [KO:K03354]
121300438  [KO:K16065] [EC:2.3.2.27]
121300478  [KO:K10291]
121300605  [KO:K10577]
121300713  mgrn1a; probable E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
121300751  [KO:K03364]
121300820  [KO:K09561] [EC:2.3.2.27]
121300858  [KO:K04678] [EC:2.3.2.26]
121300913  [KO:K04416] [EC:2.7.11.25]
121300992  [KO:K10456]
121301004  [KO:K02927]
121301284  [KO:K16065] [EC:2.3.2.27]
121301304  [KO:K02207] [EC:2.3.2.23]
121301330  [KO:K02207] [EC:2.3.2.23]
121301389  [KO:K02927]
121301532  fzr1a; fizzy/cell division cycle 20 related 1a isoform X1 [KO:K03364]
121301536  [KO:K10456]
121301600  [KO:K04694]
121301897  [KO:K03350]
121301922  ube2z; ubiquitin-conjugating enzyme E2 Z isoform X1 [KO:K10585] [EC:2.3.2.23]
121302017  [KO:K10605] [EC:2.3.2.27]
121302072  [KO:K07868]
121302283  [KO:K10599] [EC:2.3.2.27]
121302395  ube2s; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
121302451  [KO:K06689] [EC:2.3.2.23]
121302550  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
121302581  [KO:K22517] [EC:2.3.2.27]
121302617  [KO:K04707] [EC:2.3.2.27]
121302730  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
121302792  [KO:K10612]
121303082  [KO:K06689] [EC:2.3.2.23]
121303192  [KO:K07868]
121303518  [KO:K10607] [EC:2.3.2.27]
121303625  [KO:K10607] [EC:2.3.2.27]
121304555  [KO:K13305] [EC:2.3.2.26]
121304715  [KO:K02207] [EC:2.3.2.23]
121304766  [KO:K03875]
121304824  sae1; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
121305213  elob; elongin-B [KO:K03873]
121305514  [KO:K10592] [EC:2.3.2.26]
121305990  ube2m; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
121306188  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
121306283  syvn1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
121306659  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
121306676  [KO:K10447]
121306893  rhobtb4; rho related BTB domain containing 4 isoform X1 [KO:K07868]
121307161  [KO:K02207] [EC:2.3.2.23]
121307227  [KO:K10599] [EC:2.3.2.27]
121307258  [KO:K04552] [EC:2.3.2.23]
121307572  [KO:K10585] [EC:2.3.2.23]
121307614  ddb1; DNA damage-binding protein 1 isoform X1 [KO:K10610]
121307615  [KO:K07868]
121307689  [KO:K10588] [EC:2.3.2.26]
121307875  [KO:K06688] [EC:2.3.2.23]
121307987  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
121308426  ubb; polyubiquitin-B [KO:K08770]
121308499  trim37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
121308535  ube2g1a; ubiquitin-conjugating enzyme E2 G1a [KO:K10575] [EC:2.3.2.23]
121308566  [KO:K10602] [EC:2.3.2.27]
121309156  keap1b; kelch-like ECH-associated protein 1B [KO:K10456]
121309367  [KO:K10577]
121309408  ube4a; ubiquitin conjugation factor E4 A isoform X1 [KO:K10596] [EC:2.3.2.27]
121309453  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
121309512  [KO:K12456]
121310373  [KO:K10589] [EC:2.3.2.26]
121310839  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
121311037  [KO:K03870]
121312708  [KO:K05633] [EC:2.3.2.26]
121312791  [KO:K03347]
121312856  [KO:K10582] [EC:2.3.2.23]
121312880  [KO:K20217] [EC:2.3.2.23]
121312881  [KO:K20217] [EC:2.3.2.23]
121313249  [KO:K10593] [EC:2.3.2.26]
121313409  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
121313410  [KO:K03872]
121313980  [KO:K16063] [EC:2.3.2.-]
121314065  [KO:K10589] [EC:2.3.2.26]
121314089  [KO:K03870]
121314160  [KO:K05633] [EC:2.3.2.26]
121314253  [KO:K03347]
121314357  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
121314358  [KO:K03872]
121314766  [KO:K20217] [EC:2.3.2.23]
121314767  [KO:K20217] [EC:2.3.2.23]
121314784  ube2ql1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
121314934  [KO:K10593] [EC:2.3.2.26]
121315448  [KO:K10578] [EC:2.3.2.23]
121315672  [KO:K10586] [EC:2.3.2.23]
121316088  [KO:K10594] [EC:2.3.2.26]
121316144  fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
121316151  [KO:K02977]
121316301  prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
121316749  [KO:K10586] [EC:2.3.2.23]
121316750  [KO:K04416] [EC:2.7.11.25]
121316847  ercc8; DNA excision repair protein ERCC-8 [KO:K10570]
121317167  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
121317285  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
121317488  ubox5; RING finger protein 37 isoform X1 [KO:K10600]
121317596  ube2j1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
121317976  [KO:K06643] [EC:2.3.2.27]
121318113  [KO:K13305] [EC:2.3.2.26]
121318161  [KO:K10576] [EC:2.3.2.23]
121318314  [KO:K03875]
121318397  [KO:K10580] [EC:2.3.2.23]
121318420  [KO:K10291]
121318627  [KO:K10447]
121318828  cul4b; cullin-4B [KO:K10609]
121318839  [KO:K10573] [EC:2.3.2.23]
121318906  [KO:K04725] [EC:2.3.2.27]
121319263  [KO:K05632] [EC:2.3.2.26]
121319306  birc7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
121319700  [KO:K10580] [EC:2.3.2.23]
121319808  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
121319946  [KO:K10576] [EC:2.3.2.23]
121320080  [KO:K06643] [EC:2.3.2.27]
121320092  vhll; von Hippel-Lindau-like protein [KO:K03871]
121320645  [KO:K08285] [EC:2.3.2.27]
121320698  [KO:K03353]
121320744  [KO:K10447]
121320873  [KO:K10609]
121320902  herc3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
121321014  [KO:K10595] [EC:2.3.2.26]
121321020  [KO:K10587] [EC:2.3.2.26]
121321149  [KO:K03357]
121321435  [KO:K10260]
121321732  [KO:K10615] [EC:2.3.2.26]
121321838  [KO:K25229]
121321847  [KO:K03362]
121321942  [KO:K06689] [EC:2.3.2.23]
121322059  [KO:K07868]
121322060  [KO:K06689] [EC:2.3.2.23]
121322074  [KO:K04555] [EC:2.3.2.23]
121322179  [KO:K20217] [EC:2.3.2.23]
121322463  [KO:K10687] [EC:2.3.2.34]
121322865  trip12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
121323127  [KO:K10611]
121323285  [KO:K03869]
121323356  [KO:K10687] [EC:2.3.2.34]
121323396  [KO:K10699] [EC:6.2.1.45]
121323589  [KO:K04555] [EC:2.3.2.23]
121323605  [KO:K20217] [EC:2.3.2.23]
121323973  ube2kb; ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) isoform X1 [KO:K04649] [EC:2.3.2.23]
121324205  [KO:K06689] [EC:2.3.2.23]
121324253  [KO:K10574] [EC:2.3.2.23]
121324310  [KO:K03094]
121324395  [KO:K03362]
121324587  [KO:K03350]
121325280  [KO:K04506] [EC:2.3.2.27]
121325524  wwp2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
121325647  ube2d1b; ubiquitin-conjugating enzyme E2 D1b [KO:K06689] [EC:2.3.2.23]
121325675  [KO:K10615] [EC:2.3.2.26]
121325752  [KO:K10685] [EC:6.2.1.45]
121325978  [KO:K07868]
121326084  [KO:K03362]
121326257  [KO:K25229]
121326500  [KO:K10590] [EC:2.3.2.26]
121326572  aire; autoimmune regulator [KO:K10603]
121326650  [KO:K10584] [EC:2.3.2.23]
121326747  [KO:K03364]
121326760  [KO:K03869]
121326861  cop1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
121327008  [KO:K10594] [EC:2.3.2.26]
121327169  [KO:K10611]
121327247  [KO:K03363]
121327867  [KO:K10609]
121327922  [KO:K08285] [EC:2.3.2.27]
121327935  [KO:K10595] [EC:2.3.2.26]
121327963  [KO:K03353]
121328008  [KO:K10447]
121328180  [KO:K10587] [EC:2.3.2.26]
121328338  [KO:K10570]
121328420  [KO:K10099]
121328461  uba1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
121328582  [KO:K10597] [EC:2.3.2.27]
121328599  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
121328988  [KO:K03178] [EC:6.2.1.45]
121329025  [KO:K04554] [EC:2.3.2.23]
121329055  [KO:K10592] [EC:2.3.2.26]
121329119  [KO:K10686] [EC:6.2.1.64]
121329151  [KO:K10099]
121329187  [KO:K04554] [EC:2.3.2.23]
121329306  vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
121329311  [KO:K04649] [EC:2.3.2.23]
121329873  [KO:K03175] [EC:2.3.2.27]
121330784  [KO:K10604] [EC:2.3.2.27]
121330930  [KO:K04678] [EC:2.3.2.26]
121330955  [KO:K09561] [EC:2.3.2.27]
121331018  [KO:K04694]
121331043  [KO:K03364]
121331169  [KO:K10143] [EC:2.3.2.27]
121331183  [KO:K03363]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
pspa03050  Proteasome
KO pathway
ko04120   

DBGET integrated database retrieval system