KEGG   PATHWAY: rmp03013
Entry
rmp03013                    Pathway                                
Name
Nucleocytoplasmic transport - Rhipicephalus microplus (southern cattle tick)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
rmp03013  Nucleocytoplasmic transport
rmp03013

Other DBs
GO: 0050658
Organism
Rhipicephalus microplus (southern cattle tick) [GN:rmp]
Gene
119185808  aladin-like [KO:K14320]
119175805  nucleoporin NUP42-like [KO:K14321]
119172000  LOW QUALITY PROTEIN: nucleoporin GLE1-like [KO:K18723]
119181706  DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
119163532  mRNA export factor-like [KO:K14298]
119177962  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
119161321  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
119181806  nucleoporin 88-like [KO:K14318]
119166796  LOW QUALITY PROTEIN: E3 SUMO-protein ligase RanBP2-like [KO:K12172] [EC:2.3.2.-]
119170422  ran GTPase-activating protein 1-like isoform X1 [KO:K14319]
119160935  uncharacterized protein LOC119160935 isoform X1 [KO:K14319]
119179697  SUMO-conjugating enzyme UBC9 [KO:K10577]
119169981  small ubiquitin-related modifier 3-like [KO:K12160]
119178701  small ubiquitin-related modifier-like [KO:K12160]
119181493  LOW QUALITY PROTEIN: nuclear pore complex protein Nup160-like [KO:K14303]
119174232  nuclear pore complex protein Nup85-like isoform X1 [KO:K14304]
119184994  protein SEC13 homolog [KO:K14004]
119186756  nuclear pore complex protein Nup107-like [KO:K14301]
119162136  nuclear pore complex protein Nup107-like [KO:K14301]
119162187  nuclear pore complex protein Nup107-like [KO:K14301]
119165476  nuclear pore complex protein Nup107-like [KO:K14301]
119177782  nuclear pore complex protein Nup107-like [KO:K14301]
119168316  nuclear pore complex protein Nup107-like [KO:K14301]
119184977  LOW QUALITY PROTEIN: nuclear pore complex protein Nup133-like [KO:K14300]
119171967  nucleoporin SEH1-like [KO:K14299]
119174997  nucleoporin Nup43-like [KO:K14305]
119164479  nucleoporin Nup37-like [KO:K14302]
119170733  serine/arginine repetitive matrix protein 2-like isoform X1 [KO:K25129]
119178366  nuclear pore glycoprotein p62-like [KO:K14306]
119170237  nuclear pore complex protein Nup58-like isoform X1 [KO:K14307]
119170461  nuclear pore complex protein Nup54-like [KO:K14308]
119172703  LOW QUALITY PROTEIN: nuclear pore complex protein Nup205-like [KO:K14310]
119174903  LOW QUALITY PROTEIN: nucleoporin NUP188 homolog [KO:K14311]
119180326  nuclear pore complex protein Nup155-like [KO:K14312]
119166994  nuclear pore complex protein Nup93-like [KO:K14309]
119181593  nucleoporin NUP35-like [KO:K14313]
119180917  nucleoporin NDC1-like [KO:K14315]
119181467  nuclear pore membrane glycoprotein 210-like [KO:K14314]
119181777  nuclear pore membrane glycoprotein 210-like [KO:K14314]
119161789  nuclear envelope pore membrane protein POM 121-like [KO:K14316]
119170064  transmembrane protein 33-like [KO:K20724]
119180347  nucleoprotein TPR-like [KO:K09291]
119179905  nuclear pore complex protein Nup50-like [KO:K14295]
119164835  LOW QUALITY PROTEIN: nuclear pore complex protein Nup153-like [KO:K14296]
119174394  importin subunit alpha-5-like [KO:K15043]
119188178  LOW QUALITY PROTEIN: importin subunit alpha-4-like [KO:K23583]
119170890  importin subunit alpha-8-like [KO:K15042]
119187521  importin subunit alpha-7-like [KO:K15042]
119174817  LOW QUALITY PROTEIN: importin subunit alpha-7-like [KO:K15042]
119159524  importin subunit beta-1-like isoform X1 [KO:K14293]
119180897  transportin-1-like [KO:K18752]
119162090  transportin-1-like [KO:K18752]
119164401  LOW QUALITY PROTEIN: transportin-3-like [KO:K15436]
119187392  importin-4-like [KO:K20221]
119159718  LOW QUALITY PROTEIN: importin-5-like [KO:K20222]
119169136  importin-7-like [KO:K20223]
119174577  importin-9-like isoform X1 [KO:K20224]
119164671  importin-11-like [KO:K25201]
119181380  importin-13-like isoform X1 [KO:K25202]
119159559  snurportin-1-like isoform X1 [KO:K13151]
119164405  LOW QUALITY PROTEIN: exportin-1-like [KO:K14290]
119186206  exportin-2-like [KO:K18423]
119174794  exportin-T-like isoform X1 [KO:K14288]
119174811  exportin-4-like isoform X1 [KO:K25203]
119166965  LOW QUALITY PROTEIN: exportin-5-like [KO:K14289]
119179301  exportin-6-like [KO:K25204]
119175985  exportin-7-B-like isoform X1 [KO:K18460]
119173663  LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran-like [KO:K07936]
119170533  elongation factor 1-alpha [KO:K03231]
119159422  phosphorylated adapter RNA export protein-like [KO:K14291]
119159492  nuclear cap-binding protein subunit 1-like isoform X1 [KO:K12882]
119180761  nuclear cap-binding protein subunit 2 [KO:K12883]
119165505  uncharacterized protein LOC119165505 [KO:K12883]
119159631  60S ribosomal export protein NMD3-like [KO:K07562]
119187916  RNA-binding protein 8A-like [KO:K12876]
119180965  protein mago nashi homolog [KO:K12877]
119176041  protein CASC3-like isoform X1 [KO:K14323]
119176042  protein CASC3-like [KO:K14323]
119176692  protein CASC3-like [KO:K14323]
119166929  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
119174472  histone deacetylase complex subunit SAP18-like [KO:K14324]
119167014  pinin-like isoform X1 [KO:K13114]
119179648  aly/REF export factor 2-like [KO:K12881]
119182959  regulator of nonsense transcripts 1-like [KO:K14326] [EC:5.6.2.5 5.6.2.3]
119174744  LOW QUALITY PROTEIN: regulator of nonsense transcripts 2-like [KO:K14327]
119166954  LOW QUALITY PROTEIN: nuclear RNA export factor 1-like [KO:K14284]
119163918  NTF2-related export protein 1-like [KO:K14285]
119176872  NTF2-related export protein-like [KO:K14285]
119161134  spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
119173942  spliceosome RNA helicase DDX39B-like [KO:K12812] [EC:5.6.2.7]
119170044  ATP-dependent RNA helicase DDX39A-like [KO:K12812] [EC:5.6.2.7]
119175006  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
119159515  partner of Y14 and mago-like isoform X1 [KO:K14294]
119164819  THO complex subunit 1-like [KO:K12878]
119177351  THO complex subunit 2-like [KO:K12879]
119172005  LOW QUALITY PROTEIN: THO complex subunit 5 homolog [KO:K13174]
119179472  THO complex subunit 6 homolog [KO:K13175]
119174099  THO complex subunit 7 homolog isoform X1 [KO:K13176]
119166735  THO complex subunit 3-like [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
rmp03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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