KEGG   PATHWAY: rtem03013
Entry
rtem03013                   Pathway                                
Name
Nucleocytoplasmic transport - Rana temporaria (common frog)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
rtem03013  Nucleocytoplasmic transport
rtem03013

Other DBs
GO: 0050658
Organism
Rana temporaria (common frog) [GN:rtem]
Gene
120929325  AAAS; aladin isoform X1 [KO:K14320]
120940166  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
120914189  GLE1; nucleoporin GLE1 [KO:K18723]
120916194  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
120919484  RAE1; mRNA export factor isoform X1 [KO:K14298]
120928756  NUP98; LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96 [KO:K14297]
120940296  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
120926587  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
120926499  E3 SUMO-protein ligase RanBP2-like [KO:K12172] [EC:2.3.2.-]
120945412  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
120943431  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
120918480  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
120943741  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
120943845  SUMO3; small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
120917169  NUP160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
120918467  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
120945018  SEC13; protein SEC13 homolog [KO:K14004]
120931993  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
120940846  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
120937404  NUP43; nucleoporin Nup43 [KO:K14305]
120932130  NUP37; nucleoporin Nup37 [KO:K14302]
120928965  LOW QUALITY PROTEIN: protein ELYS-like [KO:K25129]
120937586  protein ELYS-like [KO:K25129]
120913085  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
120929217  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
120916514  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
120932872  NUP205; LOW QUALITY PROTEIN: nuclear pore complex protein Nup205 [KO:K14310]
120914168  NUP188; nucleoporin NUP188 isoform X1 [KO:K14311]
120927678  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
120917702  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
120943940  NUP35; nucleoporin NUP35 [KO:K14313]
120945909  NDC1; nucleoporin NDC1 [KO:K14315]
120945298  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
120927570  POM121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
120923808  TMEM33; transmembrane protein 33 [KO:K20724]
120921884  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
120932932  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
120940745  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
120928083  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
120915283  importin subunit alpha-1-like [KO:K15043]
120943648  KPNA7; importin subunit alpha-8 isoform X1 [KO:K15043]
120929085  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
120943987  importin subunit alpha-3-like [KO:K23583]
120936714  KPNA4; importin subunit alpha-3 [KO:K23583]
120926822  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
120918455  KPNB1; importin subunit beta-1 [KO:K14293]
120930111  TNPO1; transportin-1 isoform X1 [KO:K18752]
120933368  TNPO2; transportin-2 isoform X1 [KO:K18727]
120931611  TNPO3; transportin-3 isoform X1 [KO:K15436]
120941339  IPO4; importin-4 [KO:K20221]
120926318  IPO5; importin-5 [KO:K20222]
120916952  IPO7; importin-7 [KO:K20223]
120932814  IPO8; importin-8 [KO:K18755]
120927279  IPO9; importin-9 isoform X1 [KO:K20224]
120929158  IPO11; importin-11 [KO:K25201]
120922736  importin-13-like [KO:K25202]
120931485  SNUPN; snurportin-1 [KO:K13151]
120937700  XPO1; LOW QUALITY PROTEIN: exportin-1 [KO:K14290]
120918953  CSE1L; exportin-2 [KO:K18423]
120932018  XPOT; exportin-T [KO:K14288]
120929236  XPO4; exportin-4 isoform X1 [KO:K25203]
120938071  XPO5; exportin-5 isoform X1 [KO:K14289]
120943322  XPO6; exportin-6 [KO:K25204]
120933127  XPO7; exportin-7 isoform X1 [KO:K18460]
120941026  GTP-binding nuclear protein Ran [KO:K07936]
120935402  RAN; GTP-binding nuclear protein Ran [KO:K07936]
120937035  elongation factor 1-alpha, somatic form [KO:K03231]
120919606  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
120941531  elongation factor 1-alpha [KO:K03231]
120926782  elongation factor 1-alpha, oocyte form [KO:K03231]
120932315  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
120946251  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
120935668  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
120936716  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
120920488  RBM8A; RNA-binding protein 8A [KO:K12876]
120945906  MAGOH; protein mago nashi homolog [KO:K12877]
120918794  CASC3; protein CASC3 isoform X1 [KO:K14323]
120929234  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
120943373  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
120920996  PNN; pinin [KO:K13114]
120918921  ALYREF; THO complex subunit 4 [KO:K12881]
120913284  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
120931698  UPF2; LOW QUALITY PROTEIN: regulator of nonsense transcripts 2 [KO:K14327]
120913700  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
120926457  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
120917577  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
120913722  NXT2; NTF2-related export protein 2 [KO:K14285]
120913263  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
120926872  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
120929513  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
120940908  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
120913745  THOC2; THO complex subunit 2 [KO:K12879]
120939427  THOC5; THO complex subunit 5 homolog [KO:K13174]
120942898  THOC6; THO complex subunit 6 homolog [KO:K13175]
120939290  THO complex subunit 7 homolog [KO:K13176]
120945197  THOC7; THO complex subunit 7 homolog [KO:K13176]
120932228  THOC3; THO complex subunit 3 isoform X1 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
rtem03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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