KEGG   PATHWAY: sclv04144
Entry
sclv04144                   Pathway                                
Name
Endocytosis - Styela clava (leathery sea squirt)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
sclv04144  Endocytosis
sclv04144

Other DBs
GO: 0006897
Organism
Styela clava (leathery sea squirt) [GN:sclv]
Gene
120343461  ADP-ribosylation factor 6-like [KO:K07941]
120329899  ADP-ribosylation factor 6-like [KO:K07941]
120325747  LOW QUALITY PROTEIN: ADP-ribosylation factor 6-like [KO:K07941]
120332894  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
120343890  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
120335257  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
120336126  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
120336127  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
120345166  dynamin-1-like isoform X1 [KO:K01528] [EC:3.6.5.5]
120345405  clathrin light chain B-like isoform X1 [KO:K04645]
120341966  clathrin heavy chain 1 [KO:K04646]
120334039  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
120340669  AP-2 complex subunit mu isoform X1 [KO:K11826]
120344712  AP-2 complex subunit sigma-like [KO:K11827]
120328208  AP-2 complex subunit sigma [KO:K11827]
120348691  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
120343230  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
120337504  zinc finger FYVE domain-containing protein 16-like isoform X1 [KO:K04679]
120348023  mothers against decapentaplegic homolog 3-like [KO:K04500]
120347798  mothers against decapentaplegic homolog 3-like [KO:K23605]
120342709  serine/threonine receptor-like kinase NFP [KO:K05094] [EC:2.7.10.1]
120342893  receptor tyrosine-protein kinase let-23-like [KO:K05094] [EC:2.7.10.1]
120326326  E3 ubiquitin-protein ligase CBL-B-B-like isoform X1 [KO:K22517] [EC:2.3.2.27]
120338480  SH3 domain-containing kinase-binding protein 1-like isoform X1 [KO:K12470]
120342003  endophilin-A3-like [KO:K11247]
120344496  endophilin-B1-like isoform X1 [KO:K11248]
120343554  uncharacterized protein LOC120343554 isoform X1 [KO:K12562]
120344155  epsin-2-like [KO:K12471]
120328398  epsin-1-like [KO:K12471]
120340519  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
120340755  spartin-like [KO:K19366]
120341401  spartin-like [KO:K19366]
120345808  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
120337301  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
120333900  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
120344880  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NRDP1-like [KO:K11981] [EC:2.3.2.27]
120334182  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
120334286  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
120332141  LOW QUALITY PROTEIN: NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
120337250  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
120341639  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
120343533  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
120345691  rhodopsin kinase grk7-a-like [KO:K08291] [EC:2.7.11.16]
120338834  G protein-coupled receptor kinase 5-like isoform X1 [KO:K08291] [EC:2.7.11.16]
120328475  beta-arrestin-1-like isoform X1 [KO:K04439]
120327937  wiskott-Aldrich syndrome protein-like [KO:K23612]
120329022  uncharacterized protein LOC120329022 isoform X1 [KO:K23612]
120335647  actin-related protein 2 isoform X1 [KO:K17260]
120337491  actin-related protein 3 [KO:K18584]
120328148  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
120337962  actin-related protein 2/3 complex subunit 2-like isoform X1 [KO:K05758]
120346326  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
120331238  actin-related protein 2/3 complex subunit 4 [KO:K05755]
120345035  actin-related protein 2/3 complex subunit 5-A-like [KO:K05754]
120330325  WAS/WASL-interacting protein family member 1-like isoform X1 [KO:K19475]
120343240  heat shock 70 kDa protein II-like [KO:K03283]
120343250  heat shock cognate 71 kDa protein-like [KO:K03283]
120343254  heat shock 70 kDa protein homolog [KO:K03283]
120343255  major heat shock 70 kDa protein Bbb-like [KO:K03283]
120343262  heat shock cognate 71 kDa protein-like [KO:K03283]
120343266  heat shock 70 kDa protein II-like [KO:K03283]
120343430  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
120343432  heat shock 70 kDa protein-like [KO:K03283]
120343433  heat shock 70 kDa protein II-like [KO:K03283]
120343458  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
120343471  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
120343534  heat shock 70 kDa protein cognate 4-like [KO:K03283]
120343535  heat shock cognate 71 kDa protein-like [KO:K03283]
120343536  heat shock 70 kDa protein II-like [KO:K03283]
120343547  heat shock 70 kDa protein 1-like [KO:K03283]
120328696  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120333404  heat shock 70 kDa protein-like [KO:K03283]
120333406  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120333407  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120341957  heat shock 70 kDa protein II-like [KO:K03283]
120341958  heat shock 70 kDa protein II-like [KO:K03283]
120341968  heat shock 70 kDa protein II-like [KO:K03283]
120341969  heat shock cognate 71 kDa protein-like [KO:K03283]
120341970  heat shock 70 kDa protein II-like [KO:K03283]
120341971  heat shock cognate 71 kDa protein-like [KO:K03283]
120341972  heat shock 70 kDa protein II-like [KO:K03283]
120342073  heat shock 70 kDa protein II-like [KO:K03283]
120342225  heat shock 70 kDa protein II-like [KO:K03283]
120342233  heat shock 70 kDa protein II-like isoform X1 [KO:K03283]
120342234  heat shock 70 kDa protein-like [KO:K03283]
120342333  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120342390  heat shock cognate 71 kDa protein-like [KO:K03283]
120342403  heat shock cognate 71 kDa protein [KO:K03283]
120342404  heat shock 70 kDa protein 1B-like [KO:K03283]
120342414  heat shock 70 kDa protein cognate 4-like [KO:K03283]
120334019  heat shock 70 kDa protein 1-like [KO:K03283]
120334030  heat shock 70 kDa protein II-like [KO:K03283]
120342918  heat shock 70 kDa protein II-like [KO:K03283]
120342969  heat shock 70 kDa protein II-like [KO:K03283]
120343013  heat shock 70 kDa protein 1A-like [KO:K03283]
120343030  heat shock 70 kDa protein-like [KO:K03283]
120343032  heat shock 70 kDa protein-like [KO:K03283]
120343056  uncharacterized protein LOC120343056 [KO:K03283]
120343059  putative heat shock 70 kDa protein 7 [KO:K03283]
120343064  heat shock 70 kDa protein-like [KO:K03283]
120343068  heat shock 70 kDa protein II-like [KO:K03283]
120343069  heat shock cognate 71 kDa protein-like [KO:K03283]
120343089  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120343091  chromosome partition protein Smc-like [KO:K03283]
120343098  heat shock 70 kDa protein II-like [KO:K03283]
120343099  heat shock 70 kDa protein 4L-like [KO:K03283]
120343104  heat shock 70 kDa protein 1-like [KO:K03283]
120343109  uncharacterized protein LOC120343109 [KO:K03283]
120343132  heat shock 70 kDa protein II-like [KO:K03283]
120333622  WASH complex subunit 4-like [KO:K18465]
120335291  WASH complex subunit 5-like [KO:K18464]
120326292  WASH complex subunit 1-like [KO:K18461]
120341515  WASH complex subunit 1-like [KO:K18461]
120331927  WASH complex subunit 3-like [KO:K18463]
120328983  F-actin-capping protein subunit alpha-1-like [KO:K10364]
120328006  F-actin-capping protein subunit beta-like [KO:K10365]
120326913  vacuolar protein sorting-associated protein 29-like [KO:K18467]
120327043  vacuolar protein sorting-associated protein 29-like [KO:K18467]
120348124  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
120344169  vacuolar protein sorting-associated protein 35-like [KO:K18468]
120345046  sorting nexin-12-like [KO:K17918]
120337621  ubiquitin carboxyl-terminal hydrolase 8-like [KO:K11839] [EC:3.4.19.12]
120330105  STAM-binding protein-like [KO:K11866] [EC:3.4.19.12]
120348060  STAM-binding protein-like [KO:K11866] [EC:3.4.19.12]
120327668  ras-related protein Rab-7a-like [KO:K07897]
120345509  hepatocyte growth factor-regulated tyrosine kinase substrate-like isoform X1 [KO:K12182]
120342779  signal transducing adapter molecule 2-like isoform X1 [KO:K04705]
120329011  tumor susceptibility gene 101 protein-like [KO:K12183]
120344810  multivesicular body subunit 12B-like [KO:K12186]
120330954  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
120336123  vacuolar protein sorting-associated protein 37A-like [KO:K12185]
120347656  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
120331100  vacuolar-sorting protein SNF8-like [KO:K12188]
120331104  vacuolar protein-sorting-associated protein 36-like [KO:K12190]
120346516  vacuolar protein-sorting-associated protein 25-like [KO:K12189]
120337628  charged multivesicular body protein 6-like [KO:K12195]
120345444  charged multivesicular body protein 4b-like [KO:K12194]
120325712  charged multivesicular body protein 4b-like [KO:K12194]
120333126  charged multivesicular body protein 3-like [KO:K12193]
120336822  charged multivesicular body protein 2a-like [KO:K12191]
120340190  charged multivesicular body protein 2b-like [KO:K12192]
120336690  charged multivesicular body protein 7-like [KO:K15053]
120339099  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
120347186  vacuolar protein sorting-associated protein 4-like isoform X1 [KO:K12196]
120331561  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
120332082  charged multivesicular body protein 1a-like [KO:K12197]
120342167  charged multivesicular body protein 5-like [KO:K12198]
120337455  IST1 homolog [KO:K19476]
120342159  programmed cell death 6-interacting protein-like isoform X1 [KO:K12200]
120325449  maspardin-like [KO:K19367]
120333722  sorting nexin-2-like [KO:K17917]
120325687  sorting nexin-6-like isoform X1 [KO:K17920]
120325688  sorting nexin-6-like isoform X1 [KO:K17920]
120336903  tyrosine-protein kinase JAK2-like [KO:K05704] [EC:2.7.10.2]
120330934  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
120326040  transforming protein RhoA [KO:K04513]
120348305  riboflavin-binding protein-like [KO:K13649]
120340543  folate receptor gamma-like [KO:K13649]
120343070  folate receptor gamma-like [KO:K13649]
120339019  caveolin-3-like [KO:K06278]
120339599  caveolin-3-like [KO:K12959]
120331626  EH domain-containing protein 3-like isoform X1 [KO:K12476]
120329439  ras-related protein Rab-5B-like [KO:K07888]
120329445  rab GTPase-binding effector protein 1-like [KO:K12480]
120339525  rabenosyn-5-like isoform X1 [KO:K12481]
120348133  RUN and FYVE domain-containing protein 2-like isoform X1 [KO:K12482]
120348134  RUN and FYVE domain-containing protein 2-like isoform X1 [KO:K12482]
120342782  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 45-like [KO:K12479]
120339428  sorting nexin-4-like [KO:K17919]
120333971  ras-related protein Rab-10-like [KO:K07903]
120345707  ras-related protein Rab-8B-like [KO:K07901]
120341383  ras-related protein Rab-8B-like isoform X1 [KO:K07901]
120342109  ras-related protein Rab-35-like [KO:K07876]
120332639  ras-related protein RABA1e-like [KO:K07904]
120341605  ras-related protein Rab11D-like [KO:K07904]
120332134  ras-related protein Rab-11B-like isoform X1 [KO:K07905]
120339017  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
120331394  kinesin heavy chain-like [KO:K10396]
120332705  kinesin heavy chain-like isoform X1 [KO:K10396]
120344282  rab11 family-interacting protein 4B-like [KO:K12485]
120334044  rab11 family-interacting protein 4B-like [KO:K12485]
120338234  serine/arginine repetitive matrix protein 2-like isoform X1 [KO:K04237]
120338427  partitioning defective 6 homolog beta-like [KO:K06093]
120345485  protein kinase C iota type-like [KO:K06069] [EC:2.7.11.13]
120344505  cdc42 homolog [KO:K04393]
120345073  cdc42 homolog [KO:K04393]
120328725  cell division control protein 42 homolog isoform X1 [KO:K04393]
120345299  stromal membrane-associated protein 1-like [KO:K12486]
120346912  ARF GTPase-activating protein GIT2-like [KO:K12487]
120332088  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
120327648  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like [KO:K12489]
120340501  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K18439]
120342181  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12491]
120345960  ADP-ribosylation factor GTPase-activating protein 1-like isoform X1 [KO:K12492]
120348629  ADP-ribosylation factor GTPase-activating protein 1-like isoform X1 [KO:K12492]
120330712  ADP-ribosylation factor GTPase-activating protein 2-like [KO:K12493]
120331703  ADP-ribosylation factor GTPase-activating protein 3-like isoform X1 [KO:K12493]
120334825  PH and SEC7 domain-containing protein 3-like [KO:K12494]
120336967  IQ motif and SEC7 domain-containing protein 1-like [KO:K12495]
120337325  cytohesin-1-like [KO:K18441]
120345498  brefeldin A-inhibited guanine nucleotide-exchange protein 1-like [KO:K18442]
120347006  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1-like isoform X1 [KO:K18443]
120331768  ADP-ribosylation factor 6-like [KO:K07937]
120332164  ADP-ribosylation factor 1-like [KO:K07937]
120332209  uncharacterized protein LOC120332209 [KO:K07937]
120340444  ADP-ribosylation factor-like [KO:K07938]
120339022  ADP-ribosylation factor 4-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
sclv04070  Phosphatidylinositol signaling system
sclv04130  SNARE interactions in vesicular transport
sclv04142  Lysosome
sclv04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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