KEGG   PATHWAY: setr04666
Entry
setr04666                   Pathway                                
Name
Fc gamma R-mediated phagocytosis - Suncus etruscus (white-toothed pygmy shrew)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
setr04666  Fc gamma R-mediated phagocytosis
setr04666

Other DBs
GO: 0006909
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
126015875  immunoglobulin alpha-2 heavy chain-like [KO:K06856]
126011869  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
126013988  low affinity immunoglobulin gamma Fc region receptor III-A-like isoform X1 [KO:K06463]
126004337  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
126017360  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
126020443  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
126003376  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
126012035  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126012036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126011501  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
126030200  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
126011086  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126001552  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
126013417  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126033346  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126028133  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126006378  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
126019034  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
126017276  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126027269  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
126013204  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
126023927  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
125998044  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126021920  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
126029893  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126033704  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126014260  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
126020067  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
126020108  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
126020233  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
126020234  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
126006213  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
126005888  MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561]
126011289  MARCKSL1; MARCKS-related protein [KO:K13536]
126011919  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
126012160  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
126030829  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
126000943  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
126010980  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
126027311  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
126017297  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126030861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126027978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126031245  NCF1; neutrophil cytosol factor 1 [KO:K08011]
126025477  SCIN; scinderin [KO:K05768]
126008795  GSN; gelsolin isoform X1 [KO:K05768]
125997407  VAV3; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3 [KO:K05730]
126031136  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
126009330  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
125994825  cell division control protein 42 homolog [KO:K04393]
126024665  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
125998704  cell division control protein 42 homolog [KO:K04393]
126018299  cell division control protein 42 homolog [KO:K04393]
126011308  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
126028736  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
125999254  WAS; actin nucleation-promoting factor WAS [KO:K05747]
126028574  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
126024353  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
126009209  ACTR3; actin-related protein 3 [KO:K18584]
126030448  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
126030449  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
126000882  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
126001964  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
126013945  actin-related protein 2/3 complex subunit 3 [KO:K05756]
126030661  actin-related protein 2/3 complex subunit 3 [KO:K05756]
126013498  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
126009670  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
126030488  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126006381  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126005873  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
126011102  WASF2; actin-binding protein WASF2 [KO:K05748]
126015651  WASF3; actin-binding protein WASF3 isoform X1 [KO:K06083]
126013242  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
126017532  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
126031287  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
126030738  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
125998819  CFL2; cofilin-2 [KO:K05765]
126018087  CFL1; cofilin-1 [KO:K05765]
126030397  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
126004531  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
125997479  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
125999524  ARF6; ADP-ribosylation factor 6 [KO:K07941]
126021156  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
126033713  CRKL; crk-like protein [KO:K04438]
126033605  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
125997105  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
126024064  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
126011023  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
126013464  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560]
126002111  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
126018129  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
126018145  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
126029540  LAT; linker for activation of T-cells family member 1 [KO:K07362]
126030283  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
126020406  AMPH; amphiphysin isoform X1 [KO:K12562]
126008843  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
126001096  MYO10; LOW QUALITY PROTEIN: unconventional myosin-X [KO:K12559]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
setr04020  Calcium signaling pathway
setr04142  Lysosome
setr04144  Endocytosis
setr04810  Regulation of actin cytoskeleton
KO pathway
ko04666   
LinkDB

DBGET integrated database retrieval system