KEGG   PATHWAY: setr04020
Entry
setr04020                   Pathway                                
Name
Calcium signaling pathway - Suncus etruscus (white-toothed pygmy shrew)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
setr04020  Calcium signaling pathway
setr04020

Other DBs
GO: 0019722
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
125994821  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
125994875  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
125994891  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125994915  ADRB1; beta-1 adrenergic receptor [KO:K04141]
125994998  TACR2; substance-K receptor [KO:K04223]
125995054  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
125995947  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
125995972  TFEB; transcription factor EB [KO:K15590]
125996266  VEGFA; vascular endothelial growth factor A [KO:K05448]
125996360  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
125997104  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125997353  NGF; beta-nerve growth factor [KO:K02582]
125997540  CASQ2; calsequestrin-2 [KO:K23445]
125998033  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
125998045  F2R; proteinase-activated receptor 1 [KO:K03914]
125998055  HRH1; histamine H1 receptor [KO:K04149]
125998066  OXTR; oxytocin receptor [KO:K04229]
125998068  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
125998103  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125998170  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
125998718  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
125998733  GRPR; gastrin-releasing peptide receptor isoform X1 [KO:K04169]
125998737  VEGFD; vascular endothelial growth factor D [KO:K05449]
125998817  [KO:K05850] [EC:7.2.2.10]
125999147  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
125999155  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
125999420  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
125999516  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
125999532  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
126000344  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
126000571  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
126000737  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
126000769  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
126000814  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
126000864  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
126000994  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
126001031  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
126001036  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
126001049  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
126001075  FGF10; fibroblast growth factor 10 [KO:K04358]
126001088  P2RX2; P2X purinoceptor 2 [KO:K05216]
126001221  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
126001222  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
126001307  [KO:K02183]
126001942  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
126002075  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
126003291  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
126003300  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
126003304  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
126003322  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
126003391  [KO:K15041]
126003432  PDGFC; platelet-derived growth factor C [KO:K05450]
126003511  [KO:K04634]
126003512  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
126003583  BDKRB2; B2 bradykinin receptor [KO:K03916]
126003591  BDKRB1; B1 bradykinin receptor [KO:K03915]
126003621  CALM1; calmodulin-1 [KO:K02183]
126003641  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
126003686  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
126003741  EDNRA; endothelin-1 receptor [KO:K04197]
126003743  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
126003777  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
126003833  FGF2; fibroblast growth factor 2 [KO:K18497]
126003977  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
126004171  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
126004189  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
126004344  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
126004384  AVPR1B; vasopressin V1b receptor [KO:K04227]
126004843  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
126005929  MCOLN2; mucolipin-2 [KO:K04993]
126005939  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126005960  MCOLN3; mucolipin-3 [KO:K04994]
126006047  PLN; cardiac phospholamban [KO:K05852]
126006104  PTK2B; LOW QUALITY PROTEIN: protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
126006125  PTGFR; LOW QUALITY PROTEIN: prostaglandin F2-alpha receptor [KO:K04262]
126006357  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
126006376  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
126006402  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126006406  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
126006428  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
126006491  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
126006568  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
126006578  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
126006634  FGF6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
126006857  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
126006877  FGF20; fibroblast growth factor 20 [KO:K04358]
126006944  FGF23; fibroblast growth factor 23 [KO:K22428]
126007138  TRDN; triadin [KO:K23449]
126007180  VEGFC; vascular endothelial growth factor C [KO:K05449]
126007252  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
126008496  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
126008536  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
126008870  [KO:K04161]
126009193  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
126009206  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
126009459  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
126011169  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
126011191  PTAFR; platelet-activating factor receptor [KO:K04279]
126011895  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
126011901  FGF18; fibroblast growth factor 18 [KO:K04358]
126011954  HRH2; histamine H2 receptor [KO:K04150]
126012016  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
126012227  DRD1; D(1A) dopamine receptor [KO:K04144]
126012641  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
126013230  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
126013297  [KO:K02183]
126013298  [KO:K02183]
126013317  GNAS; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
126013337  [KO:K04632]
126013368  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
126013529  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
126013733  ADORA2B; adenosine receptor A2b [KO:K04267]
126013881  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
126013891  NTSR1; neurotensin receptor type 1 [KO:K04211]
126013961  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
126014034  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
126014104  SMIM6; small integral membrane protein 6 [KO:K26468]
126014134  CASQ1; calsequestrin-1 [KO:K23468]
126014140  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
126014417  MST1R; LOW QUALITY PROTEIN: macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
126015702  FGF9; fibroblast growth factor 9 [KO:K04358]
126015747  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
126015875  [KO:K06856]
126015921  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
126015982  CALML4; calmodulin-like protein 4 [KO:K02183]
126016055  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
126016073  SLN; sarcolipin [KO:K22642]
126016177  EDNRB; endothelin receptor type B [KO:K04198]
126016231  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
126016247  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
126016368  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
126017276  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126017277  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126017297  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126017327  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
126017569  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
126017588  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126017649  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
126017696  P2RX3; P2X purinoceptor 3 [KO:K05217]
126017939  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
126018105  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
126018162  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
126018349  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
126018393  TNNC2; troponin C, skeletal muscle [KO:K12042]
126018395  [KO:K04282]
126018799  TPCN2; two pore channel protein 2 [KO:K14077]
126018800  FGF19; fibroblast growth factor 19 [KO:K22603]
126018801  FGF3; fibroblast growth factor 3 [KO:K04358]
126019083  FGF4; fibroblast growth factor 4 [KO:K04358]
126019119  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
126019129  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
126020032  FGF7; fibroblast growth factor 7 [KO:K04358]
126020235  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
126020311  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
126020472  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
126020481  [KO:K00476] [EC:1.14.11.16]
126020490  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
126020656  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
126020805  GRIN1; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1 [KO:K05208]
126020857  P2RX5; P2X purinoceptor 5 [KO:K05219]
126021011  P2RX1; P2X purinoceptor 1 [KO:K05215]
126021768  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
126021825  [KO:K04809]
126022028  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
126022173  AVPR1A; vasopressin V1a receptor [KO:K04226]
126022196  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
126022364  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
126022424  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
126022490  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
126022729  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
126022840  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
126022960  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
126023244  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
126023867  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
126023931  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
126023953  CALM2; calmodulin-2 [KO:K02183]
126024026  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
126024144  [KO:K15041]
126024424  TACR1; substance-P receptor [KO:K04222]
126024570  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
126024674  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
126024677  TGFA; protransforming growth factor alpha [KO:K08774]
126024759  ADRB2; beta-2 adrenergic receptor [KO:K04142]
126024785  HTR4; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 4 [KO:K04160]
126025476  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
126025486  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
126025545  AGTR1; type-1 angiotensin II receptor [KO:K04166]
126026245  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
126027080  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
126027251  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
126027269  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
126027310  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
126027311  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
126027342  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
126027551  TACR3; neuromedin-K receptor [KO:K04224]
126027570  EGF; pro-epidermal growth factor [KO:K04357]
126027649  [KO:K15040]
126027768  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
126027877  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
126027880  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
126027928  FGF1; fibroblast growth factor 1 [KO:K18496]
126027945  C14H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
126027978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126028196  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
126028224  [KO:K04348] [EC:3.1.3.16]
126028268  CALM3; calmodulin-3 [KO:K02183]
126028397  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
126028507  RYR1; ryanodine receptor 1 [KO:K04961]
126028539  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
126028612  FGF21; fibroblast growth factor 21 [KO:K22429]
126028617  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
126029517  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
126029580  ORAI2; protein orai-2 isoform X1 [KO:K16057]
126029708  [KO:K08794] [EC:2.7.11.17]
126029834  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
126029847  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
126030243  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
126030326  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
126030328  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126030452  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
126030453  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
126030454  TBXA2R; thromboxane A2 receptor [KO:K04264]
126030482  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126030532  FGF22; fibroblast growth factor 22 [KO:K04358]
126030555  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
126030565  TPCN1; two pore channel protein 1 [KO:K16896]
126030608  P2RX4; P2X purinoceptor 4 [KO:K05218]
126030681  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
126030687  P2RX7; P2X purinoceptor 7 [KO:K05220]
126030732  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
126030742  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
126030795  RYR2; ryanodine receptor 2 [KO:K04962]
126030820  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
126030861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126030871  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
126030882  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126030904  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
126030927  ORAI3; protein orai-3 [KO:K16058]
126030929  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
126031051  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
126031142  MCOLN1; mucolipin-1 [KO:K04992]
126031238  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
126031280  [KO:K02183]
126031368  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
126031392  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
126032087  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
126032236  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
126032296  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
126032312  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
126032353  CCKAR; cholecystokinin receptor type A [KO:K04194]
126032431  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126032552  RYR3; ryanodine receptor 3 [KO:K04963]
126032579  STIM2; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
126032628  FGF5; fibroblast growth factor 5 [KO:K04358]
126033558  MRLN; myoregulin [KO:K22643]
126033693  ADORA2A; adenosine receptor A2a [KO:K04266]
126033697  P2RX6; P2X purinoceptor 6 [KO:K05221]
126033783  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
setr04010  MAPK signaling pathway
setr04070  Phosphatidylinositol signaling system
setr04210  Apoptosis
setr04720  Long-term potentiation
setr04730  Long-term depression
KO pathway
ko04020   

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