KEGG   PATHWAY: stru04912
Entry
stru04912                   Pathway                                
Name
GnRH signaling pathway - Salmo trutta (river trout)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
stru04912  GnRH signaling pathway
stru04912

Organism
Salmo trutta (river trout) [GN:stru]
Gene
115193385  progonadoliberin-3 [KO:K05252]
115153238  progonadoliberin-3 [KO:K05252]
115150200  progonadoliberin-2-like [KO:K05252]
115207108  progonadoliberin-2 [KO:K05252]
115173691  gonadotropin-releasing hormone II receptor-like [KO:K04280]
115175783  gonadotropin-releasing hormone II receptor-like [KO:K04280]
115177142  gonadotropin-releasing hormone II receptor-like isoform X1 [KO:K04280]
115179884  gonadotropin-releasing hormone II receptor-like isoform X1 [KO:K04280]
115151992  gonadotropin-releasing hormone II receptor-like [KO:K04280]
115196761  gonadotropin-releasing hormone II receptor-like [KO:K04280]
115168329  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
115166205  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
115169640  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
115158652  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
115157130  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
115173833  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
115175633  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
115191681  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
115175579  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
115177411  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
115155606  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
115160940  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
115167808  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
115168355  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
115165462  adenylate cyclase type 6-like isoform X1 [KO:K08046] [EC:4.6.1.1]
115166185  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
115167552  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
115203287  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
115161910  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
115156513  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
115171775  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
115178829  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
115147400  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
115206444  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
115157937  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115181703  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
115169621  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
115171557  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
115178387  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
115157154  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115204162  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
115170922  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
115178533  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
115147454  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
115196317  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
115164831  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
115159209  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
115149346  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
115199825  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
115192595  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
115158280  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
115179716  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
115196175  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
115184997  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115174482  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115174483  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115162398  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
115172491  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115172765  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115198619  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115199598  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
115150503  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115150859  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115207563  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115207911  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
115152168  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115197365  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115168596  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
115165965  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
115193937  calmodulin [KO:K02183]
115174612  calmodulin [KO:K02183]
115153074  calmodulin [KO:K02183]
115158469  calmodulin [KO:K02183]
115162136  calm1; calmodulin-1 [KO:K02183]
115154660  calmodulin [KO:K02183]
115162984  calmodulin [KO:K02183]
115166807  calmodulin-like protein 4 isoform X1 [KO:K02183]
115172411  calmodulin [KO:K02183]
115150950  calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
115203522  calmodulin-like protein 4 [KO:K02183]
115197130  calmodulin-like protein 4 isoform X1 [KO:K02183]
115204259  calmodulin-A isoform X1 [KO:K02183]
115205945  calmodulin [KO:K02183]
115194123  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
115189418  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115180818  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like [KO:K04515] [EC:2.7.11.17]
115193805  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
115153189  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115154883  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
115159892  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
115164110  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
115156739  calcium/calmodulin-dependent protein kinase type II delta 1 chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115200524  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
115201212  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115203793  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115198135  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
115204505  calcium/calmodulin-dependent protein kinase type II subunit alpha-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115171658  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
115177626  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
115208609  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
115205322  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
115181935  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
115182231  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
115150559  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
115150786  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
115207643  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
115207853  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
115168317  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
115166217  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
115208210  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
115168069  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
115166484  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
115167827  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
115150281  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
115208150  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
115160088  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
115179118  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
115196032  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
115171523  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
115195304  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
115203817  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
115152798  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
115200875  mitogen-activated protein kinase kinase kinase 4-like [KO:K04428] [EC:2.7.11.25]
115153520  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
115171844  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
115201695  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
115207531  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
115152195  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115180302  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115180375  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115169006  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115169019  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
115165421  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115165434  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115166089  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
115151057  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115207356  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115197396  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115198903  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
115198904  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115161285  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
115192191  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
115193835  pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
115169910  cytosolic phospholipase A2-like isoform X1 [KO:K16342] [EC:3.1.1.4]
115158767  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
115194414  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
115194416  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
115194417  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
115194418  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
115154424  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
115179121  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
115151868  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
115148967  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
115196210  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
115167934  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
115165589  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
115150079  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
115208382  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
115168105  cell division control protein 42 homolog isoform X1 [KO:K04393]
115185212  cell division control protein 42 homolog [KO:K04393]
115188175  cell division control protein 42 homolog [KO:K04393]
115175951  cell division control protein 42 homolog [KO:K04393]
115165776  cell division control protein 42 homolog isoform X1 [KO:K04393]
115177487  cell division control protein 42 homolog [KO:K04393]
115173517  cell division control protein 42 homolog isoform X1 [KO:K04393]
115150657  cell division control protein 42 homolog isoform X1 [KO:K04393]
115171440  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115156176  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
115201273  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115202704  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115178289  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
115208730  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
115194041  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115157756  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115174527  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115152965  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115159070  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115149487  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115201108  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115204538  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115192441  transcription factor AP-1-like [KO:K04448]
115169534  transcription factor AP-1-like [KO:K04448]
115158459  transcription factor AP-1-like [KO:K04448]
115157247  transcription factor AP-1-like [KO:K04448]
115149542  transcription factor AP-1-like [KO:K04448]
115160168  transcription factor AP-1-like [KO:K04448]
115201499  gonadotropin subunit beta-2 [KO:K08521]
115201502  gonadotropin subunit beta-2 [KO:K08521]
115192044  glycoprotein hormones alpha chain 2 [KO:K08522]
115162552  glycoprotein hormones alpha chain 1-like [KO:K08522]
115172139  glycoprotein hormones alpha chain 1 [KO:K08522]
115202069  glycoprotein hormones alpha chain 2-like [KO:K08522]
115175167  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
115172956  protein-tyrosine kinase 2-beta-like isoform X1 [KO:K05871] [EC:2.7.10.2]
115147339  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
115167017  72 kDa type IV collagenase-like [KO:K01398] [EC:3.4.24.24]
115203309  72 kDa type IV collagenase-like [KO:K01398] [EC:3.4.24.24]
115169490  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
115157316  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
115194394  matrix metalloproteinase-14-like [KO:K07763] [EC:3.4.24.80]
115198396  matrix metalloproteinase-14-like isoform X1 [KO:K07763] [EC:3.4.24.80]
115168302  proheparin-binding EGF-like growth factor [KO:K08523]
115153925  proheparin-binding EGF-like growth factor [KO:K08523]
115205616  proheparin-binding EGF-like growth factor [KO:K08523]
115169555  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
115157224  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
115150387  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
115195550  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
115171377  growth factor receptor-bound protein 2 [KO:K04364]
115177728  growth factor receptor-bound protein 2-like [KO:K04364]
115147195  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
115201822  growth factor receptor-bound protein 2 [KO:K04364]
115161897  son of sevenless homolog 2-like [KO:K03099]
115178772  son of sevenless homolog 1-like isoform X1 [KO:K03099]
115172982  sos2; son of sevenless homolog 2 [KO:K03099]
115208487  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
115152114  GTPase HRas-like [KO:K02833]
115197299  GTPase HRas isoform X1 [KO:K02833]
115152163  GTPase KRas isoform X1 [KO:K07827]
115171866  GTPase HRas-like [KO:K07827]
115207704  GTPase HRas-like [KO:K07827]
115197360  GTPase KRas isoform X1 [KO:K07827]
115168396  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
115166136  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
115149903  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115192967  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115192626  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115169411  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115158253  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
115157409  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115165075  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115192138  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115170800  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115200671  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115168566  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
115174700  early growth response protein 1-like [KO:K09203]
115153935  early growth response protein 1-like [KO:K09203]
115148477  early growth response protein 1-like [KO:K09203]
115205429  early growth response protein 1-like [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
stru04010  MAPK signaling pathway
stru04020  Calcium signaling pathway
stru04060  Cytokine-cytokine receptor interaction
stru04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
LinkDB

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