KEGG   PATHWAY: svg04144
Entry
svg04144                    Pathway                                
Name
Endocytosis - Sturnus vulgaris (common starling)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
svg04144  Endocytosis
svg04144

Other DBs
GO: 0006897
Organism
Sturnus vulgaris (common starling) [GN:svg]
Gene
106858953  ARF6; ADP-ribosylation factor 6 [KO:K07941]
106857990  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
106863783  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
106849152  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
106859639  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
106852274  DNM3; dynamin-3 [KO:K01528] [EC:3.6.5.5]
106851318  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
106863691  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
106859666  CLTA; clathrin light chain A [KO:K04644]
106852997  CLTB; clathrin light chain B isoform X1 [KO:K04645]
106853313  CLTC; clathrin heavy chain 1 [KO:K04646]
106864868  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
106851545  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
106853343  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
106850351  AP2M1; AP-2 complex subunit mu [KO:K11826]
106864386  AP2S1; AP-2 complex subunit sigma [KO:K11827]
106863915  EHD2; LOW QUALITY PROTEIN: EH domain-containing protein 2 [KO:K12469]
106853946  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
106857782  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
106850468  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
106849780  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
106861527  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
106861050  PML; protein PML [KO:K10054] [EC:2.3.2.-]
106865043  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
106852157  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
106850386  TFRC; transferrin receptor protein 1 [KO:K06503]
106860008  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106851489  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
106859491  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
106865281  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
106853000  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
106852146  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
106858164  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
106861371  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
106852875  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
106859741  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
106860080  SH3GL3; endophilin-A3 [KO:K11247]
106851052  SH3GL2; endophilin-A1 [KO:K11247]
106857635  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
106851337  SH3GLB2; endophilin-B2 [KO:K21269]
106863225  AMPH; amphiphysin isoform X1 [KO:K12562]
106861391  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
106854348  EPN3; epsin-3 isoform X1 [KO:K12471]
106850181  EPN2; epsin-2 isoform X1 [KO:K12471]
106849789  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
106857125  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
106848775  SPG20; spartin isoform X1 [KO:K19366]
106851841  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
106863658  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
106855290  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
106851517  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106859182  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
106849829  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
106856954  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
106849856  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
106858797  LDLRAP1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
106860380  low density lipoprotein receptor adapter protein 1-like isoform X1 [KO:K12474]
106852720  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
106854432  C-C chemokine receptor type 5-like [KO:K04180]
106854486  C-C chemokine receptor type 5-like [KO:K04180]
106860274  C-X-C chemokine receptor type 2-like [KO:K05050]
106849899  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
106854173  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
106852347  ADRBK2; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
106854669  ADRBK1; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
106852994  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
106859484  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
106865301  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
106856608  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
106854070  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
106863644  ACTR2; actin-related protein 2 [KO:K17260]
106849918  ACTR3; actin-related protein 3 [KO:K18584]
106850700  ACTR3B; actin-related protein 3B [KO:K18584]
106849850  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
106849862  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
106860288  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
106852370  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
106850870  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
106859455  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
106855362  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
106858728  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
106864329  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
106855488  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
106857479  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
106862221  DNAJC6; putative tyrosine-protein phosphatase auxilin [KO:K09526]
106853627  KIAA1033; WASH complex subunit 7 isoform X1 [KO:K18465]
106849515  KIAA0196; WASH complex subunit strumpellin [KO:K18464]
106852597  FAM21C; WASH complex subunit FAM21C isoform X1 [KO:K18462]
106849404  WAS protein family homolog 1 [KO:K18461]
106853664  CCDC53; WASH complex subunit CCDC53 isoform X1 [KO:K18463]
106862904  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
106863876  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
106856396  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
106852410  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
106857316  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
106857485  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
106856794  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
106853760  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
106860167  SNX3; sorting nexin-3 isoform X1 [KO:K17918]
106860057  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
106862882  STAMBP; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
106861835  RAB7A; ras-related protein Rab-7a [KO:K07897]
106859944  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
106863708  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
106863720  STAM; LOW QUALITY PROTEIN: signal transducing adapter molecule 1 [KO:K04705]
106853200  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
106855413  MVB12B; multivesicular body subunit 12B [KO:K12186]
106864182  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
106852363  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
106862542  VPS37D; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
106854685  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
106851486  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
106848750  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
106858719  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
106859914  CHMP6; charged multivesicular body protein 6 [KO:K12195]
106853067  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
106849848  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
106864100  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
106862204  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
106863434  CHMP7; charged multivesicular body protein 7 [KO:K15053]
106850826  VPS4B; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
106861281  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
106860676  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
106860322  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
106852035  CHMP1A; charged multivesicular body protein 1a isoform X1 [KO:K12197]
106855661  CHMP5; charged multivesicular body protein 5 [KO:K12198]
106861278  IST1; IST1 homolog isoform X1 [KO:K19476]
106860005  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
106852166  SPG21; maspardin [KO:K19367]
106851870  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
106861556  SNX1; sorting nexin-1 [KO:K17917]
106851997  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
106857281  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
106862152  SNX6; sorting nexin-6 [KO:K17920]
106857764  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
106851547  HRAS; GTPase HRas [KO:K02833]
106864236  interleukin-2 receptor subunit alpha-like [KO:K05068]
106858521  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
106853684  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
106849172  RHOA; transforming protein RhoA [KO:K04513]
106864610  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
106864696  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
106864697  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
106850603  riboflavin-binding protein-like [KO:K13649]
106856626  folate receptor alpha-like [KO:K13649]
106861737  folate receptor gamma-like [KO:K13649]
106863114  CAV1; caveolin-1 [KO:K06278]
106863115  CAV2; caveolin-2 [KO:K12958]
106850464  CAV3; caveolin-3 [KO:K12959]
106853917  EHD3; EH domain-containing protein 3 [KO:K12476]
106848991  EHD4; EH domain-containing protein 4 [KO:K12477]
106860960  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
106857354  RAB5A; ras-related protein Rab-5A [KO:K07887]
106858645  RAB5C; ras-related protein Rab-5C [KO:K07889]
106860245  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
106851882  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
106852492  RAB4A; ras-related protein Rab-4A [KO:K07879]
106859586  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
106857333  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
106862363  VPS45; vacuolar protein sorting-associated protein 45 [KO:K12479]
106850466  SNX4; sorting nexin-4 [KO:K17919]
106850125  RAB31; ras-related protein Rab-31 [KO:K07891]
106851717  RAB22A; ras-related protein Rab-22A [KO:K07891]
106860391  RAB10; ras-related protein Rab-10 [KO:K07903]
106851948  ras-related protein Rab-10-like [KO:K07903]
106857122  RAB8A; ras-related protein Rab-8A [KO:K07901]
106864893  RAB35; ras-related protein Rab-35 [KO:K07876]
106861142  ras-related protein Rab-11A-like [KO:K07904]
106852179  RAB11A; ras-related protein Rab-11A [KO:K07904]
106858012  RAB11B; ras-related protein Rab-11B [KO:K07905]
106850897  RAB11FIP2; rab11 family-interacting protein 2 [KO:K12484]
106862044  RAB11FIP1; rab11 family-interacting protein 1 [KO:K12484]
106862438  RAB11FIP5; rab11 family-interacting protein 5 [KO:K12484]
106859030  ZFYVE27; protrudin [KO:K19368]
106862554  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
106862636  KIF5A; kinesin heavy chain isoform 5A [KO:K10396]
106855574  KIF5B; kinesin-1 heavy chain [KO:K10396]
106854304  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
106860611  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
106855558  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
106852507  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
106853051  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
106860931  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
106857709  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
106859643  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
106856405  CDC42; cell division control protein 42 homolog [KO:K04393]
106849563  SMAP1; stromal membrane-associated protein 1 [KO:K12486]
106853318  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
106852425  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
106865124  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
106856635  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
106861851  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
106858856  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
106860807  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
106856588  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
106850014  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
106861321  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
106861802  AGAP3; LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 [KO:K12491]
106861982  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
106862644  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
106851711  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
106860953  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
106856514  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
106860018  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
106855331  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
106856782  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
106863812  IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
106849407  IQSEC3; IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
106858573  CYTH4; cytohesin-4 [KO:K18441]
106863936  CYTH2; cytohesin-2 [KO:K18441]
106849114  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
106859949  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
106853060  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
106851228  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
106855329  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
106851610  ARF1; ADP-ribosylation factor 1 [KO:K07937]
106862671  ARF3; ADP-ribosylation factor 3 isoform X1 [KO:K07938]
106863582  ARF4; ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
svg04060  Cytokine-cytokine receptor interaction
svg04070  Phosphatidylinositol signaling system
svg04130  SNARE interactions in vesicular transport
svg04142  Lysosome
svg04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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