KEGG   PATHWAY: xco04371
Entry
xco04371                    Pathway                                
Name
Apelin signaling pathway - Xiphophorus couchianus (Monterrey platyfish)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
xco04371  Apelin signaling pathway
xco04371

Other DBs
GO: 0060183
Organism
Xiphophorus couchianus (Monterrey platyfish) [GN:xco]
Gene
114146909  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
114151481  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
114141804  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
114156097  adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
114152719  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
114147875  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
114140049  adenylate cyclase type 6-like isoform X1 [KO:K08046] [EC:4.6.1.1]
114160600  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
114142861  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
114146247  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
114140665  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
114158148  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
114160082  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
114144541  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
114150831  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114144649  prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114146401  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
114159753  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114156439  hormone-sensitive lipase-like isoform X1 [KO:K07188] [EC:3.1.1.79]
114138258  lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
114139238  apln; apelin [KO:K05225]
114145467  apela; apelin receptor early endogenous ligand [KO:K25355]
114155252  apelin receptor A [KO:K04174]
114156465  apelin receptor B-like [KO:K04174]
114150105  apelin receptor B-like [KO:K04174]
114159947  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
114144764  guanine nucleotide-binding protein G(k) subunit alpha-like isoform X1 [KO:K04630]
114134997  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
114135550  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
114160933  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
114135385  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
114142780  gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
114153320  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04537]
114142261  gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
114155971  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like [KO:K07825]
114150637  gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
114143252  guanine nucleotide-binding protein subunit beta-5b-like [KO:K04539]
114136820  gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
114134327  gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
114152707  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114138288  gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
114146062  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
114150938  gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
114147618  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
114160428  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04543]
114134067  gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
114153735  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8-like isoform X1 [KO:K04544]
114144684  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
114150158  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114146970  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
114150888  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
114148300  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
114144853  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
114155441  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
114152167  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2-like [KO:K04549]
114154374  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
114151385  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634]
114150060  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634]
114138347  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
114133784  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114158603  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114158604  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
114157441  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
114135479  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
114136183  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114157038  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
114141097  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114161320  ryanodine receptor 1-like isoform X1 [KO:K04961]
114153062  ryanodine receptor 1-like isoform X1 [KO:K04961]
114137831  ryanodine receptor 2-like [KO:K04962]
114150588  ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
114158772  ryanodine receptor 3-like isoform X1 [KO:K04963]
114134298  ryanodine receptor 3-like isoform X1 [KO:K04963]
114158311  calm1; calmodulin-1 [KO:K02183]
114143062  calml4; calmodulin-like protein 4 [KO:K02183]
114161563  calm3; calmodulin-3 [KO:K02183]
114138153  calm2; calmodulin-2 [KO:K02183]
114134100  calmodulin [KO:K02183]
114154866  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
114137801  protein kinase C epsilon type-like isoform X1 [KO:K18050] [EC:2.7.11.13]
114151921  prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
114141527  Na(+)/H(+) exchanger beta-like isoform X1 [KO:K05742]
114155455  Na(+)/H(+) exchanger beta-like [KO:K05742]
114133481  sodium/calcium exchanger 2-like [KO:K05849]
114134113  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
114137698  slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
114152680  sodium/calcium exchanger 1-like [KO:K05849]
114157464  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
114144451  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
114153009  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
114148756  mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
114151595  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
114160258  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
114146754  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
114152072  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
114155283  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
114135493  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
114146921  myosin light chain 3-like [KO:K12749]
114149012  myosin light chain 4-like [KO:K12750]
114135737  hras; GTPase HRas [KO:K02833]
114156567  kras; GTPase KRas isoform X1 [KO:K07827]
114160036  GTPase HRas-like [KO:K07827]
114147892  ras-related protein R-Ras2-like [KO:K07830]
114143027  rras2; ras-related protein R-Ras2 [KO:K07830]
114148358  mras; ras-related protein M-Ras [KO:K07831]
114140577  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114157072  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114151477  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114160039  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
114154145  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114144564  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
114161868  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
114153064  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
114144881  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
114144370  rps6; 40S ribosomal protein S6 [KO:K02991]
114144834  40S ribosomal protein S6-like [KO:K02991]
114148414  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like isoform X1 [KO:K21289] [EC:2.7.1.153]
114161029  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
114144896  pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
114145294  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
114159701  phosphoinositide 3-kinase regulatory subunit 5-like isoform X1 [KO:K21290]
114144319  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
114161603  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114137948  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114134115  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114146827  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
114153578  early growth response protein 1-A-like [KO:K09203]
114139216  egr1; early growth response protein 1 [KO:K09203]
114137693  jag1; protein jagged-1 [KO:K06052]
114133235  protein jagged-1-like isoform X1 [KO:K06052]
114160516  neurogenic locus notch homolog protein 2-like [KO:K20995]
114143123  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
114143385  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
114157271  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
114141968  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
114151964  becn1; beclin-1 isoform X1 [KO:K08334]
114144309  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
114151846  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
114139383  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
114136075  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
114149149  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
114150901  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
114155009  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
114146413  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
114149978  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
114148431  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
114146518  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
114136781  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
114137891  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
114135195  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
114157549  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
114161210  nrf1; nuclear respiratory factor 1 isoform X1 [KO:K11831]
114151223  tfam; transcription factor A, mitochondrial [KO:K11830]
114146012  klf2; Krueppel-like factor 2 [KO:K17845]
114160463  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
114145490  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
114141675  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
114151980  gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
114148609  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
114150793  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
114140844  histone deacetylase 4-like isoform X1 [KO:K11406] [EC:3.5.1.98]
114147881  histone deacetylase 4-like isoform X1 [KO:K11406] [EC:3.5.1.98]
114147886  hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
114151634  mef2a; myocyte-specific enhancer factor 2A isoform X1 [KO:K09260]
114151139  mef2b; myocyte-specific enhancer factor 2B [KO:K09261]
114155146  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
114149405  myocyte-specific enhancer factor 2C-like [KO:K04454]
114140794  myocyte-specific enhancer factor 2D homolog isoform X1 [KO:K09262]
114156621  myocyte-specific enhancer factor 2D homolog isoform X1 [KO:K09262]
114149782  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
114155259  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
114156401  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
114142996  mothers against decapentaplegic homolog 3 [KO:K23605]
114154836  mothers against decapentaplegic homolog 4-like [KO:K04501]
114149415  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
114141666  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
114150601  acta2; actin, aortic smooth muscle [KO:K12313]
114152223  B-cadherin-like isoform X1 [KO:K05689]
114150042  cadherin-1-like [KO:K05689]
114137625  B-cadherin-like isoform X1 [KO:K05689]
114137627  cadherin-1-like [KO:K05689]
114158412  ccn2; connective tissue growth factor [KO:K06827]
114137076  agtr1; type-1 angiotensin II receptor [KO:K04166]
114158035  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
114155004  plat; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
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