KEGG   PATHWAY: xco04814
Entry
xco04814                    Pathway                                
Name
Motor proteins - Xiphophorus couchianus (Monterrey platyfish)
Class
Cellular Processes; Cell motility
Pathway map
xco04814  Motor proteins
xco04814

Organism
Xiphophorus couchianus (Monterrey platyfish) [GN:xco]
Gene
114134167  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
114133207  dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
114148039  dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
114156446  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
114146216  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
114142884  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
114156573  cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
114138227  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
114153330  dynein light chain 2, cytoplasmic-like [KO:K10418]
114161559  dynein light chain 2, cytoplasmic [KO:K10418]
114154720  dynein light chain 2, cytoplasmic-like [KO:K10418]
114136076  dynein light chain roadblock-type 1 [KO:K10419]
114136077  dynein light chain roadblock-type 1-like [KO:K10419]
114134622  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
114158522  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
114148215  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
114140659  dynein light chain Tctex-type 1-like [KO:K10420]
114146462  tctex1 domain-containing protein 1-like [KO:K25421]
114148665  dnah7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
114152319  dnah9; dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
114148844  dnah12; dynein heavy chain 12, axonemal [KO:K10408]
114141781  dynein heavy chain 11, axonemal-like isoform X1 [KO:K10408]
114141805  dnah5; dynein heavy chain 5, axonemal [KO:K10408]
114147067  dynein heavy chain 11, axonemal-like isoform X1 [KO:K10408]
114155530  dnah3; dynein heavy chain 3, axonemal [KO:K10408]
114158054  dnah2; dynein heavy chain 2, axonemal [KO:K10408]
114135946  dnah1; dynein heavy chain 1, axonemal [KO:K10408]
114150351  dnah8; dynein heavy chain 8, axonemal [KO:K10408]
114155030  dnah10; dynein heavy chain 10, axonemal [KO:K10408]
114135562  dnai1; dynein intermediate chain 1, axonemal [KO:K10409]
114155658  dnai2; dynein intermediate chain 2, axonemal [KO:K11143]
114150462  wdr63; WD repeat-containing protein 63 [KO:K24722]
114146759  wdr78; WD repeat-containing protein 78 [KO:K24723]
114152208  WD repeat-containing protein 78-like [KO:K24723]
114141020  dnali1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
114155347  dnal1; dynein light chain 1, axonemal [KO:K10411]
114145610  dnal4; dynein light chain 4, axonemal [KO:K10412]
114134782  dynactin subunit 1-like isoform X1 [KO:K04648]
114157364  dynactin subunit 1-like isoform X1 [KO:K04648]
114135623  dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
114141627  dctn3; dynactin subunit 3 [KO:K10425]
114139353  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
114159972  dctn5; dynactin subunit 5 [KO:K10427]
114144333  dctn6; dynactin subunit 6 [KO:K10428]
114157560  dynactin subunit 6-like [KO:K10428]
114149402  beta-centractin [KO:K16575]
114158230  actr10; actin-related protein 10 [KO:K16576]
114142937  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
114142666  F-actin-capping protein subunit alpha-1-like [KO:K10364]
114135592  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
114153572  BICD family-like cargo adapter 2 isoform X1 [KO:K16756]
114154829  bicdl1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
114133393  BICD family-like cargo adapter 1 [KO:K16756]
114149494  hook3; protein Hook homolog 3 isoform X1 [KO:K16536]
114140589  tubulin alpha chain-like [KO:K07374]
114140795  tubulin alpha chain-like [KO:K07374]
114141078  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
114141079  tubulin alpha-1A chain [KO:K07374]
114150684  tubulin alpha chain-like isoform X1 [KO:K07374]
114140346  tubulin alpha-8 chain-like [KO:K07374]
114140468  tubulin alpha-1B chain [KO:K07374]
114150188  tubulin alpha-1B chain-like [KO:K07374]
114147943  tubulin alpha chain [KO:K07374]
114147944  tubulin alpha chain-like [KO:K07374]
114147945  tubulin alpha chain-like [KO:K07374]
114150302  tubulin alpha-1C chain-like [KO:K07374]
114150386  tubulin alpha-1 chain-like [KO:K07374]
114144632  tubulin beta-4B chain-like [KO:K07375]
114145912  tubulin beta-4B chain-like isoform X1 [KO:K07375]
114155498  tubulin beta-1 chain-like [KO:K07375]
114141673  tubulin beta chain [KO:K07375]
114160209  tubulin beta-4B chain-like [KO:K07375]
114161889  tubulin beta-4B chain-like isoform X1 [KO:K07375]
114155393  tubulin beta chain-like [KO:K07375]
114146693  tubulin beta chain-like isoform X1 [KO:K07375]
114161588  tubulin beta chain-like isoform X1 [KO:K07375]
114135820  tubulin beta chain-like [KO:K07375]
114135091  tubulin beta-4B chain-like [KO:K07375]
114154726  tubb4b; tubulin beta-4B chain [KO:K07375]
114160268  tubg1; tubulin gamma-1 chain [KO:K10389]
114133681  tubd1; tubulin delta chain [KO:K10390]
114158262  tube1; tubulin epsilon chain isoform X1 [KO:K10391]
114135963  kinesin heavy chain-like isoform X1 [KO:K10396]
114136832  kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
114140909  kinesin heavy chain-like [KO:K10396]
114146588  kinesin-1 heavy chain [KO:K10396]
114144845  kinesin heavy chain-like [KO:K10396]
114148634  kinesin heavy chain-like [KO:K10396]
114155748  klc1; kinesin light chain 1 isoform X1 [KO:K10407]
114157303  klc2; kinesin light chain 2 isoform X1 [KO:K10407]
114137455  kinesin light chain 1-like isoform X1 [KO:K10407]
114133511  kinesin light chain 1-like isoform X1 [KO:K10407]
114139220  kif3a; kinesin-like protein KIF3A isoform X1 [KO:K10394]
114144204  kif3b; kinesin-like protein KIF3B [KO:K20196]
114146079  kinesin-associated protein 3-like [KO:K25388]
114141363  kinesin-associated protein 3-like isoform X1 [KO:K25388]
114133805  kinesin-like protein KIF3B [KO:K20197]
114158393  kif3c; kinesin-like protein KIF3C [KO:K20197]
114135424  kif17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
114143106  kif1b; kinesin-like protein KIF1B isoform X1 [KO:K10392]
114140511  kif1c; kinesin-like protein KIF1C [KO:K10392]
114145792  kinesin-like protein KIF1A isoform X1 [KO:K10392]
114150889  kinesin-like protein KIF1A isoform X1 [KO:K10392]
114158903  kinesin-like protein KIF13B isoform X1 [KO:K17914]
114142341  kif13a; kinesin-like protein KIF13A isoform X1 [KO:K17914]
114143399  kinesin-like protein KIF13B isoform X1 [KO:K17914]
114151572  kif14; kinesin-like protein KIF14 [KO:K17915]
114144286  kif16b; kinesin-like protein KIF16B isoform X1 [KO:K17916]
114138262  uncharacterized protein LOC114138262 isoform X1 [KO:K17916]
114134166  stard9; stAR-related lipid transfer protein 9 [KO:K16491]
114152679  chromosome-associated kinesin KIF4-like [KO:K10395]
114143615  kif7; kinesin-like protein KIF7 [KO:K18806]
114154541  kif21a; kinesin-like protein KIF21A isoform X1 [KO:K24185]
114146729  kinesin-like protein KIF21A isoform X1 [KO:K24185]
114135613  kif21b; kinesin-like protein KIF21B isoform X1 [KO:K24185]
114155050  kif27; kinesin-like protein KIF27 [KO:K24186]
114138019  kif11; kinesin-like protein KIF11 isoform X1 [KO:K10398]
114149908  kinesin-like protein KIF11 [KO:K10398]
114137105  kinesin-like protein KIF20A isoform X1 [KO:K10402]
114153489  kif20a; kinesin-like protein KIF20A isoform X1 [KO:K10402]
114138007  kif20b; kinesin-like protein KIF20B isoform X1 [KO:K10402]
114151461  kinesin-like protein KIF20A isoform X1 [KO:K10402]
114143544  kif23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
114161026  cenpe; centromere-associated protein E isoform X1 [KO:K11498]
114143180  kif18a; kinesin-like protein KIF18A [KO:K10401]
114152285  kif19; kinesin-like protein KIF19 [KO:K26157]
114134759  kif6; kinesin-like protein KIF6 isoform X1 [KO:K10397]
114134323  kif22; kinesin-like protein KIF22 [KO:K10403]
114159109  kinesin-like protein KIF26A isoform X1 [KO:K10404]
114142836  kif26b; kinesin-like protein KIF26B isoform X1 [KO:K10404]
114159026  kinesin-like protein KIF26B isoform X1 [KO:K10404]
114134083  kif26a; kinesin-like protein KIF26A isoform X1 [KO:K10404]
114134031  kif15; kinesin-like protein KIF15 [KO:K10400]
114154626  uncharacterized protein LOC114154626 [KO:K10393]
114154981  kif2a; kinesin-like protein KIF2A isoform X1 [KO:K10393]
114149379  kinesin-like protein KIF2A [KO:K10393]
114146910  kinesin-like protein KIF2C isoform X1 [KO:K10393]
114155745  carboxy-terminal kinesin 2-like [KO:K10405]
114142948  kifc3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
114141735  kinesin-like protein KIFC3 [KO:K10406]
114154337  kinesin-like protein KIN-14I isoform X1 [KO:K10406]
114143042  myo1e; unconventional myosin-Ie isoform X1 [KO:K10356]
114155886  unconventional myosin-Ig-like [KO:K10356]
114141585  unconventional myosin-Ie-like isoform X1 [KO:K10356]
114151305  unconventional myosin-If-like [KO:K10356]
114161679  myo1c; unconventional myosin-Ic isoform X1 [KO:K10356]
114147874  myo1b; unconventional myosin-Ib isoform X1 [KO:K10356]
114150236  unconventional myosin-Ih-like [KO:K10356]
114154912  unconventional myosin-Ih-like isoform X1 [KO:K10356]
114152123  myo1d; unconventional myosin-Id [KO:K10356]
114153332  unconventional myosin-Ic-like isoform X1 [KO:K10356]
114137237  myo3a; myosin-IIIa isoform X1 [KO:K08834] [EC:2.7.11.1]
114147468  myo3b; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
114161313  unconventional myosin-Va-like isoform X1 [KO:K10357]
114149370  myo5b; unconventional myosin-Vb isoform X1 [KO:K10357]
114150586  unconventional myosin-Va-like [KO:K10357]
114143250  myo5a; unconventional myosin-Va isoform X1 [KO:K10357]
114135548  myo5c; unconventional myosin-Vc isoform X1 [KO:K10357]
114158949  myo6; unconventional myosin-VI isoform X1 [KO:K10358]
114134683  unconventional myosin-VI-like isoform X1 [KO:K10358]
114152478  unconventional myosin-VIIa-like isoform X1 [KO:K10359]
114161913  myo7a; unconventional myosin-VIIa isoform X1 [KO:K10359]
114151550  unconventional myosin-VIIb-like [KO:K21868]
114147108  unconventional myosin-VIIa-like isoform X1 [KO:K21868]
114150511  myo9b; unconventional myosin-IXb isoform X1 [KO:K10360]
114142749  myo9a; unconventional myosin-IXa isoform X1 [KO:K10360]
114148085  unconventional myosin-X-like isoform X1 [KO:K12559]
114146245  myo10; unconventional myosin-X [KO:K12559]
114144818  unconventional myosin-XV-like [KO:K10361]
114151115  unconventional myosin-XV-like isoform X1 [KO:K10361]
114159541  myo15a; unconventional myosin-XV [KO:K10361]
114148171  myo16; unconventional myosin-XVI isoform X1 [KO:K17481]
114133648  myo18a; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
114153120  unconventional myosin-XVIIIa-like isoform X1 [KO:K10362]
114150250  myo18b; unconventional myosin-XVIIIb isoform X1 [KO:K10362]
114153338  myo19; unconventional myosin-XIX isoform X1 [KO:K25838]
114141099  myosin-7-like isoform X1 [KO:K24220]
114134977  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
114134978  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
114135657  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
114160517  myosin heavy chain, fast skeletal muscle-like isoform X1 [KO:K24220]
114160519  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
114160520  myosin heavy chain, fast skeletal muscle isoform X1 [KO:K24220]
114141098  myosin-7B-like [KO:K24220]
114136525  myosin-6-like [KO:K17751]
114146201  myosin-7-like isoform X1 [KO:K17751]
114146202  myosin-7 [KO:K17751]
114146203  myosin-7-like isoform X1 [KO:K17751]
114146204  myosin-7 [KO:K17751]
114144378  myosin-9-like [KO:K10352]
114144537  myh11; myosin-11 isoform X1 [KO:K10352]
114144540  myosin-10-like isoform X1 [KO:K10352]
114147544  myh9; myosin-9 isoform X1 [KO:K10352]
114160186  myosin-10 isoform X1 [KO:K10352]
114148704  myosin light chain 1, skeletal muscle isoform [KO:K05738]
114146921  myosin light chain 3-like [KO:K12749]
114149012  myosin light chain 4-like [KO:K12750]
114135133  myosin light polypeptide 6-like [KO:K12751]
114143869  myosin light polypeptide 6 isoform X1 [KO:K12751]
114155283  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
114135493  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
114154123  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
114135165  myosin regulatory light polypeptide 9 [KO:K12755]
114146547  myosin regulatory light polypeptide 9-like [KO:K12757]
114136749  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
114159509  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
114134490  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
114150601  acta2; actin, aortic smooth muscle [KO:K12313]
114143458  acta1; actin, alpha skeletal muscle [KO:K12314]
114159161  actin, alpha cardiac [KO:K12314]
114134391  actc1; actin, alpha cardiac muscle 1 [KO:K12314]
114133993  actin, alpha cardiac [KO:K12314]
114144351  actin, cytoplasmic 2 [KO:K05692]
114159761  actb; actin, cytoplasmic 1 [KO:K05692]
114144490  troponin C, slow skeletal and cardiac muscles [KO:K05865]
114141254  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
114153622  troponin I, slow skeletal muscle-like [KO:K10371]
114135511  troponin I, slow skeletal muscle-like [KO:K10371]
114136603  troponin I, slow skeletal muscle-like isoform X1 [KO:K10371]
114136614  troponin I, slow skeletal muscle-like [KO:K10371]
114133822  troponin I, slow skeletal muscle-like [KO:K10371]
114133828  troponin I, slow skeletal muscle-like [KO:K10371]
114141478  troponin I, slow skeletal muscle-like isoform X1 [KO:K10371]
114148313  troponin T, slow skeletal muscle-like isoform X1 [KO:K10372]
114136508  troponin T, slow skeletal muscle-like isoform X1 [KO:K10372]
114151061  troponin C, skeletal muscle-like [KO:K12042]
114150378  troponin C, skeletal muscle [KO:K12042]
114143135  troponin I, fast skeletal muscle-like isoform X1 [KO:K12043]
114143137  troponin I, fast skeletal muscle-like [KO:K12043]
114143138  troponin I, fast skeletal muscle-like [KO:K12043]
114143139  troponin I, fast skeletal muscle-like [KO:K12043]
114143299  troponin I, fast skeletal muscle-like isoform X1 [KO:K12043]
114143124  troponin T, fast skeletal muscle isoforms-like isoform X1 [KO:K12046]
114142656  troponin T, fast skeletal muscle isoforms-like isoform X1 [KO:K12046]
114154603  troponin T, cardiac muscle isoforms-like [KO:K12045]
114161238  troponin T, cardiac muscle isoforms-like isoform X1 [KO:K12045]
114152649  tnnt2; troponin T, cardiac muscle isoform X1 [KO:K12045]
114135510  troponin T, cardiac muscle isoforms-like isoform X1 [KO:K12045]
114143406  tropomyosin alpha-1 chain-like isoform X1 [KO:K10373]
114161103  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
114149125  tropomyosin beta chain [KO:K10374]
114140176  tropomyosin alpha-4 chain-like isoform X1 [KO:K09290]
114156001  tropomyosin alpha-3 chain [KO:K09290]
114146153  tropomyosin alpha-1 chain-like isoform X1 [KO:K10375]
114151241  tpm4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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