KEGG   PATHWAY: zca04120
Entry
zca04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Zalophus californianus (California sea lion)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
zca04120  Ubiquitin mediated proteolysis
zca04120

Other DBs
GO: 0016567
Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113928746  polyubiquitin [KO:K04551]
113913252  UBC; polyubiquitin-C [KO:K08770]
113939421  UBB; polyubiquitin-B [KO:K08770]
113917744  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
113929895  ubiquitin [KO:K02927]
113909325  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
113909631  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
113926956  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
118356282  ubiquitin-60S ribosomal protein L40 [KO:K02927]
113923441  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
113931435  ubiquitin-60S ribosomal protein L40 [KO:K02927]
113937178  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
113919708  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
113929881  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
113933691  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
113930621  ubiquitin-40S ribosomal protein S27a [KO:K02977]
113930195  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
113936547  SAE1; SUMO-activating enzyme subunit 1 isoform X1 [KO:K10684] [EC:6.2.1.45]
113935821  UBA2; SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
113916945  UBA3; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
113918533  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
113925078  UBA6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
113931060  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
113929535  UBE2B; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
113927470  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
113927586  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
113929793  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
113911176  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
118357092  ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
113908695  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
113926466  ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
113938513  UBE2C; ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
113922337  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
118356099  ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
118356159  ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
113912383  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
113939779  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
113924587  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
113928935  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
113922229  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
113927191  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
113917437  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
113922522  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
113925368  ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
113916334  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
113917978  UBE2E2; ubiquitin-conjugating enzyme E2 E2 isoform X1 [KO:K20217] [EC:2.3.2.23]
113920717  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
113917201  ubiquitin-conjugating enzyme E2 E3-like [KO:K20217] [EC:2.3.2.23]
113914193  ubiquitin-conjugating enzyme E2 E2-like isoform X1 [KO:K20217] [EC:2.3.2.23]
118356330  ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
113920150  UBE2F; NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
113939396  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
113916468  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
113911036  UBE2H; ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
113932738  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
113927073  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
113934283  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
113925012  UBE2K; ubiquitin-conjugating enzyme E2 K isoform X1 [KO:K04649] [EC:2.3.2.23]
113913216  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
113913343  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
113925299  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
113936476  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
113912642  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
113912649  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
113908682  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
113915403  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
113936467  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
113913082  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113924852  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113934675  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113934949  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113917738  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113919777  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113920077  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
118356740  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
113937257  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
118357136  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113927102  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113938033  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113922003  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
118356002  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
118356374  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
113939278  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
113929204  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
113933441  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
113909677  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
113934972  UBE2R2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
113918650  CDC34; ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
113935876  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
113935004  UBE2U; ubiquitin-conjugating enzyme E2 U isoform X1 [KO:K10584] [EC:2.3.2.23]
113931064  UBE2W; ubiquitin-conjugating enzyme E2 W isoform X2 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
113939355  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
113937068  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
113908914  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
113912613  UBE3B; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
113911263  UBE3C; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
113932332  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
113939397  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
113937583  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
113915511  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
113936099  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
113919714  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
113908913  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
113912440  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
113931521  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
113922873  UBR5; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
113908941  HERC1; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
113910566  HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
113924213  HERC3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
113920823  HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
113914093  UBE4A; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
113931888  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
113932153  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
113912461  PPIL2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
113915355  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
113937687  UBOX5; RING finger protein 37 isoform X1 [KO:K10600]
113921844  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
113914209  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
113917547  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
113935307  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
113927504  PRKN; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
113935952  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
113931318  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
113909431  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
113913973  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113929708  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
113932273  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
113924554  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
113914287  baculoviral IAP repeat-containing protein 2 [KO:K16060]
113914288  baculoviral IAP repeat-containing protein 3 [KO:K16060]
113930311  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
113938341  BIRC7; baculoviral IAP repeat-containing protein 7 [KO:K16061]
113908947  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
113912287  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
113932464  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
113916489  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
113914145  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
113926220  NHLRC1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
113917872  AIRE; autoimmune regulator [KO:K10603]
113932492  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
113939007  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
113937099  FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
113931252  MID1; E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
113934859  TRIM32; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
113939361  TRIM37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
113921968  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
113911560  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
113910992  CUL1; cullin-1 [KO:K03347]
113928408  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
113917386  S-phase kinase-associated protein 1 [KO:K03094]
113925388  S-phase kinase-associated protein 1-like [KO:K03094]
113937446  S-phase kinase-associated protein 1-like [KO:K03094]
113938072  S-phase kinase-associated protein 1-like [KO:K03094]
113928951  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
113914801  LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 11-like [KO:K03362]
113920925  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
113928995  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
113924562  FBXW7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
113908531  FBXO2; F-box only protein 2 [KO:K10099]
113929301  FBXO4; F-box only protein 4 isoform X1 [KO:K10291]
113922690  CUL2; cullin-2 [KO:K03870]
113920662  LOW QUALITY PROTEIN: cullin-2-like [KO:K03870]
113935698  ELOC; LOW QUALITY PROTEIN: elongin-C [KO:K03872]
113911427  elongin-C-like [KO:K03872]
113937395  elongin-C [KO:K03872]
113913983  elongin-C-like [KO:K03872]
113931799  ELOB; elongin-B [KO:K03873]
113918488  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
113919447  CUL3; cullin-3 [KO:K03869]
113915830  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
113931406  KLHL13; kelch-like protein 13 isoform X1 [KO:K10447]
113934666  KLHL9; kelch-like protein 9 [KO:K10447]
113924740  RHOBTB2; rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
113923529  RHOBTB1; rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
113930967  CUL4B; cullin-4B isoform X1 [KO:K10609]
113920237  CUL4A; cullin-4A isoform X1 [KO:K10609]
118356612  cullin-4B-like isoform X1 [KO:K10609]
113913493  DDB1; DNA damage-binding protein 1 isoform X1 [KO:K10610]
113927049  LOW QUALITY PROTEIN: DNA damage-binding protein 1-like [KO:K10610]
113913864  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
113929509  ERCC8; DNA excision repair protein ERCC-8 isoform X2 [KO:K10570]
113909936  DET1; DET1 homolog isoform X1 [KO:K10571]
113918755  RNF7; LOW QUALITY PROTEIN: RING-box protein 2 [KO:K10611]
113914263  CUL5; LOW QUALITY PROTEIN: cullin-5 [KO:K10612]
113932751  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
113939748  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
113927376  CUL7; cullin-7 isoform X1 [KO:K10613]
113912641  FBXW8; F-box/WD repeat-containing protein 8 [KO:K10264]
113908134  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
113921376  anaphase-promoting complex subunit 11-like [KO:K03358]
113934582  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
113933647  CDC20; cell division cycle protein 20 homolog [KO:K03363]
113918443  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
113937361  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
113939316  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
113924705  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
113912743  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
113919358  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
113912799  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
113928387  CDC23; cell division cycle protein 23 homolog [KO:K03355]
113924269  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
113925350  anaphase-promoting complex subunit 10-like [KO:K03357]
113934368  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
113916768  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
113915956  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 13-like [KO:K12456]
113915118  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
113923526  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
zca03050  Proteasome
KO pathway
ko04120   
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