KEGG   PATHWAY: pcao03013
Entry
pcao03013                   Pathway                                
Name
Nucleocytoplasmic transport - Phalacrocorax carbo (great cormorant)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pcao03013  Nucleocytoplasmic transport
pcao03013

Other DBs
GO: 0050658
Organism
Phalacrocorax carbo (great cormorant) [GN:pcao]
Gene
104039303  KPNB1; importin subunit beta-1 [KO:K14293]
104039414  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
104039479  IPO5; importin-5 [KO:K20222]
104039792  NDC1; nucleoporin NDC1 [KO:K14315]
104039850  PNN; pinin [KO:K13114]
104039858  RAE1; mRNA export factor [KO:K14298]
104040039  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104040043  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
104040078  SEC13; protein SEC13 homolog [KO:K14004]
104040201  SEH1L; nucleoporin SEH1 [KO:K14299]
104040345  NXT2; NTF2-related export protein 2 [KO:K14285]
104040348  [KO:K12877]
104040380  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
104040578  ALYREF; THO complex subunit 4 [KO:K12881]
104040688  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
104040940  [KO:K14306]
104040945  [KO:K20223]
104041158  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
104041316  IPO9; importin-9 [KO:K20224]
104041371  [KO:K18655] [EC:5.6.2.7]
104041445  GLE1; nucleoporin GLE1 [KO:K18723]
104041543  KPNA6; importin subunit alpha-7 [KO:K15042]
104041588  NUP160; LOW QUALITY PROTEIN: nuclear pore complex protein Nup160 [KO:K14303]
104041713  RAN; GTP-binding nuclear protein Ran [KO:K07936]
104041804  NUP35; nucleoporin NUP53 [KO:K14313]
104041878  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
104042037  XPO4; exportin-4 [KO:K25203]
104042244  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
104042481  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
104042545  NUP54; LOW QUALITY PROTEIN: nucleoporin p54 [KO:K14308]
104043101  IPO8; importin-8 [KO:K18755]
104043208  [KO:K12883]
104043863  THOC5; LOW QUALITY PROTEIN: THO complex subunit 5 homolog [KO:K13174]
104043897  XPO6; exportin-6 [KO:K25204]
104044004  CSE1L; exportin-2 isoform X1 [KO:K18423]
104044100  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
104044110  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
104044370  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
104044400  SNUPN; snurportin-1 [KO:K13151]
104044427  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
104044490  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
104044550  NUP98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
104044722  TPR; nucleoprotein TPR [KO:K09291]
104044761  AAAS; aladin [KO:K14320]
104045062  NUPL1; LOW QUALITY PROTEIN: nucleoporin p58/p45 [KO:K14307]
104045326  IPO11; LOW QUALITY PROTEIN: importin-11 [KO:K25201]
104045498  NUP85; LOW QUALITY PROTEIN: nuclear pore complex protein Nup85 [KO:K14304]
104045730  XPO5; LOW QUALITY PROTEIN: exportin-5 [KO:K14289]
104045744  NUP43; nucleoporin Nup43 [KO:K14305]
104045780  NUPL2; nucleoporin-like protein 2 [KO:K14321]
104045809  NUP37; nucleoporin Nup37 [KO:K14302]
104045987  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
104046334  THOC1; THO complex subunit 1 [KO:K12878]
104046584  THOC2; THO complex subunit 2 [KO:K12879]
104046781  KPNA2; importin subunit alpha-1 [KO:K15043]
104047572  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
104047806  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
104048097  NUP214; LOW QUALITY PROTEIN: nuclear pore complex protein Nup214 [KO:K14317]
104048286  [KO:K12883]
104048894  THOC3; THO complex subunit 3 [KO:K12880]
104049292  THOC7; THO complex subunit 7 homolog [KO:K13176]
104049407  XPOT; exportin-T [KO:K14288]
104049869  IPO13; importin-13 [KO:K25202]
104050109  KPNA3; importin subunit alpha-4 [KO:K23583]
104050613  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
104050833  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
104050866  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
104051289  CASC3; protein CASC3 [KO:K14323]
104051317  KPNA1; importin subunit alpha-5 [KO:K23940]
104051684  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
104051801  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
104052121  TNPO1; transportin-1 [KO:K18752]
104052293  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
104052384  NUP188; nucleoporin NUP188 homolog [KO:K14311]
104052420  KPNA5; importin subunit alpha-6 [KO:K15042]
104052426  TMEM33; transmembrane protein 33 [KO:K20724]
104052515  [KO:K23583]
104052646  XPO7; exportin-7 [KO:K18460]
104053038  [KO:K15043]
104053092  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104053203  [KO:K13171]
104053575  [KO:K14309]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pcao03015  mRNA surveillance pathway
KO pathway
ko03013   

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