KEGG   PATHWAY: pleu04666
Entry
pleu04666                   Pathway                                
Name
Fc gamma R-mediated phagosome formation - Peromyscus leucopus (white-footed mouse)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
pleu04666  Fc gamma R-mediated phagosome formation
pleu04666

Other DBs
GO: 0006909
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114681114  Pla2g4e; LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
114681118  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
114681139  Pla2g4d; cytosolic phospholipase A2 delta isoform X2 [KO:K16342] [EC:3.1.1.4]
114681142  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114682367  [KO:K06498]
114682714  Crkl; crk-like protein [KO:K04438]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682779  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
114683196  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684216  Vav2; guanine nucleotide exchange factor VAV2 isoform X4 [KO:K05730]
114684268  Arf6; ADP-ribosylation factor 6 [KO:K07941]
114684677  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
114685666  Amph; amphiphysin [KO:K12562]
114685999  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
114686543  Vav1; proto-oncogene vav [KO:K05730]
114687406  [KO:K06083]
114687523  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114687550  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
114688360  Pip5k1c; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689172  Plpp2; LOW QUALITY PROTEIN: phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
114689480  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
114689606  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689890  Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560]
114689891  [KO:K06463]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114691309  [KO:K04393]
114691441  Crk; adapter molecule crk isoform X1 [KO:K04438]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691639  Bin1; myc box-dependent-interacting protein 1 isoform X2 [KO:K12562]
114692203  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114692452  Myo10; unconventional myosin-X [KO:K12559]
114692579  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
114692902  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
114693369  Cfl2; cofilin-2 [KO:K05765]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693645  Limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
114693708  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
114694032  Limk2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
114694231  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114694258  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
114695084  Scin; adseverin [KO:K05768]
114695226  Dnm2; dynamin-2 isoform X1 [KO:K23484]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114696773  Pla2g4a; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
114696876  Marcks; LOW QUALITY PROTEIN: myristoylated alanine-rich C-kinase substrate [KO:K12561]
114696943  Actr3; actin-related protein 3 [KO:K18584]
114697206  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114697222  Asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
114697457  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
114697539  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
114697727  Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
114697890  Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
114698662  Gab2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
114698679  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114698861  Asap2; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
114699281  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
114699957  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
114700059  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
114700306  Lat; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
114701271  Was; wiskott-Aldrich syndrome protein [KO:K05747]
114701275  [KO:K04393]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703628  Plpp1; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
114703682  Actr2; actin-related protein 2 isoform X3 [KO:K17260]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703899  Pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704562  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
114704703  Gsn; gelsolin isoform X1 [KO:K05768]
114704956  [KO:K05765]
114705554  Hck; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
114705646  Marcksl1; MARCKS-related protein [KO:K13536]
114705854  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
114705950  Wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
114706606  Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707026  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
114707192  Ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
114707507  Wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707541  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
114707564  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
114708186  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
114709090  Prkce; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
114709166  Cfl1; cofilin-1 [KO:K05765]
114709280  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
114709870  [KO:K06274]
114710028  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
114710233  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
114710523  [KO:K04371] [EC:2.7.11.24]
119086087  Fcgr2a; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472]
119086108  [KO:K06083]
119088838  [KO:K04438]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
pleu04020  Calcium signaling pathway
pleu04142  Lysosome biogenesis
pleu04144  Endocytosis
pleu04145  Phagosome
pleu04810  Regulation of actin cytoskeleton
KO pathway
ko04666   

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