Entry Name TGF-beta signaling pathway - Poecilia reticulata (guppy)
Description The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Poecilia reticulata (guppy) [GN:
pret ]
Gene 103459981 ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
103462627 thsd4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377 ]
103470779 ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X2 [KO:K04382 ] [EC:3.1.3.16 ]
103471312 smad1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676 ]
103474595 ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
103476545 ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559 ]
103482387 bambi; BMP and activin membrane-bound inhibitor homolog [KO:K10162 ]
Compound Reference Authors Shi Y, Massague J.
Title Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Journal Reference Authors Derynck R, Zhang YE.
Title Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
Journal Reference Authors Massague J.
Title How cells read TGF-beta signals.
Journal Reference Authors Siegel PM, Massague J.
Title Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
Journal Reference Authors Shimasaki S, Moore RK, Otsuka F, Erickson GF.
Title The bone morphogenetic protein system in mammalian reproduction.
Journal Reference Authors De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
Title The establishment of Spemann's organizer and patterning of the vertebrate embryo.
Journal Reference Authors Gumienny TL, Padgett RW.
Title The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
Journal Reference Authors Hamada H, Meno C, Watanabe D, Saijoh Y.
Title Establishment of vertebrate left-right asymmetry.
Journal Reference Authors Chang H, Brown CW, Matzuk MM.
Title Genetic analysis of the mammalian transforming growth factor-beta superfamily.
Journal Reference Authors Morita K, Chow KL, Ueno N.
Title Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
Journal Development 126:1337-47 (1999)
Reference Authors Krishna S, Maduzia LL, Padgett RW.
Title Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
Journal Development 126:251-60 (1999)
Reference Authors Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
Title ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
Journal Reference Authors Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
Title Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
Journal Reference Authors Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
Title Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
Journal Reference Authors Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
Title Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
Journal Reference Authors Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
Title Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
Journal Reference Authors Anderson GJ, Frazer DM
Title Iron metabolism meets signal transduction.
Journal Reference Authors Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
Title Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
Journal Reference Authors Ganz T, Nemeth E
Title Iron homeostasis in host defence and inflammation.
Journal Reference Authors Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
Title Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
Journal Reference Authors Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
Title DRAGON, a bone morphogenetic protein co-receptor.
Journal Reference Authors Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
Title On Iron Metabolism and Its Regulation.
Journal Reference Authors Ikushima H, Miyazono K
Title TGFbeta signalling: a complex web in cancer progression.
Journal Reference Authors Wu M, Wu S, Chen W, Li YP
Title The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
Journal Related KO pathway
