Entry Name mTOR signaling pathway - Pseudoliparis swirei (Mariana hadal snailfish)
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Organism Pseudoliparis swirei (Mariana hadal snailfish) [GN:
pswi ]
Gene 130188187 strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
130188198 depdc5; LOW QUALITY PROTEIN: GATOR complex protein DEPDC5 [KO:K20404 ]
130191747 castor2; LOW QUALITY PROTEIN: cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081 ]
130193807 pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649 ]
130194667 lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
130195936 slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780 ]
130196351 clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421 ]
130196528 castor1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080 ]
130197673 pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
130197903 eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
130199457 dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
130199948 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
130200857 lrp6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
130201734 atp6v1c2; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 1-B [KO:K02148 ]
130203219 telo2; telomere length regulation protein TEL2 homolog [KO:K11137 ]
130205119 mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410 ]
130205168 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
130206885 eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X1 [KO:K03259 ]
130206948 atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
130208406 wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572 ]
130208955 si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402 ]
130210442 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
130211115 si:dkey-202g17.3; 4F2 cell-surface antigen heavy chain [KO:K06519 ]
130211774 dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
130212908 mios; LOW QUALITY PROTEIN: GATOR complex protein MIOS [KO:K20407 ]
130212947 deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402 ]
130212990 fnip1; LOW QUALITY PROTEIN: folliculin-interacting protein 1 [KO:K20400 ]
130213463 tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
130213472 wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related KO pathway
