KEGG   PATHWAY: pswi04140
Entry
pswi04140                   Pathway                                
Name
Autophagy - animal - Pseudoliparis swirei (Mariana hadal snailfish)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
pswi04140  Autophagy - animal
pswi04140

Other DBs
GO: 0006914
Organism
Pseudoliparis swirei (Mariana hadal snailfish) [GN:pswi]
Gene
130187966  atg5; autophagy protein 5 [KO:K08339]
130188307  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
130188345  wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
130188433  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
130188487  supt20; transcription factor SPT20 homolog [KO:K21245]
130188566  [KO:K08342] [EC:3.4.22.-]
130188581  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
130188942  nbr1b; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
130189027  rras; ras-related protein R-Ras [KO:K07830]
130189051  zgc:55558; GTPase KRas [KO:K07827]
130189125  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
130189132  wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
130189243  smcr8a; guanine nucleotide exchange protein smcr8a isoform X1 [KO:K23611]
130189362  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
130189520  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
130189546  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130189569  rab1aa; RAB1A, member RAS oncogene family a [KO:K07874]
130189949  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
130190011  [KO:K04688] [EC:2.7.11.1]
130190198  [KO:K07920]
130190218  [KO:K04345] [EC:2.7.11.11]
130190546  atg4da; cysteine protease atg4da [KO:K08342] [EC:3.4.22.-]
130190568  tsc2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
130190639  rptor; regulatory-associated protein of mTOR [KO:K07204]
130190675  smcr8b; LOW QUALITY PROTEIN: guanine nucleotide exchange protein smcr8b [KO:K23611]
130191375  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
130191523  [KO:K08341]
130191596  epg5; ectopic P granules protein 5 homolog isoform X1 [KO:K23883]
130191646  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
130191914  hmgb1a; high mobility group protein B1a [KO:K10802]
130191919  [KO:K21248]
130191977  [KO:K07925]
130192387  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
130192406  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
130192477  [KO:K08341]
130192500  lamp1a; lysosome-associated membrane glycoprotein 1a [KO:K06528]
130192980  rras2; ras-related protein R-Ras2 [KO:K07830]
130193010  [KO:K08803] [EC:2.7.11.1]
130193025  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
130193169  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
130193455  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
130193487  cts12; procathepsin L [KO:K01365] [EC:3.4.22.15]
130193593  uba52; ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
130193727  rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
130193748  [KO:K07901]
130193754  [KO:K00922] [EC:2.7.1.153]
130193807  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
130193843  rab42a; ras-related protein Rab-42a [KO:K07925]
130194122  [KO:K02649]
130194253  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
130194267  atg4b; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
130194393  atg4c; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
130194460  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
130194871  dapk2b; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
130194898  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
130194985  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
130195018  ambra1b; activating molecule in BECN1-regulated autophagy protein 1B isoform X1 [KO:K17985]
130195239  kras; GTPase KRas isoform X1 [KO:K07827]
130195891  [KO:K02833]
130195943  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
130196195  [KO:K02649]
130196368  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
130196398  [KO:K04382] [EC:3.1.3.16]
130196458  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
130196472  ctsla; cathepsin La isoform X1 [KO:K01365] [EC:3.4.22.15]
130196478  ykt6; synaptobrevin homolog YKT6 [KO:K08516]
130196757  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
130196925  vps33a; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
130197067  si:dkey-240h12.4; death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
130197099  snap29; synaptosomal-associated protein 29 [KO:K08509]
130197253  vamp8; vesicle-associated membrane protein 8 [KO:K08512]
130197303  wdfy3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
130197330  dapk1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
130197411  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
130197517  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
130197545  rheb; GTP-binding protein Rheb isoform X1 [KO:K07208]
130197660  [KO:K02649]
130197673  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
130197901  atg10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
130197942  [KO:K26797]
130197948  gorasp1a; Golgi reassembly-stacking protein 1a isoform X1 [KO:K26797]
130198080  [KO:K00922] [EC:2.7.1.153]
130198106  rb1cc1; LOW QUALITY PROTEIN: RB1-inducible coiled-coil protein 1 [KO:K17589]
130198131  atg9b; autophagy-related protein 9B [KO:K17907]
130198144  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
130198180  prkacbb; LOW QUALITY PROTEIN: protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
130198503  dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
130198510  [KO:K07901]
130198876  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
130198892  bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
130199044  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
130199335  [KO:K04724]
130199780  [KO:K21247]
130199948  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
130199953  gorasp2; Golgi reassembly-stacking protein 2 [KO:K26797]
130200466  optn; optineurin [KO:K19946]
130200472  tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
130200712  prkcq; LOW QUALITY PROTEIN: protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
130201005  eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
130201053  [KO:K11248]
130201186  rragcb; ras-related GTP binding Cb [KO:K16186]
130201245  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
130201285  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
130201416  atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
130201439  [KO:K17906]
130201440  mrasa; ras-related protein M-Ras [KO:K07831]
130201552  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
130201579  atg9a; autophagy-related protein 9A [KO:K17907]
130201598  rragd; ras-related GTP-binding protein D [KO:K16186]
130201623  c9orf72; guanine nucleotide exchange factor C9orf72 homolog isoform X1 [KO:K23609]
130201757  [KO:K17603]
130201953  hif1aa; hypoxia inducible factor 1 subunit alpha a isoform X1 [KO:K08268]
130201975  ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
130202228  zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
130202308  [KO:K04427] [EC:2.7.11.25]
130202411  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
130202493  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
130202674  stx7l; syntaxin-7 [KO:K08488]
130202881  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
130203011  [KO:K01363] [EC:3.4.22.1]
130203227  pdpk1b; 3-phosphoinositide dependent protein kinase 1b isoform X1 [KO:K06276] [EC:2.7.11.1]
130203344  nrbf2b; nuclear receptor-binding factor 2b [KO:K21246]
130203361  mapk8b; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
130203476  calcoco2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
130203543  nbr1a; NBR1 autophagy cargo receptor a isoform X1 [KO:K17987]
130203573  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
130203703  zgc:101559; ras-related protein Rab-33B-like isoform X1 [KO:K07920]
130203741  [KO:K17908]
130203882  wdr45b; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
130203897  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
130203942  epas1a; endothelial PAS domain-containing protein 1 [KO:K08268]
130204042  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
130204404  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
130204450  atg3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
130204504  [KO:K07187]
130204594  vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
130204985  si:ch73-234b20.5; vesicle-associated membrane protein 8 isoform X1 [KO:K08512]
130205147  ulk1b; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
130205168  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
130205275  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
130205338  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
130205358  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
130205448  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
130205535  wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
130205557  [KO:K07359] [EC:2.7.11.17]
130205561  lamp1b; lysosome-associated membrane glycoprotein 1b [KO:K06528]
130205792  wdr41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
130206102  [KO:K26797]
130206139  vps41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
130206311  sh3glb1a; endophilin-B1a [KO:K11248]
130206752  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
130206764  irs2b; insulin receptor substrate 2 [KO:K07187]
130206778  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130206792  bnip4; BCL2 interacting protein 4 [KO:K15464]
130206828  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
130207033  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
130207056  [KO:K07874]
130207186  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
130208063  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
130208068  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
130208218  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
130208297  [KO:K10435]
130208330  si:dkey-13a21.4; ras-related protein rab7 isoform X1 [KO:K07897]
130208375  atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
130208405  rab7a; ras-related protein Rab-7a [KO:K07897]
130208604  [KO:K04958]
130208665  [KO:K06068] [EC:2.7.11.13]
130208681  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
130208699  [KO:K04570]
130208737  [KO:K07897]
130208821  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
130208955  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
130209341  atg2a; autophagy-related protein 2 homolog A [KO:K17906]
130209426  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
130209446  rab33ba; RAB33B, member RAS oncogene family a [KO:K07920]
130209497  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
130209624  igbp1; immunoglobulin-binding protein 1 [KO:K17606]
130209680  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
130209713  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
130209935  [KO:K04382] [EC:3.1.3.16]
130210315  tax1bp1a; tax1-binding protein 1 homolog A isoform X1 [KO:K21347]
130210344  rps6kb1b; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
130210360  vmp1; vacuole membrane protein 1 isoform X1 [KO:K21248]
130210379  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
130210442  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
130210496  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130210550  hif1al; hypoxia inducible factor 1 subunit alpha, like isoform X1 [KO:K08268]
130210815  [KO:K04456] [EC:2.7.11.1]
130210861  hmgb1b; high mobility group protein B1b [KO:K10802]
130211048  si:ch211-11n16.2; zinc finger FYVE domain-containing protein 1 [KO:K17603]
130211208  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
130211575  atg101; autophagy-related protein 101 [KO:K19730]
130211665  badb; BCL2 associated agonist of cell death b [KO:K02158]
130211779  [KO:K07187]
130211865  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
130211974  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
130211992  [KO:K07925]
130211999  uvrag; UV radiation resistance-associated gene protein [KO:K21249]
130212043  [KO:K00922] [EC:2.7.1.153]
130212187  rab1ba; zRAB1B, member RAS oncogene family a [KO:K07874]
130212275  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
130212375  rraga; ras-related GTP-binding protein A [KO:K16185]
130212756  rragca; ras-related GTP binding Ca [KO:K16186]
130212791  atg12; ubiquitin-like protein ATG12 [KO:K08336]
130212887  stx17; syntaxin-17 [KO:K08491]
130212947  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
130213068  tax1bp1b; tax1-binding protein 1 homolog B isoform X1 [KO:K21347]
130213180  pik3r4; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
130213316  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
130213495  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
pswi04010  MAPK signaling pathway
pswi04141  Protein processing in endoplasmic reticulum
pswi04142  Lysosome
pswi04150  mTOR signaling pathway
pswi04910  Insulin signaling pathway
KO pathway
ko04140   

DBGET integrated database retrieval system