KEGG   PATHWAY: pswi04010
Entry
pswi04010                   Pathway                                
Name
MAPK signaling pathway - Pseudoliparis swirei (Mariana hadal snailfish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pswi04010  MAPK signaling pathway
pswi04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Pseudoliparis swirei (Mariana hadal snailfish) [GN:pswi]
Gene
130187898  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
130188217  mapk8ip3; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
130188260  si:ch211-195b15.8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130188305  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
130188307  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
130188386  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
130188457  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
130188471  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
130188527  [KO:K04856]
130188579  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130188608  [KO:K19662] [EC:2.7.11.13]
130188618  atf4b; LOW QUALITY PROTEIN: activating transcription factor 4b [KO:K04374]
130188657  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
130188659  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
130188662  [KO:K03283]
130188685  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a isoform X1 [KO:K04867]
130188772  [KO:K04433] [EC:2.7.12.2]
130188804  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
130188864  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
130188944  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
130188951  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
130188979  [KO:K16342] [EC:3.1.1.4]
130188983  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
130188986  [KO:K04869]
130188995  [KO:K04347]
130189001  cacng5b; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
130189027  rras; ras-related protein R-Ras [KO:K07830]
130189051  zgc:55558; GTPase KRas [KO:K07827]
130189106  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
130189187  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
130189270  [KO:K04866]
130189362  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
130189521  gna12a; guanine nucleotide-binding protein subunit alpha-12a isoform X1 [KO:K04346]
130189546  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130189644  [KO:K02677] [EC:2.7.11.13]
130189649  [KO:K04869]
130189651  [KO:K04870]
130189652  [KO:K04866]
130189721  si:ch211-79m20.1; platelet-derived growth factor subunit B [KO:K17386]
130189730  [KO:K25416]
130189801  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
130189891  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
130189916  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
130189990  rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
130190034  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
130190042  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
130190052  rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
130190125  [KO:K04429] [EC:2.7.11.1]
130190177  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
130190218  [KO:K04345] [EC:2.7.11.11]
130190241  [KO:K19662] [EC:2.7.11.13]
130190313  [KO:K04868]
130190369  [KO:K04358]
130190456  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
130190550  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
130190566  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
130190594  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130190623  fgf8b; fibroblast growth factor 8b [KO:K04358]
130190716  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
130190740  cacna1ab; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
130191323  [KO:K04386]
130191520  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
130191576  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
130191725  [KO:K04438]
130191752  [KO:K05090] [EC:2.7.10.1]
130191892  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
130191999  hspb1; heat shock protein beta-1 [KO:K04455]
130192048  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
130192239  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
130192282  fgf3; fibroblast growth factor 3 [KO:K04358]
130192284  fgf4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
130192285  fgf19; fibroblast growth factor 19 [KO:K22603]
130192351  [KO:K03283]
130192387  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
130192406  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
130192530  [KO:K04434]
130192590  [KO:K04349]
130192652  vegfd; vascular endothelial growth factor D [KO:K05449]
130192771  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
130192868  fgf7; fibroblast growth factor 7 [KO:K04358]
130192980  rras2; ras-related protein R-Ras2 [KO:K07830]
130193188  efna3a; ephrin-A3 isoform X1 [KO:K05462]
130193190  [KO:K04373] [EC:2.7.11.1]
130193272  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
130193455  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
130193555  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
130193556  [KO:K04347]
130193576  [KO:K04381]
130193618  angpt1; angiopoietin-1 [KO:K05465]
130193677  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
130193704  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
130193789  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
130193801  [KO:K04852]
130193810  [KO:K04446]
130193884  [KO:K04449]
130193912  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
130194063  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
130194171  fgf22; fibroblast growth factor 22 [KO:K04358]
130194207  [KO:K25415]
130194253  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
130194257  daxx; death domain-associated protein 6 [KO:K02308]
130194399  [KO:K16342] [EC:3.1.1.4]
130194462  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
130194485  jun; transcription factor AP-1 [KO:K04448]
130194492  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
130194898  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
130194905  [KO:K04388] [EC:2.7.11.30]
130194916  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
130194985  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
130194990  [KO:K04349]
130195135  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
130195239  kras; GTPase KRas isoform X1 [KO:K07827]
130195248  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
130195249  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
130195260  [KO:K04861]
130195263  [KO:K17333]
130195306  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130195343  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
130195357  igf2b; insulin-like growth factor 2b [KO:K13769]
130195412  kitlga; kit ligand a [KO:K05461]
130195457  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
130195729  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
130195735  [KO:K05460]
130195737  [KO:K04858]
130195833  [KO:K22428]
130195834  [KO:K04358]
130195891  [KO:K02833]
130195959  [KO:K04434]
130196071  fgf5; fibroblast growth factor 5 [KO:K04358]
130196210  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
130196239  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
130196262  efna5b; ephrin-A5b isoform X1 [KO:K05462]
130196263  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
130196271  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
130196340  fgf17; fibroblast growth factor 17 [KO:K04358]
130196345  cacna1ba; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
130196352  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
130196413  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
130196458  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
130196479  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
130196533  angpt2b; angiopoietin-2b isoform X1 [KO:K05466]
130196581  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
130196697  [KO:K03173] [EC:2.3.2.27]
130196700  ppp3cca; LOW QUALITY PROTEIN: protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348] [EC:3.1.3.16]
130196840  [KO:K04358]
130196905  [KO:K09784]
130197126  efna1a; ephrin-A1a [KO:K05462]
130197140  [KO:K05452]
130197181  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130197325  rasa1a; ras GTPase-activating protein 1 [KO:K04352]
130197339  [KO:K04519]
130197364  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
130197581  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
130197634  [KO:K04852]
130197653  [KO:K25415]
130197783  [KO:K04424] [EC:2.7.11.25]
130197944  [KO:K04448]
130198180  prkacbb; LOW QUALITY PROTEIN: protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
130198509  [KO:K25414]
130198553  jund; transcription factor jun-D [KO:K04449]
130198907  cacna1fb; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
130198943  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
130199025  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
130199044  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
130199049  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130199061  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
130199187  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
130199196  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
130199202  [KO:K04857]
130199297  flna; filamin-A isoform X1 [KO:K04437]
130199341  [KO:K04393]
130199375  ngfa; neurotrophin-7 [KO:K02582]
130199451  [KO:K04353]
130199473  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
130199525  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
130199570  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
130199602  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
130199677  [KO:K03158]
130199789  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
130199820  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
130200048  [KO:K05459]
130200161  [KO:K04864]
130200179  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
130200188  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
130200204  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
130200241  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
130200257  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
130200370  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
130200387  [KO:K07836]
130200419  [KO:K04858]
130200455  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
130200493  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
130200517  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
130200550  ntf3; neurotrophin-3 isoform X1 [KO:K04356]
130200604  hgfa; hepatocyte growth factor a [KO:K05460]
130200640  fgf23; fibroblast growth factor 23 [KO:K22428]
130200643  fgf6b; fibroblast growth factor 6b isoform X1 [KO:K04358]
130200679  [KO:K05461]
130200799  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
130200969  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
130201051  [KO:K04410] [EC:2.7.11.1]
130201129  [KO:K05085] [EC:2.7.10.1]
130201143  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
130201169  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
130201204  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
130201234  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
130201245  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
130201274  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
130201278  [KO:K04350]
130201320  fosaa; protein c-Fos [KO:K04379]
130201347  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
130201384  [KO:K04453]
130201432  efna2a; ephrin-A2 [KO:K05462]
130201440  mrasa; ras-related protein M-Ras [KO:K07831]
130201521  [KO:K04402]
130201526  fgf9; fibroblast growth factor 4A [KO:K04358]
130201567  pgfb; placenta growth factor [KO:K16859]
130201859  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
130201962  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
130201995  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
130201999  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
130202251  [KO:K04873]
130202308  [KO:K04427] [EC:2.7.11.25]
130202411  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
130202425  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
130202564  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
130202566  [KO:K16859]
130202644  max; protein max isoform X1 [KO:K04453]
130202765  [KO:K04872]
130202820  [KO:K04379]
130202866  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
130202874  [KO:K13377]
130203090  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
130203213  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b [KO:K04430] [EC:2.7.12.2]
130203221  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
130203224  [KO:K04380]
130203264  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
130203271  fgf21; fibroblast growth factor 21 [KO:K22429]
130203291  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
130203325  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
130203361  mapk8b; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
130203394  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
130203445  [KO:K04433] [EC:2.7.12.2]
130203534  ngfrb; nerve growth factor receptor b [KO:K02583]
130203598  [KO:K04392]
130203616  [KO:K04467] [EC:2.7.11.10]
130203619  [KO:K04871]
130203796  mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
130203853  dusp3a; LOW QUALITY PROTEIN: dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
130204063  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
130204111  [KO:K04466] [EC:2.7.11.25]
130204412  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
130204525  [KO:K05085] [EC:2.7.10.1]
130204531  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
130204599  [KO:K04865]
130204655  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
130204681  [KO:K05449]
130204860  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
130204873  rasgrf2a; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
130205003  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
130205329  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 isoform X1 [KO:K04402]
130205358  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
130205362  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
130205428  [KO:K04402]
130205441  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b [KO:K04348] [EC:3.1.3.16]
130205446  crkl; crk-like protein [KO:K04438]
130205517  [KO:K05462]
130205528  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
130205541  [KO:K04454]
130205620  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130205745  [KO:K03173] [EC:2.3.2.27]
130205785  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
130205786  [KO:K04455]
130205812  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
130205915  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
130205993  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
130205998  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
130206014  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
130206028  rps6ka3b; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
130206043  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130206103  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
130206121  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
130206173  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
130206432  myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
130206475  tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
130206496  myca; transcriptional regulator Myc-A [KO:K04377]
130206605  [KO:K04361] [EC:2.7.10.1]
130206633  [KO:K13769]
130206752  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
130206778  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130206842  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
130207012  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
130207016  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
130207104  [KO:K04378]
130207229  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
130207317  [KO:K06268]
130207341  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
130207371  angpt2a; angiopoietin-2a [KO:K05466]
130207452  [KO:K04406] [EC:2.7.11.1]
130207464  fas; tumor necrosis factor receptor superfamily member 23 [KO:K04390]
130207538  ret; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
130207552  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
130207553  [KO:K16342] [EC:3.1.1.4]
130207554  [KO:K16342] [EC:3.1.1.4]
130207612  [KO:K04467] [EC:2.7.11.10]
130207637  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
130207714  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
130207780  [KO:K04353]
130208009  [KO:K04857]
130208052  angpt4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05465]
130208082  tgfa; protransforming growth factor alpha [KO:K08774]
130208099  [KO:K04393]
130208271  [KO:K04859]
130208282  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
130208312  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
130208331  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
130208441  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
130208500  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
130208586  mapk14b; mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
130208679  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
130208716  [KO:K04444] [EC:2.7.11.1]
130208723  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
130208760  ngfb; nerve growth factor [KO:K02582]
130208781  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130208810  [KO:K04423] [EC:2.7.11.25]
130209013  [KO:K04465]
130209021  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
130209197  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
130209235  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
130209282  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
130209351  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
130209426  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
130209438  fgf24; fibroblast growth factor 24 [KO:K04358]
130209500  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
130209503  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
130209516  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
130209563  fgf18a; fibroblast growth factor 18a [KO:K04358]
130209644  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
130209742  fgf20b; fibroblast growth factor 20b [KO:K04358]
130209766  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
130209792  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
130209810  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
130209822  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
130209824  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
130209861  fgf16; fibroblast growth factor 16 [KO:K04358]
130209868  cd40lg; CD40 ligand [KO:K04389]
130209934  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
130209937  fgf2; fibroblast growth factor 2 [KO:K18497]
130210015  [KO:K02187] [EC:3.4.22.56]
130210096  [KO:K04439]
130210207  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
130210285  [KO:K03283]
130210298  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
130210364  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
130210386  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
130210443  crk; adapter molecule crk [KO:K04438]
130210496  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130210504  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
130210589  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
130210696  [KO:K04723]
130210700  nf1a; neurofibromin [KO:K08052]
130210815  [KO:K04456] [EC:2.7.11.1]
130210921  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
130210959  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
130211036  relb; proto-oncogene c-Rel isoform X1 [KO:K09253]
130211057  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
130211062  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
130211342  pdgfd; platelet-derived growth factor D [KO:K05450]
130211351  [KO:K08053]
130211482  [KO:K04419] [EC:2.7.11.25]
130211483  rela; transcription factor p65 isoform X1 [KO:K04735]
130211606  [KO:K04348] [EC:3.1.3.16]
130211746  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
130211750  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
130211870  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
130212035  [KO:K12361]
130212061  arrb2b; arrestin, beta 2b [KO:K04439]
130212676  [KO:K05459]
130212742  si:dkey-246i14.3; ephrin-A4 isoform X1 [KO:K05462]
130212744  efna1b; ephrin-A1b [KO:K05462]
130212745  efna3b; ephrin-A3b [KO:K05462]
130212812  stmn1b; stathmin 1b [KO:K04381]
130212884  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130212975  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
130213123  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
130213141  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
130213163  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
130213187  [KO:K04446]
130213198  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
130213272  [KO:K05459]
130213274  [KO:K05459]
130213275  [KO:K05459]
130213282  [KO:K05459]
130213322  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
130213350  cacng8b; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04873]
130213463  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
130213488  cdc42l; cell division cycle 42, like [KO:K04393]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pswi04070  Phosphatidylinositol signaling system
pswi04110  Cell cycle
pswi04115  p53 signaling pathway
pswi04210  Apoptosis
pswi04310  Wnt signaling pathway
KO pathway
ko04010   

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