Entry Name Fc epsilon RI signaling pathway - Pteropus vampyrus (large flying fox)
Description Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map pvp04664 Fc epsilon RI signaling pathway
Other DBs Organism Pteropus vampyrus (large flying fox) [GN:
pvp ]
Gene 105292093 ALOX5AP; arachidonate 5-lipoxygenase-activating protein isoform X1 [KO:K20735 ]
105293353 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
105293539 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
105294623 RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
105296605 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105299371 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
105300730 FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089 ]
105303397 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
105304587 LAT; linker for activation of T-cells family member 1 [KO:K07362 ]
105305030 MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090 ]
105307215 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105307575 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
105308956 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
105311532 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kawakami T, Galli SJ.
Title Regulation of mast-cell and basophil function and survival by IgE.
Journal Reference Authors Siraganian RP.
Title Mast cell signal transduction from the high-affinity IgE receptor.
Journal Reference Authors Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title Immunobiology 6th edition
Journal Garland Science Publishing (2005)
Reference Authors Turner H, Kinet JP.
Title Signalling through the high-affinity IgE receptor Fc epsilonRI.
Journal Reference Authors Gilfillan AM, Tkaczyk C.
Title Integrated signalling pathways for mast-cell activation.
Journal Reference Authors Nadler MJ, Matthews SA, Turner H, Kinet JP.
Title Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
Journal Reference Authors Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
Title Essential role for Gab2 in the allergic response.
Journal Reference Authors Nadler MJ, Kinet JP.
Title Uncovering new complexities in mast cell signaling.
Journal Related pvp04070 Phosphatidylinositol signaling system
KO pathway
