Entry Name Renin secretion - Pteropus vampyrus (large flying fox)
Description The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Other DBs Organism Pteropus vampyrus (large flying fox) [GN:
pvp ]
Gene 105288852 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105288884 KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X2 [KO:K04936 ]
105289083 CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027 ]
105289151 CLCA2; LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 2 [KO:K05028 ]
105289200 ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056 ]
105289761 PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755 ] [EC:3.1.4.17 ]
105291472 ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141 ]
105292292 ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262 ]
105293031 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105293683 ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor [KO:K04587 ]
105293685 PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755 ] [EC:3.1.4.17 ]
105295155 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
105295517 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
105296533 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105296936 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
105297202 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
105297298 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850 ]
105298404 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
105298737 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
105302622 PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
105304363 CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
105309056 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
105309351 PTGER2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259 ]
105309689 CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Kurtz A
Title Renin release: sites, mechanisms, and control.
Journal Reference Authors Schweda F, Friis U, Wagner C, Skott O, Kurtz A
Title Renin release.
Journal Reference Authors Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
Title Physiology of kidney renin.
Journal Reference Authors Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
Title Regulation of renin secretion by renal juxtaglomerular cells.
Journal Reference Authors Kim SM, Briggs JP, Schnermann J
Title Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
Journal Reference Authors Kurtz A
Title Control of renin synthesis and secretion.
Journal Reference Authors Kurtz A, Wagner C
Title Cellular control of renin secretion.
Journal J Exp Biol 202:219-25 (1999)
Reference Authors Persson PB
Title Renin: origin, secretion and synthesis.
Journal Reference Authors Schweda F, Kurtz A
Title Cellular mechanism of renin release.
Journal Reference Authors Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
Title Classical Renin-Angiotensin system in kidney physiology.
Journal Reference Authors Harrison-Bernard LM
Title The renal renin-angiotensin system.
Journal Reference Authors Schnermann J, Briggs JP
Title Synthesis and secretion of renin in mice with induced genetic mutations.
Journal Reference Authors Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
Title Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
Journal Reference Authors Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
Title Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
Journal Related KO pathway
