KEGG   PATHWAY: pyu04350
Entry
pyu04350                    Pathway                                
Name
TGF-beta signaling pathway - Puma yagouaroundi (jaguarundi)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
pyu04350  TGF-beta signaling pathway
pyu04350

Other DBs
GO: 0007179
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121010703  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
121010704  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121010738  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
121011198  RHOA; transforming protein RhoA [KO:K04513]
121011578  [KO:K23106]
121012230  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
121012242  TGIF2; homeobox protein TGIF2 [KO:K19553]
121012266  GDF5; growth/differentiation factor 5 isoform X1 [KO:K04664]
121012343  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
121012472  BMP2; bone morphogenetic protein 2 [KO:K21283]
121012557  RGMB; RGM domain family member B isoform X1 [KO:K06847]
121012861  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
121013822  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
121014670  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
121015091  GREM2; gremlin-2 isoform X1 [KO:K23318]
121015285  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
121015844  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
121017436  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
121017630  TFR2; transferrin receptor protein 2 isoform X1 [KO:K23910]
121017659  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
121018482  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
121018714  EMP3; epithelial membrane protein 3 [KO:K26257]
121018940  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
121019422  SKI; ski oncogene [KO:K26503]
121019602  [KO:K04498] [EC:2.3.1.48]
121019893  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
121020297  ID4; DNA-binding protein inhibitor ID-4 [KO:K17695]
121020319  HFE; hereditary hemochromatosis protein isoform X1 [KO:K26535]
121020511  BMP6; bone morphogenetic protein 6 [KO:K16620]
121020862  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
121021387  AMH; muellerian-inhibiting factor [KO:K04665]
121021578  FMOD; fibromodulin [KO:K08121]
121021825  HJV; hemojuvelin isoform X1 [KO:K23100]
121022205  [KO:K19558]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022312  TNF; tumor necrosis factor [KO:K03156]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023040  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
121023683  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121024248  [KO:K26503]
121024497  GDF7; growth/differentiation factor 7 [KO:K20013]
121025405  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
121025542  IGSF1; immunoglobulin superfamily member 1 [KO:K26168]
121027010  TMEM53; transmembrane protein 53 isoform X1 [KO:K28359]
121028153  CUL1; cullin-1 isoform X1 [KO:K03347]
121028933  INHBA; inhibin beta A chain [KO:K04667]
121028998  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
121029607  BMP5; bone morphogenetic protein 5 [KO:K04663]
121029931  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
121030420  INHBB; inhibin beta B chain [KO:K22687]
121030536  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
121030588  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
121030589  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
121030926  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
121030956  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
121031781  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
121032078  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
121032188  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
121032920  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121032949  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
121032957  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121033118  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
121033147  TGIF1; homeobox protein TGIF1 [KO:K19383]
121033470  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
121033562  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121033694  [KO:K14736]
121033695  [KO:K14736]
121033982  SKIL; ski-like protein [KO:K18499]
121034089  CHRD; chordin isoform X1 [KO:K04657]
121034524  [KO:K04685]
121034732  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121035373  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
121036378  TFRC; transferrin receptor protein 1 [KO:K06503]
121036391  NRROS; transforming growth factor beta activator LRRC33 isoform X1 [KO:K26317]
121036743  NODAL; nodal homolog [KO:K04666]
121036894  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
121037673  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
121038039  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
121038482  AMHR2; LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
121038490  SP1; transcription factor Sp1 [KO:K04684]
121038552  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
121039316  LRRC32; transforming growth factor beta activator LRRC32 isoform X1 [KO:K26316]
121039795  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121040286  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
121040293  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
121040637  DCN; decorin [KO:K04660]
121040808  LEMD3; inner nuclear membrane protein Man1 [KO:K19410]
121040881  INHBC; inhibin beta C chain [KO:K22688]
121040882  INHBE; inhibin beta E chain [KO:K22689]
121041076  IFNG; interferon gamma [KO:K04687]
121041452  GREM1; gremlin-1 [KO:K23318]
121041482  THBS1; thrombospondin-1 [KO:K16857]
121041667  FBN1; fibrillin-1 [KO:K06825]
121041871  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
121041878  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121041939  [KO:K23377]
121041961  NEO1; neogenin isoform X1 [KO:K06766]
121042011  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
121042448  RGMA; repulsive guidance molecule A [KO:K23096]
121042729  GDF6; growth/differentiation factor 6 [KO:K20012]
121042977  MYC; myc proto-oncogene protein [KO:K04377]
121044065  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
121044328  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
121044498  FST; follistatin isoform X1 [KO:K04661]
121044690  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121044752  NOG; noggin [KO:K04658]
121045446  E2F4; transcription factor E2F4 [KO:K04682]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
pyu04010  MAPK signaling pathway
pyu04110  Cell cycle
pyu04120  Ubiquitin mediated proteolysis
pyu04210  Apoptosis
KO pathway
ko04350   

DBGET integrated database retrieval system