KEGG   PATHWAY: pyu04010
Entry
pyu04010                    Pathway                                
Name
MAPK signaling pathway - Herpailurus yagouaroundi (jaguarundi)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pyu04010  MAPK signaling pathway
pyu04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Herpailurus yagouaroundi (jaguarundi) [GN:pyu]
Gene
121010255  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
121010328  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
121010516  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121010818  CD14; monocyte differentiation antigen CD14 [KO:K04391]
121010979  FGF18; fibroblast growth factor 18 [KO:K04358]
121011009  JUND; transcription factor jun-D [KO:K04449]
121011080  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
121011239  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
121011253  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
121011333  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011501  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
121011504  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
121011574  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
121011805  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
121011861  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
121011871  [KO:K03283]
121012141  STK4; serine/threonine-protein kinase 4 [KO:K04411]
121012211  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
121012369  ANGPT4; angiopoietin-4 [KO:K05467]
121012441  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
121012732  FGF9; fibroblast growth factor 9 [KO:K04358]
121012779  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
121012786  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
121012848  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
121013195  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
121013213  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
121013330  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
121013336  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
121013412  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
121013519  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
121013741  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
121013786  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
121013826  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
121013900  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
121014015  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
121014032  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
121014070  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
121014090  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121014214  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
121014663  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
121014746  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
121015025  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015257  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
121015303  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
121015305  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
121015306  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
121015308  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121015350  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
121015457  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
121015675  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
121015745  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
121015758  ARRB2; beta-arrestin-2 [KO:K04439]
121015779  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
121015826  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
121015982  TP53; cellular tumor antigen p53 [KO:K04451]
121016358  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
121016402  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121016435  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
121016438  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
121016588  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
121016729  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
121016834  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121017018  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121017046  NF1; neurofibromin [KO:K08052]
121017182  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
121017247  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
121017297  CRK; adapter molecule crk isoform X1 [KO:K04438]
121017369  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
121017425  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
121017467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121017559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121017703  HSPB1; heat shock protein beta-1 [KO:K04455]
121017794  [KO:K04393]
121017912  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121018087  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
121018181  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
121018482  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
121018591  RELB; transcription factor RelB [KO:K09253]
121018653  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
121018739  FGF21; fibroblast growth factor 21 [KO:K22429]
121018756  NTF4; neurotrophin-4 [KO:K12457]
121018775  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
121018786  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
121018827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
121018828  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
121018830  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
121018831  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
121019078  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
121019131  TGFA; protransforming growth factor alpha [KO:K08774]
121019337  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
121019340  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
121019368  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
121019369  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121020155  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
121020261  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
121020286  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
121020761  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121020862  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
121020945  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
121021368  PSPN; persephin [KO:K25416]
121021432  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121021495  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
121021573  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
121021710  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
121021714  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
121021720  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
121021881  FGF22; fibroblast growth factor 22 [KO:K04358]
121021952  FGF23; fibroblast growth factor 23 [KO:K22428]
121021982  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
121021990  FGF6; fibroblast growth factor 6 [KO:K04358]
121022070  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
121022112  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121022119  NTF3; neurotrophin-3 [KO:K04356]
121022175  TAOK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022312  TNF; tumor necrosis factor [KO:K03156]
121022360  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
121022432  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
121022813  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023034  CRKL; crk-like protein [KO:K04438]
121023168  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
121023591  STMN1; stathmin [KO:K04381]
121023653  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
121023732  VEGFB; vascular endothelial growth factor B [KO:K16858]
121023744  FGF19; fibroblast growth factor 19 [KO:K22603]
121023745  FGF4; fibroblast growth factor 4 [KO:K04358]
121023802  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
121023900  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
121023958  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
121023959  RELA; transcription factor p65 [KO:K04735]
121023964  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
121023965  INS; insulin [KO:K04526]
121023993  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
121024012  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
121024845  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
121024990  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
121025049  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
121025062  FLNA; filamin-A isoform X1 [KO:K04437]
121025078  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
121025099  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
121025147  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121025193  EFNA4; ephrin-A4 [KO:K05462]
121025238  [KO:K03283]
121025312  EFNA3; ephrin-A3 [KO:K05462]
121025328  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
121025344  FGF16; fibroblast growth factor 16 [KO:K04358]
121025636  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
121025662  VEGFD; vascular endothelial growth factor D [KO:K05449]
121026060  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
121026094  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121026171  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
121026457  [KO:K03283]
121026473  [KO:K03283]
121027064  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
121027214  JUN; transcription factor AP-1 [KO:K04448]
121027286  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
121027288  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121027378  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121027641  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
121027680  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
121027738  NRAS; GTPase NRas [KO:K07828]
121027743  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
121027749  NGF; beta-nerve growth factor [KO:K02582]
121028117  PDGFC; platelet-derived growth factor C [KO:K05450]
121028241  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121028446  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121028792  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
121028796  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
121029283  DAXX; death domain-associated protein 6 [KO:K02308]
121029354  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121029356  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121029480  SRF; serum response factor [KO:K04378]
121029504  VEGFA; vascular endothelial growth factor A [KO:K05448]
121029788  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121030066  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
121030401  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
121030560  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
121030707  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
121030728  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
121030939  [KO:K03283]
121031012  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
121031014  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
121031737  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121031854  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
121031875  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121031911  MAX; protein max isoform X1 [KO:K04453]
121031929  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121031994  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
121032000  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
121032059  PGF; placenta growth factor isoform X1 [KO:K16859]
121032071  FOS; proto-oncogene c-Fos [KO:K04379]
121032078  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
121032189  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121033019  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121033234  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
121033462  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
121033562  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121033707  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
121033726  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
121033754  RASA2; ras GTPase-activating protein 2 [KO:K08053]
121033966  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
121034102  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
121034154  [KO:K04723]
121034351  AREG; amphiregulin [KO:K09782]
121034362  EREG; proepiregulin [KO:K09784]
121034541  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
121034732  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121034769  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
121035518  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
121035532  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
121035557  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
121035565  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121035753  [KO:K04370]
121036101  [KO:K03283]
121036392  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
121036791  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121036923  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121036970  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
121037105  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121037160  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
121037217  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121037313  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121037542  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
121038481  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
121038550  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
121038645  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
121038701  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121038914  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121039287  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
121039327  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121039432  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121039602  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
121039641  VEGFC; vascular endothelial growth factor C [KO:K05449]
121039672  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
121039780  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121039822  [KO:K04370]
121039877  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121039893  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
121039962  FGF20; fibroblast growth factor 20 [KO:K04358]
121040098  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
121040120  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121040314  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
121040318  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121040322  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
121040328  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
121040395  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
121040410  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
121040524  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
121040653  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
121040655  KITLG; kit ligand [KO:K05461]
121040748  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
121040776  RAP1B; ras-related protein Rap-1b [KO:K07836]
121040880  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
121040944  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041478  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
121041554  [KO:K16342] [EC:3.1.1.4]
121041557  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
121041559  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
121041561  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
121041681  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121041887  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
121042263  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
121042474  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121042759  STK3; serine/threonine-protein kinase 3 [KO:K04412]
121042850  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
121042977  MYC; myc proto-oncogene protein [KO:K04377]
121043484  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
121043535  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121043625  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
121043676  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
121043684  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
121044329  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
121044367  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121044369  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
121044407  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121044420  FGF10; fibroblast growth factor 10 [KO:K04358]
121044460  IL1B; interleukin-1 beta [KO:K04519]
121044461  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
121044785  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
121044817  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
121044899  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
121044914  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
121045000  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
121045013  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121045071  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
121045129  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
121045448  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
121045484  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X4 [KO:K17333]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pyu04070  Phosphatidylinositol signaling system
pyu04110  Cell cycle
pyu04115  p53 signaling pathway
pyu04210  Apoptosis
pyu04310  Wnt signaling pathway
pyu04668  TNF signaling pathway
KO pathway
ko04010   

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