KEGG   PATHWAY: rbb04115
Entry
rbb04115                    Pathway                                
Name
p53 signaling pathway - Rhinopithecus bieti (black snub-nosed monkey)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
rbb04115  p53 signaling pathway
rbb04115

Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108512689  [KO:K02187] [EC:3.4.22.56]
108513008  PIDD1; p53-induced death domain-containing protein 1 [KO:K10130]
108513288  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
108514363  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
108514516  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
108514614  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
108516053  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108516338  RRM2; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
108517356  [KO:K04506] [EC:2.3.2.27]
108517380  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
108517523  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
108517558  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
108518169  SFN; 14-3-3 protein sigma [KO:K06644]
108518218  SESN2; sestrin-2 [KO:K20394]
108518939  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
108519271  CD82; CD82 antigen isoform X1 [KO:K06509]
108519399  TSC2; tuberin isoform X1 [KO:K07207]
108520195  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
108521881  SIVA1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
108521962  DDB2; DNA damage-binding protein 2 [KO:K10140]
108523439  [KO:K08738]
108523458  [KO:K10132]
108523624  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
108524009  [KO:K08738]
108524131  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
108524269  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
108524397  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108524923  [KO:K08738]
108525244  [KO:K27356]
108525394  [KO:K10135]
108526370  SERPINB5; serpin B5 [KO:K10139]
108526400  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
108526412  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108526609  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
108526966  THBS1; thrombospondin-1 [KO:K16857]
108527024  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
108527267  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
108527408  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
108527540  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108528336  CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
108528490  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
108528847  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
108530087  [KO:K08738]
108530351  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
108530611  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
108531099  PPP1R13L; LOW QUALITY PROTEIN: relA-associated inhibitor [KO:K27356]
108531451  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108531761  RPRM; protein reprimo [KO:K10128]
108532002  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108532254  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108532471  CCNG2; cyclin-G2 [KO:K10146]
108532499  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
108532870  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
108532915  [KO:K08738]
108532965  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
108533297  [KO:K08738]
108533501  CCND3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
108533808  SESN1; LOW QUALITY PROTEIN: sestrin-1 [KO:K10141]
108534795  IGFBP3; insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
108535187  MDM4; protein Mdm4 isoform X1 [KO:K10127]
108535521  [KO:K08738]
108535737  SESN3; sestrin-3 isoform X1 [KO:K10141]
108535876  ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
108535938  [KO:K06643] [EC:2.3.2.27]
108536014  TP73; tumor protein p73 isoform X1 [KO:K10148]
108536287  [KO:K08738]
108536489  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108537054  CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
108537955  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
108538612  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
108538745  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108538827  [KO:K08738]
108539896  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
108540045  CCNG1; cyclin-G1 [KO:K10145]
108540791  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
108541164  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
108541711  BID; BH3-interacting domain death agonist [KO:K04726]
108541919  RFWD2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:2.3.2.27]
108542102  STEAP3; LOW QUALITY PROTEIN: metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
108542333  EI24; LOW QUALITY PROTEIN: etoposide-induced protein 2.4 homolog [KO:K10134]
108542336  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
108543034  [KO:K10133] [EC:1.-.-.-]
108543134  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
108543462  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
108544151  ADGRB1; brain-specific angiogenesis inhibitor 1 [KO:K04596]
108544673  [KO:K10134]
108544822  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
rbb04110  Cell cycle
rbb04210  Apoptosis
rbb04218  Cellular senescence
KO pathway
ko04115   

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