Entry Name Cellular senescence - Rhinopithecus bieti (black snub-nosed monkey)
Description Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Other DBs Organism Rhinopithecus bieti (black snub-nosed monkey) [GN:
rbb ]
Gene 108512265 PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
108512375 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995 ]
108513587 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
108513614 FBXW11; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 11 [KO:K03362 ]
108514692 CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183 ]
108514714 SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605 ]
108515136 BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
108515198 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
108515354 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
108516875 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
108519603 SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500 ]
108523739 ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
108525049 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
108528336 CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
108528737 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
108529513 VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040 ]
108529563 VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862 ]
108529586 RAD50; LOW QUALITY PROTEIN: DNA repair protein RAD50 [KO:K10866 ] [EC:3.6.-.-]
108531271 RBL2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332 ]
108531451 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
108532817 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
108532870 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
108532960 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
108534276 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
108534372 TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973 ]
108534795 IGFBP3; insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138 ]
108535148 RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015 ]
108535636 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
108535749 MRE11A; LOW QUALITY PROTEIN: double-strand break repair protein MRE11A [KO:K10865 ]
108536704 GATA4; LOW QUALITY PROTEIN: transcription factor GATA-4 [KO:K09183 ]
108537064 CDKN2B; LOW QUALITY PROTEIN: cyclin-dependent kinase 4 inhibitor B [KO:K04685 ]
108538612 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
108539355 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
108539466 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
108540717 VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041 ]
108540785 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
108540953 NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
108541175 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
108544591 PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Munoz-Espin D, Serrano M
Title Cellular senescence: from physiology to pathology.
Journal Reference Authors Childs BG, Durik M, Baker DJ, van Deursen JM
Title Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Journal Reference Authors Sharpless NE, Sherr CJ
Title Forging a signature of in vivo senescence.
Journal Reference Authors Fridlyanskaya I, Alekseenko L, Nikolsky N
Title Senescence as a general cellular response to stress: A mini-review.
Journal Reference Authors Lujambio A
Title To clear, or not to clear (senescent cells)? That is the question.
Journal Reference Authors Di Mitri D, Alimonti A
Title Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
Journal Reference Authors Francica P, Aebersold DM, Medova M
Title Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
Journal Reference Authors Bartling B
Title Cellular senescence in normal and premature lung aging.
Journal Reference Authors Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
Title Programmed cell senescence during mammalian embryonic development.
Journal Reference Authors Herranz N, Gallage S, Gil J
Title TORn about SASP regulation.
Journal Reference Authors Martin N, Bernard D
Title Calcium signaling and cellular senescence.
Journal Reference Authors Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
Title Calcium homeostasis in cancer: A focus on senescence.
Journal Reference Authors McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
Title Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
Journal Reference Authors Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
Title Ras signaling through RASSF proteins.
Journal Reference Authors Barnoud T, Schmidt ML, Donninger H, Clark GJ
Title The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
Journal Reference Authors Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
Title The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Journal Reference Authors Cao X, Li M
Title A New Pathway for Senescence Regulation.
Journal Reference Authors Gire V, Dulic V
Title Senescence from G2 arrest, revisited.
Journal Reference Authors Mowla SN, Lam EW, Jat PS
Title Cellular senescence and aging: the role of B-MYB.
Journal Reference Authors Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
Title SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
Journal Reference Authors Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
Title Redox regulation of SIRT1 in inflammation and cellular senescence.
Journal Related KO pathway
