Entry
Name
Cytokine-cytokine receptor interaction - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
rro04060 Cytokine-cytokine receptor interaction
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:
rro ]
Gene
104655117 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
104656114 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
104657075 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077 ]
104657165 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
104657349 IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067 ]
104657559 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
104657589 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X6 [KO:K05160 ]
104658749 IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135 ]
104658875 PF4V1; LOW QUALITY PROTEIN: platelet factor 4 variant [KO:K05407 ]
104658898 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
104659825 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
104659848 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
104660161 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
104661649 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
104662252 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
104663344 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
104663347 IL3RA; interleukin-3 receptor subunit alpha isoform X2 [KO:K04737 ]
104663493 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
104663854 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
104663979 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
104663983 TNFRSF10D; tumor necrosis factor receptor superfamily member 10D [KO:K22702 ]
104663984 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
104663987 TNFRSF10C; tumor necrosis factor receptor superfamily member 10C [KO:K22701 ]
104664524 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
104664579 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
104664824 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
104664843 IL15RA; interleukin-15 receptor subunit alpha isoform X4 [KO:K05074 ]
104664846 IL2RA; interleukin-2 receptor subunit alpha isoform X4 [KO:K05068 ]
104665138 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
104665362 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
104665365 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
104665509 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
104665511 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X3 [KO:K05469 ]
104665638 IL4R; LOW QUALITY PROTEIN: interleukin-4 receptor subunit alpha [KO:K05071 ]
104665752 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
104666679 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X2 [KO:K05162 ]
104667694 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
104667904 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
104668929 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
104668930 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
104669600 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
104671056 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
104671084 TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
104672318 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
104673211 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
104673212 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
104675018 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
104675147 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
104675167 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X2 [KO:K05155 ]
104676086 TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
104677599 TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377 ]
104678812 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
104679248 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
104679260 TNFSF8; tumor necrosis factor ligand superfamily member 8 isoform X1 [KO:K05471 ]
104679262 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
104680008 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
104680015 IL11RA; interleukin-11 receptor subunit alpha isoform X2 [KO:K05056 ]
104680048 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
104680124 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
104680127 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
104680325 CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453 ]
104680478 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
104680603 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
104680608 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X2 [KO:K05063 ]
104682263 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
104682491 CSF2RB; cytokine receptor common subunit beta isoform X3 [KO:K04738 ]
104682498 IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway