KEGG   PATHWAY: sgh04144
Entry
sgh04144                    Pathway                                
Name
Endocytosis - Sinocyclocheilus grahami (golden-line barbel)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
sgh04144  Endocytosis
sgh04144

Other DBs
GO: 0006897
Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107548280  [KO:K08291] [EC:2.7.11.16]
107548418  [KO:K18952] [EC:2.7.11.13]
107548582  [KO:K05737]
107548638  [KO:K11247]
107548650  [KO:K00889] [EC:2.7.1.68]
107548831  [KO:K22517] [EC:2.3.2.27]
107548869  [KO:K12483]
107548879  [KO:K04646]
107548968  [KO:K04679]
107548972  [KO:K08291] [EC:2.7.11.16]
107549044  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
107549297  [KO:K04513]
107549298  [KO:K10364]
107549476  [KO:K12471]
107549571  [KO:K12481]
107549675  [KO:K06564]
107549735  [KO:K12472]
107549849  [KO:K19475]
107549994  [KO:K12495]
107550018  [KO:K18584]
107550161  itch; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
107550341  [KO:K10396] [EC:5.6.1.3]
107550402  [KO:K07903]
107550442  [KO:K06503]
107550570  [KO:K12186]
107550602  [KO:K01115] [EC:3.1.4.4]
107550671  [KO:K12489]
107550895  [KO:K12483]
107550898  [KO:K12484]
107550910  [KO:K12495]
107550963  [KO:K05754]
107551056  bin1; myc box-dependent-interacting protein 1 [KO:K12562]
107551123  [KO:K12488]
107551128  [KO:K12495]
107551152  [KO:K18441]
107551196  [KO:K04388] [EC:2.7.11.30]
107551211  [KO:K04180]
107551318  [KO:K12185]
107551345  [KO:K17260]
107551894  [KO:K12562]
107551925  [KO:K07938]
107551955  [KO:K07888]
107551976  [KO:K12192]
107552117  [KO:K18441]
107552184  [KO:K07876]
107552237  [KO:K12192]
107552679  [KO:K12472]
107552702  [KO:K00889] [EC:2.7.1.68]
107552705  [KO:K07905]
107552765  [KO:K12191]
107552787  [KO:K04237]
107552852  [KO:K04393]
107552944  [KO:K07879]
107553026  [KO:K07876]
107553101  [KO:K23605]
107553159  [KO:K07897]
107553169  [KO:K15053]
107553256  [KO:K04679]
107553262  [KO:K00909] [EC:2.7.11.14]
107553268  [KO:K11248]
107553272  [KO:K12488]
107553307  [KO:K12485]
107553413  [KO:K12476]
107553468  [KO:K12199]
107553608  [KO:K12475]
107553801  [KO:K17260]
107553903  [KO:K05632] [EC:2.3.2.26]
107553935  [KO:K12478]
107554070  [KO:K12188]
107554102  [KO:K11824]
107554119  [KO:K07876]
107554161  [KO:K12485]
107554189  [KO:K12194]
107554197  [KO:K07891]
107554261  [KO:K04646]
107554314  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
107554332  [KO:K06751]
107554341  [KO:K06751]
107554395  [KO:K12185]
107554546  [KO:K07937]
107554593  [KO:K17917]
107554719  [KO:K24782]
107554729  [KO:K12488]
107554803  [KO:K04361] [EC:2.7.10.1]
107554987  [KO:K12469]
107554991  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
107555059  kif5c; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
107555099  [KO:K18441]
107555137  [KO:K12190]
107555151  [KO:K12483]
107555304  [KO:K12491]
107555329  [KO:K10396] [EC:5.6.1.3]
107555414  [KO:K04189]
107555667  [KO:K12471]
107555728  [KO:K12196]
107555789  [KO:K12495]
107555917  [KO:K04705]
107555932  [KO:K04388] [EC:2.7.11.30]
107555933  [KO:K17919]
107555987  [KO:K12489]
107556439  [KO:K04189]
107556503  [KO:K04513]
107556517  [KO:K12185]
107556600  [KO:K18441]
107556622  [KO:K18441]
107556639  [KO:K12485]
107556673  [KO:K04705]
107556775  [KO:K06643] [EC:2.3.2.27]
107556781  [KO:K12562]
107556902  [KO:K12488]
107556915  [KO:K05094] [EC:2.7.10.1]
107556928  [KO:K05756]
107556946  [KO:K18467]
107556962  kiaa0196; WASH complex subunit strumpellin [KO:K18464]
107557076  [KO:K17918]
107557401  [KO:K07939]
107557402  [KO:K07939]
107557586  [KO:K12186]
107557642  [KO:K18439]
107557663  [KO:K13649]
107557781  [KO:K07897]
107557782  [KO:K05755]
107557787  [KO:K10396] [EC:5.6.1.3]
107557790  [KO:K04237]
107557931  [KO:K08291] [EC:2.7.11.16]
107557948  [KO:K04644]
107558102  [KO:K11866] [EC:3.4.19.12]
107558125  [KO:K12484]
107558152  [KO:K10396] [EC:5.6.1.3]
107558282  rab31; ras-related protein Rab-31 [KO:K07891]
107558309  [KO:K12183]
107558311  [KO:K02833]
107558320  [KO:K12488]
107558519  [KO:K18441]
107558544  [KO:K11248]
107558621  [KO:K18441]
107558698  [KO:K00889] [EC:2.7.1.68]
107558710  smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
107558752  [KO:K05704] [EC:2.7.10.2]
107558824  [KO:K06069] [EC:2.7.11.13]
107558917  [KO:K04513]
107558942  [KO:K12199]
107558945  [KO:K12198]
107558965  [KO:K12198]
107559044  [KO:K18441]
107559287  [KO:K12494]
107559300  [KO:K12482]
107559301  [KO:K12482]
107559346  [KO:K11826]
107559380  vps4b; vacuolar protein sorting-associated protein 4B [KO:K12196]
107559457  [KO:K15053]
107559593  [KO:K04646]
107559620  [KO:K07939]
107559629  [KO:K07939]
107559901  [KO:K07939]
107559912  [KO:K07941]
107560020  [KO:K17917]
107560031  [KO:K04646]
107560042  [KO:K21269]
107560120  [KO:K17917]
107560609  [KO:K12186]
107560888  [KO:K05070]
107560923  [KO:K18442]
107560924  [KO:K06093]
107561098  [KO:K06751]
107561215  [KO:K06751]
107561317  [KO:K12192]
107561350  [KO:K18441]
107561420  [KO:K19476]
107561583  [KO:K12185]
107561586  rabep1; LOW QUALITY PROTEIN: rab GTPase-binding effector protein 1 [KO:K12480]
107561610  [KO:K12475]
107561686  [KO:K12193]
107561710  [KO:K08291] [EC:2.7.11.16]
107561785  [KO:K12474]
107561820  [KO:K12195]
107561923  [KO:K12474]
107561939  [KO:K04439]
107561948  [KO:K04674] [EC:2.7.11.30]
107562018  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
107562066  [KO:K04679]
107562076  [KO:K19475]
107562224  [KO:K12491]
107562272  [KO:K17917]
107562426  [KO:K06751]
107562427  [KO:K06751]
107562428  [KO:K06751]
107562440  [KO:K06751]
107562459  [KO:K12958]
107562464  [KO:K06093]
107562465  [KO:K18442]
107562512  [KO:K19475]
107562521  [KO:K03175] [EC:2.3.2.27]
107562649  [KO:K07897]
107562777  [KO:K04513]
107562781  [KO:K10364]
107562835  [KO:K02833]
107562836  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
107562879  [KO:K12474]
107562905  [KO:K18439]
107562928  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
107563039  [KO:K18466]
107563050  [KO:K12494]
107563060  [KO:K12482]
107563118  [KO:K01528] [EC:3.6.5.5]
107563295  [KO:K04679]
107563306  [KO:K00909] [EC:2.7.11.14]
107563442  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
107563518  [KO:K00909] [EC:2.7.11.14]
107563570  [KO:K19475]
107563596  [KO:K12490]
107563599  [KO:K07897]
107563645  [KO:K07938]
107563809  [KO:K10396] [EC:5.6.1.3]
107563826  [KO:K04237]
107563848  [KO:K11866] [EC:3.4.19.12]
107563900  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
107564055  [KO:K04644]
107564111  [KO:K12494]
107564137  [KO:K05758]
107564147  [KO:K05050]
107564148  [KO:K05050]
107564243  [KO:K06503]
107564704  [KO:K05754]
107564797  [KO:K12495]
107564860  [KO:K00889] [EC:2.7.1.68]
107564895  [KO:K18461]
107564909  [KO:K12495]
107565039  [KO:K08291] [EC:2.7.11.16]
107565090  [KO:K12469]
107565094  [KO:K12493]
107565115  [KO:K12484]
107565269  [KO:K12487]
107565428  chmp1b; charged multivesicular body protein 1b [KO:K12197]
107565582  [KO:K00889] [EC:2.7.1.68]
107565655  [KO:K12494]
107565734  [KO:K04393]
107566077  [KO:K12488]
107566165  [KO:K04674] [EC:2.7.11.30]
107566170  [KO:K04180]
107566223  smap2; stromal membrane-associated protein 2 [KO:K12486]
107566381  [KO:K12489]
107566389  [KO:K17917]
107566403  kif5a; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
107566457  [KO:K04361] [EC:2.7.10.1]
107566804  [KO:K00889] [EC:2.7.1.68]
107566835  chmp1a; charged multivesicular body protein 1a [KO:K12197]
107566862  [KO:K12494]
107566866  [KO:K12494]
107566873  [KO:K12495]
107566963  [KO:K12194]
107567123  [KO:K11247]
107567269  [KO:K11827]
107567568  [KO:K04439]
107567639  [KO:K07889]
107567741  [KO:K00910] [EC:2.7.11.15]
107567850  [KO:K12484]
107567933  [KO:K12492]
107567956  [KO:K07876]
107568004  [KO:K21269]
107568141  [KO:K10396] [EC:5.6.1.3]
107568151  [KO:K01528] [EC:3.6.5.5]
107568180  [KO:K05755]
107568242  ldlr; low-density lipoprotein receptor isoform X1 [KO:K12473]
107568329  [KO:K01528] [EC:3.6.5.5]
107568342  [KO:K04189]
107568383  [KO:K12473]
107568464  [KO:K18439]
107568558  [KO:K12493]
107568601  [KO:K08291] [EC:2.7.11.16]
107568960  [KO:K11247]
107569020  [KO:K18584]
107569134  [KO:K06751]
107569139  [KO:K04388] [EC:2.7.11.30]
107569166  [KO:K10396] [EC:5.6.1.3]
107569479  [KO:K04439]
107569573  [KO:K12484]
107569579  [KO:K12484]
107569757  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
107569798  [KO:K10364]
107569805  [KO:K04513]
107569974  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
107570235  [KO:K12494]
107570437  [KO:K07938]
107570507  [KO:K12495]
107570914  [KO:K06751]
107570999  [KO:K05632] [EC:2.3.2.26]
107571132  [KO:K23484]
107571143  [KO:K05754]
107571178  [KO:K18441]
107571358  [KO:K06751]
107571578  [KO:K04513]
107571870  [KO:K12471]
107571871  [KO:K12471]
107571983  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
107572341  [KO:K05069]
107572619  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
107572912  [KO:K12186]
107572914  [KO:K12186]
107573252  snx2; sorting nexin-2 [KO:K17917]
107573294  [KO:K05633] [EC:2.3.2.26]
107573971  [KO:K12194]
107573980  [KO:K18443]
107574002  [KO:K12958]
107574005  [KO:K06278]
107574271  [KO:K06751]
107574425  [KO:K06751]
107574426  [KO:K06751]
107574486  [KO:K07941]
107574648  [KO:K12471]
107574842  [KO:K06278]
107575474  [KO:K11248]
107575511  [KO:K11826]
107575566  [KO:K12494]
107575727  [KO:K23612]
107575737  [KO:K06751]
107575755  [KO:K06751]
107575829  kiaa1033; WASH complex subunit 7 [KO:K18465]
107576490  [KO:K12958]
107576532  [KO:K18584]
107576546  [KO:K05754]
107576656  [KO:K12959]
107576804  [KO:K22517] [EC:2.3.2.27]
107576912  [KO:K18441]
107577074  [KO:K12471]
107577114  [KO:K12474]
107577121  [KO:K12195]
107577128  [KO:K03283]
107577152  [KO:K00909] [EC:2.7.11.14]
107577178  [KO:K04645]
107577360  [KO:K12495]
107577467  [KO:K07937]
107577493  [KO:K12959]
107577653  [KO:K05070]
107577790  [KO:K19366]
107578300  [KO:K11248]
107578475  [KO:K05754]
107578484  [KO:K04646]
107578519  [KO:K21269]
107578603  [KO:K12185]
107578623  [KO:K18443]
107578647  [KO:K06093]
107579050  [KO:K04513]
107579188  [KO:K07941]
107579244  wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
107579336  [KO:K12183]
107579359  [KO:K11247]
107579584  [KO:K12197]
107579725  [KO:K12185]
107579830  [KO:K11827]
107580157  [KO:K04393]
107580272  [KO:K12197]
107580567  [KO:K12185]
107580590  [KO:K05756]
107580652  [KO:K12958]
107581311  [KO:K07938]
107581373  [KO:K19475]
107581393  [KO:K12562]
107581471  [KO:K01528] [EC:3.6.5.5]
107581598  [KO:K18441]
107581715  [KO:K05757]
107581717  [KO:K04678] [EC:2.3.2.26]
107581764  [KO:K05757]
107581770  [KO:K12471]
107581961  [KO:K05095] [EC:2.7.10.1]
107582190  [KO:K10396] [EC:5.6.1.3]
107582250  spg20; spartin isoform X1 [KO:K19366]
107582305  [KO:K12477]
107582398  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107582509  [KO:K18462]
107582533  [KO:K12484]
107582563  [KO:K12488]
107582573  [KO:K18466]
107582617  [KO:K03283]
107582632  [KO:K04646]
107582670  [KO:K17260]
107582684  [KO:K17920]
107582691  [KO:K23612]
107582752  [KO:K12191]
107583017  [KO:K11824]
107583079  [KO:K07876]
107583198  [KO:K17260]
107583299  [KO:K04678] [EC:2.3.2.26]
107583317  [KO:K05069]
107583401  [KO:K12484]
107583426  [KO:K12487]
107583709  [KO:K12471]
107583728  [KO:K06093]
107583745  [KO:K05087] [EC:2.7.10.1]
107583760  [KO:K23605]
107583770  [KO:K07904]
107583815  [KO:K12478]
107583945  [KO:K23612]
107583981  [KO:K12488]
107584026  [KO:K12562]
107584075  [KO:K12188]
107584132  [KO:K18441]
107584151  stam; signal transducing adapter molecule 1 [KO:K04705]
107584445  [KO:K05755]
107584495  [KO:K12958]
107584510  [KO:K12959]
107584553  [KO:K13305] [EC:2.3.2.26]
107584743  [KO:K12495]
107584775  [KO:K19475]
107584845  [KO:K04189]
107584936  [KO:K18442]
107585201  [KO:K17920]
107585203  [KO:K23612]
107585257  [KO:K04674] [EC:2.7.11.30]
107585263  [KO:K05094] [EC:2.7.10.1]
107585298  [KO:K12484]
107585328  [KO:K12486]
107585454  [KO:K05093] [EC:2.7.10.1]
107585522  snx5; sorting nexin-5 [KO:K17920]
107585540  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
107585770  [KO:K03283]
107585850  [KO:K11247]
107586035  [KO:K01115] [EC:3.1.4.4]
107586162  [KO:K04439]
107586321  [KO:K12491]
107586329  [KO:K12198]
107586358  [KO:K11247]
107586643  [KO:K17920]
107586741  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
107586743  [KO:K06503]
107586751  [KO:K01115] [EC:3.1.4.4]
107586824  [KO:K12193]
107587083  [KO:K12482]
107587193  [KO:K19366]
107587195  [KO:K08291] [EC:2.7.11.16]
107587200  [KO:K05095] [EC:2.7.10.1]
107587312  [KO:K12185]
107587364  [KO:K12475]
107587371  [KO:K13712] [EC:2.7.1.68]
107587390  [KO:K05754]
107587442  [KO:K21269]
107587635  [KO:K05632] [EC:2.3.2.26]
107587683  ap2b1; AP-2 complex subunit beta [KO:K11825]
107587717  [KO:K12469]
107587863  [KO:K04393]
107588053  [KO:K12196]
107588112  eps15l1; epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
107588265  [KO:K19475]
107588586  [KO:K03283]
107588664  [KO:K12486]
107588734  [KO:K18466]
107588964  [KO:K00910] [EC:2.7.11.15]
107588983  [KO:K07897]
107589054  [KO:K12474]
107589099  [KO:K12494]
107589463  [KO:K05070]
107589565  [KO:K18462]
107589578  [KO:K18443]
107589608  snx6; sorting nexin-6 [KO:K17920]
107589711  [KO:K05737]
107589809  [KO:K04674] [EC:2.7.11.30]
107589828  [KO:K19366]
107589894  [KO:K05754]
107590090  [KO:K17918]
107590199  [KO:K18463]
107590232  [KO:K06503]
107590246  [KO:K01115] [EC:3.1.4.4]
107590295  [KO:K12470]
107590355  [KO:K11248]
107590370  [KO:K07937]
107590453  [KO:K05757]
107590469  [KO:K05704] [EC:2.7.10.2]
107590617  [KO:K09526]
107590802  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
107590827  sh3gl3; endophilin-A3 isoform X1 [KO:K11247]
107590889  [KO:K12488]
107590939  [KO:K12477]
107590969  [KO:K06643] [EC:2.3.2.27]
107591026  [KO:K18468]
107591170  [KO:K09526]
107591296  [KO:K11247]
107591345  [KO:K06069] [EC:2.7.11.13]
107591487  [KO:K12186]
107591611  [KO:K12479]
107591619  [KO:K12200]
107591621  [KO:K12471]
107591757  [KO:K10364]
107591759  [KO:K04678] [EC:2.3.2.26]
107591763  [KO:K04513]
107591778  [KO:K05757]
107591785  [KO:K05757]
107591788  [KO:K04513]
107591953  [KO:K12485]
107591969  [KO:K12184]
107592022  [KO:K07887]
107592062  [KO:K19475]
107592111  [KO:K07887]
107592127  [KO:K07904]
107592360  [KO:K18439]
107592500  [KO:K18464]
107592522  [KO:K07904]
107592577  [KO:K12489]
107592650  ap2s1; AP-2 complex subunit sigma isoform X1 [KO:K11827]
107592679  [KO:K00889] [EC:2.7.1.68]
107592688  [KO:K07905]
107592720  [KO:K12472]
107592732  [KO:K12196]
107592928  [KO:K12184]
107593114  pard3; partitioning defective 3 homolog [KO:K04237]
107593269  [KO:K07903]
107593545  [KO:K12479]
107593555  [KO:K12200]
107593606  [KO:K07887]
107593659  [KO:K22518] [EC:2.3.2.27]
107593755  arf1; ADP-ribosylation factor 1 [KO:K07937]
107593770  [KO:K11826]
107593814  [KO:K04439]
107593838  [KO:K12196]
107593954  [KO:K17848]
107594019  [KO:K11981] [EC:2.3.2.27]
107594023  [KO:K12489]
107594167  [KO:K18441]
107594265  [KO:K19368]
107594413  [KO:K17260]
107594738  [KO:K05087] [EC:2.7.10.1]
107594761  [KO:K19367]
107594966  rbsn; rabenosyn-5 [KO:K12481]
107594993  [KO:K12185]
107595059  [KO:K11247]
107595140  [KO:K18442]
107595305  [KO:K12489]
107595392  [KO:K11839] [EC:3.4.19.12]
107595479  [KO:K12469]
107595502  [KO:K01528] [EC:3.6.5.5]
107595508  [KO:K11825]
107595689  [KO:K18467]
107595708  [KO:K22518] [EC:2.3.2.27]
107595797  cltb; clathrin light chain B isoform X1 [KO:K04645]
107595928  [KO:K12487]
107595985  [KO:K00909] [EC:2.7.11.14]
107596068  [KO:K04705]
107596078  [KO:K04388] [EC:2.7.11.30]
107596089  snx4; sorting nexin-4 [KO:K17919]
107596108  [KO:K01115] [EC:3.1.4.4]
107596241  [KO:K12472]
107596257  [KO:K00889] [EC:2.7.1.68]
107596281  [KO:K07905]
107596328  [KO:K12491]
107596425  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
107596428  [KO:K03175] [EC:2.3.2.27]
107596435  [KO:K02833]
107596436  [KO:K12183]
107596507  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
107596551  [KO:K06093]
107596566  arpc2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
107596601  [KO:K18463]
107596606  [KO:K05050]
107596607  [KO:K05050]
107596688  [KO:K00889] [EC:2.7.1.68]
107596785  [KO:K12194]
107596793  [KO:K07891]
107596921  [KO:K06093]
107596941  [KO:K05087] [EC:2.7.10.1]
107596977  [KO:K07904]
107597008  iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
107597081  [KO:K12489]
107597170  [KO:K07939]
107597171  [KO:K07939]
107597172  [KO:K07939]
107597220  [KO:K12475]
107597287  [KO:K12487]
107597332  [KO:K21269]
107597438  [KO:K04363] [EC:2.7.10.1]
107597524  [KO:K18466]
107597532  [KO:K03283]
107597642  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
107597650  [KO:K12474]
107597810  [KO:K01528] [EC:3.6.5.5]
107598088  [KO:K12476]
107598172  [KO:K07888]
107598197  [KO:K24782]
107598242  [KO:K11247]
107598344  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
107598357  [KO:K05754]
107598387  [KO:K12471]
107598405  [KO:K13712] [EC:2.7.1.68]
107598483  [KO:K19368]
107598694  [KO:K18468]
107598748  [KO:K12192]
107598870  [KO:K18465]
107598884  [KO:K23612]
107599000  [KO:K04513]
107599021  [KO:K00889] [EC:2.7.1.68]
107599090  [KO:K05754]
107599219  [KO:K01115] [EC:3.1.4.4]
107599254  [KO:K11247]
107599295  [KO:K12182]
107599337  [KO:K23484]
107599353  [KO:K12195]
107599444  [KO:K07905]
107599447  [KO:K00889] [EC:2.7.1.68]
107599450  [KO:K07897]
107599465  [KO:K17848]
107599476  [KO:K12489]
107599553  [KO:K00889] [EC:2.7.1.68]
107599721  [KO:K04361] [EC:2.7.10.1]
107599726  [KO:K12491]
107599798  [KO:K12472]
107599823  [KO:K18952] [EC:2.7.11.13]
107599954  [KO:K18439]
107599973  [KO:K07939]
107599983  [KO:K07939]
107600226  [KO:K11247]
107600239  [KO:K07891]
107600279  [KO:K05755]
107600284  [KO:K07897]
107600347  [KO:K19476]
107600399  [KO:K01115] [EC:3.1.4.4]
107600444  [KO:K12183]
107600445  [KO:K02833]
107600517  [KO:K04388] [EC:2.7.11.30]
107600561  [KO:K17920]
107600647  [KO:K18461]
107600658  [KO:K12495]
107600673  [KO:K12486]
107600714  [KO:K19367]
107600727  [KO:K19475]
107600766  [KO:K12185]
107600783  [KO:K12480]
107600823  [KO:K12489]
107600891  [KO:K13305] [EC:2.3.2.26]
107600906  [KO:K10591] [EC:2.3.2.26]
107601097  [KO:K05070]
107601264  [KO:K12485]
107601274  [KO:K05757]
107601300  [KO:K07937]
107601392  [KO:K17918]
107601443  [KO:K18441]
107601516  [KO:K12483]
107601660  [KO:K04180]
107601723  [KO:K04707] [EC:2.3.2.27]
107601823  [KO:K12494]
107601830  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
107601834  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
107601837  [KO:K12488]
107601855  [KO:K07879]
107601905  [KO:K04363] [EC:2.7.10.1]
107602045  [KO:K11866] [EC:3.4.19.12]
107602073  [KO:K07897]
107602122  [KO:K11826]
107602218  [KO:K04679]
107602305  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
107602340  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
107602389  [KO:K19475]
107602496  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
107602725  [KO:K23484]
107602767  [KO:K04679]
107602873  [KO:K12562]
107603065  [KO:K06564]
107603137  [KO:K04513]
107603155  [KO:K04393]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
sgh04060  Cytokine-cytokine receptor interaction
sgh04070  Phosphatidylinositol signaling system
sgh04130  SNARE interactions in vesicular transport
sgh04142  Lysosome biogenesis
sgh04350  TGF-beta signaling pathway
KO pathway
ko04144   

DBGET integrated database retrieval system