KEGG   PATHWAY: sgh04142
Entry
sgh04142                    Pathway                                
Name
Lysosome biogenesis - Sinocyclocheilus grahami (golden-line barbel)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
sgh04142  Lysosome biogenesis
sgh04142

Other DBs
GO: 0005764
Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107548328  [KO:K15590]
107548529  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
107548807  [KO:K06501]
107548879  [KO:K04646]
107548952  [KO:K02146]
107549048  [KO:K06497]
107549069  [KO:K20174]
107549292  [KO:K20464]
107549616  spg11; spatacsin [KO:K19026]
107549675  [KO:K06564]
107549693  laptm4a; lysosomal-associated transmembrane protein 4A [KO:K12387]
107549738  [KO:K12390]
107549926  [KO:K12390]
107550015  bloc1s5; biogenesis of lysosome-related organelles complex 1 subunit 5 [KO:K20187]
107550020  [KO:K02154]
107550075  [KO:K20002]
107550158  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
107550180  [KO:K15014]
107550433  [KO:K12385]
107550480  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
107550487  [KO:K12388]
107550623  [KO:K24155]
107550681  [KO:K06562]
107550762  [KO:K06528]
107550826  [KO:K20463]
107550965  [KO:K14638]
107551016  [KO:K12393]
107551160  [KO:K16184]
107551337  [KO:K12382]
107551349  [KO:K15014]
107551357  [KO:K02154]
107551367  [KO:K02153]
107551467  ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
107551548  [KO:K20174]
107551762  [KO:K16186]
107551816  [KO:K12398]
107551911  [KO:K14379] [EC:3.1.3.2]
107552220  [KO:K09105]
107552398  [KO:K15014]
107552490  [KO:K02155]
107552497  [KO:K12395]
107552649  [KO:K07955]
107552718  ap1m1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
107552959  [KO:K12391]
107553103  [KO:K12359]
107553127  [KO:K02147]
107553130  [KO:K12305] [EC:3.6.1.6]
107553159  [KO:K07897] [EC:3.6.5.2]
107553201  [KO:K01369] [EC:3.4.22.34]
107553319  [KO:K07204]
107553535  [KO:K12386]
107553853  [KO:K20464]
107554066  [KO:K12381] [EC:3.1.6.-]
107554078  [KO:K20402]
107554102  [KO:K11824]
107554162  [KO:K08568] [EC:3.4.18.1]
107554171  [KO:K08568] [EC:3.4.18.1]
107554218  ap4b1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
107554224  [KO:K09455]
107554261  [KO:K04646]
107554274  naglu; alpha-N-acetylglucosaminidase isoform X1 [KO:K01205] [EC:3.2.1.50]
107554303  [KO:K12402]
107554456  gnptg; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
107554517  [KO:K01137] [EC:3.1.6.14]
107554639  acp2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
107554667  [KO:K02154]
107554807  [KO:K01319] [EC:3.4.21.20]
107554813  [KO:K20822]
107554947  [KO:K20818]
107556042  [KO:K20182]
107556249  [KO:K01366] [EC:3.4.22.16]
107556324  [KO:K12311] [EC:3.2.1.24]
107556374  [KO:K01206] [EC:3.2.1.51]
107556382  [KO:K12387]
107556386  [KO:K02148]
107556477  [KO:K01197] [EC:3.2.1.35]
107556495  [KO:K01197] [EC:3.2.1.35]
107556497  [KO:K20820]
107556570  [KO:K12307]
107556597  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
107556672  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
107556869  [KO:K12350] [EC:3.1.4.12]
107556903  [KO:K04370]
107556946  [KO:K18467]
107556998  fig4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
107556999  [KO:K25442]
107557005  [KO:K01363] [EC:3.4.22.1]
107557158  [KO:K03661]
107557193  slc2a6; solute carrier family 2, facilitated glucose transporter member 6 [KO:K08144]
107557242  [KO:K02154]
107557307  [KO:K02151]
107557308  [KO:K20399]
107557367  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
107557385  [KO:K12398]
107557422  [KO:K15014]
107557507  [KO:K13289] [EC:3.4.16.5]
107557611  [KO:K01365] [EC:3.4.22.15]
107557781  [KO:K07897] [EC:3.6.5.2]
107557892  ctbs; di-N-acetylchitobiase [KO:K12310] [EC:3.2.1.-]
107557948  [KO:K04644]
107558029  [KO:K01365] [EC:3.4.22.15]
107558053  [KO:K12391]
107558203  tlr3; toll-like receptor 3 [KO:K05401]
107558257  [KO:K08512]
107558273  [KO:K03661]
107558337  [KO:K20184]
107558424  [KO:K06501]
107558472  [KO:K02148]
107558491  [KO:K20183]
107558711  [KO:K12307]
107558840  [KO:K01275] [EC:3.4.14.1]
107558853  [KO:K20397]
107558854  [KO:K20397]
107558920  [KO:K09455]
107559096  [KO:K02149]
107559225  [KO:K12316] [EC:3.2.1.20]
107559296  [KO:K01373] [EC:3.4.22.41]
107559314  [KO:K10532] [EC:2.3.1.78]
107559324  [KO:K12398]
107559346  [KO:K11826]
107559455  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
107559592  [KO:K08509]
107559593  [KO:K04646]
107559665  [KO:K16186]
107559862  osbpl2; oxysterol-binding protein-related protein 2 [KO:K20174]
107559890  ap5m1; AP-5 complex subunit mu-1 [KO:K19023]
107560017  [KO:K12397]
107560031  [KO:K04646]
107560055  [KO:K08509]
107560065  [KO:K01134] [EC:3.1.6.8]
107560092  [KO:K14410] [EC:3.1.3.2]
107560205  [KO:K01202] [EC:3.2.1.46]
107560251  [KO:K06528]
107560423  dnase2b; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
107560512  [KO:K13289] [EC:3.4.16.5]
107560649  [KO:K14379] [EC:3.1.3.2]
107560757  [KO:K02154]
107560796  [KO:K20463]
107560953  [KO:K05648]
107561115  atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
107561143  [KO:K12400]
107561397  [KO:K02147]
107561411  [KO:K05648]
107561424  [KO:K01132] [EC:3.1.6.4]
107561521  ap1g1; AP-1 complex subunit gamma-1 [KO:K12391]
107561678  npc2; epididymal secretory protein E1 isoform X1 [KO:K13443]
107561719  osbpl6; oxysterol-binding protein-related protein 6 [KO:K20463]
107561796  [KO:K21398]
107561813  [KO:K12394]
107561871  [KO:K04992]
107562082  [KO:K12394]
107562274  [KO:K12397]
107562578  [KO:K12382]
107562586  [KO:K02154]
107562649  [KO:K07897] [EC:3.6.5.2]
107562698  [KO:K20181]
107562740  [KO:K05401]
107562816  [KO:K01374] [EC:3.4.22.42]
107562852  [KO:K20174]
107562884  [KO:K12404]
107562920  [KO:K10532] [EC:2.3.1.78]
107562924  [KO:K12348] [EC:3.5.1.23]
107563039  [KO:K18466]
107563163  vps13a; vacuolar protein sorting-associated protein 13A [KO:K19525]
107563204  [KO:K20463]
107563252  [KO:K20402]
107563260  [KO:K12384]
107563261  [KO:K12384]
107563334  [KO:K01074] [EC:3.1.2.22]
107563345  [KO:K20463]
107563433  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
107563453  [KO:K12359]
107563463  [KO:K02146]
107563519  [KO:K04993]
107563599  [KO:K07897] [EC:3.6.5.2]
107563778  [KO:K20463]
107563880  [KO:K05404]
107563887  [KO:K09105]
107563919  [KO:K20002]
107564011  [KO:K16184]
107564055  [KO:K04644]
107564110  [KO:K14995]
107564188  vamp7; vesicle-associated membrane protein 7 [KO:K08515]
107564202  [KO:K16185]
107564227  [KO:K07203] [EC:2.7.11.1]
107564304  tlr7; toll-like receptor 7 [KO:K05404]
107564305  [KO:K10170]
107564331  lamp5; lysosome-associated membrane glycoprotein 5 [KO:K28774]
107564370  [KO:K14209]
107564403  [KO:K12394]
107564463  [KO:K14638]
107564479  [KO:K12384]
107564985  [KO:K16186]
107565146  [KO:K19363]
107565173  [KO:K12316] [EC:3.2.1.20]
107565194  [KO:K02148]
107565197  [KO:K12387]
107565475  [KO:K10532] [EC:2.3.1.78]
107565531  [KO:K20174]
107565688  [KO:K20463]
107565726  [KO:K19022]
107565754  [KO:K02148]
107565804  [KO:K01369] [EC:3.4.22.34]
107565819  [KO:K12307]
107566065  [KO:K12401]
107566131  [KO:K15014]
107566147  [KO:K16750]
107566178  [KO:K03662]
107566394  [KO:K12399]
107566395  dmxl1; dmX-like protein 1 [KO:K24155]
107566718  [KO:K12385]
107566879  [KO:K06562]
107566902  [KO:K02152]
107566906  [KO:K14995]
107567147  [KO:K12384]
107567198  [KO:K14209]
107567269  [KO:K11827]
107567331  [KO:K01374] [EC:3.4.22.42]
107567357  [KO:K02154]
107567372  [KO:K02155]
107567567  [KO:K02154]
107567705  [KO:K12395]
107567845  [KO:K19024]
107567857  [KO:K19024]
107567911  [KO:K15014]
107568008  [KO:K05016]
107568061  [KO:K20189]
107568214  [KO:K02149]
107568287  [KO:K08366]
107568291  [KO:K20189]
107568311  [KO:K15014]
107568384  ap1m2; AP-1 complex subunit mu-2 [KO:K12393]
107568477  [KO:K03662]
107568939  litaf; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
107569115  [KO:K01382] [EC:3.4.23.34]
107569393  [KO:K12382]
107569397  [KO:K02154]
107569421  manba; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
107569568  [KO:K10161]
107569570  [KO:K10161]
107569693  gga3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
107569762  [KO:K07955]
107569979  [KO:K00921] [EC:2.7.1.150]
107569987  [KO:K10089]
107570111  [KO:K01275] [EC:3.4.14.1]
107570453  [KO:K12307]
107570656  mcoln3; mucolipin-3 [KO:K04994]
107570815  [KO:K20456]
107570862  [KO:K12373] [EC:3.2.1.52]
107571031  [KO:K20174]
107571341  [KO:K12400]
107571451  man2b1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
107571626  [KO:K01368] [EC:3.4.22.27]
107571775  [KO:K24155]
107571914  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
107571985  [KO:K06528]
107572021  [KO:K20183]
107572064  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
107572256  [KO:K01217] [EC:3.2.1.76]
107572551  [KO:K02150]
107572581  [KO:K25442]
107572590  [KO:K01204] [EC:3.2.1.49]
107572672  [KO:K20187]
107572785  [KO:K06497]
107573080  [KO:K07955]
107573128  [KO:K20819]
107573175  [KO:K12404]
107573216  [KO:K12384]
107573489  [KO:K01197] [EC:3.2.1.35]
107573512  [KO:K01197] [EC:3.2.1.35]
107573533  [KO:K12404]
107573571  [KO:K20185]
107573766  [KO:K12399]
107573851  [KO:K08512]
107573859  [KO:K04994]
107573894  [KO:K24738]
107573972  [KO:K12393]
107574102  arsb; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
107574207  [KO:K20818]
107574444  [KO:K21398]
107574686  [KO:K03662]
107574746  [KO:K19022]
107574855  [KO:K01369] [EC:3.4.22.34]
107574978  [KO:K06528]
107575226  [KO:K08568] [EC:3.4.18.1]
107575230  [KO:K07955]
107575294  [KO:K02150]
107575511  [KO:K11826]
107575563  [KO:K16185]
107575616  [KO:K12382]
107575887  [KO:K12359]
107576090  [KO:K14638]
107576314  [KO:K01379] [EC:3.4.23.5]
107576564  [KO:K01371] [EC:3.4.22.38]
107577178  [KO:K04645]
107577335  [KO:K02147]
107577412  [KO:K01204] [EC:3.2.1.49]
107577489  [KO:K04993]
107577551  [KO:K08515]
107577586  [KO:K16184]
107577661  [KO:K07955]
107578132  gm2a; ganglioside GM2 activator [KO:K12383]
107578270  [KO:K01186] [EC:3.2.1.18]
107578338  [KO:K01379] [EC:3.4.23.5]
107578425  [KO:K06528]
107578483  [KO:K08239] [EC:2.7.8.17]
107578484  [KO:K04646]
107578557  [KO:K20179]
107578689  [KO:K01369] [EC:3.4.22.34]
107578803  [KO:K06546]
107578987  [KO:K14209]
107579169  [KO:K20174]
107579236  [KO:K01137] [EC:3.1.6.14]
107579806  [KO:K01137] [EC:3.1.6.14]
107579815  [KO:K02150]
107579830  [KO:K11827]
107579889  [KO:K02150]
107580089  [KO:K20463]
107580136  tmem251; transmembrane protein 251 [KO:K26747]
107580233  [KO:K01363] [EC:3.4.22.1]
107580479  [KO:K19022]
107581073  [KO:K01137] [EC:3.1.6.14]
107581333  [KO:K14379] [EC:3.1.3.2]
107581372  [KO:K28455]
107581413  [KO:K20180]
107581516  [KO:K16750]
107581528  [KO:K20402]
107581763  ap5z1; AP-5 complex subunit zeta-1 [KO:K19025]
107581771  [KO:K12389]
107581850  [KO:K12399]
107582233  [KO:K01074] [EC:3.1.2.22]
107582370  [KO:K12403]
107582375  [KO:K12388]
107582442  [KO:K19022]
107582535  [KO:K19024]
107582573  [KO:K18466]
107582632  [KO:K04646]
107582674  [KO:K15014]
107583017  [KO:K11824]
107583118  [KO:K12399]
107583194  [KO:K25442]
107583260  [KO:K01379] [EC:3.4.23.5]
107583495  [KO:K01202] [EC:3.2.1.46]
107583500  [KO:K01365] [EC:3.4.22.15]
107583558  [KO:K12360]
107583577  [KO:K25442]
107583641  [KO:K02147]
107583676  [KO:K16186]
107583715  [KO:K12360]
107583812  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
107583955  gns; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
107583987  [KO:K02150]
107584082  arsg; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
107584137  [KO:K01052] [EC:3.1.1.13]
107584222  mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
107584247  [KO:K01206] [EC:3.2.1.51]
107584249  [KO:K01206] [EC:3.2.1.51]
107584309  neu1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
107584380  mfsd8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
107584465  [KO:K07955]
107584515  [KO:K09455]
107584577  [KO:K12397]
107584738  [KO:K14077]
107584739  [KO:K14077]
107584777  [KO:K28455]
107584805  [KO:K20180]
107584878  [KO:K09105]
107584963  [KO:K02145] [EC:7.1.2.2]
107585117  [KO:K13444] [EC:1.8.3.7]
107585233  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
107585268  [KO:K01192] [EC:3.2.1.25]
107585335  [KO:K12301]
107585367  [KO:K20821]
107585428  [KO:K12397]
107585451  [KO:K15014]
107585484  [KO:K19027]
107585756  [KO:K12395]
107585784  [KO:K14209]
107585890  [KO:K02144]
107586019  [KO:K19525]
107586161  [KO:K12402]
107586353  [KO:K12404]
107586409  [KO:K12396]
107586894  [KO:K01074] [EC:3.1.2.22]
107586896  [KO:K13443]
107586928  [KO:K01197] [EC:3.2.1.35]
107586947  sgsh; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
107586997  [KO:K20185]
107587014  [KO:K27947]
107587086  [KO:K01373] [EC:3.4.22.41]
107587315  [KO:K08512]
107587418  [KO:K05656]
107587497  scarb2; lysosome membrane protein 2 [KO:K12384]
107587575  hyal2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
107587576  [KO:K01197] [EC:3.2.1.35]
107587598  [KO:K13289] [EC:3.4.16.5]
107587683  ap2b1; AP-2 complex subunit beta [KO:K11825]
107587757  rragc; ras-related GTP-binding protein C [KO:K16186]
107587832  [KO:K01368] [EC:3.4.22.27]
107587833  [KO:K01368] [EC:3.4.22.27]
107587836  [KO:K01371] [EC:3.4.22.38]
107588109  [KO:K20174]
107588120  [KO:K01365] [EC:3.4.22.15]
107588188  bloc1s3; biogenesis of lysosome-related organelles complex 1 subunit 3 [KO:K20186]
107588245  [KO:K28455]
107588298  [KO:K01202] [EC:3.2.1.46]
107588358  [KO:K01136] [EC:3.1.6.13]
107588449  [KO:K02153]
107588528  [KO:K20179]
107588530  dmxl2; dmX-like protein 2 [KO:K24155]
107588662  [KO:K20821]
107588676  [KO:K12301]
107588685  zfyve26; zinc finger FYVE domain-containing protein 26 [KO:K19027]
107588734  [KO:K18466]
107588983  [KO:K07897] [EC:3.6.5.2]
107589010  [KO:K01137] [EC:3.1.6.14]
107589031  [KO:K10170]
107589172  [KO:K06129] [EC:3.1.1.5]
107589448  [KO:K12301]
107589449  [KO:K01074] [EC:3.1.2.22]
107589777  [KO:K02148]
107589951  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
107590144  [KO:K15590]
107590216  gnptab; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
107590283  [KO:K14379] [EC:3.1.3.2]
107590479  [KO:K02151]
107590499  [KO:K20399]
107590582  [KO:K05016]
107590719  [KO:K12316] [EC:3.2.1.20]
107590907  [KO:K12403]
107590951  [KO:K01365] [EC:3.4.22.15]
107590952  [KO:K01365] [EC:3.4.22.15]
107591026  [KO:K18468]
107591235  [KO:K02145] [EC:7.1.2.2]
107591329  [KO:K12388]
107591391  [KO:K12391]
107591494  [KO:K01195] [EC:3.2.1.31]
107591583  [KO:K12389]
107591677  [KO:K01074] [EC:3.1.2.22]
107591678  [KO:K12301]
107591777  [KO:K01197] [EC:3.2.1.35]
107591781  [KO:K20820]
107591782  [KO:K01197] [EC:3.2.1.35]
107591814  [KO:K12388]
107591918  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
107591935  [KO:K01125] [EC:3.1.4.45]
107592066  [KO:K20463]
107592135  [KO:K20398]
107592150  [KO:K01158] [EC:3.1.22.1]
107592268  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
107592296  [KO:K02145] [EC:7.1.2.2]
107592300  [KO:K01365] [EC:3.4.22.15]
107592366  [KO:K02154]
107592369  [KO:K12392]
107592371  [KO:K05642]
107592476  [KO:K20398]
107592517  [KO:K01158] [EC:3.1.22.1]
107592587  [KO:K20189]
107592650  ap2s1; AP-2 complex subunit sigma isoform X1 [KO:K11827]
107592705  [KO:K20174]
107592736  [KO:K20174]
107592744  [KO:K01365] [EC:3.4.22.15]
107592770  [KO:K01363] [EC:3.4.22.1]
107593055  [KO:K01197] [EC:3.2.1.35]
107593085  [KO:K01565] [EC:3.10.1.1]
107593238  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
107593327  [KO:K12396]
107593561  [KO:K08239] [EC:2.7.8.17]
107593648  [KO:K20189]
107593691  [KO:K08491]
107593725  [KO:K12394]
107593770  [KO:K11826]
107594117  fuca2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
107594160  [KO:K01052] [EC:3.1.1.13]
107594173  vps13c; vacuolar protein sorting-associated protein 13C [KO:K19525]
107594301  [KO:K20456]
107594317  [KO:K12394]
107594472  [KO:K14077]
107594630  [KO:K12393]
107594810  [KO:K01279] [EC:3.4.14.9]
107594835  [KO:K01363] [EC:3.4.22.1]
107594963  [KO:K07203] [EC:2.7.11.1]
107594988  [KO:K08512]
107595029  abcb9; ATP-binding cassette sub-family B member 9 [KO:K05656]
107595259  [KO:K12373] [EC:3.2.1.52]
107595357  bloc1s6; biogenesis of lysosome-related organelles complex 1 subunit 6 [KO:K20188]
107595438  [KO:K01197] [EC:3.2.1.35]
107595508  [KO:K11825]
107595603  [KO:K20189]
107595619  [KO:K01186] [EC:3.2.1.18]
107595689  [KO:K18467]
107595797  cltb; clathrin light chain B isoform X1 [KO:K04645]
107595854  [KO:K00921] [EC:2.7.1.150]
107595864  [KO:K06528]
107596330  [KO:K08491]
107596457  [KO:K13289] [EC:3.4.16.5]
107596624  [KO:K20402]
107596655  [KO:K20463]
107596675  [KO:K10089]
107596705  [KO:K01201] [EC:3.2.1.45]
107596856  [KO:K08568] [EC:3.4.18.1]
107597129  [KO:K16186]
107597154  [KO:K12386]
107597524  [KO:K18466]
107597677  [KO:K15014]
107597942  hexb; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
107597985  [KO:K01368] [EC:3.4.22.27]
107597987  [KO:K01368] [EC:3.4.22.27]
107598220  [KO:K20189]
107598233  [KO:K08366]
107598348  [KO:K14209]
107598431  [KO:K01201] [EC:3.2.1.45]
107598447  [KO:K01201] [EC:3.2.1.45]
107598641  [KO:K23282]
107598694  [KO:K18468]
107598722  [KO:K09105]
107598834  [KO:K01197] [EC:3.2.1.35]
107598911  [KO:K01197] [EC:3.2.1.35]
107599026  [KO:K08144]
107599180  [KO:K24915]
107599418  [KO:K09455]
107599450  [KO:K07897] [EC:3.6.5.2]
107599453  [KO:K20822]
107599687  [KO:K01205] [EC:3.2.1.50]
107599718  [KO:K02154]
107599859  [KO:K12307]
107599895  [KO:K03661]
107599918  [KO:K01134] [EC:3.1.6.8]
107599925  abca2; ATP-binding cassette sub-family A member 2 [KO:K05642]
107599930  [KO:K12392]
107599936  [KO:K01365] [EC:3.4.22.15]
107599937  [KO:K02145] [EC:7.1.2.2]
107599966  [KO:K02154]
107600182  [KO:K12348] [EC:3.5.1.23]
107600284  [KO:K07897] [EC:3.6.5.2]
107600512  [KO:K01125] [EC:3.1.4.45]
107600701  [KO:K28455]
107601199  [KO:K23863]
107601278  [KO:K24628]
107601371  [KO:K23863]
107601471  [KO:K06546]
107601802  [KO:K10532] [EC:2.3.1.78]
107601834  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
107601875  [KO:K12398]
107601989  [KO:K02148]
107602030  [KO:K24915]
107602073  [KO:K07897] [EC:3.6.5.2]
107602122  [KO:K11826]
107602125  [KO:K20181]
107602403  [KO:K20463]
107602599  aga; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
107602789  [KO:K12394]
107602950  [KO:K01369] [EC:3.4.22.34]
107603030  [KO:K04992]
107603065  [KO:K06564]
107603102  [KO:K12387]
Compound
C00002  ATP
C00008  ADP
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Reference
PMID:19672277
  Authors
Saftig P, Klumperman J
  Title
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
  Journal
Nat Rev Mol Cell Biol 10:623-35 (2009)
DOI:10.1038/nrm2745
Reference
PMID:31611045
  Authors
Savini M, Zhao Q, Wang MC
  Title
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
  Journal
Trends Cell Biol 29:876-887 (2019)
DOI:10.1016/j.tcb.2019.08.008
Reference
PMID:33433692
  Authors
Meyer-Schwesinger C
  Title
Lysosome function in glomerular health and disease.
  Journal
Cell Tissue Res 385:371-392 (2021)
DOI:10.1007/s00441-020-03375-7
Reference
PMID:34345172
  Authors
Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
  Title
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
  Journal
Int J Nanomedicine 16:5065-5098 (2021)
DOI:10.2147/IJN.S321343
Reference
PMID:36096887
  Authors
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
  Title
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
  Journal
Nat Commun 13:5351 (2022)
DOI:10.1038/s41467-022-33025-1
Reference
PMID:38357444
  Authors
Liu Q, Wang W, Xu L, Zhang Q, Wang H
  Title
The host mannose-6-phosphate pathway and viral infection.
  Journal
Front Cell Infect Microbiol 14:1349221 (2024)
DOI:10.3389/fcimb.2024.1349221
Reference
PMID:38711187
  Authors
He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
  Title
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
  Journal
Med Res Rev 44:2472-2509 (2024)
DOI:10.1002/med.22047
Reference
PMID:40759742
  Authors
Radulovic M, Yang C, Stenmark H
  Title
Lysosomal membrane homeostasis and its importance in physiology and disease.
  Journal
Nat Rev Mol Cell Biol 27:71-87 (2026)
DOI:10.1038/s41580-025-00873-w
Reference
PMID:41214333
  Authors
Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
  Title
Mechanistic insights into cargo sorting and export from the Golgi apparatus.
  Journal
Nat Rev Mol Cell Biol 26:940-956 (2025)
DOI:10.1038/s41580-025-00907-3
Related
pathway
sgh00511  Other glycan degradation
sgh00531  Glycosaminoglycan degradation
sgh04130  SNARE interactions in vesicular transport
sgh04140  Autophagy - animal
sgh04144  Endocytosis
sgh04145  Phagocytosis
sgh04150  mTOR signaling pathway
sgh04620  Toll-like receptor signaling pathway
KO pathway
ko04142   

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