KEGG   PATHWAY: tfn04150
Entry
tfn04150                    Pathway                                
Name
mTOR signaling pathway - Trachypithecus francoisi (Francois's langur)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
tfn04150  mTOR signaling pathway
tfn04150

Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117061986  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
117062361  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
117062427  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117062715  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
117062727  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
117063243  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
117063728  [KO:K02991]
117064102  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
117064128  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
117064187  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
117064531  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
117064599  WNT8A; protein Wnt-8a [KO:K00714]
117065023  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
117065045  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
117065053  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
117065134  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
117065200  [KO:K02991]
117065206  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117065708  [KO:K16344]
117065907  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
117066678  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117066804  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
117066878  FZD2; frizzled-2 [KO:K02235]
117067034  [KO:K00312]
117067211  WNT9B; protein Wnt-9b [KO:K01064]
117067326  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
117067396  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117067437  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
117067470  WNT3; proto-oncogene Wnt-3 [KO:K00312]
117067590  FLCN; folliculin [KO:K09594]
117067800  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
117068492  WNT8B; protein Wnt-8b [KO:K00714]
117068535  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117068756  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
117068782  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
117069127  [KO:K02152]
117069445  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
117069667  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117070145  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117070473  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117070501  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
117071286  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117071318  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
117072099  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
117072297  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117072307  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
117072598  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081]
117072635  FZD1; frizzled-1 [KO:K02432]
117072941  WNT2; protein Wnt-2 [KO:K00182]
117073094  FZD9; frizzled-9 [KO:K02842]
117073269  WNT16; protein Wnt-16 [KO:K01558]
117073449  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
117073458  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
117073572  RHEB; GTP-binding protein Rheb [KO:K07208]
117073735  TSC1; hamartin isoform X1 [KO:K07206]
117074535  WNT3A; protein Wnt-3a [KO:K00312]
117074634  NRAS; GTPase NRas [KO:K07828]
117074665  WNT9A; protein Wnt-9a [KO:K01064]
117074897  LAMTOR5; ragulator complex protein LAMTOR5 isoform X1 [KO:K16344]
117075022  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117075585  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
117075601  [KO:K16344]
117076307  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
117076331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117076490  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117076502  WNT2B; protein Wnt-2b [KO:K00182]
117076717  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117076722  LAMTOR2; ragulator complex protein LAMTOR2 isoform X1 [KO:K20398]
117077273  [KO:K07205]
117077554  RRAGB; LOW QUALITY PROTEIN: ras-related GTP-binding protein B [KO:K16185]
117077848  RPS6KA3; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
117078738  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
117078854  FZD6; frizzled-6 isoform X1 [KO:K02376]
117078964  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
117079180  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
117079218  [KO:K02152]
117079885  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
117080124  WNT11; protein Wnt-11 [KO:K01384]
117080233  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
117080241  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
117081014  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
117081143  INS; insulin [KO:K04526]
117081165  FZD4; frizzled-4 isoform X1 [KO:K02354]
117081433  RHOA; transforming protein RhoA [KO:K04513]
117081485  LAMTOR1; ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
117081688  HRAS; GTPase HRas isoform X1 [KO:K02833]
117081994  [KO:K03259]
117082015  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
117082038  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
117082166  [KO:K03259]
117082680  [KO:K02991]
117083018  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
117083244  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
117083269  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117083292  WNT7A; protein Wnt-7a [KO:K00572]
117083458  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117083502  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117083761  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117083793  [KO:K06276] [EC:2.7.11.1]
117083812  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
117084122  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117084479  [KO:K04366] [EC:2.7.11.1]
117084670  [KO:K03259]
117084893  [KO:K02991]
117085700  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
117085883  [KO:K02152]
117086074  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117086736  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
117086832  [KO:K03259]
117086926  TNF; tumor necrosis factor isoform X1 [KO:K03156]
117086928  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
117087485  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117087606  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117088050  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
117088186  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
117088210  FZD8; frizzled-8 [KO:K02375]
117089166  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
117089178  FZD10; frizzled-10 [KO:K02842]
117089249  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
117089531  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
117090059  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
117090185  WNT1; proto-oncogene Wnt-1 [KO:K03209]
117090187  WNT10B; protein Wnt-10b [KO:K01357]
117090216  [KO:K02151]
117090502  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
117090649  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117090718  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
117091606  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
117091710  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117091956  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117091972  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
117092065  [KO:K02152]
117092123  [KO:K02991]
117092662  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117092750  [KO:K02150]
117092832  RRAGC; ras-related GTP-binding protein C [KO:K16186]
117092887  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
117093012  SESN2; sestrin-2 [KO:K20394]
117093058  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117093159  WNT4; protein Wnt-4 [KO:K00408]
117093322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
117093348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117093472  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
117093896  [KO:K02152]
117094272  FZD3; frizzled-3 isoform X1 [KO:K02329]
117094400  CAB39; calcium-binding protein 39 isoform X1 [KO:K08272]
117094413  [KO:K02150]
117094439  IRS1; LOW QUALITY PROTEIN: insulin receptor substrate 1 [KO:K16172]
117094507  WNT10A; protein Wnt-10a [KO:K01357]
117094509  WNT6; protein Wnt-6 [KO:K00445]
117094596  FZD5; frizzled-5 [KO:K02375]
117094645  FZD7; frizzled-7 [KO:K02432]
117094657  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
117094781  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
117095630  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117096074  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
117096179  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
117096234  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
117096275  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
117096327  WNT7B; protein Wnt-7b [KO:K00572]
117096339  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
117096550  [KO:K02991]
117096627  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117096887  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117097077  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
117097165  [KO:K02152]
117097504  [KO:K13302] [EC:2.7.11.1]
117097801  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
117097810  TSC2; tuberin isoform X1 [KO:K07207]
117097851  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
117097890  WDR24; GATOR complex protein WDR24 [KO:K20408]
117097929  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
117098612  RRAGA; ras-related GTP-binding protein A [KO:K16185]
117098620  RPS6; 40S ribosomal protein S6 [KO:K02991]
117098782  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
117099604  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
tfn00561  Glycerolipid metabolism
tfn04010  MAPK signaling pathway
tfn04140  Autophagy - animal
tfn04151  PI3K-Akt signaling pathway
tfn04152  AMPK signaling pathway
tfn04810  Regulation of actin cytoskeleton
tfn04910  Insulin signaling pathway
KO pathway
ko04150   

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