KEGG   PATHWAY: tfn04010
Entry
tfn04010                    Pathway                                
Name
MAPK signaling pathway - Trachypithecus francoisi (Francois's langur)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
tfn04010  MAPK signaling pathway
tfn04010

Other DBs
GO: 0000165
Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117061979  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
117062187  IL1A; interleukin-1 alpha [KO:K04383]
117062188  IL1B; interleukin-1 beta [KO:K04519]
117062283  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
117062285  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117062379  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
117062421  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
117062427  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117062489  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
117063715  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
117063724  [KO:K04393]
117063914  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
117064128  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
117064180  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117064215  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117064366  FLNA; LOW QUALITY PROTEIN: filamin-A [KO:K04437]
117064804  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117064847  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
117064932  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
117064940  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
117064967  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117065039  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
117065085  FGF10; fibroblast growth factor 10 [KO:K04358]
117065147  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
117065345  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117065429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117065449  FGF18; fibroblast growth factor 18 [KO:K04358]
117065462  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117065594  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
117065596  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117065679  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117065686  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
117065752  CD14; monocyte differentiation antigen CD14 [KO:K04391]
117066362  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
117066507  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
117066601  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
117066678  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117066854  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
117066905  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117067059  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117067088  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117067107  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
117067192  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117067229  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
117067394  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
117067395  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117067396  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117067436  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
117067564  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
117067583  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
117067607  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
117067629  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
117067669  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
117067678  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
117067758  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
117067881  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
117067885  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117067958  CRK; adapter molecule crk isoform X1 [KO:K04438]
117068518  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
117068535  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117068587  ANGPT4; angiopoietin-4 [KO:K05467]
117068819  STK4; serine/threonine-protein kinase 4 [KO:K04411]
117069299  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
117069314  FOS; proto-oncogene c-Fos [KO:K04379]
117069324  PGF; placenta growth factor isoform X1 [KO:K16859]
117069468  MAX; protein max isoform X1 [KO:K04453]
117069537  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
117069667  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117070036  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117070145  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117070310  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
117070458  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
117070473  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117070685  FGF7; fibroblast growth factor 7 [KO:K04358]
117070813  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
117070841  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
117070845  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
117070893  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
117071115  [KO:K16342] [EC:3.1.1.4]
117071121  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
117071286  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117071546  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
117072297  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117072460  HSPB1; heat shock protein beta-1 [KO:K04455]
117072561  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
117072614  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117072632  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
117073210  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
117073436  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117073506  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117073672  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117074128  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
117074239  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117074284  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
117074406  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117074523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
117074574  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
117074605  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117074634  NRAS; GTPase NRas [KO:K07828]
117074791  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
117074794  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
117074842  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
117074917  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
117074964  FGF9; fibroblast growth factor 9 [KO:K04358]
117075139  [KO:K02187] [EC:3.4.22.56]
117075154  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
117075155  EFNA4; ephrin-A4 [KO:K05462]
117075231  NRTN; neurturin [KO:K25414]
117075343  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
117075427  NGF; beta-nerve growth factor [KO:K02582]
117075607  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
117075703  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
117075922  ELK4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
117075968  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
117076028  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
117076128  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
117076159  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
117076182  EFNA1; ephrin-A1 [KO:K05462]
117076300  EFNA2; ephrin-A2 [KO:K05462]
117076331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117076490  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117076514  JUND; transcription factor jun-D [KO:K04449]
117076562  PSPN; persephin [KO:K25416]
117076573  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
117076717  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117076785  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117076828  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
117077518  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
117077528  FGF16; fibroblast growth factor 16 [KO:K04358]
117077572  VEGFD; vascular endothelial growth factor D [KO:K05449]
117077848  RPS6KA3; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
117078187  DUSP9; LOW QUALITY PROTEIN: dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
117078298  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
117078321  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
117078341  IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
117078829  STK3; serine/threonine-protein kinase 3 [KO:K04412]
117078846  MYC; myc proto-oncogene protein [KO:K04377]
117079102  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
117079898  FGF3; fibroblast growth factor 3 [KO:K04358]
117080013  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
117080074  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
117080232  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117080419  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
117080423  [KO:K04375]
117080426  FGF19; fibroblast growth factor 19 [KO:K22603]
117080601  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
117080722  FGF4; fibroblast growth factor 4 [KO:K04358]
117080965  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117080984  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
117081142  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
117081143  INS; insulin [KO:K04526]
117081288  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
117081404  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
117081405  RELA; transcription factor p65 [KO:K04735]
117081420  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
117081424  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
117081560  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
117081565  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
117081589  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
117081688  HRAS; GTPase HRas isoform X1 [KO:K02833]
117081782  [KO:K04381]
117082018  MAP3K8; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
117082068  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
117082188  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
117082351  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
117082599  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117082610  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117082612  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
117082864  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117083004  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117083013  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
117083269  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117083313  [KO:K02187] [EC:3.4.22.56]
117083696  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
117083841  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
117083885  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
117084098  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
117084132  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
117084287  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
117084381  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
117084453  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
117084479  [KO:K04366] [EC:2.7.11.1]
117085041  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117085362  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117085405  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
117085480  AREG; amphiregulin [KO:K09782]
117085482  EREG; proepiregulin [KO:K09784]
117085601  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
117085603  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
117085606  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117085710  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117085754  [KO:K04392]
117085785  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
117085877  FGF2; fibroblast growth factor 2 [KO:K18497]
117086157  VEGFC; vascular endothelial growth factor C [KO:K05449]
117086196  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
117086221  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
117086685  [KO:K03283]
117086926  TNF; tumor necrosis factor isoform X1 [KO:K03156]
117086963  HSPA1A; LOW QUALITY PROTEIN: heat shock 70 kDa protein 1A [KO:K03283]
117086964  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
117087045  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
117087120  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
117087121  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117087252  SRF; serum response factor isoform X1 [KO:K04378]
117087278  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
117087484  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117087485  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117087581  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
117087606  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117087609  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
117087931  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
117088478  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
117089322  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
117089388  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
117089531  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
117089648  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
117089655  KITLG; kit ligand isoform X1 [KO:K05461]
117089741  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
117089746  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
117089777  RAP1B; ras-related protein Rap-1b [KO:K07836]
117089884  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
117089952  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
117090029  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
117090100  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
117090194  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
117090258  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117090498  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117090649  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117090658  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
117090673  FGF6; fibroblast growth factor 6 [KO:K04358]
117090674  FGF23; fibroblast growth factor 23 [KO:K22428]
117090701  [KO:K04850]
117090711  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
117091353  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
117091378  RELB; transcription factor RelB isoform X1 [KO:K09253]
117091439  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
117091486  PLA2G4C; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
117091544  NTF4; neurotrophin-4 [KO:K12457]
117091573  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
117091587  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
117091710  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117091712  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
117091714  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
117091956  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117091958  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
117091985  JUN; transcription factor AP-1 [KO:K04448]
117092072  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
117092073  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117092120  FGF20; fibroblast growth factor 20 [KO:K04358]
117092158  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117092476  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
117092478  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
117092651  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
117092721  ARTN; artemin [KO:K25415]
117092974  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117093037  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
117093058  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117093083  STMN1; stathmin isoform X1 [KO:K04381]
117093160  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117093193  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117093258  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
117093783  FGF21; fibroblast growth factor 21 [KO:K22429]
117094169  [KO:K05085] [EC:2.7.10.1]
117094398  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117094833  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117094849  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
117094867  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117095001  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
117095159  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
117095630  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117095965  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
117096246  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
117096273  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117096275  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
117096276  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117096460  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
117096463  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117096466  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117096471  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
117096627  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117096632  CRKL; crk-like protein [KO:K04438]
117096887  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117096888  [KO:K04381]
117096914  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117097099  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117097302  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
117097478  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
117097840  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
117097871  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
117097913  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117097942  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
117098362  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
117098409  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117098498  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
117098609  [KO:K07836]
117098682  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
117098896  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
117098928  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
117099070  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
117099135  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
117099582  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117099768  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
tfn04070  Phosphatidylinositol signaling system
tfn04110  Cell cycle
tfn04115  p53 signaling pathway
tfn04210  Apoptosis
tfn04310  Wnt signaling pathway
tfn04668  TNF signaling pathway
KO pathway
ko04010   

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