Entry Name PI3K-Akt signaling pathway - Trachypithecus francoisi (Francois's langur)
Description The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Trachypithecus francoisi (Francois's langur) [GN:
tfn ]
Gene 117072614 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
117074284 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
117091573 FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454 ]
117087278 VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
117065039 GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452 ]
117067192 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
117069667 SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099 ]
117094439 IRS1; LOW QUALITY PROTEIN: insulin receptor substrate 1 [KO:K16172 ]
117073672 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
117069568 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
117069279 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230 ]
117065046 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
117082099 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
117070006 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
117077624 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
117076154 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
117075908 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
117087558 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
117092868 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
117078318 COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237 ]
117077535 COL4A5; LOW QUALITY PROTEIN: collagen alpha-5(IV) chain [KO:K06237 ]
117084197 COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238 ]
117083761 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
117084122 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
117093348 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
117065206 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
117092662 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
117075022 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
117080883 LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1-like [KO:K04289 ]
117093437 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
117072288 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
117090616 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
117083766 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
117070643 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
117069650 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826 ]
117081093 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
117075268 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541 ]
117079628 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542 ]
117098113 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542 ]
117062877 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542 ]
117092172 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
117085990 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542 ]
117075701 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
117091448 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
117070184 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545 ]
117098624 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545 ]
117098837 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
117072627 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
117092073 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
117097878 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
117072272 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
117067187 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
117073770 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
117067709 PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290 ]
117067711 PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290 ]
117066804 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
117094781 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
117077273 LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205 ]
117064531 EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
117082166 eukaryotic translation initiation factor 4E type 2-like [KO:K03259 ]
117085700 EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259 ]
117086832 eukaryotic translation initiation factor 4E type 2-like [KO:K03259 ]
117090059 EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258 ]
117083098 MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631 ]
117073702 MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629 ]
117065862 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
117093595 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
117082567 PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354 ]
117065664 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354 ]
117085110 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354 ]
117093681 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
117069083 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583 ]
117069819 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583 ]
117099195 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583 ]
117084149 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583 ]
117087239 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584 ]
117069493 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584 ]
117079876 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584 ]
117071357 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584 ]
117082786 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584 ]
117075891 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584 ]
117069698 LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079 ]
117065177 CRTC2; LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 2 [KO:K16333 ]
117088006 PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340 ] [EC:3.1.3.16 ]
117071450 TCL1A; T-cell leukemia/lymphoma protein 1A isoform X1 [KO:K10167 ]
117071453 TCL1B; T-cell leukemia/lymphoma protein 1B isoform X1 [KO:K16836 ]
117090495 CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624 ]
117074605 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
117094598 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
117094833 ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
117096463 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
117079895 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
117099006 CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
117073578 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
117075642 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
117072944 CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
117086987 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049 ]
117075676 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
117090100 NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465 ]
117078341 IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210 ]
117085710 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
Compound C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Engelman JA, Luo J, Cantley LC
Title The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Journal Reference Authors Song G, Ouyang G, Bao S
Title The activation of Akt/PKB signaling pathway and cell survival.
Journal Reference Authors Hers I, Vincent EE, Tavare JM
Title Akt signalling in health and disease.
Journal Reference Authors Duronio V
Title The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
Journal Reference Authors Kim D, Chung J.
Title Akt: versatile mediator of cell survival and beyond.
Journal Reference Authors Koyasu S
Title The role of PI3K in immune cells.
Journal Reference Authors Okkenhaug K, Vanhaesebroeck B.
Title PI3K in lymphocyte development, differentiation and activation.
Journal Reference Authors Richardson CJ, Schalm SS, Blenis J
Title PI3-kinase and TOR: PIKTORing cell growth.
Journal Reference Authors Zhang X, Tang N, Hadden TJ, Rishi AK
Title Akt, FoxO and regulation of apoptosis.
Journal Reference Authors Georgescu MM
Title PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
Journal Reference Authors West KA, Castillo SS, Dennis PA
Title Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
Journal Reference Authors Wymann MP, Pirola L
Title Structure and function of phosphoinositide 3-kinases.
Journal Reference Authors Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
Title Regulation of Raf-Akt Cross-talk.
Journal Reference Authors Kikani CK, Dong LQ, Liu F
Title "New"-clear functions of PDK1: beyond a master kinase in the cytosol?
Journal Reference Authors Blume-Jensen P, Hunter T
Title Oncogenic kinase signalling.
Journal Reference Authors Osaki M, Oshimura M, Ito H
Title PI3K-Akt pathway: its functions and alterations in human cancer.
Journal Reference Authors Noguchi M, Ropars V, Roumestand C, Suizu F
Title Proto-oncogene TCL1: more than just a coactivator for Akt.
Journal Reference Authors Lemmon MA, Schlessinger J
Title Cell signaling by receptor tyrosine kinases.
Journal Reference Authors Skaper SD
Title The neurotrophin family of neurotrophic factors: an overview.
Journal Related tfn04620 Toll-like receptor signaling pathway
tfn04662 B cell receptor signaling pathway
KO pathway LinkDB All DBs
