Usage: /srv/www/cgi/kegg/bin/get_pathwaydata.pl [-tit] map

KEGG   PATHWAY: xla04912
Entry
xla04912                    Pathway                                
Name
GnRH signaling pathway - Xenopus laevis (African clawed frog)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
xla04912  GnRH signaling pathway
xla04912

Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100101276  prkaca.S; protein kinase, cAMP-dependent, alpha catalytic subunit S homeolog [KO:K04345] [EC:2.7.11.11]
100126613  map3k4.S; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
100190767  elk1.S; ELK1, member of ETS oncogene family S homeolog [KO:K04375]
100191021  pld1.L; phospholipase D1 L homeolog [KO:K01115] [EC:3.1.4.4]
100329215  mapk11.L; mitogen-activated protein kinase 11 L homeolog [KO:K04441] [EC:2.7.11.24]
100381134  cacna1s.S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100462911  cacna1c.S; voltage-dependent L-type calcium channel subunit alpha-1C isoform X11 [KO:K04850]
100462912  cacna1d.L; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100462913  cacna1f.L; voltage-dependent L-type calcium channel subunit alpha-1D isoform X3 [KO:K04853]
100505423  [KO:K07827]
108695762  [KO:K06068] [EC:2.7.11.13]
108696257  camk2g.L; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108697134  gnrh2.L; progonadoliberin-2 [KO:K05252]
108697189  [KO:K06068] [EC:2.7.11.13]
108697191  [KO:K06068] [EC:2.7.11.13]
108697660  cdc42.S; cell division control protein 42 homolog isoform X1 [KO:K04393]
108697792  kras.S; GTPase HRas [KO:K07827]
108698108  elk1.L; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
108698322  [KO:K06068] [EC:2.7.11.13]
108698335  [KO:K06068] [EC:2.7.11.13]
108698359  [KO:K06068] [EC:2.7.11.13]
108698710  [KO:K02183]
108698752  sos2.L; son of sevenless homolog 2 isoform X2 [KO:K03099]
108698978  jmjd7-pla2g4b.L; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
108699173  [KO:K16342] [EC:3.1.1.4]
108699245  pla2g4f.L; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
108699254  plcb2.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
108699793  sos2.S; son of sevenless homolog 2 [KO:K03099]
108700467  [KO:K16342] [EC:3.1.1.4]
108700666  [KO:K04448]
108701255  [KO:K08045] [EC:4.6.1.1]
108701261  map3k2.L; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
108701403  [KO:K06068] [EC:2.7.11.13]
108701647  [KO:K19662] [EC:2.7.11.13]
108701764  map3k3.L; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
108702159  prkca.S; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
108702193  [KO:K06068] [EC:2.7.11.13]
108702302  [KO:K06068] [EC:2.7.11.13]
108702560  map3k3.S; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
108702898  adcy5.S; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
108702901  map3k2.S; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
108703189  adcy9.S; LOW QUALITY PROTEIN: adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
108703204  [KO:K19662] [EC:2.7.11.13]
108704012  raf1.L; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108704277  [KO:K06068] [EC:2.7.11.13]
108704388  [KO:K04851]
108704427  map3k1.S; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
108704565  cacna1c.L; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
108705348  adcy1.S; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
108705586  [KO:K06068] [EC:2.7.11.13]
108705600  [KO:K06068] [EC:2.7.11.13]
108707025  [KO:K07763] [EC:3.4.24.80]
108707036  [KO:K08044] [EC:4.6.1.1]
108707491  [KO:K04857]
108708023  [KO:K06068] [EC:2.7.11.13]
108708144  [KO:K04441] [EC:2.7.11.24]
108708542  adcy6.L; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
108709364  [KO:K06068] [EC:2.7.11.13]
108709441  [KO:K04960]
108710178  [KO:K04959]
108710306  gnrhr2.L; gonadotropin-releasing hormone II receptor [KO:K04280]
108710621  gnrh1.L; progonadoliberin-1 [KO:K05252]
108710907  hbegf.L; proheparin-binding EGF-like growth factor [KO:K08523]
108711159  [KO:K04441] [EC:2.7.11.24]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
108711508  calml4.L; calmodulin-like protein 4 isoform X1 [KO:K02183]
108711677  prkaca.L; protein kinase, cAMP-dependent, alpha catalytic subunit L homeolog [KO:K04345] [EC:2.7.11.11]
108711785  pld2.L; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
108712451  [KO:K06068] [EC:2.7.11.13]
108712462  [KO:K04280]
108712466  gnrhr2.S; gonadotropin-releasing hormone II receptor [KO:K04280]
108712520  krasl.S; GTPase KRas isoform X1 [KO:K07827]
108712641  [KO:K04515] [EC:2.7.11.17]
108712658  map2k7.S; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108712798  calml4.S; calmodulin-like protein 4 [KO:K02183]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
108713286  hbegf.S; proheparin-binding EGF-like growth factor isoform X1 [KO:K08523]
108714187  prkacb.L; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108714625  [KO:K04958]
108715027  adcy4.L; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
108715063  fshb.S; follitropin subunit beta [KO:K05250]
108715263  [KO:K06068] [EC:2.7.11.13]
108715909  [KO:K04441] [EC:2.7.11.24]
108716168  [KO:K06068] [EC:2.7.11.13]
108716346  [KO:K06068] [EC:2.7.11.13]
108716399  plcb4.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
108716400  [KO:K05858] [EC:3.1.4.11]
108716606  [KO:K06068] [EC:2.7.11.13]
108716660  sos1.L; son of sevenless homolog 1 [KO:K03099]
108717252  adcy3.L; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
108717254  ptk2b.L; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
108717779  [KO:K06068] [EC:2.7.11.13]
108717808  sos1.S; son of sevenless homolog 1 [KO:K03099]
108717862  [KO:K06068] [EC:2.7.11.13]
108718060  [KO:K06068] [EC:2.7.11.13]
108718097  pld1.S; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
108718304  [KO:K08043] [EC:4.6.1.1]
108718305  ptk2b.S; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
108718321  map3k1.L; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
108718586  [KO:K06068] [EC:2.7.11.13]
108718988  adcy1.L; adenylate cyclase type 1 isoform X2 [KO:K08041] [EC:4.6.1.1]
108719184  [KO:K06068] [EC:2.7.11.13]
108719413  adcy8.L; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
108719598  [KO:K06068] [EC:2.7.11.13]
108719812  map3k22.S; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
108719997  egfr.S; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
373647  src.S; tyrosine-protein kinase Src-1 [KO:K05704] [EC:2.7.10.2]
373765  gnrhr1-A; gonadotropin releasing hormone receptor type I [KO:K04280]
373823  gnrhr.L; gonadotropin releasing hormone receptor L homeolog [KO:K04280]
373843  lhb.L; luteinizing hormone subunit beta L homeolog precursor [KO:K08521]
378610  adcy9.L; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
378681  cga.S; glycoprotein hormones alpha chain [KO:K08522]
379050  jun.S; jun proto-oncogene S homeolog [KO:K04448]
379055  cdc42.L; cell division cycle 42 L homeolog [KO:K04393]
379638  map2k6.L; mitogen-activated protein kinase kinase 6 L homeolog [KO:K04433] [EC:2.7.12.2]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
379992  mapk14.S; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
380388  prkacb.S; protein kinase cAMP-activated catalytic subunit beta S homeolog [KO:K04345] [EC:2.7.11.11]
380389  mmp2.S; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
380430  src.L; tyrosine-protein kinase Src-2 [KO:K05704] [EC:2.7.10.2]
380508  camk2g.S; calcium/calmodulin dependent protein kinase (CaM kinase) II gamma S homeolog [KO:K04515] [EC:2.7.11.17]
380535  gna11.S; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) S homeolog [KO:K04635]
380558  calm2.S; calmodulin-2 A [KO:K02183]
380561  pla2g4a.L; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
394391  map2k7.L; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
394414  gnas.S; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
394425  gnaq.L; guanine nucleotide binding protein (G protein), q polypeptide L homeolog [KO:K04634]
397692  plcb3.L; phospholipase C beta 3 L homeolog [KO:K05858] [EC:3.1.4.11]
397771  kras.L; kirsten rat sarcoma viral oncogene homolog L homeolog [KO:K07827]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397789  camk2b.L; calcium/calmodulin dependent protein kinase (CaM kinase) II beta L homeolog [KO:K04515] [EC:2.7.11.17]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
398376  camk2d.L; calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X8 [KO:K04515] [EC:2.7.11.17]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
398592  mapk12.S; mitogen-activated protein kinase 12 S homeolog [KO:K04441] [EC:2.7.11.24]
398804  atf4.L; activating transcription factor 4 L homeolog [KO:K04374]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399055  adcy7.L; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
399059  gnas.L; uncharacterized protein LOC399059 [KO:K04632]
399150  map2k3; MAP kinase activator XMEK3 [KO:K04433] [EC:2.7.12.2]
399160  camk2d.S; calcium/calmodulin-dependent protein kinase type II delta chain [KO:K04515] [EC:2.7.11.17]
399162  egr1.L; early growth response protein 1-A [KO:K09203]
399254  itpr1.S; inositol 1,4,5-trisphosphate receptor type 1 S homeolog [KO:K04958]
399259  calm2.L; calmodulin-2 B [KO:K02183]
399261  gnaq.S; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
399284  camk2a.S; calcium/calmodulin-dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
399400  jun.L; jun proto-oncogene L homeolog [KO:K04448]
399406  hras.L; Harvey rat sarcoma viral oncogene homolog L homeolog [KO:K02833]
399446  nras.L; GTPase NRas [KO:K07828]
399458  grb2.L; growth factor receptor-bound protein 2-A [KO:K04364]
399471  map2k4.L; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04430] [EC:2.7.12.2]
404226  prkcd.S; protein kinase C delta S homeolog [KO:K06068] [EC:2.7.11.13]
404227  prkcd.L; protein kinase C delta L homeolog [KO:K06068] [EC:2.7.11.13]
407753  mmp14.L; matrix metallopeptidase 14 L homeolog precursor [KO:K07763] [EC:3.4.24.80]
407843  fshb.L; follicle stimulating hormone subunit beta L homeolog precursor [KO:K05250]
414518  egr1.S; early growth response protein 1-B [KO:K09203]
414728  adcy6.S; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
414729  adcy8.S; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
431908  map2k4.S; dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04430] [EC:2.7.12.2]
432256  cga.L; glycoprotein hormones, alpha polypeptide L homeolog precursor [KO:K08522]
444095  grb2.S; growth factor receptor-bound protein 2-B [KO:K04364]
445848  plcb4.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
446599  mapk7.L; mitogen-activated protein kinase 7 L homeolog [KO:K04464] [EC:2.7.11.24]
447031  prkca.L; protein kinase C, alpha L homeolog [KO:K02677] [EC:2.7.11.13]
494669  mapk11.S; mitogen-activated protein kinase 11 S homeolog [KO:K04441] [EC:2.7.11.24]
606721  calm1.S; calmodulin-1 [KO:K02183]
724072  egfr.L; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
733258  plcb1.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
734165  atf4.S; activating transcription factor 4 S homeolog [KO:K04374]
734336  map3k22.L; mitogen-activated protein kinase kinase kinase 22 L homeolog [KO:K04421] [EC:2.7.11.25]
735153  XB956263.L; uncharacterized protein LOC735153 [KO:K04441] [EC:2.7.11.24]
779103  gna11.L; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
xla04010  MAPK signaling pathway
xla04020  Calcium signaling pathway
xla04060  Cytokine-cytokine receptor interaction
xla04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   

DBGET integrated database retrieval system