KEGG   PATHWAY: xla04060
Entry
xla04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Xenopus laevis (African clawed frog)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
xla04060  Cytokine-cytokine receptor interaction
xla04060

Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100036815  cxcl8.L; uncharacterized protein LOC100036815 precursor [KO:K10030]
100036830  admp2.L; antidorsalizing morphogenetic protein 2 L homeolog precursor [KO:K21283]
100036958  il2rg.L; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
100036961  ccr7.L; C-C motif chemokine receptor 7 L homeolog [KO:K04182]
100037000  XB5945946.L; uncharacterized protein LOC100037000 precursor [KO:K10030]
100037016  [KO:K05133]
100049773  il13ra2.L; uncharacterized protein LOC100049773 [KO:K05077]
100101283  [KO:K05133]
100127268  il17ra.S; uncharacterized protein LOC100127268 [KO:K05164]
100127301  [KO:K05500]
100127311  inha.L; inhibin subunit alpha L homeolog [KO:K05500]
100137625  tnf.L; tumor necrosis factor L homeolog [KO:K03156]
100137626  tnfrsf1a.S; TNF receptor superfamily member 1A S homeolog precursor [KO:K03158]
100137662  cxcr6.L; C-X-C chemokine receptor type 6 [KO:K04191]
100158264  tnfrsf6b.L; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
100158347  il6st.L; uncharacterized protein LOC100158347 precursor [KO:K05060]
100174791  il6st.S; interleukin 6 cytokine family signal transducer S homeolog precursor [KO:K05060]
100192357  faslg.L; Fas ligand L homeolog [KO:K04389]
100192360  cxcr4.L; C-X-C chemokine receptor type 4-A [KO:K04189]
100316914  tnfsf10.S; TNF superfamily member 10 S homeolog [KO:K04721]
100381055  lif.L; leukemia inhibitory factor [KO:K05419]
100381060  ccl5.L; C-C motif chemokine 5 [KO:K12499]
100381152  ifnlr1.L; interferon lambda receptor 1 isoform X1 [KO:K05140]
100505445  epo.S; erythropoietin S homeolog precursor [KO:K05437]
100653504  cd4.S; cd4 receptor S homeolog precursor [KO:K06454]
101027283  ifng.L; interferon gamma [KO:K04687]
101243547  cxcr5.L; C-X-C motif chemokine receptor 5 L homeolog [KO:K04190]
101243548  xcxcra; C-X-C chemokine receptor type a [KO:K04188]
101243550  [KO:K05475]
101243553  csf1.S; colony stimulating factor-1 S homeolog precursor [KO:K05453]
101243554  [KO:K05090] [EC:2.7.10.1]
108695212  [KO:K04180]
108695809  cntf.L; ciliary neurotrophic factor [KO:K05420]
108695906  [KO:K05439]
108696050  [KO:K04390]
108696056  cd4.L; T-cell surface glycoprotein CD4 [KO:K06454]
108696066  tnfrsf1a.L; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108696321  clcf1.L; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421]
108696462  il10ra.L; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
108696518  [KO:K05154]
108696537  tnfrsf14.L; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
108696592  tnfrsf9.L; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
108696684  [KO:K05417]
108696990  gdf2.L; dorsalin-1 [KO:K05503]
108697037  [KO:K04188]
108697171  [KO:K04390]
108697263  prl.2.S; prolactin-2 [KO:K05439]
108697351  ltbr.S; uncharacterized protein ltbr.S isoform X1 [KO:K03159]
108697489  nodal.S; nodal homolog 4-B [KO:K04666]
108697525  cxcl12.S; stromal cell-derived factor 1 isoform X1 [KO:K10031]
108697540  clcf1.S; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421]
108697595  il10ra.S; uncharacterized protein il10ra.S isoform X3 [KO:K05134]
108697611  [KO:K05482]
108697612  [KO:K05482]
108697652  [KO:K05142]
108697673  [KO:K05146]
108697752  il11.S; interleukin-11 [KO:K05417]
108697989  [KO:K04188]
108698248  tnfsf15.L; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
108698258  bmp15.L; bone morphogenetic protein 15 [KO:K05498]
108698311  [KO:K05480]
108698479  [KO:K05076]
108698566  lta.L; lymphotoxin-alpha [KO:K05468]
108698664  [KO:K22669]
108698921  cd40lg.L; CD40 ligand [KO:K03161]
108698940  ltb.L; lymphotoxin-beta [KO:K03157]
108699539  [KO:K22669]
108699541  [KO:K22669]
108699542  [KO:K22669]
108699544  [KO:K22669]
108699613  il6r.L; interleukin-6 receptor subunit alpha [KO:K05055]
108700037  tnfsf15.S; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
108700067  [KO:K05480]
108700235  tnf.S; tumor necrosis factor [KO:K03156]
108700276  tgfb1.S; transforming growth factor beta-1 proprotein-like [KO:K13375]
108700406  il6r.S; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
108700553  [KO:K05076]
108700557  cd40lg.S; CD40 ligand [KO:K03161]
108700670  ltb.S; lymphotoxin-beta [KO:K03157]
108700671  lta.S; lymphotoxin-alpha [KO:K05468]
108700680  [KO:K22669]
108700769  csf3.L; myelomonocytic growth factor [KO:K05423]
108701036  cd40.L; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
108701265  cxcr1.L; C-X-C chemokine receptor type 2 [KO:K05050]
108701335  acvr1c.L; activin receptor type-1C-like [KO:K13568] [EC:2.7.11.30]
108701455  bmpr2.L; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
108701488  [KO:K05497]
108701489  mstn.1.L; growth/differentiation factor 8 [KO:K05497]
108701563  [KO:K05071]
108701887  [KO:K05153]
108701892  il21r.L; interleukin-21 receptor [KO:K05075]
108701996  [KO:K04182]
108702184  [KO:K05414]
108702185  [KO:K05414]
108702186  [KO:K05414]
108702308  il21r.S; interleukin-21 receptor [KO:K05075]
108702362  gdf5.S; growth/differentiation factor 5 [KO:K04664]
108702485  csf3.S; granulocyte colony-stimulating factor [KO:K05423]
108702613  bmp7.1.S; bone morphogenetic protein 7 [KO:K16621]
108702672  tnfrsf6b.S; tumor necrosis factor receptor superfamily member 6B isoform X1 [KO:K05143]
108702730  cd40.S; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
108702885  tgfbr2l.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108702893  inhbb.S; inhibin beta B chain [KO:K22687]
108702964  acvr1c.S; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
108703031  ackr3.S; atypical chemokine receptor 3 [KO:K04304]
108703078  mstn.2.S; growth/differentiation factor 8 [KO:K05497]
108703079  mstn.1.S; growth/differentiation factor 8 [KO:K05497]
108703132  [KO:K05071]
108703409  [KO:K05477]
108703506  [KO:K10035]
108703544  [KO:K05474]
108703852  [KO:K24382]
108703951  [KO:K05422]
108704082  il17c.S; interleukin-17C [KO:K05491]
108704305  tnfrsf12a.S; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
108704493  cxcl11.S; C-X-C motif chemokine 11-1 [KO:K12671]
108704502  cxcl13.S; C-X-C motif chemokine 13 [KO:K10032]
108704520  eda2r.L; tumor necrosis factor receptor superfamily member 27 isoform X2 [KO:K05163]
108704661  [KO:K05138]
108704662  [KO:K05140]
108704665  [KO:K05061]
108705224  cxcr5.S; C-X-C chemokine receptor type 5 [KO:K04190]
108705275  [KO:K24382]
108705278  [KO:K05422]
108705442  [KO:K05138]
108706143  [KO:K10030]
108706149  [KO:K10030]
108706171  cxcl10.S; C-X-C motif chemokine 10 [KO:K12671]
108706178  cxcl9.S; C-X-C motif chemokine 10 [KO:K12671]
108706296  gdf15.S; protein DVR-1 [KO:K05504]
108706672  [KO:K05433]
108706748  bmpr1b.S; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
108706768  cxcl2.S; growth-regulated alpha protein [KO:K10030]
108706769  cxcl8.S; interleukin-8 [KO:K10030]
108706820  bmp3.S; bone morphogenetic protein 3-like [KO:K05496]
108706872  amh.S; muellerian-inhibiting factor [KO:K04665]
108707060  lif.S; leukemia inhibitory factor-like isoform X2 [KO:K05419]
108707301  ghr.S; growth hormone receptor [KO:K05080]
108707308  osmr.S; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
108707309  lifr.S; leukemia inhibitory factor receptor [KO:K05058]
108707361  [KO:K05512]
108707362  cntfr.S; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
108707419  [KO:K05131]
108707514  [KO:K16622]
108707638  relt.L; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
108707672  [KO:K05066]
108707703  il10.L; interleukin-10 [KO:K05443]
108707728  [KO:K05173]
108707740  inhbc.2.L; inhibin beta C chain [KO:K22688]
108707761  il17d.L; interleukin-17D [KO:K05492]
108707873  [KO:K05130]
108707874  [KO:K05133]
108707875  [KO:K05133]
108707876  il10rb.L; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
108707981  [KO:K05066]
108707982  [KO:K05067]
108708058  ngf.L; nerve growth factor-like [KO:K02582]
108708328  ccl4.L; C-C motif chemokine 4 homolog [KO:K12964]
108708329  [KO:K05408]
108708404  [KO:K04386]
108708405  [KO:K04386]
108708406  il1r2.L; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
108708407  il18r1.1.L; interleukin-18 receptor 1 [KO:K05173]
108708408  il18rap.L; interleukin-18 receptor accessory protein [KO:K05174]
108708463  tnfsf13b.L; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
108708536  acvrl1.L; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
108708537  acvr1b.L; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
108708568  gdf11.1.L; growth/differentiation factor 11 isoform X1 [KO:K22679]
108708718  tnfrsf19.L; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
108708915  [KO:K22667]
108708988  acvrl1.S; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
108709067  [KO:K05066]
108709068  [KO:K05067]
108709094  ccl5.S; eotaxin isoform X1 [KO:K12499]
108709106  il10.S; interleukin-10 [KO:K05443]
108709130  inhbc.1.S; inhibin beta B chain [KO:K22688]
108709230  [KO:K05130]
108709389  ngf.S; nerve growth factor isoform X2 [KO:K02582]
108709602  [KO:K16622]
108709690  edar.S; tumor necrosis factor receptor superfamily member EDAR isoform X5 [KO:K05162]
108709706  il1r1.S; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
108709836  [KO:K22679]
108709859  inhbc.2.S; inhibin beta C chain [KO:K22688]
108709904  [KO:K04672] [EC:2.7.11.30]
108709968  tnfrsf19.S; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
108709971  il17d.S; interleukin-17D [KO:K05492]
108710037  relt.S; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
108710256  [KO:K05446]
108710348  [KO:K04666]
108710587  [KO:K05445]
108710900  bmpr1b.L; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
108710928  gdf9.L; growth/differentiation factor 9 [KO:K22673]
108710938  [KO:K05490]
108711085  cxcl2.L; interleukin-8 isoform X1 [KO:K10030]
108711090  [KO:K10030]
108711093  [KO:K10030]
108711151  cxcl10.L; C-X-C motif chemokine 10 [KO:K12671]
108711226  cxcl13.L; C-X-C motif chemokine 13 [KO:K10032]
108711250  [KO:K10032]
108711253  lep.L; leptin [KO:K05424]
108711427  il16.L; pro-interleukin-16 [KO:K22628]
108711549  bmp10.L; bone morphogenetic protein 10 [KO:K22670]
108711577  il1b.L; interleukin-1 beta [KO:K04519]
108711635  [KO:K04666]
108711649  [KO:K04666]
108711650  [KO:K04666]
108711691  [KO:K04738]
108711718  [KO:K19598]
108711732  [KO:K05472]
108711734  [KO:K10035]
108711778  [KO:K05474]
108711827  epo.L; erythropoietin isoform X2 [KO:K05437]
108712256  [KO:K05164]
108712268  il12b.S; interleukin-12 subunit beta isoform X2 [KO:K05425]
108712279  [KO:K04666]
108712315  [KO:K22628]
108712369  [KO:K04687]
108712458  bmp10.S; bone morphogenetic protein 10 [KO:K22670]
108712487  [KO:K05446]
108712673  nodal1.S; nodal homolog isoform X1 [KO:K04666]
108712674  [KO:K04666]
108712739  [KO:K04519]
108712945  bmp7.2.S; bone morphogenetic protein 7-like [KO:K16621]
108713078  admp.L; bone morphogenetic protein 2 [KO:K21283]
108713225  gdf15.L; protein DVR-1 [KO:K05504]
108713254  [KO:K05490]
108713269  gdf9.S; growth/differentiation factor 9 [KO:K22673]
108713528  [KO:K05062]
108713530  [KO:K05082]
108713565  [KO:K05069]
108714101  il17c.L; interleukin-17C isoform X1 [KO:K05491]
108714150  il34.L; interleukin-34 isoform X1 [KO:K22633]
108714211  [KO:K05064]
108714212  [KO:K05064]
108714562  csf2rb.L; cytokine receptor common subunit beta isoform X1 [KO:K04738]
108714709  [KO:K05166]
108714710  [KO:K05168]
108715004  faslg.S; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108715025  [KO:K05069]
108715045  il17rc.S; interleukin-17 receptor C isoform X1 [KO:K05166]
108715469  il34.S; interleukin-34 isoform X1 [KO:K22633]
108715845  il5ra.S; interleukin-5 receptor subunit alpha [KO:K05067]
108715899  il17re.S; interleukin-17 receptor E [KO:K05168]
108716243  [KO:K05507]
108716349  thpo.L; thrombopoietin [KO:K06854]
108716374  ccl20.L; C-C motif chemokine 20 [KO:K14625]
108716914  bmp5.L; bone morphogenetic protein 5 [KO:K04663]
108716971  il1rap.L; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
108717006  tnfsf10.L; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
108717155  [KO:K05137]
108717157  [KO:K16062]
108717203  gdf7.L; growth/differentiation factor 6-A [KO:K20013]
108717212  tnfrsf21.L; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
108717487  [KO:K05507]
108717503  [KO:K05494]
108717504  [KO:K05494]
108717570  thpo.S; thrombopoietin [KO:K06854]
108717596  ccl20.S; C-C motif chemokine 20-like [KO:K14625]
108717597  [KO:K05507]
108717706  tgfb2.S; transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
108717881  [KO:K05132]
108717882  [KO:K05136]
108718013  bmp5.S; bone morphogenetic protein 5 isoform X2 [KO:K04663]
108718047  il1rap.S; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
108718215  [KO:K05137]
108718219  [KO:K14625]
108718277  tnfrsf21.S; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
108718397  [KO:K05513]
108718407  [KO:K05057]
108718408  lifr.L; leukemia inhibitory factor receptor [KO:K05058]
108718487  il6.L; interleukin-6 [KO:K05405]
108718641  xcr1.L; chemokine XC receptor 1 [KO:K04193]
108718646  ccr3.L; C-C chemokine receptor type 3 isoform X1 [KO:K04178]
108718818  [KO:K16062]
108718829  [KO:K16062]
108718839  il11ra.L; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
108718850  [KO:K05059]
108718935  tgfbr2.L; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
108718985  inhba.L; inhibin beta A chain [KO:K04667]
108718986  [KO:K04178]
108719019  ccr9.L; C-C chemokine receptor type 9 [KO:K04184]
108719029  [KO:K04674] [EC:2.7.11.30]
108719099  [KO:K05147]
108719128  bmp6.L; bone morphogenetic protein 6 [KO:K16620]
108719358  [KO:K20012]
108719391  tnfrsf11b.L; tumor necrosis factor receptor superfamily member 11B isoform X2 [KO:K05148]
108719613  [KO:K05433]
108719702  [KO:K04191]
108719963  tgfbr2.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108719965  amh.L; muellerian-inhibiting factor [KO:K04665]
108720005  inhba.S; inhibin beta A chain [KO:K04667]
108720006  [KO:K05063]
108720089  [KO:K05147]
121396840  [KO:K22669]
373558  nodal6.L; nodal homolog 6 L homeolog precursor [KO:K04666]
373585  nodal5.2.L; nodal homolog 5, gene 2 L homeolog precursor [KO:K04666]
373597  nodal3.2.L; nodal homolog 3-B precursor [KO:K04666]
373606  il1b.S; interleukin 1 beta S homeolog [KO:K04519]
373617  gh2.S; somatotropin-B precursor [KO:K05438]
373618  prlr.L; prolactin receptor precursor [KO:K05081]
373801  tgfb2.L; transforming growth factor beta-2 proprotein precursor [KO:K13376]
373812  prlr.S; prolactin receptor [KO:K05081]
373815  tgfbr2l.L; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
373820  gdf7.S; growth differentiation factor 7 S homeolog precursor [KO:K20013]
373821  ngfr.S; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
378537  nodal3.1.L; nodal homolog 3-A precursor [KO:K04666]
378543  nodal1.L; nodal homolog precursor [KO:K04666]
378580  gh1.L; somatotropin-A-like [KO:K05438]
378661  inhbc.1.L; inhibin subunit beta C L homeolog precursor [KO:K22688]
378780  bmp2.S; bone morphogenetic protein 2-A precursor [KO:K21283]
379584  rell1.S; RELT-like 1 [KO:K26541]
379625  bmp7.2.L; bone morphogenetic protein 7 precursor [KO:K16621]
380208  edar.L; ectodysplasin A receptor L homeolog precursor [KO:K05162]
380373  cxcr4.S; C-X-C chemokine receptor type 4-B [KO:K04189]
380560  bmp7.1.L; bone morphogenetic protein 7, gene 1 L homeolog [KO:K16621]
394305  gdf3.S; growth/differentiation factor 3 precursor [KO:K22672]
397711  bmpr1a.L; bone morphogenetic protein receptor type 1A L homeolog precursor [KO:K04673] [EC:2.7.11.30]
397712  bmpr1a.S; bone morphogenetic protein receptor type 1A S homeolog precursor [KO:K04673] [EC:2.7.11.30]
397778  tgfb1.L; transforming growth factor beta-1 proprotein precursor [KO:K13375]
397835  nodal2.L; nodal homolog 2-A precursor [KO:K04666]
397859  acvr2b.S; activin A receptor type 2B S homeolog precursor [KO:K13596] [EC:2.7.11.30]
397873  bmp2.L; bone morphogenetic protein 2-B precursor [KO:K21283]
397874  bmp4.L; bone morphogenetic protein 4 precursor [KO:K04662]
397981  bmpr2.S; bone morphogenetic protein receptor type II S homeolog [KO:K04671] [EC:2.7.11.30]
398053  admp.S; anti-dorsalizing morphogenic protein S homeolog precursor [KO:K21283]
398068  nodal.L; nodal homolog 4-A precursor [KO:K04666]
398129  ngfr.L; nerve growth factor receptor L homeolog precursor [KO:K02583]
398134  nradd.L; neurotrophin receptor associated death domain L homeolog precursor [KO:K02583]
398153  ghr.L; growth hormone receptor precursor [KO:K05080]
398309  cxcr1.S; C-X-C motif chemokine receptor 1 S homeolog [KO:K05050]
398310  ackr3.L; atypical chemokine receptor 3 L homeolog [KO:K04304]
398614  gdf10.L; growth/differentiation factor 10 precursor [KO:K22674]
399030  cxcl12.L; stromal cell-derived factor 1 isoform beta precursor [KO:K10031]
399035  tnfrsf12a.L; tumor necrosis factor receptor superfamily member 12A L homeolog precursor [KO:K05149]
399083  acvr1.S; activin A receptor type 1 S homeolog precursor [KO:K04675] [EC:2.7.11.30]
399103  acvr1.L; activin A receptor type 1 L homeolog precursor [KO:K04675] [EC:2.7.11.30]
399144  gdf6.S; growth differentiation factor 6 S homeolog precursor [KO:K20012]
399154  gh1.S; growth hormone 1 S homeolog precursor [KO:K05438]
399277  acvr2b.L; activin receptor type-2B precursor [KO:K13596] [EC:2.7.11.30]
399280  inhbb.L; inhibin subunit beta B L homeolog precursor [KO:K22687]
399283  acvr2a.L; activin receptor type-2A precursor [KO:K04670] [EC:2.7.11.30]
399295  tgfbr1.S; transforming growth factor beta receptor I S homeolog precursor [KO:K04674] [EC:2.7.11.30]
399322  bmp4.S; bone morphogenetic protein 4 precursor [KO:K04662]
399354  bmp3.L; bone morphogenetic protein 3 precursor [KO:K05496]
399454  acvr1b.S; activin A receptor type 1B S homeolog precursor [KO:K13567] [EC:2.7.11.30]
404688  tnfrsf10b.L; tumor necrosis factor receptor superfamily member 10b L homeolog precursor [KO:K04722]
431922  rell1.L; RELT-like 1 L homeolog [KO:K26541]
432338  nradd.S; neurotrophin receptor associated death domain S homeolog precursor [KO:K02583]
443669  cxcr3.L; C-X-C chemokine receptor type 3 [KO:K04188]
444169  ccr7.S; chemokine (C-C motif) receptor 7 [KO:K04182]
444627  cxcl14.L; chemokine (C-X-C motif) ligand 14 L homeolog precursor [KO:K10033]
444716  tnfrsf11b.S; tumor necrosis factor receptor superfamily member 11b S homeolog precursor [KO:K05148]
446295  gdf5.L; growth differentiation factor 5 L homeolog precursor [KO:K04664]
446320  prl.1.L; prolactin, gene 1 L homeolog [KO:K05439]
446770  csf3r.L; granulocyte colony-stimulating factor receptor [KO:K05061]
446849  il10rb.S; interleukin 10 receptor subunit beta S homeolog precursor [KO:K05135]
447378  rell2.L; RELT-like protein 2 [KO:K26541]
447644  il5ra.L; interleukin 5 receptor subunit alpha L homeolog precursor [KO:K05067]
494705  ccr2.L; uncharacterized protein LOC494705 [KO:K04180]
494782  ackr4.L; uncharacterized protein LOC494782 [KO:K04186]
495087  acvr2a.S; uncharacterized protein LOC495087 precursor [KO:K04670] [EC:2.7.11.30]
495398  il13ra2.S; interleukin 13 receptor subunit alpha 2 S homeolog [KO:K05077]
495479  csf2rb.S; colony stimulating factor 2 receptor beta common subunit S homeolog precursor [KO:K04738]
495517  [KO:K05131]
496105  [KO:K05131]
496322  tnfsf11.L; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
677862  gdf1.S; protein DVR-1 precursor [KO:K05495]
733333  tnfsf11.S; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
733364  ebi3.S; interleukin-27 subunit beta isoform X2 [KO:K24476]
734176  nodal6.S; nodal homolog 6 S homeolog precursor [KO:K04666]
734211  epor.L; erythropoietin receptor precursor [KO:K05079]
734226  lep.S; leptin precursor [KO:K05424]
734227  lepr.S; leptin receptor [KO:K05062]
734391  prl.1.S; uncharacterized protein LOC734391 [KO:K05439]
734440  bmp6.S; bone morphogenetic protein 6 S homeolog precursor [KO:K16620]
780748  nodal5.L; nodal homolog 5 L homeolog precursor [KO:K04666]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

DBGET integrated database retrieval system