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ENTRY	nt06275
Name	Acute myeloid leukemia
Category	Disease view; Cancer
Pathway	hsa05221 Acute myeloid leukemia
Disease	H00003 Acute myeloid leukemia
Display	drug-target relation   disease type

ERK signaling       D1  |                         N00215    KITLG → KIT → GRB2 → SOS → RAS → RAF → MEK → ERK N00003        KIT* → GRB2 → SOS → RAS → RAF → MEK → ERK N00217    FLT3LG → FLT3 → GRB2 → SOS → RAS → RAF → MEK → ERK       D1,D2  |                         N00004        FLT3* → GRB2 → SOS → RAS → RAF → MEK → ERK N00012                    (KRAS*,NRAS*) → RAF → MEK → ERK → CCND1 PI3K signaling       D1  |                     N00045    KITLG → KIT → PI3K → PIP3 → AKT → MTOR → S6K N00046        KIT* → PI3K → PIP3 → AKT ⊣ BAD N00218    FLT3LG → FLT3 → GRB2 → SOS → RAS → PI3K → PIP3 → AKT → MTOR       D1,D2  |                             N00031        FLT3* → GRB2 → SOS → RAS → PI3K → PIP3 → AKT ⊣ BAD N00032                    (KRAS*,NRAS*) → PI3K → PIP3 → AKT ⊣ BAD JAK-STAT signaling N00219    FLT3LG → FLT3 → STAT5       D1,D2  |         N00054        FLT3* → STAT5 ⇒ PIM1/2 Transcription N00116    RUNX1* ⌿ (CSF1R,MPO,CSF2,IL.. N00111    AML1-ETO ⊣ CEBPA ⇒ PER2 N00112    AML1-ETO ⊣ SPI1 ⇒ (CD14,ITGAM,FCGR1A.. N00108    AML1-ETO ⇒ JUP N00109    PML-RARA ⇒ (JUP,CCNA1) N00113    PML-RARA ⫤ (CEBPE,BCL2A1) N00110    PLZF-RARA ⇒ (JUP,CCNA1,MYC) N00114    PLZF-RARA ⫤ DUSP6

		Drug name
D1	D05029	Midostaurin (JAN/USAN/INN)
D2	D10800	Gilteritinib fumarate (JAN/USAN)