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ENTRY	nt06515
Name	Regulation of kinetochore-microtubule interactions
Category	Pathway view; Cellular process
Pathway	hsa04110 Cell cycle
Disease	H01288 Mosaic variegated aneuploidy syndrome H00268 Lissencephaly H00269 Primary microcephaly H01881 Complex cortical dysplasia with other brain malformations
Display	drug-target relation   disease type

N01525    CENPA = CENPC = CENP-LN+CENP-HIKM+.. = CENP-TWSX     SSMGA             CENPT*   N01526    CPC = CENPC = MIS12C+KNL1C+CENP-.. → CPC+CENPC+MIS12C+K.. = CENP-TWSX = NDC80C     MCPH4         KNL1*   N01532            MIS12 = CEP57 = (MAD1+MAD2)     MVA2             CEP57*     PC                 MAD1*   N01529    AURKB − NDC80 = MPS1 − KNL1 = (BUB1+BUB3+BUBR1) = (MAD1+MAD2) → KNL1+MCC     MCPH30/CRC                 BUB1*     MVA1/CRC                 BUBR1*   N01533                        TRIP13+MAD2L1BP ⊣ MCC ⊣ ANAPC     MVA3                     TRIP13*   N01536    NDC80C = (SKA1+SKA2+SKA3) = PP1 ⊣ (MPS1,AURKB)     NSLH2         PPP1CB*   N01531    (AURKA,AURKB) ⊣ PP1 − CENPE+(SKAP+Astrin.. = NDC80C     CRC AURKA*     MCPH13         CENPE*     ROCHIS         SKAP*   N01534    BUB1+CENPF = RZZ = (NDE1+NDEL1+LIS1),.. = Dynein     STROMS CENPF*     LIS4/MHAC         NDE1*     LIS1         LIS1*     HMN7B/Perry         DCTN1*     CMT2O/SMALED1/MRD13             DYNC1H1*     SRTD3             DYNC2H1*     NEDMIBA             DYNC1I2*     SRTD15             DYNC2LI1*   N01535    (CENPF,BUBR1) = CENPE = microtubule     LIS3         TUBA1A*     KTCN         TUBA3D*     ALS22         TUBA4A*     MACTHC2         TUBA8*     CDCBM6/CSCSC1         TUBB*     MACTHC1         TUBB1*     CDCBM5         TUBB2A*     CDCBM7         TUBB2B*     CDCBM1/CFEOM3A         TUBB3*     HLD6/DYT4         TUBB4A*     LCAEOD         TUBB4B*     FPVEPD         TUBB6*     OOMD2         TUBB8*   N01544    CDK5RAP2 = gamma-TuRC+TPX2 = ch-TOG = microtubule     MCPH3 CDK5RAP2* N01549        gamma-TuRC = Augumin = TPX2+microtubule     CDCBM4     TUBG1*     PAMDDFS     TUBGCP2*     MCCRP3     TUBGCP4*     MCCRP1     TUBGCP6*   N01547    AURKA − (TACC3+ch-TOG) → (TACC3+ch-TOG) = microtubule → clathrin = (TACC3+ch-TOG) = microtubule N01548                    CLTC+PIK3C2A = TACC3     MRD56                 CLTC*     OCSKD                 PIC3C2A*   N01553        (CLIP1,CLIP2)+(CLA.. = EB1 = microtubule   N01561    (AURKA,AURKB) ⊣ (MCAK+KIF18B) = EB1,EB3 = microtubule   N01562    PLK1 → KIF2A = DDA3 = microtubule N01563    (AURKA,AURKB) ⊣ KIF2A     CDCBM3     KIF2A*

		Disease name	Disease category
SSMGA	H02607	Short stature and microcephaly with genital anomalies	Congenital malformation
MCPH4	H00269	Primary microcephaly	Congenital malformation
MVA2	H01288	Mosaic variegated aneuploidy syndrome	Chromosomal abnormality
PC	H00024	Prostate cancer	Cancer
MCPH30/CRC	H00269	Primary microcephaly	Congenital malformation
	H00020	Colorectal cancer	Cancer
MVA1/CRC	H01288	Mosaic variegated aneuploidy syndrome	Chromosomal abnormality
	H00020	Colorectal cancer	Cancer
MVA3	H01288	Mosaic variegated aneuploidy syndrome	Chromosomal abnormality
NSLH2	H02191	Noonan-like syndrome with loose anagen hair	Congenital malformation
CRC	H00020	Colorectal cancer	Cancer
MCPH13	H00269	Primary microcephaly	Congenital malformation
ROCHIS	H02585	Roifman-Chitayat syndrome	Immune system disease
STROMS	H01814	Stromme syndrome	Congenital malformation
LIS4/MHAC	H00268	Lissencephaly	Congenital malformation
	H01870	Microhydranencephaly	Congenital malformation
LIS1	H00268	Lissencephaly	Congenital malformation
HMN7B/Perry	H00856	Distal hereditary motor neuropathies	Nervous system disease
	H00879	Perry syndrome	Neurodegenerative disease
CMT2O/SMALED1/MRD13	H00264	Charcot-Marie-Tooth disease	Neurodegenerative disease
	H00455	Spinal muscular atrophy	Neurodegenerative disease
	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
SRTD3	H02157	Short-rib thoracic dysplasia	Congenital malformation
NEDMIBA	H02461	Neurodevelopmental disorder with microcephaly	Congenital malformation
SRTD15	H02157	Short-rib thoracic dysplasia	Congenital malformation
LIS3	H00268	Lissencephaly	Congenital malformation
KTCN	H00789	Keratoconus	Nervous system disease
ALS22	H00058	Amyotrophic lateral sclerosis (ALS)	Neurodegenerative disease
MACTHC2	H01740	Macrothrombocytopenia	Hematologic disease
CDCBM6/CSCSC1	H01881	Complex cortical dysplasia with other brain malformations	Congenital malformation
	H01579	Congenital symmetric circumferential skin creases	Congenital malformation
MACTHC1	H01740	Macrothrombocytopenia	Hematologic disease
CDCBM5	H01881	Complex cortical dysplasia with other brain malformations	Congenital malformation
CDCBM7	H01881	Complex cortical dysplasia with other brain malformations	Congenital malformation
CDCBM1/CFEOM3A	H01881	Complex cortical dysplasia with other brain malformations	Congenital malformation
	H00838	Congenital fibrosis of the extraocular muscles	Nervous system disease
HLD6/DYT4	H00679	Hypomyelinating leukodystrophy	Inherited metabolic disorder
	H00831	Primary dystonia	Nervous system disease
LCAEOD	H00837	Leber congenital amaurosis	Nervous system disease
FPVEPD	H02594	Congenital facial palsy with ptosis and velopharyngeal dysfunction	Nervous system disease
OOMD2	H01897	Oocyte/zygote/embryo maturation arrest	Reproductive system disease
MCPH3	H00269	Primary microcephaly	Congenital malformation
CDCBM4	H01881	Complex cortical dysplasia with other brain malformations	Congenital malformation
PAMDDFS	H02606	Pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures	Congenital malformation
MCCRP3	H01880	Autosomal recessive microcephaly and chorioretinopathy	Congenital malformation
MCCRP1	H01880	Autosomal recessive microcephaly and chorioretinopathy	Congenital malformation
MRD56	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
OCSKD	H02595	Oculoskeletodental syndrome	Congenital malformation
CDCBM3	H01881	Complex cortical dysplasia with other brain malformations	Congenital malformation